103 completed, 29 unknown, 19 recruiting, 16 terminated. 61 Phase 2, 60 Phase 3, 30 Phase 4, 28 Phase 1, 27 Not applicable.
Follow Isoniazid: new trials by email Literature Review of Isoniazid trials Research Report on Isoniazid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Trial of Stratified Patient-Centered Treatment Regimens for Active TB (SPECTRA-TB) Isoniazid, Rifampin, Pyrazinamide - Tuberculosis | Phase 2 | Not yet recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 900 | 2026-10-30 | 2026-08-19 |
| Optimal Treatment Duration for Radiographically Apparent, Bacteriologically Unconfirmed TB, Identified Through Active Case Finding (RADIO-TB Trial) Isoniazid (H), Rifampicin (R), Pyrazinamide (Z) - Tuberculosis (TB) | Phase 3 | Recruiting | University College, London | 784 | 2026-10-12 | 2026-10-26 |
| Re-evaluating the Duration in Children of TB Treatment Rifampicin, Isoniazid, Pyrazinamide - Tuberculosis | Phase 2 | Not yet recruiting | University of Wisconsin, Madison | 230 | 2026-10-01 | 2026-09-29 |
| A Study of Daily Rifapentine Combined With Isoniazid (1HP) for Tuberculosis Prevention in Children Less Than 13 Years of Age With and Without HIV Rifapentine, Isoniazid, Dolutegravir - Tuberculosis | Phase 1 / Phase 2 | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 144 | 2026-09-28 | 2026-10-19 |
| Study of Combinations of Novel Promising Drugs for Pulmonary Tuberculosis TBAJ-587 50 mg, Pretomanid 200mg, Linezolid 600Mg Tab - Tuberculosis, Pulmonary | Phase 2 | Not yet recruiting | TASK Applied Science | 135 | 2026-09-25 | 2026-09-25 |
| AIPH-TB: AI-Optimised Pyrazinamide-Hydroxychloroquine vs Standard RIPE for Drug-Sensitive Pulmonary Tuberculosis - A Phase II RCT Pyrazinamide and Hydroxychloroquine (AI-Optimised), Standard RIPE Regimen (Rifampicin, Isoniazid, Pyrazinamide, Ethambutol) - Pulmonary Tuberculosis | Phase 2 | Not yet recruiting | Ministry of Health, Saudi Arabia | 200 | 2026-09-01 | 2026-03-12 |
| Bedaquiline Roll-out Evidence in Contacts and People Living With HIV to Prevent TB Bedaquiline, Isoniazid, rifapentine, Levofloxacin - Tuberculosis, Latent | Phase 2 / Phase 3 | Recruiting | Johns Hopkins University | 2530 | 2026-05-08 | 2026-10-20 |
| Pharmacokinetics of Antituberculosis Drugs in Breastfeeding Women Standard dose rifampicin, High dose rifampicin, Standard dose isoniazid - Tuberculosis Infection, Healthy Volunteer | Phase 1 | Not yet recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 60 | 2026-04-01 | 2026-02-10 |
| ATORvastatin in Pulmonary TUBerculosis: a POPulation PharmacoKinetics -PharmacoDynamics Sub-study (ATORTUB popPK-PD) Atorvastatin 20 mg, Atorvastatin 40 mg, Atorvastatin 60 mg - Pulmonary Tuberculosis (TB) | Phase 2 | Recruiting | Obafemi Awolowo University Teaching Hospital | 80 | 2026-01-03 | 2026-01-23 |
| A Phase I Study Investigating the Local Tolerability and Pharmacokinetics of Isoniazid (INH) Inhalation by Wet Nebulization in Patients With Tuberculosis Isoniazid - Tuberculosis | Phase 1 | Recruiting | University Medical Center Groningen | 8 | 2025-12-01 | 2026-07-16 |
| Window Prophylaxis for Pediatric Tuberculosis Prevention Trial Tuberculosis window prophylaxis with weekly rifapentine and isoniazid for 12 weeks, Standard of care tuberculosis prophylaxis with weekly rifapentine and isoniazid for 12 weeks - Tuberculosis Infection, Household Contacts | Not applicable | Recruiting | Pontificia Universidad Catolica de Chile | 647 | 2025-10-27 | 2025-12-29 |
| Phase 2 Trial to Evaluate the Safety and Tolerability and Early Bactericidal Activity of RESP30TB in Tuberculosis RESP30TB, HRZE (Rifampicin, Isoniazid, Pyrazinamide, Ethambutol combination) - Pulmonary Tuberculoses | Phase 2 | Recruiting | Thirty Respiratory Limited | 24 | 2025-10-13 | 2026-01-12 |
| Short-Course Regimen With Bedaquiline, Moxifloxacin and Pyrazinamide for Early Bactericidal Activity in Drug-Susceptible Tuberculosis Bedaquiline (B), Moxifloxacin, Pyrazinamide (PZA) - Tuberculosis, Pulmonary, Drug-Susceptible Pulmonary Tuberculosis | Phase 2 | Not yet recruiting | Shanghai Pulmonary Hospital, Shanghai, China | 45 | 2025-08-20 | 2025-08-19 |
| Ultra-Short Regimen for Elderly DS-TB Bedaquiline (B), Sitafloxacin (S), Linezolid (L) - Pulmonary Tuberculosis | Phase 3 | Not yet recruiting | Shenzhen Third People's Hospital | 300 | 2025-07-25 | 2025-07-22 |
