23 completed. 23 Phase 2, 5 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 23 | Completed 23 |
| Phase 1 | 5 | Completed 5 |
| Phase 3 | 2 | Completed 2 |
Follow Trauma: new trials by email Literature Review of Trauma trials Research Report on Trauma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cold Stored Platelet in Hemorrhagic Shock Cold Stored Platelets (CSP), Standard Care - Trauma, Hemorrhage | Phase 2 | Completed | Jason Sperry | 200 | 2022-06-21 | 2024-12-18 |
| REmimazolam Infusion in the Context of Hypnotic Shortage in the Critical Care Unit During the Pandemic of COVID-19: REHSCU Study Remimazolam - Acute Respiratory Failure, COVID-19 | Phase 2 | Completed | Nantes University Hospital | 30 | 2020-11-30 | 2021-11-04 |
| PK PD Study of IDA and Azithromycin for NTDs ( ComboNTDs ) Azithromycin, Albendazole, Ivermectin - Lymphatic Filariasis, Yaws | Phase 2 | Completed | Lihir Medical Centre | 42 | 2018-09-01 | 2019-02-28 |
| Humacyte Acellular Tissue Engineered Vessel (ATEV) in Patients With Vascular Trauma Acellular Tissue Engineered Vessel (ATEV) - Trauma, Vascular System Injury | Phase 2 / Phase 3 | Completed | Humacyte, Inc. | 72 | 2018-09-01 | 2026-07-29 |
| Acellular Adipose Tissue (AAT) for Soft Tissue Reconstruction Acellular Adipose Tissue (AAT) - Soft Tissue Injuries, Trauma | Phase 2 | Completed | Johns Hopkins University | 15 | 2018-06-21 | 2026-05-12 |
| Low Dose Ketamine Intra Nasal Traumatology Ketamine, Placebo - Trauma | Phase 2 | Completed | University of Monastir | 1102 | 2018-01-01 | 2019-07-02 |
| Role of Prophylactic Metoclopramide With Tramadol in Trauma Patients Tramadol, Metoclopramide, Placebo - Trauma, Opioid Analgesic Adverse Reaction | Phase 2 | Completed | University of Malaya | 191 | 2017-07-01 | 2017-12-26 |
| Fibrinogen Early In Severe Trauma studY Fibrinogen Concentrate, Cryoprecipitate - Trauma, Haemorrhage | Phase 2 | Completed | Gold Coast Hospital and Health Service | 100 | 2016-12-01 | 2018-03-05 |
| Implementing Treatment Algorithms for the Correction of Trauma Induced Coagulopathy VHA algorithm - Hemorrhage, Coagulopathy | Phase 2 | Completed | Queen Mary University of London | 412 | 2016-06-01 | 2018-08-29 |
| Dexmedetomidine Versus Propofol for Prolonged Sedation in Poly Traumatized Mechanically Ventilated Patients Dexmedetomidine, Propofol - Trauma | Phase 2 / Phase 3 | Completed | Assiut University | 60 | 2015-11-01 | 2016-08-23 |
| BraveMind: Advancing the Virtual Iraq/Afghanistan PTSD Exposure Therapy Virtual Reality Exposure Therapy (VRET) - Trauma, Post-Traumatic Stress Disorder | Phase 2 | Completed | Emory University | 15 | 2015-05-01 | 2017-08-09 |
| Pilot Randomized Trial of Fibrinogen in Trauma Haemorrhage Fibrinogen, Placebo - Trauma, Haemorrhage | Phase 2 | Completed | Copenhagen University Hospital, Rigshospitalet | 40 | 2015-02-01 | 2017-04-11 |
| Fibrinogen in the Initial Resuscitation of Severe Trauma (FiiRST) Fibrinogen concentrate, Placebo Comparator - Trauma, Injury | Phase 1 / Phase 2 | Completed | Sunnybrook Health Sciences Centre | 50 | 2014-10-01 | 2016-04-14 |
| Feasibility Study of Geko vs. IPCs in Trauma geko, IPCs - Trauma, Venous Thromboembolism | Phase 2 | Completed | Hamilton Health Sciences Corporation | 20 | 2013-07-01 | 2015-03-19 |
| Cell Therapy for Craniofacial Bone Defects Ixmyelocel-T, Autogenous Bone Grafting - Cleft Palate, Trauma | Phase 1 / Phase 2 | Completed | University of Michigan | 18 | 2012-08-01 | 2017-05-04 |
| Fibrinogen Concentrate (FGTW) in Trauma Patients, Presumed to Bleed (FI in TIC) Human Fibrinogen Concentrate, Placebo - Trauma, Massive Hemorrhage | Phase 1 / Phase 2 | Completed | Medical University Innsbruck | 67 | 2011-09-01 | 2015-12-08 |
