16 recruiting, 8 not yet recruiting, 4 completed, 1 terminated. 18 Not applicable, 5 Phase 2, 4 Phase 3, 1 Phase 1, 1 Phase 4.
Follow this condition Literature Review of Treatment Resistant Depression (TRD) trials Research Report on Treatment Resistant Depression (TRD)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ketamine-Assisted Psychotherapy for Treatment-Resistant Depression Ketamine hydrochloride injection - Treatment Resistant Depression (TRD), Chronic Pain | Phase 2 | Not yet recruiting | University of Rochester | 25 | 2026-12-01 | 2026-09-24 |
| A Randomized, Double-Blind Controlled Comparison of NRX-101 vs. Placebo for Adults Being Treated With Robotic Transcranial Magnetic Stimulation for Treatment Resistant Depression: The SPARC-TMS Trial Neuronavigated robotic-enabled TMS, NRX-101, Sham TMS - Treatment Resistant Depression, Treatment Resistant Depression (TRD) | Phase 2 / Phase 3 | Recruiting | NeuroRx, Inc. | 240 | 2026-12-01 | 2026-10-21 |
| Home-Based Randomized Trial of Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression Spaced Transcranial Direct Current Stimulation (tDCS), Sham Spaced tDCS - Treatment Resistant Depression (TRD), Major Depressive Disorder (MDD) | Not applicable | Not yet recruiting | University of California, San Diego | 74 | 2026-10-15 | 2026-09-22 |
| Ketogenic Diet and Neuromodulation in Treatment Resistant Depression Accelerated Intermittent Theta Burst Stimulation (iTBS), Ketogenic Diet, Canadian Food Guide-Aligned Diet - Major Depressive Disorder (MDD), Treatment Resistant Depression (TRD) | Not applicable | Not yet recruiting | Sunnybrook Health Sciences Centre | 60 | 2026-10-01 | 2026-09-25 |
| One-Day cTBS Over the Precuneus Precuneus-targeted continuous theta-burst stimulation, Left dorsolateral prefrontal cortex intermittent theta-burst stimulation, Sham transcranial magnetic stimulation - Depressive Disorder, Treatment-Resistant, Treatment Resistant Depression (TRD) | Not applicable | Recruiting | Mclean Hospital | 69 | 2026-09-08 | 2026-09-11 |
| Ketamine Treatment for Treatment-Resistant Depression - the Role of Framing Psychedelic framing, Biomedical framing - Treatment Resistant Depression (TRD) | Not applicable | Not yet recruiting | Valdemar Landgren | 120 | 2026-09-01 | 2026-09-17 |
| Lumateperone for Late-Life Depression Lumateperone, Placebo - Treatment Resistant Depression (TRD), Late Life Depression (LLD) | Phase 3 | Recruiting | Eric Lenze | 100 | 2026-09-01 | 2026-09-16 |
| Study of rTMS in Maintenance in Treatment Resistant Depression Transcranial Magnetic Stimulation, quetiapine - Treatment Resistant Depression (TRD) | Phase 3 | Not yet recruiting | All India Institute of Medical Sciences, Bhubaneswar | 68 | 2026-08-30 | 2026-08-12 |
| Treatment Resistance in Psychiatric Disorders: the Search for Biological Markers Predictive of Response to Treatment Blood sampling, lumbar puncture, stool sampling, skin microbiopsy and psychometrics scales - Schizophrenia, Treatment Resistant Depression (TRD) | Not applicable | Recruiting | Centre Hospitalier St Anne | 700 | 2026-08-20 | 2026-09-21 |
| Neuronavigated aiTBS for TRD aiTBS - Treatment Resistant Depression (TRD) | Not applicable | Not yet recruiting | University of Texas Southwestern Medical Center | 247 | 2026-07-01 | 2026-01-09 |
| Dehydroepiandrosterone (DHEA) as Augmentation of Standard Antidepressants in Treatment-resistant Depression. Dehydroepiandrosterone (DHEA), Placebo - Treatment Resistant Depression (TRD) | Phase 3 | Recruiting | Charite University, Berlin, Germany | 320 | 2026-06-22 | 2026-09-28 |
| Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression Psychedelic Integration Coaching - Treatment Resistant Depression (TRD) | Not applicable | Recruiting | Massachusetts General Hospital | 20 | 2026-04-17 | 2026-07-23 |
| Accelerated iTBS for Major Depression Accelerated Intermittent Theta Burst Stimulation (iTBS) - Major Depressive Disorder (MDD), Treatment Resistant Depression (TRD) | Not applicable | Recruiting | Istanbul University - Cerrahpasa | 35 | 2026-03-08 | 2026-05-22 |
| Feasibility Trial of Exercise as a Priming Strategy for rTMS Treatment in Difficult-to-Treat Depression Theta burst stimulation - Major Depressive Disorder (MDD), Treatment Resistant Depression (TRD) | Not applicable | Recruiting | The Royal Ottawa Mental Health Centre | 20 | 2026-03-01 | 2026-09-29 |