| Comparison of the Outcome of Treatment With Silymarin or N-Aceylcysteine in Patients Taking Anti-Tuberculous Drugs for Tuberculosis at a Tertiary Care Hospital , Karachi Silymarin 420 mg, N Acetyl Cysteine, Rifampicin (RMP) Ethambutol (E) Isoniazid (H) Pyrazinamid (Z) - Drug Induced Liver Injury, Tuberculosis (TB) | Phase 1 | Not yet recruiting | Liaquat National Hospital & Medical College | 410 | 2025-07-01 | 2025-07-10 |
| A PAN-USR TB Multi-Center Trial Bedaquiline (B), Sitafloxacin (S), Linezolid (L) - Pulmonary Tuberculosis | Phase 3 | Recruiting | Shenzhen Third People's Hospital | 610 | 2025-06-18 | 2025-12-01 |
| Short-Course Anti-tuberculosis Regimens for Mild Spinal Tuberculosis Rifampin, Isoniazid, Rifapentine (RPT) - Mild Spinal Tuberculosis | Phase 2 | Not yet recruiting | Shandong University | 300 | 2025-04-05 | 2025-04-08 |
| Trial of Novel Regimens for the Treatment of Pulmonary Tuberculosis Isoniazid, Rifampicin, Pyrazinamide - Pulmonary Tuberculosis | Phase 2 | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 315 | 2025-03-11 | 2026-10-19 |
| A Study of the Early Effects, Safety, and Acceptability of Oral Alpibectir in Combination With Ethionamide Alpibectir 45 mg once daily (OD) plus Ethionamide 125 mg OD, Alpibectir 45 mg OD plus Ethionamide 250 mg OD, Isoniazid, rifampicin, pyrazinamide and ethambutol fixed dose combination, weight based - Tuberculosis | Phase 2 | Recruiting | TASK Applied Science | 60 | 2025-03-03 | 2025-03-07 |
| Shortened Regimen for Drug-susceptible TB in Children Isoniazid, Rifampin, Pyrazinamide - Tuberculosis, Tuberculosis, Pulmonary | Phase 3 | Recruiting | Johns Hopkins University | 860 | 2025-01-15 | 2026-07-24 |
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Tuberculosis (113) · Tuberculosis, Pulmonary (49) · Latent Tuberculosis (32) · HIV Infections (27) · Acquired Immunodeficiency Syndrome (21) · Tuberculosis, Multidrug-Resistant (10) · AIDS-Related Opportunistic Infections (8) · Diabetes Mellitus (4) · Tuberculosis, Meningeal (4) · Infertility, Female (3) · AIDS-Related Complex (2) · Chemical and Drug Induced Liver Injury (2) · Diabetes Mellitus, Type 2 (2) · HIV Seropositivity (2) · Hepatitis (2)
National Institute of Allergy and Infectious Diseases (NIAID) (28) · Centers for Disease Control and Prevention (13) · National Taiwan University Hospital (7) · Aswan University Hospital (6) · Johns Hopkins University (6) · University of Cape Town (6) · Global Alliance for TB Drug Development (5) · Tuberculosis Research Centre, India (5) · Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections (4) · Beijing Chest Hospital (4) · Instituto Nacional de Salud Publica, Mexico (4) · Huashan Hospital (3) · Michael Hoelscher (3) · Obafemi Awolowo University Teaching Hospital (3) · TASK Applied Science (3)
South Africa (51) · United States (35) · Uganda (30) · Brazil (21) · India (21) · China (15) · Tanzania (15) · Zimbabwe (15) · Haiti (14) · Kenya (14) · Thailand (14) · Philippines (12) · Botswana (11) · Malawi (11) · Canada (10)
Marc Weiner, MD (4) · Bolanle A Omotoso, MD (3) · Amita Gupta, MD, MHS (2) · Antonio Rivero, MD PhD (2) · Clifton E Barry, Ph.D. (2) · Dick Menzies, MD (2) · Felipes Diez, MD (2) · Fernando Lozano, MD PhD (2) · Gordin F (2) · Jose Carlos Escribano, MD (2) · Joseph A Kovacs, M.D. (2)
PMID 36808186, PMID 22150035, PMID 25359354, PMID 25904367, PMID 27243774, PMID 29393655, PMID 31866327, PMID 32539440, PMID 32785709, PMID 33542052, PMID 36949623, PMID 38768617, PMID 12809582, PMID 15276398, PMID 15840453, PMID 15844071, PMID 16470119, PMID 16776446, PMID 16988514, PMID 17085459, PMID 17504682, PMID 17517835, PMID 17928422, PMID 18070980, PMID 18230259, PMID 18366444, PMID 18419884, PMID 18787216, PMID 18795962, PMID 18989231, PMID 19406981, PMID 19542476, PMID 19564361, PMID 19588358, PMID 19656705, PMID 19886982, PMID 19923475, PMID 19965813, PMID 20002783, PMID 20607114, PMID 20610636, PMID 20627913, PMID 20632458, PMID 20660695, PMID 21283017, PMID 21460373, PMID 21492926, PMID 21494548, PMID 21541021, PMID 21732833
U01AI068636 (3), 2009 (1), 2019 (1), R01AI048526 (1), R01DA041271 (1), R01HD074944 (1), R21AI172182 (1), U01AI051315 (1), U01AI068632 (1), U01AI134585 (1), U01AI152961 (1), U01AI170426 (1), U01AI192041 (1), U54DK083909 (1), UM1AI068636 (1)