91 completed, 17 recruiting, 15 terminated, 15 unknown. 55 Phase 2, 54 Phase 3, 20 Phase 4, 15 Phase 1, 11 Not applicable.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing a Novel Combination Treatment (Arm D) Versus Standard of Care for Intensive Phase Treatment for Mycobacterium Abscessus Pulmonary Disease in People With or Without Cystic Fibrosis in the Finding the Optimal Regimen for Mycobacterium Abscessus Treatment (FORMaT) Adaptive Platform Trial Sulbactam 25mg/kg -Durlobactam 25mg/kg (Every 6 hours), Ceftriaxone for Injection, Amoxicillin - Mycobacterium Abscessus Pulmonary Disease, Mycobacterium Abscessus Infection | Phase 2 | Not yet recruiting | The University of Queensland | 300 | 2027-04-01 | 2026-03-20 |
| Oral Antibiotic Pharmacokinetics in Young Infants Linezolid (LZD) - Linezolid Pharmacokinetics in Young Infants, Pharmacokinetic Analysis | Phase 4 | Not yet recruiting | University of Colorado, Denver | 40 | 2027-01-01 | 2026-09-11 |
| Study of Combinations of Novel Promising Drugs for Pulmonary Tuberculosis TBAJ-587 50 mg, Pretomanid 200mg, Linezolid 600Mg Tab - Tuberculosis, Pulmonary | Phase 2 | Not yet recruiting | TASK Applied Science | 135 | 2026-09-25 | 2026-09-25 |
| Sorfequiline-based Regimens in Adults With Newly Diagnosed Drug-sensitive Pulmonary TB sorfequiline, Pretomanid, Linezolid - Tuberculosis, Pulmonary | Phase 2 | Recruiting | Global Alliance for TB Drug Development | 100 | 2026-07-09 | 2026-08-19 |
| Comprehensive Ambulatory Antibiotics for the Treatment of Congenital Syphilis Linezolid (LZD), Amoxicillin, Benzathine Penicillin G - Syphilis, Congenital | Phase 2 | Recruiting | London School of Hygiene and Tropical Medicine | 90 | 2026-05-04 | 2026-10-22 |
| Bactericidal Activity and Safety of Nicotinamide in Combination With Bedaquiline, Pretomanid, and Linezolid in Drug-susceptible Pulmonary Tuberculosis Bedaquiline, pretomanid, linezolid, Nicotinamide (NAM) - Drug Susceptible Pulmonary Tuberculosis | Phase 2 | Suspended | Gates Medical Research Institute | 165 | 2026-04-17 | 2026-08-10 |
| Bactericidal Activity of TBD09 in Combination With Other Drugs in Pulmonary Tuberculosis Bedaquiline, pretomanid and TBD09, Bedaquiline, pretomanid and linezolid - Drug Susceptible Pulmonary Tuberculosis | Phase 2 | Recruiting | Gates Medical Research Institute | 150 | 2026-04-14 | 2026-07-30 |
| Therapeutic Drug Monitoring for Linezolid in the Treatment of Rifampin-resistant Tuberculosis Therapeutic Drug Monitoring for Linezolid - Rifampin-resistant Tuberculosis, Drug-resistant Tuberculosis | Not applicable | Recruiting | Albert Einstein College of Medicine | 280 | 2026-04-07 | 2026-05-04 |
| Bacteriophage Therapy for Mycobacterium Abscessus Pulmonary Infection Mycobacteriophage Muddy_HRMN0052, Amikacin Injection, Clofazimine - Non-Tuberculous Mycobacterial (NTM) Pneumonia, Mycobacterium Abscessus Infection | Phase 1 | Enrolling by invitation | Vancouver Coastal Health | 1 | 2026-01-11 | 2026-06-03 |
| Clinical Study on the Early Bactericidal Activity of Contezolid Against Mycobacterium Abscessus Disease Contezolid, linezolid - Monotherapy, Mycobacterium Abscessus Infection | Phase 2 | Enrolling by invitation | Beijing Chest Hospital | 24 | 2026-01-01 | 2026-01-28 |
| Microbiological Characteristics of Biofilm on Double J Ureteral Stents After Lithotripsy. Linezolid (LZD), N-Acetyl Cysteine (NAC) - Double J Stent | Phase 4 | Not yet recruiting | Menoufia University | 100 | 2026-01-01 | 2025-12-24 |
| A Study of Quabodepistat-containing Regimens for the Treatment of Drug-resistant Pulmonary Tuberculosis BPaQM, BPaLM, BPaQ - Pulmonary Tuberculosis | Phase 3 | Recruiting | Otsuka Pharmaceutical Development & Commercialization, Inc. | 532 | 2025-10-16 | 2026-05-06 |
| Optimizing Linezolid Dosing in Patients With Advanced Renal Impairment: a Therapeutic Drug Monitoring-based Evaluation Linezolid (IV and PO) - Kidney Disease | Phase 4 | Not yet recruiting | Alexandria University | 50 | 2025-10-15 | 2025-08-24 |
