68 completed, 38 unknown, 31 recruiting, 13 not yet recruiting. 51 Not applicable, 18 Phase 4, 12 Phase 2, 8 Phase 3, 1 Phase 1.
Follow Endocarditis: new trials by email Literature Review of Endocarditis trials Research Report on Endocarditis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of Fosfomycin-containing Antibiotic Regimens for the Treatment of Infective Endocarditis in Clinical Practice Fosfomycin - Infective Endocarditis (IE) | Not yet recruiting | Ente Ospedaliero Ospedali Galliera | 120 | 2027-01-10 | 2026-11-10 | |
| Dalbavancin Therapy for Infective Endocarditis Dalbavancin administration, Standard of Care (Investigator Choice) - Endocarditis Infective, Endocarditis, Bacterial | Phase 3 | Not yet recruiting | Stefan Hagel | 184 | 2026-12-01 | 2026-07-13 |
| Metabolic Profiling Among Patients Suspected of Infective Endocarditis - PPSIE Comparing Metabolomes of Bloodstream Infections Versus Infective Endocarditis Blood sample - Infective Endocarditis (IE) | Not applicable | Not yet recruiting | University Hospital, Angers | 240 | 2026-11-01 | 2026-11-04 |
| A Study of Ceftobiprole Compared With Standard Antibiotic Treatment in Children With Staphylococcus Aureus Bacteremia (SAB) Infection, Including Right-sided Heart Infection Ceftobiprole medocaril sodium, Standard of Care (SOC) - Staphylococcus Aureus Bacteremia, Endocarditis, Bacterial | Phase 3 | Not yet recruiting | ISTx, LLC | 60 | 2026-10-30 | 2026-11-10 |
| AngioVac Aspiration Therapy Registry Retrospective analysis of assigned treatment - Intracardiac Thrombus, Intracardiac Mass | Not yet recruiting | Charite University, Berlin, Germany | 1000 | 2026-10-01 | 2026-10-20 | |
| A Prospective Diagnostic Trial of Al[¹⁸F]F-NOTA-folate PET in Patients With Suspected Cardiac Sarcoidosis and Infective Endocarditis Al[¹⁸F]F-NOTA-folate PET imaging, [15O]water PET imaging, Echocardiography - Cardiac Sarcoidosis, Infective Endocarditis | Not applicable | Recruiting | Turku University Hospital | 143 | 2026-09-14 | 2026-09-21 |
| Oritavancin for Treatment of Serious Cardiac Infections Oritavancin - Infective Endocarditis, Cardiac Device Infection | Phase 2 | Not yet recruiting | Kirby Institute | 20 | 2026-07-01 | 2026-04-29 |
| Rifampin-free Regimen Versus Rifampin-containing Regimen in the Treatment of Staphylococcal Prosthetic Valve Endocarditis Rifampin-free regimen, Rifampin containing regimen - Infective Endocarditis | Phase 3 | Recruiting | Nantes University Hospital | 422 | 2026-06-11 | 2026-10-21 |
| Long Term Management and Outcomes of Surgical and Non Surgical Infective Endocarditis Infective Endocarditis (IE) | Active not recruiting | Centro Cardiologico Monzino | 1046 | 2026-06-01 | 2026-09-17 | |
| Anemia Therapy in Patients With Infective Endocarditis Adjunctive anemia therapy - Infective Endocarditis (IE), Severe Anemia | Phase 4 | Recruiting | Copenhagen University Hospital, Rigshospitalet | 74 | 2026-05-15 | 2026-05-29 |
| The Study Tests if Preoperative Dental Screening is Superior to no Preoperative Dental Screening in Improving the Outcome of Patients Undergoing Surgical Cardiac Valve Replacement or Transcatheter Cardiac Valve Implantation. Preoperative dental screening, No preoperative dental screening - Infective Endocarditis (IE), Heart Valve Disease | Not applicable | Recruiting | Region Skane | 1300 | 2026-05-06 | 2026-05-19 |
| From Commensalism to Pathogenicity: Exploring the Pathophysiology of Bacteremia to Better Understand Enterococcus Faecalis Infective Endocarditis Microbiological sampling (swab collection) - Infective Endocarditis (IE) | Not applicable | Recruiting | University Hospital, Clermont-Ferrand | 90 | 2026-04-17 | 2026-10-13 |
| Percutaneous AngioVac Vegetation Extraction (PAVE) to Remove Right Heart Vegetations in Patients With Infective Endocarditis AngioVac System - Infective Endocarditis (IE) | Not applicable | Not yet recruiting | Angiodynamics, Inc. | 30 | 2026-04-01 | 2026-04-22 |
