13 completed, 3 terminated, 2 unknown, 1 active not recruiting. 20 Phase 3, 7 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 20 | Completed 13, Terminated 3, Unknown 2, Active not recruiting 1, Recruiting 1 |
| Phase 2 | 7 | Completed 4, Unknown 2, Terminated 1 |
Follow Tobacco Dependence: new trials by email Literature Review of Tobacco Dependence trials Research Report on Tobacco Dependence
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Semaglutide for Smoking Cessation in Patients With Diabetes Semaglutide, Nicotine replacement - Diabetes Mellitus, Type 2, Nicotine Addiction | Phase 3 | Recruiting | Ottawa Heart Institute Research Corporation | 100 | 2026-02-13 | 2026-09-08 |
| Early Withdrawal Exposure and Negative Affect Withdrawal (NAW) Regulation Training for Smoking Cessation cognitive-behavioral withdrawal regulation strategies, relaxation strategies, early withdrawal exposure - Tobacco Dependence | Phase 3 | Active not recruiting | University of Alabama at Birmingham | 400 | 2019-08-01 | 2026-10-30 |
| Study to Determine the Efficacy and Safety of a Novel Nicotine Replacement Therapy Nicotine Spray, Placebo - Tobacco Dependence | Phase 3 | Completed | McNeil Consumer Healthcare Division of McNEIL-PPC, Inc. | 1198 | 2015-01-31 | 2019-01-08 |
| Studying the Effects of Administration of Polyunsaturated Fatty Acids (PUFAS) of Omega-3 Series in Nicotine Dependence Omega 3, Placebo - Tobacco Dependence, Nicotine Dependence | Phase 3 | Completed | Federal University of São Paulo | 58 | 2013-01-01 | 2020-10-14 |
| Tailoring Varenicline to Individual Needs (TVIN Study) Varenicline, Placebo - Tobacco Dependence, Smoking Cessation | Phase 3 | Completed | Queen Mary University of London | 200 | 2011-07-01 | 2013-04-25 |
| Varenicline Treatment for Active Alcoholic Smokers Varenicline, placebo - Smoking, Tobacco Dependence | Phase 2 / Phase 3 | Completed | Mayo Clinic | 33 | 2011-06-01 | 2018-02-05 |
| Tobacco Intervention in Buprenorphine Treatment Innovative System, Standard Treatment Control (STC) - Tobacco Dependence | Phase 3 | Completed | University of California, San Francisco | 175 | 2011-04-01 | 2018-11-13 |
| Combination of Nicotine Replacement Therapy (NRT) and Varenicline to Increase Cessation of Tobacco (CONVICT Study) Nicotine Patch, Placebo, Varenicline - Tobacco Dependence, Smoking Cessation | Phase 3 | Completed | Queen Mary University of London | 117 | 2011-04-01 | 2012-10-11 |
| Study to Determine if a New Nicotine Replacement Therapy Can Safely Help Smokers to Quit Smoking Placebo, Nicotine - Tobacco Dependence | Phase 3 | Terminated | McNeil Consumer Healthcare Division of McNEIL-PPC, Inc. | 257 | 2011-03-01 | 2012-04-23 |
| Efficacy and Safety of Varenicline Among HIV-infected Patients Varenicline, Placebo - HIV Infections, Tobacco Dependence | Phase 3 | Completed | ANRS, Emerging Infectious Diseases | 248 | 2009-10-01 | 2014-07-29 |
| Varenicline for Long-term Nicotine Replacement Therapy (NRT) Users support and visits, varenicline, placebo - Tobacco Dependence | Phase 2 / Phase 3 | Unknown | University Hospital, Gentofte, Copenhagen | 200 | 2009-09-01 | 2009-09-15 |
| Use of Varenicline for 4-weeks Prior to Quitting Varenicline, Placebo - Tobacco Dependence, Smoking Cessation | Phase 3 | Completed | Queen Mary University of London | 101 | 2009-07-01 | 2013-12-12 |
| Nicotine Lozenge or Tobacco-Free Snuff for Smokeless Tobacco Reduction nicotine lozenges, tobacco-free snuff - Tobacco Dependence | Phase 2 / Phase 3 | Completed | Mayo Clinic | 81 | 2009-01-01 | 2013-09-13 |
| S-Adenosyl-L-Methionine (SAMe) for Smoking Abstinence S-Adenosyl-L-Methionine, placebo - Tobacco Dependence | Phase 2 / Phase 3 | Completed | Mayo Clinic | 150 | 2008-09-01 | 2011-09-09 |
