7 completed, 4 unknown, 3 not yet recruiting, 1 recruiting. 16 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 16 | Completed 7, Unknown 4, Not yet recruiting 3, Recruiting 1, Terminated 1 |
Follow Tonsillectomy: new trials by email Literature Review of Tonsillectomy trials Research Report on Tonsillectomy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Suzetrigine in Tonsillectomy for Opioid-sparing Pain Management Suzetrigine, Acetaminophen, oxycodone - Tonsillectomy, Pharyngoplasty | Phase 4 | Not yet recruiting | Stanford University | 58 | 2026-11-01 | 2026-09-16 |
| Sphenopalatine Ganglion Block for Pain Relief After Pediatric Adenotonsillectomy Sphenopalatine ganglion block (Ropivacaine), Sham sphenopalatine ganglion block (Saline) - Postoperative Pain, Tonsillectomy | Phase 4 | Not yet recruiting | Vinícius C Quintão, MD, MSc, PhD | 145 | 2026-09-15 | 2026-08-28 |
| Topical Magnesium Sulfate Versus Peritonsillar Bupivacaine for Post-Tonsillectomy Pain Relief in Children Magnesium Sulfate, Bupivacaine - Post-tonsillectomy Pain, Tonsillectomy | Phase 4 | Not yet recruiting | Assiut University | 40 | 2026-09-01 | 2026-08-12 |
| Muscle Relaxation for Pediatric Adenotonsillectomy Rocuronium, Sugammadex, Anesthesia without neuromuscular blockade - Tonsillectomy | Phase 4 | Completed | University of Texas Southwestern Medical Center | 172 | 2024-04-10 | 2025-07-28 |
| Ketamine Gargle for Pain After Pediatric Tonsillectomy Ketamine Hydrochloride in saline, Normal Saline (0.9% NaCl) - Postoperative Pain, Tonsillectomy | Phase 4 | Completed | Hospital Universitario de Caracas | 420 | 2024-01-10 | 2026-05-05 |
| Handheld-multimedia Versus Oral Midazolam in Pediatric on Perioperative Anxiety Midazolam oral solution, IPAD - Perioperative Anxiety, Preanesthetic Medication | Phase 4 | Unknown | Universitair Ziekenhuis Brussel | 150 | 2020-02-01 | 2021-05-04 |
| Remifentanil Tapering and Post-adenotonsillectomy Pain in Children Remifentanil, Sodium Chloride 9mg/mL - Child, Only, Pain | Phase 4 | Terminated | University Hospital, Akershus | 6 | 2020-01-16 | 2023-08-22 |
| Betamethasone (Betapred®) as Premedication for Reducing Postoperative Vomiting and Pain After Tonsillectomy Betamethason Sodium Phosphate, 10% glucose solution - Tonsillectomy, Pain | Phase 4 | Unknown | Umeå University | 100 | 2019-09-10 | 2024-05-14 |
| Gabapentin Premedication to Reduce Postoperative Pain for Pediatric Tonsillectomy Gabapentin - Tonsillitis, Tonsillectomy | Phase 4 | Recruiting | Children's Healthcare of Atlanta | 50 | 2018-07-31 | 2019-07-24 |
| EXPAREL Post-tonsillectomy Clinical Trial Adjunct Exparel (bupivacaine liposome suspension 1.3%), Standard Care - Tonsillectomy | Phase 4 | Completed | Paul Hoff | 42 | 2018-02-15 | 2026-10-30 |
| Dexamethasone-bupivacaine Versus Bupivacaine for Tonsillectomy Pain. Bupivacaine 0.5%, Bupivacaine 0.5% , Dexamethasone, Nacl 0,9 % - Tonsillectomy | Phase 4 | Unknown | Sisli Hamidiye Etfal Training and Research Hospital | 120 | 2017-12-15 | 2018-02-23 |
