7 completed, 5 recruiting, 4 unknown, 3 not yet recruiting. 9 Not applicable, 2 Phase 1, 2 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 9 | Unknown 3, Not yet recruiting 2, Recruiting 2, Active not recruiting 1, Terminated 1 |
| Phase 1 | 2 | Completed 2 |
| Phase 2 | 2 | Completed 2 |
| Phase 4 | 1 | Completed 1 |
Follow Catatonia: new trials by email Literature Review of Catatonia trials Research Report on Catatonia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Optimizing Stimulation Parameters for Electroconvulsive Therapy Electroconvulsive Therapy - Depression - Major Depressive Disorder, Catatonia | Not applicable | Not yet recruiting | University of Pennsylvania | 64 | 2026-12-01 | 2026-09-04 |
| Dissecting Immunological and Autoimmune Mechanisms of Neuropsychiatric Diseases Neuropsychiatric Symptom | Not yet recruiting | King's College London | 300 | 2026-10-01 | 2026-08-27 | |
| Treatment Resistance in Psychiatric Disorders: the Search for Biological Markers Predictive of Response to Treatment Blood sampling, lumbar puncture, stool sampling, skin microbiopsy and psychometrics scales - Schizophrenia, Treatment Resistant Depression (TRD) | Not applicable | Recruiting | Centre Hospitalier St Anne | 700 | 2026-08-20 | 2026-09-21 |
| Management of Catatonic Features in Adolescents With Profound Autism Intranasal Midazolam (Benzodiazepine Challenge Test), Oral Clonazepam, Electroconvulsive Therapy (ECT) - Autism Spectrum Disorder, Catatonia | Not applicable | Active not recruiting | Tanta University | 30 | 2026-01-01 | 2026-03-27 |
| EEG Microstate and Neuroinflammatory Biomarkers in Older Age Patients With Major Depressive Disorder Receiving ECT Electroconvulsive Therapy - Major Depression Moderate, Major Depression Severe | Recruiting | Istanbul University - Cerrahpasa | 62 | 2025-12-01 | 2026-07-31 | |
| tDCS for Catatonic Depression in Down Syndrome: A Pilot Study Transcranial stimulation - Down Syndrome | Not applicable | Recruiting | Hôpital le Vinatier | 62 | 2025-09-12 | 2026-06-11 |
| Immunogenomic Analyses of Pediatric Catatonia Genetic: Genomic sequencing and molecular diagnostic results, if any., Phage display ImmunoPrecipiation Sequencing (PhIP-Seq) - Catatonia | Not applicable | Not yet recruiting | Rady Pediatric Genomics & Systems Medicine Institute | 120 | 2024-12-01 | 2024-11-14 |
| Catatonic Syndrome in Adult Patients at Basurto Hospital: A Descriptive Study of Incidence, Comorbidity, and Short-Term Outcomes Catatonia | Recruiting | Beatriz Rodriguez Cabo | 40 | 2024-01-01 | 2026-05-12 | |
| Catatonia: Effectiveness of Transcranial Direct Current Electrostimulation (CATATOES) Active tDCS, Sham tDCS - Catatonia | Not applicable | Unknown | Centre Hospitalier St Anne | 70 | 2023-12-01 | 2023-11-24 |
| Personalized Prospective Study Evaluation of the Efficacy and Safety of Noninvasive Neuromodulation of TMS in Subjects With Catatonia rTMS, Placebo - Catatonia, Schizophrenia | Not applicable | Unknown | Moscow Psychiatric Hospital No. 1 Named after N.A. Alexeev | 60 | 2023-11-01 | 2023-12-19 |
| Use of MRI and cTBS for Catatonia in Autism Continuous Theta Burst in Transcranial Magnetic Stimulation - Autism Spectrum Disorder, Catatonia | Phase 1 | Completed | Vanderbilt University Medical Center | 26 | 2023-08-23 | 2025-12-31 |
| Therapies for Down Syndrome Regression Disorder Lorazepam, Intravenous immunoglobulin (IVIG), Tofacitinib - Down Syndrome, Regression | Phase 2 | Completed | University of Colorado, Denver | 66 | 2023-06-29 | 2026-09-03 |
| Clonidine to Prevent Delirium After Electroconvulsive Therapy. Clonidine, Placebo - Major Depressive Disorder, Catatonia | Phase 4 | Completed | Insel Gruppe AG, University Hospital Bern | 130 | 2021-04-27 | 2026-05-19 |
