54 completed, 46 recruiting, 22 unknown, 19 active not recruiting. 46 Not applicable, 43 Phase 2, 28 Phase 1, 15 Phase 3, 2 Early Phase 1.
Follow Spinal Puncture: new trials by email Literature Review of Spinal Puncture trials Research Report on Spinal Puncture
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing the Safety of Anti-Cancer Drug, CX-5461 (Pidnarulex), in Treating Lymphoma With Specific Changes in the MYC Gene Biopsy Procedure, Biospecimen Collection, Computed Tomography - Burkitt Lymphoma, Double-Expressor Lymphoma | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 50 | 2027-01-11 | 2026-10-14 |
| Testing Safe Doses of Anti-Cancer Medicines, 5-Flurouracil (5-FU) and Tretinoin (ATRA), Added to the Usual Cancer Treatment of Ependymoma Biospecimen Collection, Echocardiography Test, Fluorouracil - Childhood Posterior Fossa Ependymoma | Phase 1 / Phase 2 | Not yet recruiting | Children's Oncology Group | 70 | 2026-12-11 | 2026-09-30 |
| Testing the Addition of a New Anti-Cancer Drug, Glofitamab to Usual Chemotherapy for Burkitt and Double Hit Lymphoma Biospecimen Collection, Bone Marrow Biopsy, Carboplatin - Recurrent Burkitt Lymphoma, Recurrent High Grade B-Cell Lymphoma With MYC and BCL2 Rearrangements | Phase 2 / Phase 3 | Not yet recruiting | National Cancer Institute (NCI) | 271 | 2026-10-30 | 2026-08-19 |
| ANCILLARY STUDY No. 3 NS-PARK-OMICS lumbar puncture - PARKINSON DISEASE (Disorder) | Not yet recruiting | Institut National de la Santé Et de la Recherche Médicale, France | 80 | 2026-10-15 | 2026-09-22 | |
| FH-WT1-E50 TCR T Cells With Azacitidine for the Treatment of Minimal Residual Disease Positive Acute Myeloid Leukemia Autologous HLA-A*02:01-restricted CD4+/CD8+ Anti-WT1 TCR/CD8ab-expressing T-cells, Azacitidine, Biospecimen Collection - Acute Myeloid Leukemia | Phase 1 | Recruiting | Fred Hutchinson Cancer Center | 9 | 2026-10-15 | 2026-09-17 |
| Intravenous Iron in the Management of Drug-resistant Restless Legs syndromeI Ferric Carboxymaltose Injection [Ferinject], Randomization, Questionnaire and Physical Exam - Restless Legs Syndrome (RLS) | Phase 2 | Not yet recruiting | University Hospital, Montpellier | 66 | 2026-10-01 | 2026-09-16 |
| Lumbar Punctures for the Detection of ctDNA in the Cerebrospinal Fluid of Patients With Stage III and IV Non-Small Cell Lung Cancer Biospecimen Collection, Lumbar Puncture, Magnetic Resonance Imaging - Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8 | Not applicable | Not yet recruiting | Ohio State University Comprehensive Cancer Center | 40 | 2026-09-15 | 2026-04-08 |
| Testing the Addition of Daratumumab to Chemotherapy for Treating Patients With Newly-Diagnosed T-Cell Lymphoblastic Leukemia (T-ALL) and T-Cell Lymphoblastic Lymphoma (T-LL) Biopsy Procedure, Biospecimen Collection, Bone Marrow Aspiration - Stage II T Lymphoblastic Leukemia/Lymphoma, Stage III T Lymphoblastic Leukemia/Lymphoma | Phase 2 / Phase 3 | Not yet recruiting | Children's Oncology Group | 1708 | 2026-08-28 | 2026-07-30 |
| Treatment Resistance in Psychiatric Disorders: the Search for Biological Markers Predictive of Response to Treatment Blood sampling, lumbar puncture, stool sampling, skin microbiopsy and psychometrics scales - Schizophrenia, Treatment Resistant Depression (TRD) | Not applicable | Recruiting | Centre Hospitalier St Anne | 700 | 2026-08-20 | 2026-09-21 |
