250 completed, 43 unknown, 34 recruiting, 29 terminated. 388 Phase 1, 118 Phase 2.
Follow Behavioral Symptoms: new trials by email Literature Review of Behavioral Symptoms trials Research Report on Behavioral Symptoms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Clinical Trial of Iron Supplementation for Youth With ADHD and Restless Sleep Ferrous Sulfate, Placebo - ADHD, Sleep Problems | Phase 1 / Phase 2 | Not yet recruiting | Hugo W. Moser Research Institute at Kennedy Krieger, Inc. | 70 | 2027-03-01 | 2026-05-04 |
| Reducing Firearm Suicide Among Veterans: Evaluating the Effectiveness of Peer-Delivered Lethal Means Counseling Peer Engagement and Exploration of Responsibility and Safety, Active Control - Suicide, Secure Firearm Storage | Phase 1 / Phase 2 | Not yet recruiting | VA Office of Research and Development | 100 | 2027-02-01 | 2026-10-26 |
| ADEPT Psilocybin-Assisted Therapy With DBT for Borderline Personality Disorder Psilocybin, Psilocybin-Assisted Therapy With Dialectical Behavior Therapy - Borderline Personality Disorder, Borderline Personality Pathology | Phase 1 | Not yet recruiting | University of Minnesota | 18 | 2026-12-01 | 2026-09-22 |
| Shortened LSD Intervention for Major Depressive Disorder LSD, Risperidone - Major Depression Moderate, Major Depression Severe | Phase 1 | Not yet recruiting | Johns Hopkins University | 10 | 2026-12-01 | 2026-11-03 |
| Pharmacokinetics and Relative Bioavailability of Intranasal vs Intramuscular Olanzapine in Healthy Adult Participants NRL-1004 2.5 mg, ZYPREXA IM 10mg, NRL-1004 5.0 mg - Healthy Adult Participants | Phase 1 | Not yet recruiting | Neurelis, Inc. | 24 | 2026-10-16 | 2026-11-06 |
| Oral and Sublingual Ketamine 75 mg of oral ketamine, Sublingual ketamine 75 mg - Major Depression Severe | Phase 1 | Not yet recruiting | Western University, Canada | 10 | 2026-10-01 | 2026-07-06 |
| Synaptic Mechanisms of Intermittent Theta Burst Stimulation for Major Depressive Disorder Sham iTBS, TMS, D-cycloserine - Major Depression, Healthy Participants | Phase 1 / Phase 2 | Recruiting | Mclean Hospital | 100 | 2026-10-01 | 2026-10-30 |
| Psilocybin as a Novel Therapy for Residual Anhedonia Psilocybin, Placebo - Anhedonia, Emotional Blunting | Phase 1 | Recruiting | NYU Langone Health | 90 | 2026-09-01 | 2026-09-15 |
| Pregnenolone for Cannabis Use Disorder and Depression Pregnenolone - Cannabis Use Disorder, Major Depressive Disorder (MDD) | Phase 1 / Phase 2 | Not yet recruiting | University of Texas Southwestern Medical Center | 20 | 2026-09-01 | 2026-07-06 |
| Wayne State Warriors Marijuana Clinical Research Program: Cannabinoid Adjunct to Prolonged Exposure & Recovery Cannabidiol (CBD) only, Placebo only, Delta-9-tetrahydrocannabinol (THC) only - PTSD, Post Traumatic Stress Disorder | Phase 1 / Phase 2 | Not yet recruiting | Leslie Lundahl | 280 | 2026-09-01 | 2026-08-26 |
| Psilocybin to Treat Depression in Spinal Cord Injury Psilocybin (Usona Institute) - Spinal Cord Injury, Depression - Major Depressive Disorder | Phase 1 / Phase 2 | Recruiting | James J. Peters Veterans Affairs Medical Center | 30 | 2026-08-06 | 2026-08-10 |
| Transcranial Magnetic Stimulation for Depression in Multiple Sclerosis Repetitive Transcranial Magnetic Stimulation (rTMS) - Multiple Sclerosis, Depression - Major Depressive Disorder | Phase 1 | Not yet recruiting | University of Calgary | 20 | 2026-06-15 | 2026-05-01 |
| Pattern Separation in Major Depressive Disorder SSRI (escitalopram or sertraline), Extended-Release Memantine, Placebo - Major Depressive Disorder (MDD) | Phase 1 | Recruiting | Jeffrey Miller | 30 | 2026-06-01 | 2026-09-15 |
| Remote Medical Monitoring of Patients With Depression Use of ThIA Medical Device - Depression Chronic, Depression and Quality of Life | Phase 1 | Recruiting | ThIA Santé Mentale | 608 | 2026-04-01 | 2026-10-16 |
| Ketamine Biomarker Validation Ketamine (0.25 mg/kg), Ketamine (0.5 mg/kg), Ketamine (0.75 mg/kg) - Treatment Resistant Depression (TRD) | Phase 1 | Withdrawn | Soterix Medical | 2025-12-20 | 2026-10-19 | |
| Dapagliflozin in Depression Fluoxetine, Dapagliflozin - Depression | Phase 1 / Phase 2 | Recruiting | Tanta University | 60 | 2025-11-01 | 2025-11-25 |
| Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia PROSOMNIA Sleep Therapy™ (PSTx), Anesthesia-Induced Sleep Therapy, Diprivan (propofol), Astra-Zeneca - Chronic Insomnia, Sleep Deprivation | Phase 1 | Not yet recruiting | Nyree Penn | 100 | 2025-11-01 | 2025-05-28 |
| Elucidating the Relevance of the Psychedelic Experience to Psilocybin's Anti-Anhedonic Effects Psilocybin (Usona Institute), Risperidone 1 MG, MRI - Depression - Major Depressive Disorder, Anhedonia | Phase 1 | Recruiting | Medical University of Vienna | 85 | 2025-11-01 | 2026-03-24 |
| Warrior CARE: Cannabis Behavioral Health Tetrahydrocannabinol, Cannabidiol, Placebo - Post Traumatic Stress Disorder, Cannabis Use | Phase 1 / Phase 2 | Recruiting | Wayne State University | 500 | 2025-09-22 | 2026-08-07 |
| Effects of Intranasal Oxytocin in Patients With Arginine-vasopressin Deficiency Intranasal Oxytocin (IN-OXT) 6 IU single dose, Intranasal Oxytocin (IN-OXT) 6 IU repeat dose, Placebo repeat dose - Vasopressin Deficiency | Phase 1 | Recruiting | Elizabeth Austen Lawson | 40 | 2025-09-10 | 2026-10-26 |
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Depression (310) · Anxiety Disorders (68) · Depressive Disorder, Major (65) · Stress Disorders, Post-Traumatic (25) · Suicide (24) · Depressive Disorder (17) · Stress, Psychological (17) · Substance-Related Disorders (16) · Depressive Disorder, Treatment-Resistant (15) · Suicidal Ideation (15) · Bipolar Disorder (14) · Mood Disorders (11) · Self-Injurious Behavior (10) · Psychomotor Agitation (9) · Aggression (8)
Behavior (386) · Mental Disorders (213) · Mood Disorders (84) · Depressive Disorder (65) · Nervous System Diseases (64) · Pathological Conditions, Signs and Symptoms (62) · Signs and Symptoms (49) · Neurologic Manifestations (35) · Central Nervous System Diseases (34) · Brain Diseases (32) · Self-Injurious Behavior (31) · Trauma and Stressor Related Disorders (27) · Chemically-Induced Disorders (23) · Stress Disorders, Traumatic (23)
Ketamine (20) · Psilocybin (14) · Cognitive Behavioral Therapy (13) · Therapeutics (13) · Transcranial Magnetic Stimulation (9) · Fluoxetine (7) · Sertraline (7) · Escitalopram (6) · Midazolam (6) · Interpersonal Psychotherapy (5) · Bupropion (4) · Citalopram (4) · Desipramine (4) · Duloxetine Hydrochloride (4) · Sodium Chloride (4)
National Institute of Mental Health (NIMH) (15) · Sandoz (13) · New York State Psychiatric Institute (8) · Yale University (8) · University of California, Los Angeles (6) · Brown University (5) · GlaxoSmithKline (5) · Mclean Hospital (5) · National Center for Complementary and Integrative Health (NCCIH) (5) · University of Minnesota (5) · VA Office of Research and Development (5) · Bristol-Myers Squibb (4) · Johns Hopkins University (4) · Medical University of South Carolina (4) · NYU Langone Health (4)
United States (232) · Canada (26) · United Kingdom (15) · China (12) · Netherlands (8) · Australia (7) · Brazil (5) · Germany (5) · Norway (5) · Sweden (5) · Israel (4) · Ireland (3) · Argentina (2) · Denmark (2) · Hong Kong (2)
Anthony Spirito, PhD (4) · Carlos A Zarate, M.D. (4) · Robert B Innis, M.D. (4) · BioXcel MM, MD (3) · Aaron T. Beck, MD (2) · David C. Mohr, Ph.D. (2) · Gregory K. Brown, PhD (2) · James Downar, MDCM, MSc (2) · Jane E. Gillham, Ph.D. (2) · Jules Kann, M.D. (2) · Jules Kann, Ph.D. (2) · Karina W Davidson, PhD (2) · Karl Johe, PhD (2)
PMID 33884617, PMID 33825765, PMID 35963959, PMID 41298372, PMID 14702256, PMID 15583741, PMID 15780843, PMID 15890495, PMID 15978266, PMID 16319710, PMID 16585452, PMID 16630205, PMID 16894061, PMID 17429407, PMID 18178322, PMID 18996507, PMID 19744406, PMID 19914605, PMID 19960132, PMID 20673547, PMID 20679587, PMID 20734360, PMID 20819978, PMID 20877297, PMID 21254315, PMID 21459988, PMID 21477416, PMID 21511342, PMID 21557878, PMID 21719124, PMID 21736514, PMID 21812908, PMID 22065593, PMID 22125120, PMID 22220591, PMID 22296967, PMID 22297150, PMID 22409700, PMID 22473055, PMID 22503959, PMID 22508957, PMID 22521148, PMID 22570264, PMID 22718043, PMID 22722512, PMID 22815471, PMID 22945620, PMID 23300127, PMID 23444147, PMID 23462072
P20MH071905 (2), 1IK2CX002877-01A1 (1), 1UG3DA066242-01 (1), 2008 (1), 2015 (1), 2018 (1), 2023 (1), F31NR010645 (1), K01AG072049 (1), K01DA029645 (1), K01MH068619 (1), K02DA021304 (1), K07CA093512 (1), K08MH094441 (1), K23AT002155 (1)