| Transthoracic Echocardiography in Assessing Patients With Suspected Endocarditis Endocarditis Infective | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 350 | 2026-03-01 | 2026-02-17 | |
| Evaluation of the Benefits of Hypnosis During Transoesophageal Echocardiography conversational hypnosis - Cardio Vascular Disease | Not applicable | Recruiting | Fondation Hôpital Saint-Joseph | 150 | 2026-02-18 | 2026-04-06 |
| Etiologic Diagnosis Algorithm in Infective Endocarditis Molecular tests (PCR, sequencing), Standard Clinical Practice - Infective Endocarditis, Microbiology | Not applicable | Recruiting | I.M. Sechenov First Moscow State Medical University | 128 | 2026-01-20 | 2026-07-02 |
| Belgian Infective Endocarditis Registry Infective Endocarditis | Not yet recruiting | Universitair Ziekenhuis Brussel | 300 | 2025-09-01 | 2025-08-28 | |
| Inflammation and Infective Endocarditis Infective Endocarditis (IE) | Withdrawn | Barts & The London NHS Trust | 2025-08-01 | 2025-11-19 | ||
| Endocarditis Clinical Awareness, Research, and Evaluation in Sweden Endocarditis Infective, Endocarditis Acute and Subacute | Active not recruiting | Karolinska Institutet | 22000 | 2025-07-01 | 2026-06-30 | |
| Evaluation of the Impact of a Patient Education Protocol on the Quality of 18F-FDG PET Imaging Indicated for Investigation of Cardiac Inflammation Sending a link to the video, Compliance questionnaire, Determination of beta-hydroxybutyrate (BHB) in capillary blood - Infective Endocarditis, Cardiac Sarcoidosis | Not applicable | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 138 | 2025-07-01 | 2025-06-19 |
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Endocarditis, Bacterial (22) · Bacteremia (19) · Endocarditis, Subacute Bacterial (10) · Sepsis (10) · Staphylococcal Infections (10) · Heart Valve Diseases (7) · Gram-Positive Bacterial Infections (6) · Acute Kidney Injury (4) · Disease (4) · Osteomyelitis (4) · Aortic Valve Disease (3) · Bacterial Infections (3) · Heart Defects, Congenital (3) · Heart Failure (3)
Cardiovascular Diseases (177) · Heart Diseases (177) · Infections (60) · Bacterial Infections and Mycoses (54) · Bacterial Infections (51) · Pathological Conditions, Signs and Symptoms (41) · Pathologic Processes (38) · Cardiovascular Infections (32) · Inflammation (27) · Systemic Inflammatory Response Syndrome (27) · Sepsis (17) · Gram-Positive Bacterial Infections (16) · Vascular Diseases (12) · Nervous System Diseases (11)
Vancomycin (9) · Daptomycin (7) · Amoxicillin (4) · Ceftriaxone (4) · Levofloxacin (4) · Cardiac Surgical Procedures (3) · Fosfomycin (3) · Gentamicins (3) · Injections (3) · Linezolid (3) · Standard of Care (3) · Ampicillin (2) · Anti-Bacterial Agents (2) · Blood Culture (2) · Blood Specimen Collection (2)
Assistance Publique - Hôpitaux de Paris (10) · Central Hospital, Nancy, France (6) · Copenhagen University Hospital, Rigshospitalet (6) · University Hospital, Strasbourg, France (5) · Assistance Publique Hopitaux De Marseille (4) · Assiut University (4) · Fondation Hôpital Saint-Joseph (4) · University Hospital, Bordeaux (4) · Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (3) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (3) · Jena University Hospital (3) · Centre Chirurgical Marie Lannelongue (2) · Centre Hospitalier Universitaire de Besancon (2) · Emil Loldrup Fosbol (2) · Fundación Pública Andaluza para la gestión de la Investigación en Sevilla (2)
France (51) · United States (21) · Denmark (15) · Italy (14) · Germany (13) · Spain (12) · Sweden (8) · United Kingdom (8) · Canada (5) · Switzerland (5) · Netherlands (4) · South Korea (3) · China (2) · Egypt (2) · Finland (2)
Xavier Duval (4) · Alain Fraisse, MD, PhD (2) · Christine Selton-Suty, MD (2) · Ali Mohammed Abd-Elwahab, professor (1) · Alicja Zientara, MD (1) · Ann-Dorthe Zwisler, MD, Ph.d. (1) · Beata Sarecka-Hujar, Professor (1) · Benoit Fontenel, MD (1) · Bhanu Sinha, MD, PhD (1)
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2019 (3), 2017 (1), 2025 (1), K23DA054363 (1), R01DA048892 (1), R01DE013559 (1)