501 completed, 191 unknown, 112 recruiting, 89 terminated. 537 Not applicable, 131 Phase 2, 85 Phase 1, 73 Phase 3, 55 Phase 4.
Follow Diabetic Foot: new trials by email Literature Review of Diabetic Foot trials Research Report on Diabetic Foot
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| On the Move: Center and Home-Based Exercise to Enhance Mobility in Diabetic Foot Ulcer Recovery 12-week exercise regimen, 12-week standard of care - Diabetic Foot Ulcer | Not applicable | Not yet recruiting | University of Maryland, Baltimore | 60 | 2027-06-01 | 2026-10-07 |
| Subcutaneous Dexpanthenol Administration and Wound Epithelialization Dexpanthenol, Standard Wound Care - Chronic Wounds, Diabetic Foot Ulcer | Not applicable | Not yet recruiting | Dilara CANBAY OZDEMIR | 40 | 2026-12-02 | 2026-10-22 |
| Clinical Efficacy of Modified Simiao Yongan Decoction and Endovascular Therapy for Diabetic Foot Ulcers Modified Simiao Yongan Decoction, Endovascular Therapy and Standard Care - Diabetic Foot Ulcer, Damp-Heat Toxins Accumulation Syndrome | Not applicable | Not yet recruiting | Chengdu University of Traditional Chinese Medicine | 120 | 2026-12-01 | 2026-09-08 |
| 18F-FDG PET/CT for Diagnosis of Diabetic Foot Osteomyelitis 18F-FDG PET/CT - Diabetic Foot Infections | Not yet recruiting | Jewish General Hospital | 150 | 2026-11-01 | 2026-09-18 | |
| Systemic Biochemical Signature and Functional Quality Index of Calcaneal Bone Marrow Aspirate in Adults Undergoing Foot or Ankle Surgery Diabetic Foot Ulcer, Wound Healing | Recruiting | Universidade Sao Francisco | 40 | 2026-10-21 | 2026-10-22 | |
| Seltoplasmid Plus Revascularization for Diabetic Infrapopliteal Chronic Limb-Threatening Ischemia Lower-Extremity Revascularization, Donaperminogene Seltoplasmid - Chronic Limb-Threatening Ischemia, Diabetic Foot Ulcer | Phase 4 | Not yet recruiting | First Affiliated Hospital of Wenzhou Medical University | 180 | 2026-10-20 | 2026-09-18 |
| a Prospective, Multicenter, Randomized Controlled Trial, With a Non-randomized Sentinel Cohort, Evaluating the Efficacy of Bioxheal, a Single-layer Placental-derived Biologic in Nonhealing Diabetic Foot Ulcers Standard of Care, BIOxHEAL (human amniotic membrane allograft) - Diabetic Foot Ulcer, Amniotic Membrane Placental Allograft | Phase 3 | Recruiting | Applied Biologics, LLC | 253 | 2026-10-08 | 2026-10-16 |
| Activity Reduction vs Advice for Plantar Hotspots in Diabetes Individualized Objectively Monitored Activity Reduction, Standard Activity-Reduction Advice - Diabetic Foot, Diabetic Peripheral Neuropathy | Not applicable | Not yet recruiting | Shifa International Hospital | 100 | 2026-10-01 | 2026-09-25 |
| Placental Cells for Diabetic Foot Ulcers Placenta Stem Cells - Diabetic Foot Ulcer | Phase 1 | Not yet recruiting | Wake Forest University Health Sciences | 12 | 2026-10-01 | 2026-07-07 |
| Evaluating the Effect of Adipose Tissue Processed With the SyntrFuge™ System in the Healing of Diabetic Foot Ulcers Syntrfuge Microfragmented Fat, Standard of Care - Diabetic Foot Ulcer | Not applicable | Not yet recruiting | Syntr Health Technologies, Inc. | 62 | 2026-09-30 | 2026-08-21 |
| Nutritional Status in Adults With Diabetic Foot Ulcers Protein supplementation and nutrition education - Diabetic Foot Ulcers (DFU), Nutrition Assessment | Not yet recruiting | Hvidovre University Hospital | 30 | 2026-09-21 | 2026-09-18 | |
| Effect of Digital-Supported Foot Care Education in Individuals With Type 2 Diabetes Digital-Supported Foot Care Education - Type 2 Diabetes Mellitus (T2DM) | Not applicable | Not yet recruiting | Siirt University | 90 | 2026-09-20 | 2026-09-10 |
| Transverse Tibial Bone Transport (TTT) in the Management of Chronic Diabetic Lower Extremity Wounds Biodynamik XT3 - Diabetic Foot Ulcer, Chronic Ulcers of the Lower Limb | Not applicable | Recruiting | Biodynamik, Inc | 100 | 2026-09-15 | 2026-09-14 |
| DiaFootCare to Promote Self-Care of Diabetic Foot Ulcers in Oman DiaFootCare Mobile Application, Usual Diabetic Foot Care - Diabetic Foot Ulcer (DFU), Diabetes Mellitus | Not applicable | Not yet recruiting | Oman Ministry of Health | 139 | 2026-09-13 | 2026-09-29 |
| The ProActive Study- Integrating a Proactive and Palliative Care Approach to Diabetic Ulcer Care Diabetic Foot Ulcer (DFU), Palliative Care | Not yet recruiting | Ulla Riis Madsen | 484 | 2026-09-01 | 2026-08-24 | |
