21 terminated. 21 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 21 | Terminated 21 |
| Phase 2 | 3 | Terminated 3 |
Follow Bipolar Disorder: new trials by email Literature Review of Bipolar Disorder trials Research Report on Bipolar Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Extension Study Evaluating The Safety And Tolerability Of Flexible Doses Of Oral Ziprasidone In Children And Adolescents With Bipolar I Disorder Ziprasidone, Placebo - Bipolar Disorder | Phase 3 | Terminated | Pfizer's Upjohn has merged with Mylan to form Viatris Inc. | 23 | 2018-12-21 | 2021-06-16 |
| Cannabidiol as an Adjunctive Treatment for Bipolar Depression Cannabidiol, Placebo - Bipolar Disorder, Bipolar Depression | Phase 2 / Phase 3 | Terminated | Hospital de Clinicas de Porto Alegre | 36 | 2017-11-01 | 2021-07-02 |
| Adjunctive Use of Celecoxib in the Treatment of Bipolar Postpartum Depression Celecoxib, Placebo - Bipolar Disorder, Postpartum Depression | Phase 3 | Terminated | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 1 | 2016-05-01 | 2022-01-20 |
| Lithium for Suicidal Behavior in Mood Disorders Lithium, Placebo - Depressive Disorder, Bipolar Disorder | Phase 2 / Phase 3 | Terminated | VA Office of Research and Development | 519 | 2015-07-08 | 2024-04-29 |
| Efficacy and Safety Trial of Flexible Doses of Oral Ziprasidone in Children and Adolescents With Bipolar I Disorder placebo oral capsules, ziprasidone oral capsules - Bipolar Disorder | Phase 3 | Terminated | Pfizer's Upjohn has merged with Mylan to form Viatris Inc. | 171 | 2014-05-23 | 2021-06-16 |
| Safety and Efficacy Study of Ramelteon (TAK-375) Tablets for Sublingual Administration (SL) in Adults With Bipolar 1 Disorder Ramelteon, Placebo - Bipolar Disorder | Phase 3 | Terminated | Takeda | 535 | 2012-08-01 | 2016-03-16 |
| Intranasal Ketamine In the Treatment of Pediatric Bipolar Disorder Ketamine hydrochloride injection, Flat tonic water (e.g., Canada Dry Tonic Water) - Bipolar Disorder | Phase 2 / Phase 3 | Terminated | Juvenile Bipolar Research Foundation | 5 | 2012-07-01 | 2017-03-16 |
| Low-Dose Adjunctive Aripiprazole in the Treatment of Bipolar Depression: Double-Blind Placebo-Controlled Pilot Study Low dose Adjunctive Aripiprazole, placebo - Bipolar Disorder, Depressive Episode | Phase 3 | Terminated | Serge Beaulieu | 2 | 2012-02-01 | 2014-07-29 |
| Efficacy and Safety of Ramelteon Sublingual as Adjunctive Therapy for Maintenance Treatment of Bipolar I Disorder Ramelteon SL, Placebo - Bipolar Disorder | Phase 3 | Terminated | Takeda | 642 | 2011-12-01 | 2016-05-16 |
| One-Year Trial of Oral Ziprasidone in Bipolar Patients With Metabolic Syndrome Ziprasidone HCL (oral) - Bipolar Disorder | Phase 3 | Terminated | Pfizer's Upjohn has merged with Mylan to form Viatris Inc. | 13 | 2010-07-01 | 2021-03-03 |
| Adjunctive Lisdexamfetamine (LDX) in Bipolar Depression Lisdexamfetamine, Placebo control - Bipolar, Depression | Phase 3 | Terminated | Lindner Center of HOPE | 50 | 2010-01-01 | 2014-03-05 |
| Efficacy Study of Lisdexamfetamine to Treat Bipolar Depression Lisdexamfetamine, Placebo - Bipolar Depression | Phase 3 | Terminated | Lindner Center of HOPE | 25 | 2010-01-01 | 2015-09-02 |
| Study of Maca Root to Treat Sexual Dysfunction Associated With the Treatment Regimen for Bipolar Disorder in Females Maca Root, Placebo - Sexual Dysfunction, Bipolar Disorder | Phase 3 | Terminated | Massachusetts General Hospital | 8 | 2008-02-26 | 2020-09-25 |
| Add-On Ramelteon in Bipolar I Disorder With Clinically Significant Sleep Disturbance Ramelteon, Placebo - Insomnia, Bipolar Disorder | Phase 3 | Terminated | Lindner Center of HOPE | 21 | 2007-12-01 | 2013-05-10 |