| Electroconvulsive Therapy Augmented With Transcranial Magnetic Stimulation for Treatment Resistant Depression Electroconvulsive therapy, Transcranial Magnetic Stimulation - Major Depressive Disorder (MDD), Treatment Resistant Depression (TRD) | Not applicable | Recruiting | Charles University, Czech Republic | 50 | 2026-01-05 | 2026-01-07 |
| Ketamine Biomarker Validation Ketamine (0.25 mg/kg), Ketamine (0.5 mg/kg), Ketamine (0.75 mg/kg) - Treatment Resistant Depression (TRD) | Phase 1 | Withdrawn | Soterix Medical | 2025-12-20 | 2026-10-19 | |
| Parcel-guided rTMS for Major Depressive Disorder Accelerated rTMS, Parcel-guided Accelerated rTMS - Treatment Resistant Depression (TRD) | Phase 2 | Not yet recruiting | Soterix Medical | 60 | 2025-12-15 | 2025-12-18 |
| Comparison of the Efficacy of Accelerated Intermittent Theta Burst Stimulation and Accelerated Continuous Theta Burst Stimulation in Patients With Treatment-Resistant Depression Transcranial Magnetic Stimulation with figure-eight coil - Treatment Resistant Depression (TRD), Transcranial Magnetic Stimulation | Not applicable | Recruiting | Ataturk University | 60 | 2025-11-15 | 2025-12-04 |
| Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression: A Home-Based Feasibility and Safety Study Spaced Transcranial Direct Current Stimulation (tDCS) - Treatment Resistant Depression (TRD), Major Depressive Disorder (MDD) | Not applicable | Recruiting | University of California, San Diego | 10 | 2025-09-27 | 2026-09-15 |
| Algorithm Guided Treatment Versus Treatment as Usual (TAU) for Patients With Treatment Resistant Depression Algorithm guided treatment (AGT), Treatment as usual (TAU) - Treatment Resistant Depression (TRD) | Phase 4 | Recruiting | Aalborg University Hospital | 80 | 2025-08-13 | 2026-04-27 |
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Depressive Disorder, Treatment-Resistant (30) · Depression (11) · Depressive Disorder, Major (9) · Bipolar Disorder (2) · Anhedonia (1) · Anxiety Disorders (1) · Catatonia (1) · Chronic Pain (1) · Depressive Disorder (1) · Epilepsy, Rolandic (1) · Inflammation (1) · Lethargy (1) · Motor Activity (1) · Neuroinflammatory Diseases (1) · Obsessive-Compulsive Disorder (1)
Mental Disorders (30) · Mood Disorders (30) · Depressive Disorder (29) · Behavior (13) · Behavioral Symptoms (12) · Pathological Conditions, Signs and Symptoms (5) · Nervous System Diseases (4) · Neurologic Manifestations (3) · Signs and Symptoms (3) · Bipolar and Related Disorders (2) · Neurobehavioral Manifestations (2) · Pathologic Processes (2) · Anxiety Disorders (1) · Brain Diseases (1) · Central Nervous System Diseases (1)
Transcranial Magnetic Stimulation (5) · Ketamine (4) · Vagus Nerve Stimulation (2) · Blood Specimen Collection (1) · Dehydroepiandrosterone (1) · Diet, Ketogenic (1) · Esketamine (1) · Midazolam (1) · Quetiapine Fumarate (1) · Saline Solution (1) · Spinal Puncture (1) · Therapeutics (1) · Transcranial Direct Current Stimulation (1) · lumateperone (1) · salicylhydroxamic acid (1)
Ataturk University (2) · Soterix Medical (2) · University of California, San Diego (2) · Aalborg University Hospital (1) · All India Institute of Medical Sciences, Bhubaneswar (1) · Assistance Publique - Hôpitaux de Paris (1) · Austin Messner (1) · Baylor College of Medicine (1) · Centre Hospitalier St Anne (1) · Charite University, Berlin, Germany (1) · Charles University, Czech Republic (1) · Dr.Yoav Domany (1) · Eric Lenze (1) · First Affiliated Hospital of Zhejiang University (1) · Istanbul University - Cerrahpasa (1)
United States (12) · Canada (3) · Turkey (Türkiye) (3) · France (2) · China (1) · Czechia (1) · Denmark (1) · Germany (1) · Israel (1) · Italy (1) · Sweden (1)
Abhishek Datta, PhD (1) · Balwinder Singh, M.D., M.S. (1) · Cana Aksoy Poyraz, Prof. Dr. (1) · Christian Otte, MD (1) · Dan V Iosifescu, MD,M.Sc. (1) · David Mischoulon, MD/PhD (1) · Elisa Briasco, MD (1) · Elisa Cavanna, MD (1) · Eric J Lenze, MD (1) · Franklin King, MD (1) · Gianluca Serafini, MD (1) · Gopalkumar Rakesh, MD (1) · Heather Adams, BSW (1)
PMID 23982301, PMID 25271445, PMID 40751860, PMID 42658837
2025 (1), 5KL2TR002379 (1), 5KL2TR002379-08 (1), K23MH144148 (1)