38 completed, 19 recruiting, 10 unknown, 5 active not recruiting. 62 Not applicable, 8 Phase 1, 5 Phase 2, 4 Phase 3, 3 Early Phase 1.
Follow Vagus Nerve Stimulation: new trials by email Literature Review of Vagus Nerve Stimulation trials Research Report on Vagus Nerve Stimulation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Vagus Nerve Stimulation on Temporomandibular Disorders. nVNS Treatment - TMD, Temporomandibular Disorders (TMDs) | Not applicable | Recruiting | Arpana Church | 10 | 2026-09-01 | 2026-09-01 |
| Vagus Nerve Stimulation for Myelopathy Vagus nerve stimulation (taVNS), Sham Stimulation - Degenerative Cervical Myelopathy | Not applicable | Recruiting | Washington University School of Medicine | 36 | 2026-04-14 | 2026-06-22 |
| Vagus Nerve Stimulation for Reaction Time vagus nerve stimulation - Healthy Subjects (HS) | Not applicable | Recruiting | Youngstown State University | 30 | 2026-04-06 | 2026-04-14 |
| Non-invasive Vagus Nerve Stimulation (nVNS) for Post-Traumatic Stress Disorder (PTSD) non-invasive vagus nerve stimulation - PTSD, Post Traumatic Stress Disorder PTSD | Not applicable | Recruiting | Acacia Clinics | 40 | 2026-03-02 | 2026-10-08 |
| Pain Neuroscience Education and Vagus Nerve Stimulation on Recovery in Individuals With Rheumatoid Arthritis Pain Neuroscience Education, Vagal Nerve Stimulation, Structured Exercises - Rheumatic Diseases, Rheumatoid Arthritis (RA) | Not applicable | Recruiting | Medipol University | 42 | 2026-02-18 | 2026-10-09 |
| Effects of Vagal Nerve Stimulation on Leg Muscle Activity and Posture in Parkinson's Disease Vagal nerve stimulation, No intervention - PARKINSON DISEASE (Disorder), Parkinson's Disease (PD) | Not applicable | Recruiting | University of Minnesota | 75 | 2026-02-10 | 2026-10-20 |
| Vagus Nerve Stimulation (VNS) Electroencephalogram (EEG) Protocol Supplement Vagus Nerve Stimulation - Treatment Resistant Depression | Not applicable | Not yet recruiting | Stanford University | 12 | 2026-01-01 | 2025-12-30 |
| Exploring the Role of taVNS in Nausea Management Vagal Nerve Stimulation, Sham stimulation - Healthy Adult Participants | Not applicable | Recruiting | Daniel Keszthelyi | 35 | 2025-12-08 | 2026-06-08 |
| A Study Of Vagus Nerve Stimulation (VNS) With Mobility Training For Gait Recovery After Chronic Ischemic Stroke Vagus nerve stimulation (VNS) paired with mobility training - Ischemic Stroke | Not applicable | Recruiting | Mayo Clinic | 20 | 2025-12-03 | 2026-02-17 |
| Non-invasive Auricular Fiber Vagus Nerve Stimulation (afVNS) for Treatment of Autism Spectrum Disorder vagus nerve stimulation - Autism Spectrum Disorder | Not applicable | Recruiting | Neuropix | 20 | 2025-12-01 | 2026-01-08 |
| Vagus Nerve Stimulation to the Ear to Improve Symptoms in Post-COVID-19 and ME/CFS transcutaneous vagus nerve stimulation - Post-COVID / Long-COVID, ME/CFS | Not applicable | Active not recruiting | University of Luxembourg | 48 | 2025-07-18 | 2025-08-08 |
| Paired Vagus Nerve Stimulation Mechanisms Vagus Nerve Stimulation (VNS) Device, Sham VNS Device, Upper Extremity Rehabilitation - Chronic Stroke | Not applicable | Terminated | NYU Langone Health | 4 | 2025-07-15 | 2026-06-12 |
| The Effect of Auricular Vagus Nerve Stimulation and Controlled Breathing Exercises on Performance and Autonomic Nervous System Vagus Nerve Stimulation, Controlled breathing exercises - Health People, Physical Activity | Not applicable | Completed | Bahçeşehir University | 64 | 2025-07-09 | 2025-12-09 |
| Alzheimer's Disease Treated With Vagus Nerve Stimulation Vagus Nerve Stimulation, Sham Vagus Nerve Stimulation - Alzheimer Disease (AD) | Not applicable | Recruiting | Beijing Municipal Administration of Hospitals | 74 | 2025-05-07 | 2025-06-06 |