| A Study Comparing Higher Dose Chemotherapy Over a Shorter Amount of Time to Lower Dose Chemotherapy Plus Maintenance Over a Longer Amount of Time in Patients With Newly Diagnosed Intermediate-Risk Rhabdomyosarcoma (IR RMS) Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Rhabdomyosarcoma | Phase 3 | Recruiting | Children's Oncology Group | 342 | 2026-07-14 | 2026-08-25 |
| Search for Circulating Tumour Cells in the Blood and/or Cerebrospinal Fluid in Patients With Recurrent Aggressive Meningiomas: Proof-of-concept Study Blood sampling, Lumbar puncture - Meningioma | Not applicable | Recruiting | University Hospital, Montpellier | 15 | 2026-07-13 | 2026-07-14 |
| Retifanlimab With or Without Difluoromethylornithine for the Treatment of Progressive High Grade Gliomas Biospecimen Collection, Eflornithine, Lumbar Puncture - Anaplastic Oligodendroglioma, Astrocytoma, IDH-Mutant, Grade 3 | Phase 1 / Phase 2 | Recruiting | Mayo Clinic | 33 | 2026-06-23 | 2026-06-24 |
| A Study to Find the Highest Dose of Cedazuridine and Decitabine Combination With Filgrastim as a Treatment Option After Hematopoietic Stem Cell Transplant in Children With High-Risk Acute Myeloid Leukemia Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Acute Myeloid Leukemia Post Cytotoxic Therapy, Recurrent Acute Myeloid Leukemia | Phase 1 | Recruiting | National Cancer Institute (NCI) | 47 | 2026-06-09 | 2026-10-22 |
| Recombinant Erwinia Asparaginase and Venetoclax in Combination With Blinatumomab for the Treatment of Relapsed or Refractory CD19 Positive B-cell Acute Lymphoblastic Leukemia Asparaginase Erwinia chrysanthemi, Biospecimen Collection, Blinatumomab - Recurrent B Acute Lymphoblastic Leukemia, Refractory B Acute Lymphoblastic Leukemia | Phase 1 | Recruiting | City of Hope Medical Center | 26 | 2026-05-13 | 2026-10-16 |
| Pralatrexate With Bendamustine and Total-Body Irradiation Followed by Donor Stem Cell Transplant for the Treatment of Relapsed or Refractory T-Cell Non-Hodgkin Lymphoma Bendamustine, Pralatrexate, Bone Marrow Aspiration - Recurrent T-Cell Non-Hodgkin Lymphoma, Refractory T-Cell Non-Hodgkin Lymphoma | Phase 1 / Phase 2 | Recruiting | Fred Hutchinson Cancer Center | 50 | 2026-04-27 | 2026-05-11 |
| Autoimmune Neurological Diseases and Those Secondary to Immunotherapy: Study of Immunological Mechanisms and Research Into Targets of Immune Attack Lumbar puncture and blood sampling - Neurological Diseases, Auto Immune Disease | Not applicable | Recruiting | Assistance Publique - Hôpitaux de Paris | 160 | 2026-04-09 | 2026-07-07 |
| Genetically Engineered Cells (CD83 CAR T Cells) for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia Autologous Anti-CD83 CAR T-cells, Biospecimen Collection, Chest Radiography - Recurrent Acute Myeloid Leukemia, Refractory Acute Myeloid Leukemia | Phase 1 | Recruiting | Roswell Park Cancer Institute | 26 | 2026-02-02 | 2026-09-24 |
| Allogeneic CMV-Specific CD19-CAR T Cells Plus CMV-MVA Triplex Vaccine After Matched Related Donor Hematopoietic Cell Transplant for the Treatment of Patients With High-Risk Acute Lymphoblastic Leukemia Allogeneic Hematopoietic Stem Cell Transplantation, Anti-CD19-CAR CMV-specific T-lymphocytes, Biospecimen Collection - Acute Lymphoblastic Leukemia | Early Phase 1 | Recruiting | City of Hope Medical Center | 15 | 2025-12-30 | 2026-04-27 |