| Smoking Cessation With Smokeless Tobacco, Nicotine Tablets and Nicotine Patches Smokeless tobacco (Oliver Twist pellets), smoking cessation counseling - Tobacco Dependence | Phase 2 / Phase 3 | Unknown | University Hospital, Gentofte, Copenhagen | 600 | 2006-04-01 | 2009-09-15 |
| Topiramate Alone and in Combination With the Nicotine Patch for Smoking Cessation: A Pilot Study Placebo (sugar pill), Topiramate, Nicotine patch - Tobacco Dependence | Phase 3 | Completed | UConn Health | 57 | 2006-04-01 | 2017-08-16 |
| Reducing Ethnic Health Disparities: Motivating HIV+ Latinos to Quit Smoking Standard Care Intervention (SCI), Culturally Tailored Intervention (CTI) - Tobacco Dependence, HIV Infections | Phase 3 | Completed | Butler Hospital | 400 | 2005-10-01 | 2013-05-03 |
| Efficacy and Safety of Bupropion for Treatment of Adolescent Smoking Bupropion - Tobacco Dependence | Phase 2 / Phase 3 | Terminated | National Institute on Drug Abuse (NIDA) | 72 | 2005-01-01 | 2016-09-23 |
| Physical Activity as an Aid for Smoking Cessation Allez Hop - Tobacco Dependence, Cardiovascular Diseases | Phase 3 | Terminated | University of Lausanne Hospitals | 600 | 2003-04-01 | 2007-08-27 |
| Safety, Tolerability and Efficacy of the Nicotine Patch and Gum for the Treatment of Adolescent Tobacco Dependence Nicotine Patch, Nicotine Gum - Tobacco Dependence | Phase 2 / Phase 3 | Completed | National Institute on Drug Abuse (NIDA) | 157 | 1999-08-01 | 2017-01-12 |
Tobacco Use Disorder (20) · Smoking Cessation (7) · Smoking (3) · Tobacco Use (3) · HIV Infections (2) · Alcoholism (1) · Behavior, Addictive (1) · Cardiovascular Diseases (1) · Diabetes Mellitus, Type 2 (1) · Motor Activity (1)
Chemically-Induced Disorders (20) · Mental Disorders (20) · Substance-Related Disorders (20) · Behavior (12) · Health Behavior (7) · Blood-Borne Infections (2) · Communicable Diseases (2) · Genital Diseases (2) · Immune System Diseases (2) · Immunologic Deficiency Syndromes (2) · Infections (2) · Lentivirus Infections (2) · RNA Virus Infections (2) · Retroviridae Infections (2) · Sexually Transmitted Diseases (2)
Varenicline (6) · Tobacco Use Cessation Devices (5) · Sugars (3) · Nicotine (2) · Bupropion (1) · Docosahexaenoic Acids (1) · Fatty Acids, Omega-3 (1) · Fish Oils (1) · Mineral Oil (1) · Nicotine Chewing Gum (1) · Nicotine Replacement Therapy (1) · Palliative Care (1) · S-Adenosylmethionine (1) · Tobacco, Smokeless (1) · Topiramate (1)
Mayo Clinic (3) · Queen Mary University of London (3) · McNeil Consumer Healthcare Division of McNEIL-PPC, Inc. (2) · National Institute on Drug Abuse (NIDA) (2) · University Hospital, Gentofte, Copenhagen (2) · ANRS, Emerging Infectious Diseases (1) · Butler Hospital (1) · Federal University of São Paulo (1) · Ottawa Heart Institute Research Corporation (1) · UConn Health (1) · University of Alabama at Birmingham (1) · University of California, San Francisco (1) · University of Lausanne Hospitals (1)
United States (11) · United Kingdom (3) · Denmark (2) · Brazil (1) · Canada (1) · France (1)
Eric T. Moolchan, M.D. (2) · Al-Rehan A A Dhanji, MB BS BSc MRCP (1) · Al-Rehan A A Dhanji, MB BS BSc MRCS (1) · Al-Rehan Abdul Aziz Dhanji, MB.BS., BSc.,MRCS. (1) · Amit Sood, M.D. (1) · Andrew Myers, MD (1) · Cassandra Stanton, Ph.D. (1) · Cheryl A Oncken, MD (1) · Daniel Qi, MD (1) · Jacques Cornuz, MD (1) · Jon O Ebbert, MD (1)
PMID 37142273, PMID 34611902, PMID 39101506, PMID 20798023, PMID 21518946, PMID 23024246, PMID 23454876, PMID 23718718, PMID 24057996, PMID 25187423, PMID 25545858, PMID 28549161, PMID 29324248, PMID 29329763, PMID 30452732, PMID 37230961, PMID 39868569
2005 (1), 2008 (1), K24AA013736 (1), M01RR006192 (1), P50DA009253 (1), R01DA018079 (1), R01DA045186 (1)