| Tachikawa Project for Prevention of Posttraumatic Stress Disorder With Polyunsaturated Fatty Acid (TPOP): TPOP-01 Study Omega-3 Polyunsaturated Fatty Acid - Trauma, Posttraumatic Stress Disorder | Phase 1 / Phase 2 | Completed | Japan Science and Technology Agency | 15 | 2008-05-01 | 2012-07-03 |
| Ascending Single Dose Study of Rhu-pGelsolin in Patients With Decreased Gelsolin Levels rhu-pGelsolin, Placebo - Low Gelsolin, Trauma | Phase 1 / Phase 2 | Completed | Critical Biologics Corporation | 40 | 2008-03-01 | 2010-09-29 |
| Adjunctive Therapy to Treat Tibial Shaft Fractures open fracture reduction - Trauma | Phase 2 | Completed | Kuros Biosurgery AG | 201 | 2007-04-01 | 2012-03-16 |
| Safety and Preliminary Efficacy of Recombinant Activated Factor VII in Subjects With Traumatic Brain Injury activated recombinant human factor VII - Acquired Bleeding Disorder, Trauma | Phase 2 | Completed | Novo Nordisk A/S | 96 | 2005-01-01 | 2017-01-12 |
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Wounds and Injuries (23) · Hemorrhage (5) · Hemostatic Disorders (3) · Sepsis (2) · Stress Disorders, Post-Traumatic (2) · Stroke (2) · Afibrinogenemia (1) · Brain Injuries (1) · Burns (1) · COVID-19 (1) · Cleft Palate (1) · Elephantiasis, Filarial (1) · Hypoxia (1) · Infections (1) · Meretoja syndrome (1)
Pathological Conditions, Signs and Symptoms (8) · Cardiovascular Diseases (7) · Pathologic Processes (7) · Vascular Diseases (7) · Hemic and Lymphatic Diseases (4) · Hematologic Diseases (3) · Hemorrhagic Disorders (3) · Brain Diseases (2) · Central Nervous System Diseases (2) · Cerebrovascular Disorders (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Infections (2) · Inflammation (2) · Lung Diseases (2) · Mental Disorders (2)
Fibrinogen (4) · Saline Solution (2) · Albendazole (1) · Azithromycin (1) · Dexmedetomidine (1) · Diethylcarbamazine (1) · Docosahexaenoic Acids (1) · Hyperbaric Oxygenation (1) · Intermittent Pneumatic Compression Devices (1) · Ivermectin (1) · Ketamine (1) · Metoclopramide (1) · Open Fracture Reduction (1) · Oxyhemoglobins (1) · Propofol (1)
Novo Nordisk A/S (3) · Assiut University (1) · Copenhagen University Hospital, Rigshospitalet (1) · Critical Biologics Corporation (1) · Emory University (1) · Gold Coast Hospital and Health Service (1) · Hamilton Health Sciences Corporation (1) · Humacyte, Inc. (1) · Intermountain Health Care, Inc. (1) · Japan Science and Technology Agency (1) · Jason Sperry (1) · Johns Hopkins University (1) · Kuros Biosurgery AG (1) · Lihir Medical Centre (1) · Medical University Innsbruck (1)
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Barbara O Rothbaum, PhD/ABPP (1) · Barto Nascimento, MD MSc (1) · Christine Gaarder, MD (1) · Damon Cooney, MD, PhD (1) · Darnell Kaigler, DDS, PhD (1) · Dietmar Fries, Prof. MD (1) · Frank Guyette, MD, MPH (1) · Hala S Abdel-Ghaffar, MD (1) · Jakob Stensballe, MD, PhD (1) · James Winearls, MBBS (1) · Jason Sperry, MD, MPH (1) · Karim Brohi, FCRS FRCA (1) · Lindell K. Weaver, MD (1) · Nouira Semir, Professor (1)
PMID 18580208, PMID 15734783, PMID 16096533, PMID 16734808, PMID 16859505, PMID 17156226, PMID 17184516, PMID 17189115, PMID 17686152, PMID 18496183, PMID 20520307, PMID 21303552, PMID 21720194, PMID 23682548, PMID 26814938, PMID 27430210, PMID 28549445, PMID 29047413, PMID 32818264, PMID 33109923, PMID 36163263, PMID 37262040, PMID 38708880, PMID 39565635, PMID 40174701, PMID 41140335, PMID 42848323
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