| Lithium Versus Paroxetine in Patients With Major Depression Who Have a Family History of Bipolar Disorder or Suicide paroxetine, lithium - Major Depressive Disorder | Phase 3 | Terminated | Nova Scotia Health Authority | 2 | 2007-06-01 | 2021-01-29 |
| FAST-A Study to Evaluate the Efficacy and Safety of Quetiapin IR in Patients With Acute Psychosis Quetiapine, Rating Scales, Self Assessment Form - Psychotic Disorders, Schizophrenia | Phase 3 | Terminated | AstraZeneca | 2007-05-01 | 2010-12-10 | |
| Estimating and Reducing the Cardiovascular Risk of Patients With Schizophrenia Drugs From Lipid Measures and Ischemic Electrocardiographic Changes aripiprazole (Abilify), ziprasidone (Geodon) - Schizophrenia, Schizoaffective Disorder | Phase 3 | Terminated | Northwestern University | 48 | 2006-01-01 | 2025-10-02 |
| Low Field Magnetic Stimulation Treatment for Bipolar Depression Echo-Planar Magnetic Resonance Imaging (EP-MRSI) - Bipolar Depression, Bipolar Disorder | Phase 3 | Terminated | Mclean Hospital | 13 | 2004-09-01 | 2012-03-14 |
| Pilot Study Evaluating the Safety and Efficacy of Open-Label Olanzapine Olanzapine - Bipolar Disorder | Phase 3 | Terminated | University Hospitals Cleveland Medical Center | 18 | 2002-07-01 | 2016-10-04 |
| Combination Therapy for the Treatment of Bipolar Disorders Lithium, Lamotrigine, Divalproex - Bipolar Disorder | Phase 3 | Terminated | University Hospitals Cleveland Medical Center | 49 | 2002-02-01 | 2016-11-07 |
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Depression (6) · Metabolic Syndrome (2) · Psychotic Disorders (2) · Schizophrenia (2) · Depression, Postpartum (1) · Depressive Disorder (1) · Depressive Disorder, Major (1) · Parasomnias (1) · Sexual Dysfunction, Physiological (1) · Sleep Initiation and Maintenance Disorders (1) · Suicide (1) · Suicide, Attempted (1)
Bipolar and Related Disorders (21) · Mental Disorders (21) · Mood Disorders (21) · Behavior (7) · Behavioral Symptoms (7) · Depressive Disorder (2) · Glucose Metabolism Disorders (2) · Hyperinsulinism (2) · Insulin Resistance (2) · Metabolic Diseases (2) · Nutritional and Metabolic Diseases (2) · Schizophrenia Spectrum and Other Psychotic Disorders (2) · Urogenital Diseases (2) · Dyssomnias (1) · Female Urogenital Diseases and Pregnancy Complications (1)
ziprasidone (4) · Lithium (3) · Aripiprazole (2) · Lisdexamfetamine Dimesylate (2) · Lithium Carbonate (2) · ramelteon (2) · Blood Specimen Collection (1) · Cannabidiol (1) · Celecoxib (1) · Echo-Planar Imaging (1) · Fluoxetine (1) · Ketamine (1) · Lamotrigine (1) · Olanzapine (1) · Paroxetine (1)
Lindner Center of HOPE (3) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (3) · Takeda (2) · University Hospitals Cleveland Medical Center (2) · AstraZeneca (1) · Hospital de Clinicas de Porto Alegre (1) · Juvenile Bipolar Research Foundation (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · Massachusetts General Hospital (1) · Mclean Hospital (1) · National Institute of Mental Health (NIMH) (1) · Northwestern University (1) · Nova Scotia Health Authority (1) · Serge Beaulieu (1) · VA Office of Research and Development (1)
United States (13) · Canada (4) · Ukraine (2) · Argentina (1) · Brazil (1) · Bulgaria (1) · Chile (1) · Colombia (1) · Czechia (1) · Germany (1) · Mexico (1) · Poland (1) · Romania (1) · Russia (1) · Serbia (1)
Birgit Ekholm, MD (1) · Christina Dording, MD (1) · Claire O'Donovan M O'Donovan, MB FRCPC (1) · David Mischoulon, MD, PhD (1) · Demitri Papolos, MD (1) · Ira R Katz, MD PhD (1) · Jaan Ruusa, MD,PhD (1) · Joseph R Calabrese, MD (1) · Keming Gao, MD, PhD (1) · Michael Rohan, MS (1) · Serge Beaulieu, MD, PhD (1) · Susan L McElroy, MD (1)
PMID 35394365, PMID 14702256, PMID 20861739, PMID 25340384, PMID 28662460, PMID 34787653, PMID 36282771, PMID 37920963
R21MH062650 (1)