30 completed, 6 terminated, 5 unknown, 2 enrolling by invitation. 16 Phase 4, 13 Phase 1, 11 Phase 3, 7 Phase 2.
Follow Ceftaroline: new trials by email Literature Review of Ceftaroline trials Research Report on Ceftaroline
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Bacteriophage Therapy for Mycobacterium Abscessus Pulmonary Infection Mycobacteriophage Muddy_HRMN0052, Amikacin Injection, Clofazimine - Non-Tuberculous Mycobacterial (NTM) Pneumonia, Mycobacterium Abscessus Infection | Phase 1 | Enrolling by invitation | Vancouver Coastal Health | 1 | 2026-01-11 | 2026-06-03 |
| Does Staphylococcus Aureus Bacteremia Early Dual Therapy Improve Outcomes? Early Dual IV Antibiotic Therapy - MRSA, Early Dual IV Antibiotic Therapy - MSSA, Single Agent IV Antibiotic Therapy - MRSA - Staphylococcus Aureus Bacteremia | Phase 4 | Enrolling by invitation | West Virginia University | 300 | 2025-09-15 | 2026-09-17 |
| Early Intravenous to Oral Antibiotic Switch in Uncomplicated Staphylococcus Aureus Bacteraemia Tab. Trimethoprim-sulfamethoxazole, Tab. Clindamycin, Tab. Cephalexin, or Tab. Linezolid, IV Cloxacillin, IV Cefazolin, IV Vancomycin, or IV Ceftaroline - Staphylococcus Aureus Bacteremia | Phase 3 | Unknown | Clinical Research Centre, Malaysia | 290 | 2024-06-28 | 2024-07-05 |
| Comparing Oral Versus Parenteral Antimicrobial Therapy Amoxicillin, amoxicillin-clavulanate, cefadroxil, cefpodoxime, cefalexin, ciprofloxacin, delafloxacin, doxycycline, levofloxacin, linezolid, Ampicillin, ampicillin-sulbactam, cefazolin, cefepime, ceftaroline, ceftazidime, ceftazidime-avibactam, dalbavancin, daptomycin, ertapenem - Endovascular Infection, Bone and Joint Infection | Phase 4 | Terminated | West Virginia University | 94 | 2023-08-04 | 2025-08-26 |
| Postoperative Antibiotic Management Duration Following Surgery for Intravenous Drug Abuse (IVDA) Endocarditis (OPTIMAL) Amoxycillin, Cefalexin, Dicloxacillin, Linezolid, Levofloxacin, Rifampicin, Ampicillin, Oxacillin, Vancomycin, Daptomycin, Ceftriaxone, Cefepime, Ceftaroline - Endocarditis | Phase 4 | Terminated | West Virginia University | 5 | 2022-03-16 | 2026-05-05 |
| Retrospective Chart Review Study to Assess Characteristics, Treatment Outcomes and Resource Use of Adults Hospitalized for CAP and CSSTi Treated With Zinforo in Multiple Countries Zinforo (ceftaroline fosamil) - Community Acquired Pneumonia, Complicated Skin and Soft Tissue Infection | Completed | Pfizer | 317 | 2020-05-17 | 2024-03-26 | |
| Pharmacokinetic and Pharmacodynamic Analysis of Ceftaroline in Children and Adolescents With Cystic Fibrosis Ceftaroline - Cystic Fibrosis | Completed | Children's Hospital Medical Center, Cincinnati | 8 | 2017-09-01 | 2026-06-01 | |
| Population Pharmacokinetic (PK) Study of Zinforo (Ceftaroline) in Critical Care Patients With Early-onset Pneumonia and Normal or Augmented Renal Clearance Ceftaroline - Pneumonia | Phase 1 | Completed | Poitiers University Hospital | 18 | 2016-12-01 | 2019-03-11 |
| Antibiotic Prophylaxis in Open Fractures Ceftaroline - Open Fractures | Phase 4 | Unknown | Olayemi Osiyemi MD | 50 | 2016-12-01 | 2016-10-28 |
| Ceftaroline Diffusion Into Cerebrospinal Fluid of Children Ceftaroline - Cerebrospinal Fluid Shunts, Ventriculoperitoneal Shunt | Phase 1 | Unknown | Basim Asmar | 12 | 2016-08-01 | 2018-10-04 |
| Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia Ceftriaxone, Moxifloxacin or Levofloxacin, Piperacillin-tazobactam - Community-acquired Pneumonia, Influenza, COVID-19 | Phase 3 | Recruiting | UMC Utrecht | 20000 | 2016-04-11 | 2024-07-12 |
| IL-10 Stratifying Tool for Towards Antibiotic Selection for MRSaB Daptomycin, Vancomycin, Ceftaroline - Bacteremia | Phase 4 | Completed | Sharp HealthCare | 40 | 2015-11-01 | 2018-02-01 |
| Safety, Tolerability and Efficacy of Ceftaroline in Paediatrics With Late-Onset Sepsis Ceftaroline Fosamil, Ampicillin, Aminoglycoside - Late-onset Sepsis | Phase 2 | Terminated | Pfizer | 11 | 2015-08-04 | 2018-09-13 |