| Wether VNS in Early Stage (3 Months) is Safe and More Beneficial for Post-stroke Motor Rehabilitation Vagus Nerve Stimulation in early stage, Vagus Nerve Stimulation in late stage - Stroke, Motor Rehabilitation | Phase 1 | Recruiting | Qilu Hospital of Shandong University | 100 | 2025-05-01 | 2025-04-22 |
| Vagus Nerve Stimulator for Autism and Other Developmental Disorders Vagus Nerve Stimulation - Autism Spectrum Disorder, Intellectual Disability | Not applicable | Withdrawn | New York State Institute for Basic Research | 2025-05-01 | 2026-02-13 | |
| Exploring the Effect of taVNS on the Acute Stress Responses Vagal Nerve Stimulation, Sham stimulation - Healthy Adult Participants | Not applicable | Completed | Daniel Keszthelyi | 60 | 2025-03-21 | 2026-06-05 |
| The Effect of taVNS and Upper GI Motility Vagal Nerve Stimulation, Sham stimulation - Healthy Adult Participants | Not applicable | Recruiting | Daniel Keszthelyi | 12 | 2025-02-25 | 2026-06-08 |
| Vagal Stimulation in Individuals With Stroke vagus nerve stimulation, classic rehabilitation - Stroke, Vagus Nerve Stimulation | Not applicable | Active not recruiting | Nermin KART | 34 | 2025-02-25 | 2026-09-16 |
| Effect of Vagus Nerve Stimulation on Trapezius Trigger Point Vagus Nerve Stimulation (nVNS), Ischemic Compression, Exercise (Control) - Myofascial Pain Syndrome, Trigger Points | Not applicable | Completed | Bahçeşehir University | 90 | 2025-01-15 | 2026-10-06 |
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Stroke (10) · Depression (6) · Pain (6) · Paresis (6) · Depressive Disorder, Treatment-Resistant (5) · Inflammation (4) · Chronic Pain (3) · Epilepsy (3) · Fibromyalgia (3) · Motor Activity (3) · Postural Orthostatic Tachycardia Syndrome (3) · Arthritis, Rheumatoid (2) · Autism Spectrum Disorder (2) · Drug Resistant Epilepsy (2) · Fatigue (2)
Cyberonics, Inc. (4) · Baylor Research Institute (3) · Daniel Keszthelyi (3) · MicroTransponder Inc. (3) · Northwell Health (3) · Riphah International University (3) · Stanford University (3) · Bahçeşehir University (2) · Istanbul Medipol University Hospital (2) · KU Leuven (2) · LivaNova (2) · Medical University of South Carolina (2) · Qilu Hospital of Shandong University (2) · University of Pittsburgh (2) · Acacia Clinics (1)
United States (32) · Turkey (Türkiye) (10) · China (8) · Netherlands (7) · Belgium (5) · United Kingdom (4) · Austria (3) · Egypt (3) · India (3) · Pakistan (3) · France (2) · Israel (2) · Norway (2) · Spain (2) · Australia (1)
Daniel Keszthelyi, MD, PhD (3) · Jane Wigginton, MD (3) · Mark Powers, PhD (3) · Michael Kilgard, PhD (3) · Richard Naftalis, MD, FAANS, FACS (3) · Robert Rennaker, PhD (3) · Seth Hays, PhD (3) · Ann Marie Warren, PhD (2) · George F Wittenberg, MD, PhD (2) · Guy Boeckxstaens, M.D. (2) · Linda Nguyen, MD (2) · Michael Foreman, MD FACS (2) · Rita Hamilton, DO (2) · A.P. Aldenkamp, Prof (1)
PMID 10528943, PMID 10839541, PMID 14531531, PMID 14571320, PMID 16139580, PMID 16139581, PMID 16139582, PMID 16678561, PMID 17030182, PMID 18571625, PMID 18786301, PMID 19258380, PMID 20400010, PMID 21030409, PMID 21475195, PMID 21543530, PMID 21812908, PMID 23360102, PMID 23929694, PMID 24255953, PMID 24652102, PMID 24870622, PMID 24917634, PMID 25187002, PMID 25689839, PMID 26049730, PMID 26601770, PMID 26645257, PMID 27059884, PMID 27221316, PMID 28248690, PMID 29072609, PMID 29276734, PMID 29467611, PMID 30294792, PMID 30355189, PMID 30472681, PMID 31685853, PMID 31885549, PMID 31903435, PMID 32229334, PMID 32232095, PMID 32258159, PMID 32358638, PMID 32380360, PMID 32471438, PMID 32476617, PMID 32586395, PMID 32967704, PMID 33590355
OT2OD028201 (1), P20GM109040 (1), R01AR053732 (1), R01HL128393 (1), UG3NS109497 (1)