11 completed, 2 active not recruiting. 5 Phase 2, 2 Not applicable, 2 Phase 3, 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Completed 4, Active not recruiting 1 |
| Not applicable | 2 | Completed 2 |
| Phase 3 | 2 | Completed 2 |
| Phase 4 | 2 | Completed 2 |
Follow Diethylcarbamazine: new trials by email Literature Review of Diethylcarbamazine trials Research Report on Diethylcarbamazine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Efficacy of Novel Combination Regimens for Treatment of Onchocerciasis Ivermectin w/ Albendazole, Ivermectin + Diethylcarbamazine + Albendazole, Moxidectin + Albendazole - Onchocercal Subcutaneous Nodule, Onchocerciasis | Phase 2 | Active not recruiting | Washington University School of Medicine | 300 | 2024-04-05 | 2025-12-18 |
| Moxidectin for LF, Cote d'Ivoire (DOLF) Ivermectin, Diethylcarbamazine, Albendazole - Lymphatic Filariasis | Phase 3 | Completed | Washington University School of Medicine | 164 | 2020-08-20 | 2026-01-29 |
| Safety of Co-administration of IDA and Azithromycin for NTDs ( ComboNTDs ) Albendazole on Day 1, Ivermectin on Day 1, Diethylcarbamazine on day 1 - Trachoma, Yaws | Phase 3 | Completed | Lihir Medical Centre | 20000 | 2018-10-01 | 2019-02-28 |
| PK PD Study of IDA and Azithromycin for NTDs ( ComboNTDs ) Azithromycin, Albendazole, Ivermectin - Lymphatic Filariasis, Yaws | Phase 2 | Completed | Lihir Medical Centre | 42 | 2018-09-01 | 2019-02-28 |
| Lymphatic Filariasis (LF) in Ivory Coast Albendazole, Ivermectin, Diethylcarbamazine - Lymphatic Filariasis | Not applicable | Completed | University Hospitals Cleveland Medical Center | 189 | 2015-01-01 | 2022-04-21 |
| Eval 3-Drug Therapy Diethylcarbamize, Albendazole and Ivermectin That Could Accelerate LF Elimination Outside of Africa Diethylcarbamazine, Albendazole, Ivermectin - Lymphatic Filariasis | Phase 2 | Completed | University Hospitals Cleveland Medical Center | 182 | 2014-05-01 | 2018-10-09 |
| Post-treatment Effects of Ivermectin (IVM) or Diethylcarbamazine (DEC) in Loiasis Diethylcarbamazine, Ivermectin - Loiasis | Phase 4 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 155 | 2012-04-01 | 2016-11-09 |
| Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis Albendazole (annual), Diethylcarbamazine (annual), Albendazole (semiannual) - Lymphatic Filariasis, Soil Transmitted Helminth Infections | Completed | Washington University School of Medicine | 17108 | 2011-05-01 | 2020-11-17 | |
| Reslizumab to Prevent Post-treatment Eosinophilia in Loiasis Reslizumab, Diethylcarbamazine, Placebo - Loiasis | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 31 | 2010-04-01 | 2022-01-27 |
| Alternate Chemotherapy Regimens for the Clearance of W.Bancrofti Infection Diethylcarbamazine, Albendazole, Doxycycline - Filarial; Infestation | Phase 4 | Completed | Indian Council of Medical Research | 146 | 2009-02-01 | 2013-12-09 |
| Effect of Albendazole Dose on Treatment of Lymphatic Filariasis Albendazole, Diethylcarbamazine - Lymphatic Filariasis | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 40 | 2007-07-01 | 2015-08-31 |
| Interaction Between HIV and Lymphatic Filariasis Diethylcarbamazine - HIV Infection, Lymphatic Filariasis | Not applicable | Completed | DBL -Institute for Health Research and Development | 2001-08-01 | 2006-02-24 | |
| Host Response to Infection and Treatment in Filarial Diseases Diethylcarbamazine - Filariasis, Helminthiasis | Active not recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 425 | 1991-03-15 | 2026-10-30 |
Elephantiasis, Filarial (9) · Filariasis (3) · Loiasis (2) · Onchocerciasis (2) · Parasitic Diseases (2) · Yaws (2) · HIV Infections (1) · Helminthiasis (1) · Mansonelliasis (1) · Neglected Diseases (1) · Onchocerciasis, Ocular (1) · Scabies (1) · Strongyloidiasis (1) · Trachoma (1) · Wounds and Injuries (1)
National Institute of Allergy and Infectious Diseases (NIAID) (4) · Washington University School of Medicine (3) · Lihir Medical Centre (2) · University Hospitals Cleveland Medical Center (2) · DBL -Institute for Health Research and Development (1) · Indian Council of Medical Research (1)
Papua New Guinea (3) · Côte d’Ivoire (2) · India (2) · United States (2) · Cameroon (1) · Indonesia (1) · Liberia (1)
Amy D Klion, M.D. (2) · Thomas B Nutman, M.D. (2) · Benjamin Koudou, PhD (1) · Catherine Bjerum, MD, MPH (1) · Christopher L King, MD PhD (1) · Gary J Weil, MD (1) · Gary Weil, MD (1) · Lourduraj J De Britto, M.D (1) · Lucy John, MD (1) · Nina O Nielsen, Ms.c (1) · Patrick Kpanyen, PhD (1) · Peter Fischer, PhD (1) · Peter Siba, PhD (1) · Peter U Fischer, Ph.D. (1) · Philip Budge, MD, PhD (1)
PMID 42848323, PMID 26486704, PMID 26691247, PMID 28329346, PMID 30403937, PMID 31641754, PMID 32055862, PMID 32561912, PMID 32818264, PMID 33674871, PMID 37243712, PMID 37262040, PMID 37616301, PMID 37721964, PMID 38587077, PMID 40345209