| Ceftaroline for Treatment of Hematogenously Acquired Staphylococcus Aureus Osteomyelitis in Children Ceftaroline Fosamil - Hematogenously Acquired Staphylococcus Aureus Osteomyelitis, Bone Infection | Phase 1 / Phase 2 | Completed | Baylor College of Medicine | 11 | 2015-06-03 | 2021-11-02 |
| Penetration of Ceftaroline Into Cerebrospinal Fluid(CSF) Ceftaroline fosamil - Meningitis, Ventriculitis | Phase 1 | Completed | Centre Hospitalier Universitaire Dijon | 10 | 2015-04-29 | 2024-02-21 |
| The Use of Ceftaroline as Surgical Prophylaxis in Surgery With Risk of MRSA Infection Ceftaroline, Cefazolin / Vancomycin - Surgical Site Infection | Phase 4 | Unknown | University of Cincinnati | 500 | 2015-01-01 | 2015-12-02 |
| Evaluation of Ceftaroline Fosamil vs Vancomycin Plus Aztreonam in the Treatment of Patients With Skin Infections. Ceftaroline fosamil, Vancomycin, Aztreonam - Complicated Skin and Soft Tissue Infection | Phase 3 | Terminated | Pfizer | 4 | 2014-06-01 | 2017-09-06 |
| Multiple-dose Pharmacokinetics of Ceftaroline During Continuous and Intermittent Renal Replacement Therapy in Patients Requiring Renal Replacement Therapy Ceftaroline in CRRT, Ceftaroline in IRRT - Infection During Renal Replacement Therapy | Phase 4 | Unknown | Medical University of Vienna | 25 | 2013-12-01 | 2022-04-14 |
| Ceftaroline in the Treatment of Bone and Joint Infections Ceftaroline - Osteomyelitis, Joint Infections | Phase 4 | Withdrawn | Orlando Health, Inc. | 2013-04-01 | 2014-08-07 | |
| A Study to Assess the Pharmacokinetics of Ceftaroline in End Stage Renal Disease Patients and Matched Healthy Subjects 200 mg Ceftaroline fosamil, 600 mg Ceftaroline fosamil - Renal Disease | Phase 1 | Completed | Pfizer | 15 | 2013-02-01 | 2017-09-05 |
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Infections (8) · Community-Acquired Pneumonia (6) · Pneumonia (6) · Bacterial Infections (5) · Cellulitis (5) · Bacteremia (4) · Soft Tissue Infections (4) · Abscess (3) · Osteomyelitis (3) · Pneumonia, Bacterial (3) · Staphylococcal Infections (3) · Staphylococcal Skin Infections (3) · Surgical Wound Infection (3) · Wound Infection (3) · Endocarditis (2)
Forest Laboratories (15) · Pfizer (10) · West Virginia University (3) · Arrevus Inc. (1) · Basim Asmar (1) · Baylor College of Medicine (1) · Centre Hospitalier Universitaire Dijon (1) · Children's Hospital Medical Center, Cincinnati (1) · Clinical Research Centre, Malaysia (1) · Gary E. Stein, Pharm.D. (1) · Henry Ford Health System (1) · Keith A. Rodvold (1) · Medical University of Vienna (1) · Olayemi Osiyemi MD (1) · Orlando Health, Inc. (1)
United States (33) · Poland (10) · Argentina (9) · Romania (8) · Russia (8) · Spain (8) · Ukraine (8) · Germany (7) · Brazil (6) · Bulgaria (6) · Chile (6) · France (6) · Hungary (6) · Georgia (5) · United Kingdom (5)
David Melnick, MD (3) · Mirjana Kujacic, MD (3) · David Melnick (2) · David Melnick, MSD (2) · Elizabeth Tranter, MBCHB MRCP (2) · Alan G Smulian, M.B.B.Ch. (1) · Alexander Vinks, PhD (1) · Arif R Sawari, MD, MSc, MBA (1) · Arif R. Sarwari, MD, MSc, MBA (1) · Arpeat Kaviya, MBChB, MRCP (1) · Colin McArthur, Dr (1) · David Mathews, MD (1)
PMID 30597021, PMID 34922058, PMID 30380060, PMID 26702925, PMID 30716446, PMID 34741280, PMID 20695801, PMID 21115456, PMID 21482570, PMID 23357290, PMID 25487791, PMID 26152131, PMID 27585969, PMID 31044546, PMID 21115454, PMID 21115455, PMID 21482566, PMID 21482568, PMID 24150927, PMID 25041494, PMID 25539586, PMID 25896707, PMID 27093162, PMID 27682068, PMID 30221827, PMID 30535190, PMID 30858203, PMID 30915685, PMID 32091493, PMID 32267771, PMID 32607967, PMID 32876697, PMID 33394942, PMID 33509275, PMID 33631065, PMID 34251506, PMID 34351721, PMID 34351722, PMID 34473343, PMID 34606578, PMID 35237053, PMID 35315874, PMID 36059138, PMID 36942550, PMID 36967714, PMID 37039790, PMID 37489818, PMID 37877585, PMID 37888913, PMID 38979062
2014 (1), 2015 (1), 2023 (1)