| Modified Pre-operative Oral Doses Acetaminophen Versus Intravenous Acetaminophen Acetaminophen - Tonsillectomy, Adenoidectomy | Phase 4 | Completed | University of California, Davis | 74 | 2017-08-28 | 2021-02-18 |
| EXPAREL® for Pain After Tonsillectomy Liposomal Bupivacaine - Tonsillectomy, Tonsillitis | Phase 4 | Completed | Mayo Clinic | 39 | 2015-05-01 | 2017-07-14 |
| Tranexamic Acid and Pediatric Adenotonsillectomy Tranexamic Acid, normal saline solution - Tonsillectomy, Adenoidectomy | Phase 4 | Completed | Irmandade Santa Casa de Misericórdia de Porto Alegre | 95 | 2010-01-01 | 2010-12-22 |
| Home Care Management of Pediatric Pain Standard Care, ATC Dosing, Structured Pain Management Program - Tonsillectomy | Phase 4 | Completed | University of California, San Francisco | 211 | 2000-06-01 | 2012-06-08 |
| Evaluation of The Effect of Bupivacaine (Marcaine) in Reducing Early Post Tonsillectomy Pain Bupivacaine, normal saline - Tonsillectomy | Phase 4 | Unknown | King Saud University | 2012-04-20 |
Pain, Postoperative (5) · Pain (4) · Agnosia (2) · Hemorrhage (2) · Tonsillitis (2) · Acute Pain (1) · Anxiety Disorders (1) · Postoperative Hemorrhage (1) · Postoperative Nausea and Vomiting (1) · Sleep Apnea Syndromes (1) · Sleep Apnea, Obstructive (1) · Snoring (1)
Pathological Conditions, Signs and Symptoms (10) · Signs and Symptoms (9) · Neurologic Manifestations (8) · Pathologic Processes (7) · Postoperative Complications (7) · Pain (4) · Nervous System Diseases (3) · Respiratory Tract Diseases (3) · Infections (2) · Neurobehavioral Manifestations (2) · Otorhinolaryngologic Diseases (2) · Perceptual Disorders (2) · Pharyngeal Diseases (2) · Pharyngitis (2) · Respiratory Tract Infections (2)
Bupivacaine (4) · Saline Solution (4) · Sodium Chloride (3) · Acetaminophen (2) · Standard of Care (2) · Anesthesia (1) · Dexamethasone (1) · Epinephrine (1) · Gabapentin (1) · Ketamine (1) · Magnesium Sulfate (1) · Midazolam (1) · Neuromuscular Blockade (1) · Neuromuscular Blocking Agents (1) · Oxycodone (1)
Assiut University (1) · Children's Healthcare of Atlanta (1) · Hospital Universitario de Caracas (1) · Irmandade Santa Casa de Misericórdia de Porto Alegre (1) · King Saud University (1) · Mayo Clinic (1) · Paul Hoff (1) · Sisli Hamidiye Etfal Training and Research Hospital (1) · Stanford University (1) · Umeå University (1) · Universitair Ziekenhuis Brussel (1) · University Hospital, Akershus (1) · University of California, Davis (1) · University of California, San Francisco (1) · University of Texas Southwestern Medical Center (1)
United States (7) · Belgium (1) · Brazil (1) · Norway (1) · Sweden (1) · Turkey (Türkiye) (1) · Venezuela (1)
Alex Van Hoorn, MD (1) · Cathy Lammers, MD (1) · Christina Calamaro, PhD, CPNP-PC (1) · Daniel L Price, MD (1) · Kimberly A Sutters, RN, PhD (1) · Krister Tano, MD, PhD (1) · Leyla Kilinc, Md (1) · Proshad Efune, MD (1) · Tristan Tham, MD (1) · Vinicius C Quintao, MD, MSc, PhD Investigator (1)
PMID 16929992, PMID 18983373, PMID 19294964, PMID 20069307, PMID 20090434, PMID 21812940, PMID 21951354, PMID 22704676, PMID 24281921, PMID 24815964, PMID 34304234, PMID 42107449
2019 (2), R01NR004826 (1)