632 completed, 127 unknown, 83 recruiting, 36 not yet recruiting. 258 Phase 3, 191 Phase 2, 132 Not applicable, 130 Phase 4, 85 Phase 1.
Follow Central Nervous System Infections: new trials by email Literature Review of Central Nervous System Infections trials Research Report on Central Nervous System Infections
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Doxycycline Boosted Therapy in Lyme Borreliosis: DoBo Study. Hydroxychloroquin, Placebo, Doxycycline - Lyme Borreliosis, Nervous System | Phase 4 | Not yet recruiting | Radboud University Medical Center | 50 | 2027-03-01 | 2026-08-27 |
| Optimizing Care for Cryptococcal Antigenemia: Evaluation of Short Course Fluconazole and ART Timing Among CrAg+ Persons With Low Titers Immediate ART Initiation, Delayed ART Initiation, 10-Week Fluconazole - Cryptococcal Antigenemia, HIV-1-infection | Phase 3 | Not yet recruiting | University of Minnesota | 505 | 2027-01-05 | 2026-09-03 |
| Oxfendazole in Mild Parenchymal Brain Cysticercosis Oxfendazole single dose, Oxfendazole three doses, albendazole plus praziquantel regime - Brain Cysticercosis | Phase 2 / Phase 3 | Not yet recruiting | Universidad Peruana Cayetano Heredia | 544 | 2026-12-01 | 2026-05-01 |
| Pain Phenotyping of Rheumatic Diseases - An Observational Study Bedside quantitative sensory testing - Rheumatic Diseases, Lupus Erythematosus, Systemic | Not yet recruiting | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | 225 | 2026-10-28 | 2026-10-23 | |
| A Trial of ALN-6457 in Adult Participants With Symptomatic Prion Disease (PrD) ALN-6457 - Prion Disease | Phase 1 / Phase 2 | Not yet recruiting | Regeneron Pharmaceuticals | 60 | 2026-10-23 | 2026-09-22 |
| Single-center, Open-label Study: Immunogenicity and Safety Observation After Vaccination With ACYW135 Meningococcal Polysaccharide Vaccine in Junior High School Students Aged 13-15 Years MPSV-ACYW - Meningococcal Disease; Meningococcal Meningitis | Phase 4 | Not yet recruiting | Zhejiang Provincial Center for Disease Control and Prevention | 200 | 2026-10-20 | 2026-10-21 |
| A Phase I/II Clinical Trial of the Diphtheria, Tetanus, Acellular Component Pertussis and Sabin Inactivated Poliomyelitis Vaccine Adsorbed Diphtheria, Tetanus, Acellular Component Pertussis and Sabin Inactivated Poliomyelitis Vaccine Adsorbed, Diphtheria, Tetanus and Acellular Component Pertussis Combined Vaccine, Diphtheria, Tetanus and Acellular Component Pertussis Combined Vaccine+Inactivated Poliomyelitis Vaccine Made From Sabin Strains - Diphtheria, Pertussis | Phase 1 / Phase 2 | Recruiting | Institute of Medical Biology, Chinese Academy of Medical Sciences | 380 | 2026-10-11 | 2026-10-23 |
| Study of BK1803 in Healthy Infants BK1803, GOBIK Aqueous Suspension Syringes, Bimmugen® Injection - Pertussis, Diphtheria | Phase 3 | Not yet recruiting | Tanabe Pharma Corporation | 344 | 2026-10-01 | 2026-08-28 |
| Exploring the Combination of Intracalvariosseous and Intravenous Antibiotics for Moderate to Severe Bacterial Meningitis Intracalvariosseous injection vancomycin/tigecycline/polymyxin B, Intravenous injection vancomycin/tigecycline/polymyxin B, Conventional treatment - Blood-Brain Barrier, Bacterial Meningitis | Not applicable | Not yet recruiting | yilong Wang | 9 | 2026-09-21 | 2026-09-17 |
| A Clinical Trial of the ACYW135 Group Meningococcal Polysaccharide-Conjugated Vaccine (CRM197 Vector) Previously vaccinated with MCV4 (CanSino), Previously vaccinated with MPSV4 (LvZhu) - Epidemic Meningitis | Not yet recruiting | CanSino Biologics Inc. | 180 | 2026-09-15 | 2026-08-03 | |
| Safety and Immunogenicity of a Recombinant Poliomyelitis Vaccine (rPV) in Comparison With IPOL Vaccine in Healthy Adults Recombinant Poliomyelitis Vaccine (rPV), Inactivated Poliomyelitis Vaccine (IPOL) - Polio Immunity | Phase 1 | Recruiting | Serum Institute of India Pvt. Ltd. | 36 | 2026-09-11 | 2026-09-29 |
| Pattern of AFP in Chhidren Admitted at Sohag University Hospital Observitional follow-up - Acute Flaccid Paralysis, AFP | Not yet recruiting | Mohamed Aboelhamd Ali | 30 | 2026-09-01 | 2026-09-11 | |
| PROSPECT Registry for Individuals at Risk for Genetic Prion Disease Prion Diseases | Recruiting | Brian Appleby | 2000 | 2026-08-25 | 2026-09-16 | |
