6 completed, 3 recruiting, 3 unknown, 2 withdrawn. 16 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 16 | Completed 6, Recruiting 3, Unknown 3, Withdrawn 2, Not yet recruiting 1, Terminated 1 |
Follow Bone Diseases, Infectious: new trials by email Literature Review of Bone Diseases, Infectious trials Research Report on Bone Diseases, Infectious
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparison of Oral Antibiotics For Bone Infections of the Leg and Foot Oral Beta-Lactam Antibiotic, Oral Non-Beta-Lactam Antibiotic - Osteomyelitis of Lower Extremities, Osteomyelitis - Foot | Phase 4 | Recruiting | Michael Garron Hospital | 1418 | 2026-02-26 | 2026-03-27 |
| Antibiotic Impregnated Beads in Osteomyelitis Antibiotic loaded calcium sulfate beads, Calcium sulfate beads (sham beads) - Osteomyelitis of the Foot, Antibiotic Impregnated Beads | Phase 4 | Not yet recruiting | University of Arizona | 100 | 2025-09-01 | 2025-07-18 |
| Trimethoprim-sulfamethoxazole vs. Clindamycin for the Treatment of Children With Invasive MRSA Infections Trimethoprim Sulfamethoxazole - Methicillin Resistant Staphylococcus Aureus, Osteomyelitis Acute | Phase 4 | Recruiting | Indiana University | 100 | 2025-05-20 | 2026-07-29 |
| BonE and Joint Infections - Simplifying Treatment in Children Trial Oral cefalexin only, IV cefazolin or IV flucloxacillin followed by oral cefalexin - Bone Infection, Septic Arthritis | Phase 4 | Recruiting | Murdoch Childrens Research Institute | 214 | 2021-06-01 | 2026-10-27 |
| Oral-only Antibiotics for Bone and Joint Infections in Children Oral co-amoxiclav or oral dicloxacillin only, IV ceftriaxon followed by oral co-amoxiclav or oral dicloxacillin - Osteomyelitis, Septic Arthritis | Phase 4 | Completed | Copenhagen University Hospital, Rigshospitalet | 180 | 2020-09-15 | 2025-04-13 |
| Ceftriaxone as Home IV for Staph Infections Ceftriaxone, Usual Antibiotics (Cloxacillin, Cefazolin, Daptomycin) - Staphylococcal Infections, Osteomyelitis | Phase 4 | Unknown | Vancouver Island Health Authority | 310 | 2019-07-11 | 2019-10-28 |
| Dalbavancin For The Treatment of Gram Positive Osteoarticular Infections Dalbavancin, Vancomycin - Bone Infection, Osteomyelitis | Phase 4 | Completed | Infectious Diseases Physicians, Inc. | 41 | 2018-01-25 | 2023-10-03 |
| Investigation of Rifampin to Reduce Pedal Amputations for Osteomyelitis in Diabetics Rifampin, Riboflavin Placebo - Osteomyelitis, Diabetes | Phase 4 | Completed | VA Office of Research and Development | 843 | 2018-01-22 | 2026-04-20 |
| Study to Evaluate the Safety and Efficacy of Secukinumab 300 mg and 150 mg in Adult Patients With Active Psoriatic Arthritis (PsA) After 16 Weeks of Treatment Compared to Placebo Secukinumab 300 mg, Secukinumab 150 mg, Placebo - Psoriatic Arthritis | Phase 4 | Completed | Novartis Pharmaceuticals | 258 | 2016-06-27 | 2021-10-07 |
| The Optimal Duration of Preoperative Anti-tuberculosis Treatment of Spinal Tuberculosis Isoniazid, Rifampicin, Ethambutol - Tuberculosis, Spinal | Phase 4 | Unknown | Beijing Chest Hospital | 400 | 2015-04-01 | 2015-06-23 |
| CERAMENT™|G - Bone Healing and Re-infection Prophylaxis Cerament G - Osteomyelitis | Phase 4 | Unknown | Dr. Olivier Borens | 15 | 2014-05-01 | 2015-12-02 |
