52 completed, 17 recruiting, 11 not yet recruiting, 11 unknown. 44 Phase 2, 34 Phase 3, 12 Phase 4, 8 Not applicable, 8 Phase 1.
Follow Ethambutol: new trials by email Literature Review of Ethambutol trials Research Report on Ethambutol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing a Novel Combination Treatment (Arm D) Versus Standard of Care for Intensive Phase Treatment for Mycobacterium Abscessus Pulmonary Disease in People With or Without Cystic Fibrosis in the Finding the Optimal Regimen for Mycobacterium Abscessus Treatment (FORMaT) Adaptive Platform Trial Sulbactam 25mg/kg -Durlobactam 25mg/kg (Every 6 hours), Ceftriaxone for Injection, Amoxicillin - Mycobacterium Abscessus Pulmonary Disease, Mycobacterium Abscessus Infection | Phase 2 | Not yet recruiting | The University of Queensland | 300 | 2027-04-01 | 2026-03-20 |
| A Trial of Stratified Patient-Centered Treatment Regimens for Active TB (SPECTRA-TB) Isoniazid, Rifampin, Pyrazinamide - Tuberculosis | Phase 2 | Not yet recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 900 | 2026-10-30 | 2026-08-19 |
| Re-evaluating the Duration in Children of TB Treatment Rifampicin, Isoniazid, Pyrazinamide - Tuberculosis | Phase 2 | Not yet recruiting | University of Wisconsin, Madison | 230 | 2026-10-01 | 2026-09-29 |
| AIPH-TB: AI-Optimised Pyrazinamide-Hydroxychloroquine vs Standard RIPE for Drug-Sensitive Pulmonary Tuberculosis - A Phase II RCT Pyrazinamide and Hydroxychloroquine (AI-Optimised), Standard RIPE Regimen (Rifampicin, Isoniazid, Pyrazinamide, Ethambutol) - Pulmonary Tuberculosis | Phase 2 | Not yet recruiting | Ministry of Health, Saudi Arabia | 200 | 2026-09-01 | 2026-03-12 |
| Enhanced Treatment Strategy for Disseminated MAC Infection in HIV Patients: A Randomized Controlled Trial Standard Triple Therapy, Experimental: Standard Triple Therapy Plus Fluoroquinolone - Opportunistic Infections, HIV Related, Disseminated Mycobacterium Avium Complex Infection | Not applicable | Not yet recruiting | Shanghai Public Health Clinical Center | 124 | 2026-04-30 | 2026-05-13 |
| ATORvastatin in Pulmonary TUBerculosis: a POPulation PharmacoKinetics -PharmacoDynamics Sub-study (ATORTUB popPK-PD) Atorvastatin 20 mg, Atorvastatin 40 mg, Atorvastatin 60 mg - Pulmonary Tuberculosis (TB) | Phase 2 | Recruiting | Obafemi Awolowo University Teaching Hospital | 80 | 2026-01-03 | 2026-01-23 |
| Optimal Treatment Duration for Radiographically Apparent, Bacteriologically Unconfirmed TB, Identified Through Active Case Finding (RADIO-TB Trial) Isoniazid (H), Rifampicin (R), Pyrazinamide (Z) - Tuberculosis (TB) | Phase 3 | Not yet recruiting | University College, London | 784 | 2025-11-01 | 2025-09-09 |
| Short-Course Regimen With Bedaquiline, Moxifloxacin and Pyrazinamide for Early Bactericidal Activity in Drug-Susceptible Tuberculosis Bedaquiline (B), Moxifloxacin, Pyrazinamide (PZA) - Tuberculosis, Pulmonary, Drug-Susceptible Pulmonary Tuberculosis | Phase 2 | Not yet recruiting | Shanghai Pulmonary Hospital, Shanghai, China | 45 | 2025-08-20 | 2025-08-19 |
| Ultra-Short Regimen for Elderly DS-TB Bedaquiline (B), Sitafloxacin (S), Linezolid (L) - Pulmonary Tuberculosis | Phase 3 | Not yet recruiting | Shenzhen Third People's Hospital | 300 | 2025-07-25 | 2025-07-22 |
| Short-term Bactericidal Effect of Contezolid in MAC-PD Contezolid, Azithromcyin, Rifampicin (RIF) - Mycobacterium Avium Complex Pulmonary Disease | Phase 4 | Recruiting | Bin Cao | 188 | 2025-07-24 | 2025-09-18 |
| Short-term Antibiotic Therapy in Mycobacterium Avium Complex Pulmonary Disease Contezolid, Azithromycin, Ethambutol (E) - Mycobacterium Avium Complex Pulmonary Disease | Phase 4 | Recruiting | Bin Cao | 188 | 2025-07-24 | 2025-10-09 |
| Comparison of the Outcome of Treatment With Silymarin or N-Aceylcysteine in Patients Taking Anti-Tuberculous Drugs for Tuberculosis at a Tertiary Care Hospital , Karachi Silymarin 420 mg, N Acetyl Cysteine, Rifampicin (RMP) Ethambutol (E) Isoniazid (H) Pyrazinamid (Z) - Drug Induced Liver Injury, Tuberculosis (TB) | Phase 1 | Not yet recruiting | Liaquat National Hospital & Medical College | 410 | 2025-07-01 | 2025-07-10 |
| A PAN-USR TB Multi-Center Trial Bedaquiline (B), Sitafloxacin (S), Linezolid (L) - Pulmonary Tuberculosis | Phase 3 | Recruiting | Shenzhen Third People's Hospital | 610 | 2025-06-18 | 2025-12-01 |