| BPaLMZ for TB Meningitis BPaLMZ Regimen - Tuberculous Meningitis, HIV | Phase 2 | Recruiting | David Boulware | 312 | 2026-07-28 | 2026-10-16 |
| Evaluating VM100 Nutritional Supplement for Improving Quality of Life in Duchenne Muscular Dystrophy Patients VM100 Nutritional Supplement - Duchenne Muscular Dystrophy, Duchenne Disease | Phase 2 | Recruiting | University of Florida | 20 | 2026-07-27 | 2026-10-08 |
| Metagenomic Analysis of the Pharynx in High Risk Partners Gonorrhea, Neisseria Gonorrhea | Not yet recruiting | Guy's and St Thomas' NHS Foundation Trust | 100 | 2026-07-14 | 2026-06-30 | |
| Safety, Pharmacokinetics and Efficacy of BV100 Plus Low Dose Polymyxin B Plus Ceftazidime/Avibactam, or Plus Cefiderocol in Patients With Pulmonary and Extrapulmonary Infections Due to Carbapenem-resistant Acinetobacter Baumannii-calcoaceticus Complex BV100 with 50 mg polymyxin B plus ceftazidime/avibactam, BV100 with 50 mg polymyxin B plus cefiderocol, Best Available Therapy (BAT) - Ventilator Associated Bacterial Pneumonia (VABP), Hospital Acquired Bacterial Pneumonia (HABP) | Phase 2 | Not yet recruiting | BioVersys AG | 120 | 2026-07-01 | 2026-02-24 |
| Intravenous Brincidofovir as an Antiviral for Treatment of Progressive Multifocal Leukoencephalopathy: A Pilot Study Brincidofovir - Progressive Multifocal Leukoencephalopathy | Phase 2 | Recruiting | National Institute of Neurological Disorders and Stroke (NINDS) | 24 | 2026-06-05 | 2026-07-22 |
| Risk of Progressive Multifocal Leukoencephalopathy Among Patients With Multiple Sclerosis Exposed to Zeposia Ozanimod - Multiple Sclerosis, Progressive Multifocal Leukoencephalopathy | Recruiting | Bristol-Myers Squibb | 15 | 2026-06-04 | 2026-07-29 | |
| Aciclovir Versus Placebo for HSV-2 Meningitis Acyclovir 50 MG/ML, Placebo - Herpes Simplex 2, Meningitis, Viral | Phase 4 | Not yet recruiting | Jacob Bodilsen | 150 | 2026-06-01 | 2025-10-01 |
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Poliomyelitis (263) · Meningitis, Meningococcal (125) · Tetanus (119) · Diphtheria (118) · Meningitis (97) · Whooping Cough (85) · Haemophilus Infections (75) · Encephalitis, Japanese (72) · Hepatitis B (71) · Meningococcal Infections (61) · Meningitis, Cryptococcal (54) · Acquired Immunodeficiency Syndrome (50) · Encephalitis, Tick-Borne (50) · HIV Infections (43) · Encephalitis (40)
Central Nervous System Diseases (952) · Infections (951) · Nervous System Diseases (951) · Neuroinflammatory Diseases (825) · Virus Diseases (556) · RNA Virus Infections (528) · Bacterial Infections and Mycoses (403) · Spinal Cord Diseases (353) · Bacterial Infections (338) · Myelitis (336) · Neuromuscular Diseases (295) · Picornaviridae Infections (291) · Brain Diseases (288) · Enterovirus Infections (287)
Meningococcal Vaccines (31) · diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae b conjugate-hepatitis B vaccine (29) · Fluconazole (28) · Poliovirus Vaccine, Inactivated (28) · Amphotericin B (23) · Tetanus Toxoid (16) · Vaccines (15) · Flucytosine (13) · Heptavalent Pneumococcal Conjugate Vaccine (13) · Blood Specimen Collection (12) · Diphtheria-Tetanus-acellular Pertussis Vaccines (12) · Pentavac (11) · 4CMenB vaccine (10) · DTaP-IPV-HB-PRP-T vaccine (10) · Japanese Encephalitis Vaccines (10)
Sanofi Pasteur, a Sanofi Company (77) · GlaxoSmithKline (54) · Pfizer (42) · National Institute of Allergy and Infectious Diseases (NIAID) (31) · Novartis Vaccines (29) · Sanofi (24) · Sinovac Biotech Co., Ltd (19) · National Institute of Neurological Disorders and Stroke (NINDS) (18) · PATH (15) · Valneva Austria GmbH (15) · Centers for Disease Control and Prevention (14) · Aga Khan University (13) · Novartis (11) · University Medical Centre Ljubljana (11) · CanSino Biologics Inc. (10)
United States (224) · China (107) · France (57) · Germany (56) · United Kingdom (36) · Italy (30) · Canada (28) · Poland (27) · Spain (26) · Australia (24) · South Korea (24) · Austria (23) · Thailand (22) · Bangladesh (21) · Brazil (21)
Ingrid Kromann (4) · Irene CM Cortese, M.D. (4) · Yuemei Hu (4) · Astrid Kaltenboeck, Ph.D. (3) · Benjamin Greenberg, MD (3)
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