| Survey on Pre-ECT Evaluation and ECT Application Depression, Catatonia | Unknown | Klinički Bolnički Centar Zagreb | 30 | 2020-04-01 | 2020-04-07 | |
| Improving the Understanding of Catatonia in Autism Autistic Disorder, Catatonia | Withdrawn | University of Michigan | 2020-03-01 | 2020-04-10 | ||
| Blood Concentration in Lorazepam and Treatment in Adult Catatonia Catatonia | Recruiting | University Hospital, Lille | 100 | 2020-01-01 | 2026-05-22 | |
| Personalized Non-invasive Neuromodulation by rTMS for Chronic and Treatment Resistant Catatonia Individualized rTMS on VERUM 1's region or network, Individualized rTMS on VERUM 2's region or network, Individualized rTMS on PLACEBO region - Schizophreniform Catatonia, Treatment Resistant | Not applicable | Unknown | University Hospital, Strasbourg, France | 17 | 2017-04-24 | 2022-04-20 |
| Prospective Treatment Study of Catatonia Patients Electroconvulsive Treatment (ECT) Right Unilateral, Electroconvulsive Treatment (ECT) - Bilateral - Catatonia | Not applicable | Terminated | Wake Forest University Health Sciences | 2 | 2017-01-01 | 2019-07-02 |
| Catatonia in Nodding Syndrome and Lorazepam Treatment Lorazepam - Catatonia, Nodding Syndrome | Phase 1 | Completed | Makerere University | 16 | 2013-03-01 | 2015-06-03 |
| Anatomical and Structural Connectivity in Two Psychotic Phenotypes : Periodic Catatonia and Cataphasia Quantitative multiparametric and functional MRI - Schizophrenia, Catatonia | Completed | University Hospital, Strasbourg, France | 162 | 2006-09-25 | 2019-10-21 |
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Schizophrenia (6) · Bipolar Disorder (4) · Psychotic Disorders (3) · Autism Spectrum Disorder (2) · Autoimmune Diseases of the Nervous System (2) · Depressive Disorder, Major (2) · Depressive Disorder, Treatment-Resistant (2) · Down Syndrome (2) · Autistic Disorder (1) · Autoimmune Diseases (1) · Depression (1) · Inflammation (1) · Intellectual Disability (1) · Mental Disorders (1)
Behavior (22) · Behavioral Symptoms (22) · Nervous System Diseases (22) · Neurobehavioral Manifestations (22) · Neurologic Manifestations (22) · Pathological Conditions, Signs and Symptoms (22) · Signs and Symptoms (22) · Mental Disorders (11) · Schizophrenia Spectrum and Other Psychotic Disorders (7) · Bipolar and Related Disorders (4) · Mood Disorders (4) · Child Development Disorders, Pervasive (3) · Depressive Disorder (3) · Abnormalities, Multiple (2) · Brain Diseases (2)
Lorazepam (2) · Risperidone (2) · Blood Specimen Collection (1) · Clonazepam (1) · Clonidine (1) · Electroconvulsive Therapy (1) · Immunoglobulins, Intravenous (1) · SB 223412 (1) · Spinal Puncture (1) · Transcranial Magnetic Stimulation (1) · Transcutaneous Electric Nerve Stimulation (1) · calcium D-pantothenate, L-cysteine drug combination (1) · tofacitinib (1)
Centre Hospitalier St Anne (2) · University Hospital, Strasbourg, France (2) · Beatriz Rodriguez Cabo (1) · GlaxoSmithKline (1) · Hôpital le Vinatier (1) · Insel Gruppe AG, University Hospital Bern (1) · Istanbul University - Cerrahpasa (1) · Janssen, LP (1) · King's College London (1) · Klinički Bolnički Centar Zagreb (1) · Makerere University (1) · Moscow Psychiatric Hospital No. 1 Named after N.A. Alexeev (1) · Rady Pediatric Genomics & Systems Medicine Institute (1) · Tanta University (1) · University Hospital, Lille (1)
France (6) · United States (6) · Croatia (1) · Egypt (1) · Russia (1) · Spain (1) · Switzerland (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Aaron Besterman, MD (1) · Alexandre Haroche, MD,PHD (1) · Angelina Kakooza-Mwesige, MMed (1) · Dirk M Dhossche, MD, PhD (1) · Elise Sannar, MD (1) · James Kimball, M.D (1) · Joaquin Espinosa, PhD (1)
PMID 21463526, PMID 21999346, PMID 21999370, PMID 26710961, PMID 29559372, PMID 35462388, PMID 41062970, PMID 42139810