11 completed, 2 recruiting, 2 unknown, 1 active not recruiting. 16 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 16 | Completed 11, Recruiting 2, Unknown 2, Active not recruiting 1 |
Follow Tobacco Dependence: new trials by email Literature Review of Tobacco Dependence trials Research Report on Tobacco Dependence
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Varenicline for Smoking Reduction in Veterans Not Ready To Quit Motivation-Phase Varenicline, Motivation-Phase Nicotine Mini-Lozenge, Cessation-Phase Combination Nicotine Replacement Therapy (NRT) - Veterans, Tobacco Use Disorder | Phase 4 | Recruiting | VA Office of Research and Development | 400 | 2026-08-17 | 2026-08-31 |
| C-Raven, a Virtual Tobacco Cessation Intervention in Residency Clinics C-Raven Virtual Tobacco Cessation Counseling, Nicotine Replacement Product, Community Health Worker - Tobacco Dependence | Phase 4 | Active not recruiting | Johns Hopkins University | 30 | 2025-12-10 | 2026-07-06 |
| Extended Intervention for Tobacco Use (EXIT) for People Experiencing Homelessness Nicotine Replacement Therapy (NRT), Wellness Coaching - Tobacco Cessation, Tobacco Abstinence | Phase 4 | Recruiting | University of California, San Francisco | 150 | 2025-11-14 | 2025-11-21 |
| C-Raven, a Virtual Tobacco Cessation Intervention in the Community C-Raven Virtual Tobacco Cessation Counseling, Nicotine Replacement Product, Community Health Worker - Tobacco Dependence | Phase 4 | Completed | Johns Hopkins University | 10 | 2024-10-30 | 2026-02-02 |
| Testing C-Raven, a Virtual Tobacco Cessation Intervention, in the Community C-Raven Virtual Tobacco Cessation Counseling, Nicotine Replacement Product, Community Health Worker - Tobacco Dependence | Phase 4 | Completed | Johns Hopkins University | 5 | 2024-04-30 | 2025-09-10 |
| Varenicline OTC Trial on Efficacy and Safety 1.0mg Varenicline b.i.d., 0.5mg Varenicline b.i.d., 0.0mg placebo Varenicline b.i.d. - Tobacco Dependence, Withdrawal Symptoms | Phase 4 | Completed | Arizona State University | 313 | 2018-05-07 | 2024-09-19 |
| UW Quitting Using Intensive Treatment Study (QUITS) Varenicline, Nicotine patch, Placebo Patch - Tobacco Dependence | Phase 4 | Completed | University of Wisconsin, Madison | 1251 | 2017-11-11 | 2023-01-23 |
| Varenicline for Co-occurring Cannabis and Tobacco Use Standard clinical care first, followed by standard clinical care and varenicline, Standard clinical care and varenicline first, followed by standard clinical care - Cannabis Dependence, Tobacco Dependence | Phase 4 | Completed | Albert Einstein College of Medicine | 7 | 2015-01-01 | 2024-09-24 |
| Effectiveness of an E-mail Tracking Intervention Among the Continued Abstinence of Tobacco Consumption electronic mail - Tobacco Dependence, Cessation of Smoking | Phase 4 | Unknown | Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina | 1064 | 2012-12-01 | 2014-06-19 |
| tDCS as Add on Therapy for Treatment of Tobacco Dependence by Standardized Behaviour Therapy tDCS, standardised behavioural therapy - Smoking Cessation, Tobacco Dependence | Phase 4 | Unknown | Ludwig-Maximilians - University of Munich | 40 | 2012-07-01 | 2012-11-27 |
| Evaluation of the Safety Profile, Quit and Reduction Rate After Nicorette® Gum and Patch Treatment Nicotine Gum, Nicotine Patch - Tobacco Dependence | Phase 4 | Completed | McNeil AB | 300 | 2009-02-01 | 2012-07-13 |
| The Pharmacogenetic Study , Readiness to Change, and Pharmacological Intervention for Smoking Cessation in Schizophrenia Hihg-doseNRT, Low-dose NRT, bupropion - Tobacco Dependence, Schizophrenia | Phase 4 | Completed | Yu-Li Hospital | 360 | 2006-01-01 | 2010-04-14 |
| Randomized Trial of Ultrashort Psychotherapy vs Sustained-Release Bupropion for Smoking Cessation sustained-release bupropion (Zyban(R)), Psychodynamic Model Training (R) = PDM(R) - Nicotine Dependence, Substance Abuse | Phase 4 | Completed | Medical University Innsbruck | 779 | 2005-07-01 | 2007-06-11 |
| Smoking Cessation Intervention: Effectiveness in Primary Care nicotine patch, nicotine lozenge, bupropion - Tobacco Dependence | Phase 4 | Completed | University of Wisconsin, Madison | 1346 | 2004-09-01 | 2015-10-14 |
| Bupropion Alone or Combined With Nicotine Gum bupropion + nicotine gum, Active bupropion-Placebo gum, Placebo bupropion-Placebo gum - Tobacco Dependence | Phase 4 | Completed | University of Wisconsin, Madison | 608 | 2001-01-01 | 2016-12-06 |
| Bupropion SR Plus Counseling for Smoking Cessation Active bupropion + counseling, Active bupropion, No counseling, Placebo medication + counseling - Tobacco Dependence, Smoking | Phase 4 | Completed | University of Wisconsin, Madison | 463 | 2001-01-01 | 2016-01-27 |
Tobacco Use Disorder (16) · Smoking Cessation (6) · Cigarette Smoking (1) · Marijuana Abuse (1) · Schizophrenia (1) · Smoking (1) · Smoking Reduction (1) · Substance Withdrawal Syndrome (1) · Substance-Related Disorders (1) · Tobacco Use (1) · Tobacco Use Cessation (1)
Chemically-Induced Disorders (16) · Mental Disorders (16) · Substance-Related Disorders (15) · Behavior (9) · Health Behavior (8) · Schizophrenia Spectrum and Other Psychotic Disorders (1) · Smoking (1) · Tobacco Smoking (1) · Tobacco Use (1)
Tobacco Use Cessation Devices (6) · Bupropion (3) · Community Health Workers (3) · Nicotine Chewing Gum (3) · Varenicline (3) · Nicotine (2) · Nicotine Replacement Therapy (2) · Counseling (1) · Transcranial Direct Current Stimulation (1) · Transdermal Patch (1)
University of Wisconsin, Madison (4) · Johns Hopkins University (3) · Albert Einstein College of Medicine (1) · Arizona State University (1) · Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina (1) · Ludwig-Maximilians - University of Munich (1) · McNeil AB (1) · Medical University Innsbruck (1) · University of California, San Francisco (1) · VA Office of Research and Development (1) · Yu-Li Hospital (1)
United States (10) · Austria (1) · China (1) · Germany (1) · Spain (1) · Taiwan (1)
Alejandra Ellison-Barnes, MD (2) · Timothy B Baker, PhD (2) · Frank Padberg, PD Dr. (1) · Gerald Zernig, M.D. (1) · Jackie Mao (1) · Jeanne Clark, MD (1) · Jessica Megan Cook, PhD (1) · Lourdes Clemente, MD (1) · Marc Casajuana, Economist (1)
PMID 37230961, PMID 17763111, PMID 18418793, PMID 20008701, PMID 22608375, PMID 34665204, PMID 42166859
P50DA019706 (2), K23DA025736 (1), P50CA084724 (1), R01DA044125 (1), R01HL109031 (1), R25DA023021 (1), R25GM104547 (1)