| Ceftaroline in the Treatment of Bone and Joint Infections Ceftaroline - Osteomyelitis, Joint Infections | Phase 4 | Withdrawn | Orlando Health, Inc. | 2013-04-01 | 2014-08-07 | |
| Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Vancomycin, Ceftaroline, Daptomycin - Health Care Associated Pneumonia, Osteomyelitis/Septic Arthritis | Phase 4 | Terminated | Henry Ford Health System | 100 | 2011-10-01 | 2023-05-03 |
| a Randomized Controlled Trial Comparing Medical and Medical-surgical Treatment in Diabetic Foot Osteomyelitis Medical/surgical treatment versus medical treatment - Diabetic Foot | Phase 4 | Withdrawn | Assistance Publique - Hôpitaux de Paris | 2008-06-01 | 2012-09-17 | |
| Efficacy and Safety Study of Infliximab (Remicade) to Treat Early Ankylosing Spondylitis infliximab - Spondylitis | Phase 4 | Completed | Gu Jieruo | 70 | 2008-01-01 | 2016-01-26 |
| Comparison of Two Antimicrobial Therapy Duration for Spondylodiscitis antibiotic - Vertebral Osteomyelitis | Phase 4 | Completed | Assistance Publique - Hôpitaux de Paris | 351 | 2006-11-01 | 2013-05-06 |
Osteomyelitis (12) · Arthritis, Infectious (6) · Spondylitis (2) · Abscess (1) · Arthritis (1) · Arthritis, Psoriatic (1) · Bacteremia (1) · Central Nervous System Infections (1) · Diabetes Mellitus (1) · Diabetic Foot (1) · Discitis (1) · Endocarditis (1) · Mastoiditis (1) · Multiple Endocrine Neoplasia Type 1 (1) · Orbital Cellulitis (1)
Bone Diseases (16) · Infections (16) · Musculoskeletal Diseases (16) · Joint Diseases (8) · Arthritis (7) · Spinal Diseases (4) · Bacterial Infections (3) · Bacterial Infections and Mycoses (3) · Endocrine System Diseases (3) · Skin and Connective Tissue Diseases (3) · Cardiovascular Diseases (2) · Gram-Positive Bacterial Infections (2) · Inflammation (2) · Pathologic Processes (2)
Cefazolin (3) · Daptomycin (3) · Ceftaroline (2) · Rifampin (2) · Vancomycin (2) · Amoxicillin-Potassium Clavulanate Combination (1) · Anti-Bacterial Agents (1) · Ceftriaxone (1) · Cloxacillin (1) · Dicloxacillin (1) · Ethambutol (1) · Infliximab (1) · Injections (1) · Isoniazid (1) · Linezolid (1)
Assistance Publique - Hôpitaux de Paris (2) · Beijing Chest Hospital (1) · Copenhagen University Hospital, Rigshospitalet (1) · Dr. Olivier Borens (1) · Gu Jieruo (1) · Henry Ford Health System (1) · Indiana University (1) · Infectious Diseases Physicians, Inc. (1) · Michael Garron Hospital (1) · Murdoch Childrens Research Institute (1) · Novartis Pharmaceuticals (1) · Orlando Health, Inc. (1) · University of Arizona (1) · VA Office of Research and Development (1) · Vancouver Island Health Authority (1)
United States (6) · Canada (2) · China (2) · Australia (1) · Denmark (1) · France (1) · Ireland (1) · New Zealand (1) · Puerto Rico (1) · Switzerland (1)
Allan Bybeck Nielsen, MD (1) · Amanda Gwee, PhD (1) · Donald Poretz, MD (1) · Eric Partlow, MD, FRCPC (1) · James Wood, MD (1) · Jose Vazquez, M.D. (1) · Louis Bernard, PU-PH (1) · Mark R. Wallace, MD (1) · Mary T Bessesen, MD (1) · Ulrikka Nygaard, Ass Prof PhD (1)
PMID 25468170, PMID 25984880, PMID 26438497, PMID 31914940, PMID 35428722, PMID 37263683, PMID 39025092