| Evaluating Autologous Platelet-Rich Fibrin Plasma for Chronic Diabetic Foot Ulcers PRFM, Standard of Care (SoC) - Diabetic Foot Ulcer (DFU), Ulcer | Phase 1 / Phase 2 | Not yet recruiting | Tiger Biosciences, LLC. | 55 | 2026-09-01 | 2026-09-25 |
| Standard Treatment Associated With Phage Therapy Versus Placebo for Diabetic Foot Ulcers Infected by S. Aureus Topical anti-Staphylococcus bacteriophage therapy, Topical placebo corresponding to anti-Staphylococcus bacteriophage therapy - Diabetic Foot, Staphylococcal Infections | Phase 1 / Phase 2 | Not yet recruiting | Centre Hospitalier Universitaire de Nīmes | 60 | 2026-09-01 | 2026-03-20 |
| Evaluation of a Paraclinical Test for the Diagnosis of Arterial Insufficiency in Diabetic Patients With Foot Ulcers Handheld Doppler - Arterial Insufficiency | Not applicable | Not yet recruiting | Groupe Hospitalier de la Rochelle Ré Aunis | 84 | 2026-09-01 | 2026-07-28 |
| Tibial Nerve Mobilization Versus Multisensory Exercises in Patients With Diabetic Foot Ulcer Tibial Nerve Mobilization, Multisensory exercises - Diabetic Foot | Not applicable | Not yet recruiting | University of Lahore | 38 | 2026-09-01 | 2026-09-25 |
| The Effect of L-Carnitine on Wound Healing in Patients With Diabetic Foot Ulcer. L- carnitine - Diabetic Foot Ulcer, Diabetic Foot Ulcer (DFU) | Phase 2 | Recruiting | Ain Shams University | 50 | 2026-09-01 | 2026-08-17 |
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Diabetes Mellitus (212) · Foot Ulcer (110) · Varicose Ulcer (74) · Ulcer (60) · Wounds and Injuries (54) · Pressure Ulcer (53) · Diabetes Complications (49) · Diabetic Neuropathies (49) · Diabetes Mellitus, Type 2 (46) · Leg Ulcer (41) · Peripheral Arterial Disease (30) · Chronic Limb-Threatening Ischemia (20) · Infections (20) · Skin Ulcer (18)
Skin and Connective Tissue Diseases (1030) · Cardiovascular Diseases (1027) · Endocrine System Diseases (1025) · Skin Diseases (1025) · Vascular Diseases (1024) · Diabetic Angiopathies (1019) · Skin Ulcer (1012) · Leg Ulcer (989) · Diabetes Complications (981) · Diabetic Neuropathies (981) · Foot Ulcer (920) · Diabetes Mellitus (818) · Nutritional and Metabolic Diseases (255) · Metabolic Diseases (246) · Glucose Metabolism Disorders (245)
Standard of Care (89) · Bandages (15) · Negative-Pressure Wound Therapy (11) · Control Groups (9) · Sodium Chloride (9) · Debridement (8) · Educational Status (8) · Collagenases (7) · Becaplermin (6) · Hyperbaric Oxygenation (6) · Exercise (5) · Extracorporeal Shockwave Therapy (5) · Hydrogels (5) · Low-Level Light Therapy (5) · Saline Solution (5)
University of Texas Southwestern Medical Center (15) · Universidad Complutense de Madrid (14) · Integra LifeSciences Corporation (13) · Anterogen Co., Ltd. (10) · Healthpoint (9) · MiMedx Group, Inc. (9) · Molnlycke Health Care AB (9) · Smith & Nephew, Inc. (9) · Assiut University (8) · Centre Hospitalier Universitaire de Nīmes (8) · ConvaTec Inc. (8) · Cairo University (7) · Oneness Biotech Co., Ltd. (7) · Organogenesis (7) · University of Michigan (7)
United States (360) · United Kingdom (57) · China (48) · France (48) · Turkey (Türkiye) (46) · Spain (39) · Canada (36) · Germany (36) · Italy (31) · Egypt (28) · Denmark (26) · Sweden (26) · Taiwan (23) · Israel (21) · Poland (18)
Herbert B Slade, MD (7) · David Armstrong, DPM, MD, PhD (6) · Lawrence Lavery, DPM MPH (5) · Chandan K Sen, PhD (4) · Lawrence Lavery, DPM (4) · Windy Cole, DPM (4) · Charles M Zelen, DPM (3) · Charles Zelen, DPM (3) · David G Armstrong, DPM, MD, PhD (3) · David Prior (3) · Isabel CN Sacco, PhD (3) · Jie Shen (3) · Prema Dhanraj, MS, MCh (3)
PMID 28614678, PMID 16291066, PMID 23958264, PMID 24767584, PMID 26738255, PMID 27269974, PMID 34187716, PMID 35534614, PMID 10693087, PMID 10720604, PMID 11319655, PMID 11926784, PMID 12589096, PMID 15353531, PMID 15793206, PMID 16291063, PMID 16389125, PMID 16758177, PMID 17277315, PMID 18612117, PMID 18990064, PMID 19383872, PMID 20032779, PMID 20332511, PMID 20336198, PMID 20655123, PMID 20818193, PMID 20876709, PMID 21540423, PMID 21636159, PMID 22417277, PMID 22883509, PMID 23159553, PMID 23222938, PMID 23613782, PMID 24657294, PMID 24822048, PMID 24843743, PMID 25329391, PMID 25493265, PMID 25538310, PMID 25580754, PMID 25705296, PMID 25765355, PMID 25860638, PMID 25897193, PMID 26340966, PMID 26578192, PMID 27076876, PMID 27926890
2015 (3), U24DK122927 (3), 2018 (2), 2019 (2), 2023 (2), 2008 (1), 2016 (1), K23DK081021 (1), K23DK131261 (1), K23HL143178 (1), P30DK017047 (1), P30DK111022 (1), R01DK125835 (1), R01DK132569 (1), R01DK139326 (1)