115 completed, 12 recruiting, 7 terminated, 6 unknown. 87 Not applicable, 20 Phase 3, 18 Phase 2, 16 Phase 4, 9 Phase 1.
Follow Tobacco Dependence: new trials by email Literature Review of Tobacco Dependence trials Research Report on Tobacco Dependence
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Chatbot for Online Support Groups to Treat Tobacco Addiction online quit-smoking support group with intelligent chatbot, online quit-smoking support group with unintelligent bot - Tobacco Dependence, Tobacco Use Disorder | Not applicable | Not yet recruiting | University of California, Irvine | 120 | 2026-12-01 | 2026-05-22 |
| Varenicline for Smoking Reduction in Veterans Not Ready To Quit Motivation-Phase Varenicline, Motivation-Phase Nicotine Mini-Lozenge, Cessation-Phase Combination Nicotine Replacement Therapy (NRT) - Veterans, Tobacco Use Disorder | Phase 4 | Recruiting | VA Office of Research and Development | 400 | 2026-08-17 | 2026-08-31 |
| Smoking Cessation Intervention Including Health Navigators to Address Unmet Social Needs of Parents Who Smoke CanCEASE with Health Navigator - Smoking Cessation, Tobacco Dependence | Not applicable | Recruiting | St. Justine's Hospital | 1000 | 2026-03-26 | 2026-07-24 |
| Semaglutide for Smoking Cessation in Patients With Diabetes Semaglutide, Nicotine replacement - Diabetes Mellitus, Type 2, Nicotine Addiction | Phase 3 | Recruiting | Ottawa Heart Institute Research Corporation | 100 | 2026-02-13 | 2026-09-08 |
| C-Raven, a Virtual Tobacco Cessation Intervention in Residency Clinics C-Raven Virtual Tobacco Cessation Counseling, Nicotine Replacement Product, Community Health Worker - Tobacco Dependence | Phase 4 | Active not recruiting | Johns Hopkins University | 30 | 2025-12-10 | 2026-07-06 |
| Extended Intervention for Tobacco Use (EXIT) for People Experiencing Homelessness Nicotine Replacement Therapy (NRT), Wellness Coaching - Tobacco Cessation, Tobacco Abstinence | Phase 4 | Recruiting | University of California, San Francisco | 150 | 2025-11-14 | 2025-11-21 |
| Cytisine vs Nicotine Replacement Therapy Cytisine, Nicotine replacement therapy (NRT) - Tobacco Dependence, COPD Asthma | Not applicable | Enrolling by invitation | Ottawa Hospital Research Institute | 200 | 2025-11-04 | 2026-03-17 |
| Reach Through Equitable Implementation in Utah Clinic Level: AAC - SDOH, AAC - Tobacco, Non-Bundled, Bundled - Tobacco Use Cessation, Tobacco Use | Not applicable | Recruiting | University of Utah | 1560 | 2025-02-13 | 2025-03-18 |
| Effect of Nicotine Gingival Fibroblast Intoxication on the Response of Periodontal Treatment periodontal non-surgical treatment - Periodontitis, Smoking Cessation | Not applicable | Enrolling by invitation | University of Liege | 56 | 2025-01-06 | 2026-04-22 |
| Effect of Yoga on Reducing Craving in Tobacco Dependent Individuals Yoga, WHO 5As model intervention - Tobacco Dependence | Not applicable | Recruiting | University of Pittsburgh | 96 | 2024-11-01 | 2026-06-05 |
| Cannabidiol for Reducing Cigarette Use Cannabidiol (CBD) 800 mg, Placebo - Tobacco Use Disorder, Tobacco Smoking | Phase 2 | Recruiting | University of California, Los Angeles | 120 | 2024-10-31 | 2026-04-13 |
| C-Raven, a Virtual Tobacco Cessation Intervention in the Community C-Raven Virtual Tobacco Cessation Counseling, Nicotine Replacement Product, Community Health Worker - Tobacco Dependence | Phase 4 | Completed | Johns Hopkins University | 10 | 2024-10-30 | 2026-02-02 |
| Positive Psychology for Smoking Cessation Individual and Group Treatment for Smoking Cessation - Mental Illness, Tobacco Dependence | Not applicable | Completed | Dartmouth-Hitchcock Medical Center | 16 | 2024-10-10 | 2025-12-18 |
| Harm Reduction for Smokers With Mental Illness SWITCH IT, E-cig Provision Only - Tobacco Dependence | Not applicable | Recruiting | Dartmouth-Hitchcock Medical Center | 250 | 2024-10-01 | 2026-01-15 |
| Use of Nicotine Pouches Among Daily Smokers 0 mg nicotine pouch, 3 mg nicotine pouch, 6 mg nicotine pouch - Tobacco Dependence | Not applicable | Recruiting | Milton S. Hershey Medical Center | 375 | 2024-09-17 | 2026-10-20 |
| Smoke-free Home Study in Subsidized Housing Smoke-free home resident intervention, Lay Health Worker coaching - Tobacco Dependence, Tobacco Smoking | Not applicable | Recruiting | University of California, San Francisco | 544 | 2024-07-12 | 2025-02-24 |
