14 completed, 6 unknown, 4 terminated, 2 not yet recruiting. 30 Phase 3, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 30 | Completed 14, Unknown 6, Terminated 4, Not yet recruiting 2, Recruiting 2, Withdrawn 2 |
| Phase 2 | 4 | Completed 2, Not yet recruiting 1, Unknown 1 |
Follow Trauma: new trials by email Literature Review of Trauma trials Research Report on Trauma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Calcium Administration in Life-saving Management During Massive Hemorrhage calcium gluconate, Control: Placebo - Massive Hemorrhage, Trauma | Phase 2 / Phase 3 | Not yet recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 81 | 2025-05-01 | 2025-02-11 |
| Empiric Calcium in Massive Transfusion Calcium Gluconate - Hemorrhage, Trauma | Phase 3 | Withdrawn | University of California, Irvine | 2025-01-01 | 2026-03-30 | |
| Frozen Platelets in the Treatmentof Traumatic or Vascular Bleeding Deep-frozen platelets - Trauma, Bleeding | Phase 3 | Unknown | Alrijne Ziekenhuis Leiderdorp | 158 | 2023-06-01 | 2023-02-01 |
| Whole Blood in Trauma Patients With Hemorrhagic Shock Transfusion of blood products - Trauma, Trauma Injury | Phase 3 | Recruiting | Fundacion Clinica Valle del Lili | 220 | 2023-01-14 | 2025-02-27 |
| Fibrinogen Early In Severe Trauma StudY II Fibrinogen Concentrate, Cryoprecipitate - Trauma, Haemorrhagic Shock | Phase 3 | Completed | Australian and New Zealand Intensive Care Research Centre | 900 | 2022-11-21 | 2026-09-09 |
| Evaluation of a Transfusion Therapy Using Whole Blood in the Management of Coagulopathy in Patients With Acute Traumatic Hemorrhage Whole blood transfusion, Fractionated blood products transfusion - Trauma, Acute Hemorrhage | Phase 3 | Completed | Direction Centrale du Service de Santé des Armées | 200 | 2021-12-04 | 2026-01-26 |
| Restarting Anticoagulation After Traumatic Intracranial Hemorrhage Anticoagulants - Hemorrhage, Intracranial Hemorrhages | Phase 3 | Not yet recruiting | University of Texas at Austin | 1100 | 2021-10-01 | 2021-05-19 |
| ErythroPOietin Alfa to Prevent Mortality and Reduce Severe Disability in Critically Ill TRAUMA Patients Epoetin Alfa 40000 UNT/ML, Sodium Chloride 0.9% - Trauma, Traumatic Injury | Phase 3 | Recruiting | Australian and New Zealand Intensive Care Research Centre | 2500 | 2020-11-09 | 2025-07-16 |
| Use of Testosterone to Prevent Post-Surgical Muscle Loss - Pilot Study Aveed 750 MG in 3 ML IM Injection, Normal Saline 3 ML IM Injection - Muscle Atrophy, Surgery | Phase 2 / Phase 3 | Unknown | The Stone Research Foundation for Sports Medicine and Arthritis | 15 | 2020-05-08 | 2021-08-31 |
| Humacyte Acellular Tissue Engineered Vessel (ATEV) in Patients With Vascular Trauma Acellular Tissue Engineered Vessel (ATEV) - Trauma, Vascular System Injury | Phase 2 / Phase 3 | Completed | Humacyte, Inc. | 72 | 2018-09-01 | 2026-07-29 |
| Efficacy of Lidocaine Patch in Acute Musculoskeletal Pain in the Emergency Department Ibuprofen, Lidocaine Patch 4% - Acute Musculoskeletal Disease, Sprains | Phase 3 | Completed | East Carolina University | 23 | 2018-06-23 | 2024-03-25 |
| Polymyxin B Monotherapy vs Combination Therapy in Critically Ill Patients With Multi-drug Resistant Pathogens Polymyxin B - Trauma, Resistant Infection | Phase 3 | Unknown | University of Puerto Rico | 40 | 2017-05-25 | 2019-02-08 |
| PREVENTion of Clot in Orthopaedic Trauma Acetylsalicylic acid, Low Molecular Weight Heparin (LMWH) - Blood Clot, Trauma | Phase 3 | Completed | Major Extremity Trauma Research Consortium | 12424 | 2017-04-24 | 2024-05-14 |
| Supplemental Enteral Protein in Critical Illness Protein supplementation, Standard enteral nutrition - Nutrition Disorder, Trauma | Phase 3 | Completed | University of Washington | 500 | 2016-11-01 | 2024-06-05 |
| Helping Children With Trauma Trauma Systems Therapy (TST), Treatment as Usual (TAU) - Trauma, Post-Traumatic Stress Disorder | Phase 3 | Terminated | NYU Langone Health | 14 | 2016-02-01 | 2017-03-31 |
| Dexmedetomidine Versus Propofol for Prolonged Sedation in Poly Traumatized Mechanically Ventilated Patients Dexmedetomidine, Propofol - Trauma | Phase 2 / Phase 3 | Completed | Assiut University | 60 | 2015-11-01 | 2016-08-23 |