| Linezolid Plus Standard of Care Linezolid 600 mg, Placebo - Staphylococcus Aureus Bloodstream Infections (BSI; Bacteremia) | Not applicable | Recruiting | University Hospital, Basel, Switzerland | 606 | 2025-10-06 | 2026-07-13 |
| Program for Rifampicin-Resistant Disease With Stratified Medicine for Tuberculosis Bedaquiline, Linezolid, Pretomanid - Tuberculosis, Pulmonary, Tuberculosis, Multidrug-Resistant | Phase 2 / Phase 3 | Recruiting | University of California, San Francisco | 400 | 2025-10-03 | 2026-09-02 |
| 6 Months of Bedaquiline(BDQ), Delamanid(DLM), Linezolid(LZD) and Levofloxacin(LFX) in RR-TB Patients in Hubei Province bedaquiline, Delamanid (DLM), Linezolid (LZD) - Treat to Target, Treatment Duration | Not applicable | Not yet recruiting | Wuhan Pulmonary Hospital | 52 | 2025-09-30 | 2025-09-30 |
| A Study on the Short-course Treatment Regimen Containing Pretomanid for Drug-resistant Tuberculosis bedaquiline, Pretomanid (Pa), linezolid - Efficacy and Safety | Not applicable | Not yet recruiting | Wuhan Pulmonary Hospital | 200 | 2025-09-01 | 2025-08-17 |
| Ultra-Short Regimen for Elderly DS-TB Bedaquiline (B), Sitafloxacin (S), Linezolid (L) - Pulmonary Tuberculosis | Phase 3 | Not yet recruiting | Shenzhen Third People's Hospital | 300 | 2025-07-25 | 2025-07-22 |
| A PAN-USR TB Multi-Center Trial Bedaquiline (B), Sitafloxacin (S), Linezolid (L) - Pulmonary Tuberculosis | Phase 3 | Recruiting | Shenzhen Third People's Hospital | 610 | 2025-06-18 | 2025-12-01 |
| Trial of Novel Regimens for the Treatment of Pulmonary Tuberculosis Isoniazid, Rifampicin, Pyrazinamide - Pulmonary Tuberculosis | Phase 2 | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 315 | 2025-03-11 | 2026-10-19 |
Showing 20 of 163. Sign in to see all of them.
Tuberculosis, Pulmonary (24) · Tuberculosis (21) · Tuberculosis, Multidrug-Resistant (21) · Bacterial Infections (14) · Cellulitis (12) · Pneumonia (11) · Extensively Drug-Resistant Tuberculosis (10) · Abscess (9) · Gram-Positive Bacterial Infections (8) · Bacteremia (6) · Pneumonia, Ventilator-Associated (6) · Skin Diseases, Bacterial (6) · Skin Diseases, Infectious (6) · Staphylococcal Infections (6) · Tuberculosis, Meningeal (6)
Pfizer (19) · National Institute of Allergy and Infectious Diseases (NIAID) (6) · Beijing Chest Hospital (5) · Global Alliance for TB Drug Development (5) · Paratek Pharmaceuticals Inc (5) · Medecins Sans Frontieres, Netherlands (4) · Arrevus Inc. (3) · Basilea Pharmaceutica (3) · Bayer (3) · Durata Therapeutics Inc., an affiliate of Allergan plc (3) · Forest Laboratories (3) · GlaxoSmithKline (3) · Huashan Hospital (3) · Melinta Therapeutics, Inc. (3) · MicuRx (3)
United States (51) · South Africa (35) · China (15) · Brazil (12) · Peru (12) · Spain (12) · France (11) · Georgia (11) · Philippines (11) · Russia (11) · Argentina (9) · Germany (9) · Ukraine (9) · Latvia (8) · Mexico (8)
Carole Mitnick, Sc.D (2) · Lorenzo Guglielmetti, MD (2) · Michael Dunne, MD (2) · Morounfolu Olugbosi, MD (2) · Philippe G Prokocimer, MD (2) · Scott Hopkins, MD (2) · Abdelhameed I Ebid (1) · Achim J Kaasch, MD (1) · Adreas Diacon (1)
PMID 30808293, PMID 33960817, PMID 34155899, PMID 36808186, PMID 24011955, PMID 24723282, PMID 24897082, PMID 25246392, PMID 25421472, PMID 27530088, PMID 28003218, PMID 28264845, PMID 31367742, PMID 33326848, PMID 33458763, PMID 34905144, PMID 35776862, PMID 36053506, PMID 36546625, PMID 37980911, PMID 39461915, PMID 41251370, PMID 15276398, PMID 15840453, PMID 16470119, PMID 16762061, PMID 16776446, PMID 16988514, PMID 18070980, PMID 18366444, PMID 18719064, PMID 18787216, PMID 18795962, PMID 18989231, PMID 19564361, PMID 19588358, PMID 19923475, PMID 20002783, PMID 20629533, PMID 20632458, PMID 21283017, PMID 21546629, PMID 22083071, PMID 22129166, PMID 22230331, PMID 22530208, PMID 22770644, PMID 23075177, PMID 23131255, PMID 23305215
2015 (2), 2016 (2), 2018 (2), 2005 (1), 2014 (1), 2025 (1), R01AI184416 (1), R21TW011035 (1), U01AI152980 (1)