| ST-067 in Combination With CD19-Directed CAR T-Cell Therapy (Liso-cel) in Relapsed/Refractory Large B-Cell Lymphoma Vevoctadekin, Bone Marrow Aspiration, Bone Marrow Biopsy - Recurrent Diffuse Large B-Cell Lymphoma, Recurrent Diffuse Large B-Cell Lymphoma, Not Otherwise Specified | Phase 1 / Phase 2 | Suspended | Fred Hutchinson Cancer Center | 33 | 2025-12-27 | 2026-09-11 |
| Asparaginase Erwinia Chrysanthemi With Chemotherapy for the Treatment of High-Risk Adults With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma Asparaginase Erwinia chrysanthemi, Biospecimen Collection, Bone Marrow Aspiration - B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative, Lymphoblastic Lymphoma | Phase 2 | Recruiting | City of Hope Medical Center | 53 | 2025-10-10 | 2026-10-13 |
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Alzheimer Disease (18) · Burkitt Lymphoma (15) · Amyotrophic Lateral Sclerosis (9) · Cognitive Dysfunction (9) · Parkinson Disease (8) · Meningeal Carcinomatosis (7) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (7) · Breast Neoplasms (6) · Carcinoma, Non-Small-Cell Lung (6) · Inflammation (6) · Leukemia, Myeloid, Acute (6) · Lung Neoplasms (6) · Lymphoma, Large B-Cell, Diffuse (5) · Multiple Sclerosis (5) · Neurodegenerative Diseases (5)
National Cancer Institute (NCI) (20) · Children's Oncology Group (9) · City of Hope Medical Center (7) · Fred Hutchinson Cancer Center (7) · Institut National de la Santé Et de la Recherche Médicale, France (4) · Mayo Clinic (4) · University of Aarhus (4) · University of Washington (4) · OHSU Knight Cancer Institute (3) · University Hospital Hradec Kralove (3) · University Hospital, Montpellier (3) · University of Exeter (3) · Assistance Publique - Hôpitaux de Paris (2) · Guy's and St Thomas' NHS Foundation Trust (2) · Istituto Auxologico Italiano (2)
United States (87) · France (25) · Canada (13) · Puerto Rico (10) · Italy (8) · Germany (7) · Australia (6) · United Kingdom (6) · Denmark (5) · Netherlands (4) · Belgium (3) · Czechia (3) · Austria (2) · Israel (2) · Spain (2)
Miroslav Cihlo, M.D. (3) · Amandeep Salhotra (2) · Daniel Becker, M.D. (2) · Diego Centonze, MD (2) · Henning Andersen, Professor (2) · Ibrahim Aldoss (2) · Jordan Gauthier (2) · Adam J Esbenshade (1) · Alain Mina, M.D. (1) · Alexandra M Stevens (1) · Alexandre Hirayama (1) · Alexandre V. Hirayama, MD (1) · Alvaro J Alencar (1)
PMID 41671463, PMID 35622074, PMID 33646153, PMID 12670853, PMID 16997419, PMID 17384377, PMID 18275454, PMID 18477382, PMID 18495051, PMID 19167786, PMID 20418301, PMID 20813339, PMID 21194898, PMID 21220675, PMID 21505900, PMID 21523461, PMID 21659625, PMID 21769456, PMID 22019547, PMID 22204998, PMID 22258019, PMID 22503160, PMID 22944553, PMID 22963265, PMID 25230144, PMID 26566655, PMID 28778448, PMID 29096697, PMID 30332335, PMID 32352148, PMID 32589970, PMID 32785820, PMID 32993772, PMID 33300151, PMID 33562569, PMID 34292305, PMID 34331515, PMID 34634256, PMID 35007127, PMID 35249485, PMID 35472722, PMID 36253968, PMID 36322825, PMID 36793451, PMID 36997799, PMID 37081528, PMID 37117993, PMID 37653269, PMID 38263073, PMID 38419144
U10CA180886 (13), P30CA033572 (7), U10CA180821 (4), K23AG052633 (3), U10CA180820 (3), U10CA180888 (2), UM1CA228823 (2), 1RC2AG036535 (1), 2015 (1), 2023 (1), K24AG045334 (1), P01CA018029 (1), P30CA015083 (1), R01AG040271 (1), R01AG050440 (1)