| Short-Course Anti-tuberculosis Regimens for Mild Spinal Tuberculosis Rifampin, Isoniazid, Rifapentine (RPT) - Mild Spinal Tuberculosis | Phase 2 | Not yet recruiting | Shandong University | 300 | 2025-04-05 | 2025-04-08 |
| Trial of Novel Regimens for the Treatment of Pulmonary Tuberculosis Isoniazid, Rifampicin, Pyrazinamide - Pulmonary Tuberculosis | Phase 2 | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 315 | 2025-03-11 | 2026-10-19 |
| A Study of the Early Effects, Safety, and Acceptability of Oral Alpibectir in Combination With Ethionamide Alpibectir 45 mg once daily (OD) plus Ethionamide 125 mg OD, Alpibectir 45 mg OD plus Ethionamide 250 mg OD, Isoniazid, rifampicin, pyrazinamide and ethambutol fixed dose combination, weight based - Tuberculosis | Phase 2 | Recruiting | TASK Applied Science | 60 | 2025-03-03 | 2025-03-07 |
| Shortened Regimen for Drug-susceptible TB in Children Isoniazid, Rifampin, Pyrazinamide - Tuberculosis, Tuberculosis, Pulmonary | Phase 3 | Recruiting | Johns Hopkins University | 860 | 2025-01-15 | 2026-07-24 |
| Platform Assessing Regimens and Durations In a Global Multisite Consortium for TB Ganfeborole, BTZ-043, Bedaquiline (B) - Pulmonary Tuberculosis | Phase 2 | Recruiting | University College, London | 2500 | 2024-01-09 | 2026-10-15 |
| ATORvastatin in Pulmonary TUBerculosis Atorvastatin 20mg, Atorvastatin 40mg, Atorvastatin 60mg - Pulmonary Tuberculosis, Tuberculosis | Phase 2 | Recruiting | Obafemi Awolowo University Teaching Hospital | 440 | 2024-01-03 | 2025-09-25 |
| Innovating Shorter, All- Oral, Precised, Individualized Treatment Regimen for Rifampicin Resistant Tuberculosis：Contezolid, Delamanid and Bedaquiline Cohort Bedaquiline, Delamanid, Contezolid - Pulmonary Tuberculosis, Rifampicin-resistant Tuberculosis | Phase 3 | Active not recruiting | Beijing Chest Hospital | 186 | 2023-12-22 | 2025-04-01 |
Showing 20 of 102. Sign in to see all of them.
Tuberculosis (45) · Tuberculosis, Pulmonary (40) · HIV Infections (20) · Acquired Immunodeficiency Syndrome (14) · Mycobacterium avium-intracellulare Infection (12) · AIDS-Related Opportunistic Infections (6) · Mycobacterium Infections, Nontuberculous (6) · Mycobacterium Infections (5) · Tuberculosis, Multidrug-Resistant (4) · Lung Diseases (3) · Sarcoidosis (3) · Infections (2) · Latent Tuberculosis (2) · Bacteremia (1) · Bacterial Infections (1)
National Institute of Allergy and Infectious Diseases (NIAID) (16) · Tuberculosis Research Centre, India (5) · Beijing Chest Hospital (4) · Centers for Disease Control and Prevention (4) · Global Alliance for TB Drug Development (3) · Johns Hopkins University (3) · Michael Hoelscher (3) · University College, London (3) · Vanderbilt University (3) · Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections (2) · Bin Cao (2) · Insmed Incorporated (2) · Obafemi Awolowo University Teaching Hospital (2) · Pharmacia (2) · Seoul National University Hospital (2)
United States (28) · South Africa (26) · Uganda (17) · India (14) · China (12) · Tanzania (10) · Brazil (9) · Philippines (9) · Vietnam (8) · Thailand (7) · Canada (6) · Haiti (6) · Peru (6) · Zimbabwe (6) · Kenya (5)
Bolanle A Omotoso, MD (2) · Nicholas Paton (2) · Olanisun O Adewole, MD (2) · Soumya Swaminathan, MD MNAMS (2) · Susan Dorman, MD (2) · Wonder P Drake, MD (2) · A K Jain, MBBS FICA (1) · A-Dong Shen, Master (1) · Alexander Pym, MB BMRCP PhD (1) · Ali Zumla, BSc MBChB MSc PhD (1) · Amina Jindani, MD (1) · Andreas Diacon, BM MD (1)
PMID 36808186, PMID 33542052, PMID 38768617, PMID 16470119, PMID 16988514, PMID 17928422, PMID 18366444, PMID 18795962, PMID 18989231, PMID 19406981, PMID 19542476, PMID 19965813, PMID 20002783, PMID 20632458, PMID 21283017, PMID 21494548, PMID 21813327, PMID 22083071, PMID 22116143, PMID 22129166, PMID 22155817, PMID 23216571, PMID 23251327, PMID 23305215, PMID 23317958, PMID 23392467, PMID 23433590, PMID 23863960, PMID 24099345, PMID 24284293, PMID 24663014, PMID 24903795, PMID 25162818, PMID 25196020, PMID 25261418, PMID 25363329, PMID 25407158, PMID 25950206, PMID 25959631, PMID 26038418, PMID 26095067, PMID 26104205, PMID 26202768, PMID 26400476, PMID 26847437, PMID 26918544, PMID 26929418, PMID 27159505, PMID 27540363, PMID 27550361
U01AI068636 (2), 2019 (1), 2023 (1), 5UL1RR024982-02 (1), R01HL117074 (1), U01AI134585 (1), U01AI170426 (1), U01AI192041 (1), UL1TR001082 (1)