| Cooling Agent Pilot Among Adult Menthol Smokers Assigning cooling agent type cigarettes, Assigning traditional tobacco type cigarettes, Assigning menthol type cigarettes - Tobacco Dependence | Not applicable | Completed | University of Kansas Medical Center | 21 | 2024-06-24 | 2025-04-06 |
| Testing C-Raven, a Virtual Tobacco Cessation Intervention, in the Community C-Raven Virtual Tobacco Cessation Counseling, Nicotine Replacement Product, Community Health Worker - Tobacco Dependence | Phase 4 | Completed | Johns Hopkins University | 5 | 2024-04-30 | 2025-09-10 |
| Tobacco Cessation Care for Cancer Patients by Automated Interactive Outreach CareConnect, AutoReach, Biospecimen samples - Cancer, Tobacco Dependence | Not applicable | Completed | University of California, San Francisco | 400 | 2023-11-27 | 2026-02-13 |
| Equitable Smoking Relapse Prevention Quitbuddy, Control, SDoH Augmentation - Tobacco Use Disorder, Tobacco Dependence | Not applicable | Withdrawn | Bryan W. Heckman | 2023-10-02 | 2024-05-08 |
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Tobacco Use Disorder (149) · Smoking Cessation (55) · Smoking (33) · Tobacco Smoking (16) · Tobacco Use Cessation (15) · Tobacco Use (14) · Cigarette Smoking (12) · Behavior, Addictive (8) · Substance-Related Disorders (7) · Vaping (5) · Alcoholism (3) · Cardiovascular Diseases (3) · Harm Reduction (3) · Mental Disorders (3) · Schizophrenia (3)
Chemically-Induced Disorders (149) · Mental Disorders (146) · Substance-Related Disorders (142) · Behavior (100) · Health Behavior (66) · Tobacco Use (13) · Smoking (12) · Compulsive Behavior (8) · Impulsive Behavior (8) · Pathological Conditions, Signs and Symptoms (4) · Alcohol-Related Disorders (3) · Blood-Borne Infections (3) · Communicable Diseases (3) · Genital Diseases (3) · Immune System Diseases (3)
Nicotine (19) · Tobacco Use Cessation Devices (18) · Varenicline (16) · Nicotine Chewing Gum (12) · Nicotine Replacement Therapy (6) · Bupropion (4) · Community Health Workers (3) · Sugars (3) · Yoga (3) · Cannabidiol (2) · Counseling (2) · Exercise (2) · Fish Oils (2) · Flavoring Agents (2) · Health (2)
McNeil AB (18) · Milton S. Hershey Medical Center (8) · University of California, San Francisco (7) · Johns Hopkins University (5) · Mayo Clinic (5) · University of Wisconsin, Madison (5) · Dartmouth-Hitchcock Medical Center (4) · H. Lee Moffitt Cancer Center and Research Institute (4) · Queen Mary University of London (4) · VA Office of Research and Development (4) · Brown University (3) · Centre for Addiction and Mental Health (3) · Massachusetts General Hospital (3) · National Institute on Drug Abuse (NIDA) (3) · Stanford University (3)
United States (96) · Sweden (16) · Canada (6) · United Kingdom (4) · Belgium (2) · China (2) · Denmark (2) · Australia (1) · Austria (1) · Brazil (1) · France (1) · Germany (1) · India (1) · Ireland (1) · Israel (1)
Elisabeth Kruse, PhD (16) · Jonathan Foulds, PhD (3) · Timothy B Baker, PhD (3) · Alejandra Ellison-Barnes, MD (2) · Eric T. Moolchan, M.D. (2) · Gary L. Humfleet, PhD (2) · Janice Tsoh, PhD (2) · Jennifer Tidey, Ph.D. (2) · Jessica Megan Cook, PhD (2) · Jonathan P Winickoff, MD, MPH (2) · Judith J Prochaska, PhD, MPH (2) · Maya Vijayaraghavan, MD (2) · Thomas Brandon, Ph.D. (2) · A. Eden Evins, MD, MPH (1) · Adrian J Esterman, PhD,MSc,BSc (1)
PMID 37142273, PMID 37230961, PMID 34611902, PMID 39101506, PMID 12745503, PMID 16960700, PMID 17763111, PMID 18381502, PMID 18418793, PMID 20008701, PMID 20078491, PMID 20124230, PMID 20798023, PMID 21317630, PMID 21518946, PMID 21785963, PMID 22011421, PMID 22608375, PMID 22695211, PMID 23024246, PMID 23454876, PMID 23718718, PMID 23801018, PMID 24057996, PMID 24467257, PMID 24878686, PMID 25005652, PMID 25074396, PMID 25118794, PMID 25187423, PMID 25192771, PMID 25209524, PMID 25419703, PMID 25545858, PMID 26422724, PMID 26916879, PMID 27215559, PMID 27797659, PMID 27856940, PMID 28158558, PMID 28442453, PMID 28483741, PMID 28549161, PMID 28673312, PMID 28747857, PMID 29025502, PMID 29137560, PMID 29324248, PMID 29329763, PMID 29504780
2008 (7), 2005 (2), P50DA019706 (2), P50DA036107 (2), R01HL109031 (2), 1IK2CX000918-01A1 (1), 2009 (1), D43TW009114 (1), F31DA043390 (1), F31DA046127 (1), K23DA018203 (1), K23DA025736 (1), K23DA032578 (1), K23DA045081 (1), K24AA013736 (1)