| Comparative Study of Loxoprofen Sodium Transdermal Patch and Loxonin® Tablets for the Treatment of Acute Trauma Transdermal Patch, Loxoprofen sodium, Placebo (for loxoprofen sodium) - Trauma, Pain | Phase 3 | Completed | Daiichi Sankyo Brasil Farmacêutica LTDA | 242 | 2015-10-01 | 2017-02-14 |
| Freeze-dried Plasma in the Initial Management of Coagulopathy in Trauma Patients Freezed-dried plasma, Fresh-frozen plasma - Trauma, Coagulopathy | Phase 3 | Completed | University Hospital, Lille | 42 | 2013-07-09 | 2026-04-22 |
| Nutritional Requirement for the Severe Trauma Patients high caloric nutritional supplement, low caloric nutritional supplement - Trauma | Phase 3 | Unknown | Asan Medical Center | 61 | 2012-11-01 | 2013-01-04 |
| Pragmatic, Randomized Optimal Platelet and Plasma Ratios 1:1:1 Blood Transfusion Ratio, 1:1:2 Blood Transfusion Ratio - Trauma | Phase 3 | Completed | The University of Texas Health Science Center, Houston | 680 | 2012-08-01 | 2019-02-08 |
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Wounds and Injuries (30) · Hemorrhage (5) · Hemostatic Disorders (4) · Critical Illness (3) · Multiple Trauma (3) · Shock, Hemorrhagic (3) · Brain Injuries, Traumatic (2) · Hypocalcemia (2) · Inflammation (2) · Muscular Atrophy (2) · Shock (2) · Sprains and Strains (2) · Stress Disorders, Post-Traumatic (2) · Thrombosis (2) · Accidental Injuries (1)
Pathological Conditions, Signs and Symptoms (16) · Pathologic Processes (12) · Cardiovascular Diseases (10) · Vascular Diseases (10) · Nervous System Diseases (7) · Neurologic Manifestations (5) · Signs and Symptoms (5) · Brain Diseases (4) · Central Nervous System Diseases (4) · Disease Attributes (4) · Hematologic Diseases (4) · Hemic and Lymphatic Diseases (4) · Hemorrhagic Disorders (4) · Infections (4) · Nutritional and Metabolic Diseases (4)
Sodium Chloride (4) · Calcium (2) · Calcium Gluconate (2) · Anticoagulants (1) · Ascorbic Acid (1) · Aspirin (1) · Blood Transfusion (1) · Cilastatin, Imipenem Drug Combination (1) · Complement C1 Inhibitor Protein (1) · Dexmedetomidine (1) · Docosahexaenoic Acids (1) · Enoxaparin (1) · Epoetin Alfa (1) · Estradiol (1) · Exchange Transfusion, Whole Blood (1)
Australian and New Zealand Intensive Care Research Centre (2) · Novo Nordisk A/S (2) · Alrijne Ziekenhuis Leiderdorp (1) · Asan Medical Center (1) · Assiut University (1) · Centre Hospitalier Universitaire Vaudois (1) · Copenhagen University Hospital, Rigshospitalet (1) · Daiichi Sankyo Brasil Farmacêutica LTDA (1) · Direction Centrale du Service de Santé des Armées (1) · East Carolina University (1) · Fundacion Clinica Valle del Lili (1) · Humacyte, Inc. (1) · Japan Science and Technology Agency (1) · Laboratorio Brasileiro de Biologia (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1)
United States (11) · France (4) · Brazil (3) · Germany (3) · Switzerland (3) · Australia (2) · Canada (2) · Netherlands (2) · New Zealand (2) · United Kingdom (2) · Belgium (1) · Colombia (1) · Czechia (1) · Denmark (1) · Egypt (1)
Abel Pereira Junior, investigator (1) · Alberto F Garcia, MD MSc (1) · Associate Professor Craig French (1) · Bartholomew Tortella, MD (1) · Femke Noorman, PhD (1) · Glenn Saxe, MD (1) · Grant O'Keefe, MD (1) · Hala S Abdel-Ghaffar, MD (1) · Jakob Stensballe, MD (1)
PMID 10319217, PMID 10376632, PMID 10623981, PMID 15269195, PMID 15851777, PMID 17121631, PMID 17349504, PMID 17785483, PMID 18199038, PMID 18444865, PMID 18625681, PMID 18687132, PMID 19374579, PMID 20175247, PMID 21793988, PMID 21988742, PMID 2205779, PMID 22252816, PMID 22752516, PMID 23394211, PMID 23616495, PMID 23697744, PMID 24191943, PMID 24335442, PMID 24514083, PMID 24996573, PMID 25066331, PMID 25430979, PMID 25461655, PMID 25481088, PMID 25647203, PMID 26151924, PMID 26259799, PMID 26335087, PMID 26452709, PMID 27418577, PMID 28731937, PMID 28840147, PMID 28930959, PMID 29274254, PMID 29766088, PMID 30030268, PMID 30447946, PMID 31050809, PMID 31604788, PMID 3344884, PMID 33797501, PMID 3461421, PMID 35141873, PMID 36153539
2005 (1), R01GM127790 (1), U01HL077863 (1)