9 completed, 3 recruiting, 2 unknown, 1 active not recruiting. 17 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 17 | Completed 9, Recruiting 3, Unknown 2, Active not recruiting 1, Enrolling by invitation 1, Withdrawn 1 |
Follow TDP-43 Proteinopathies: new trials by email Literature Review of TDP-43 Proteinopathies trials Research Report on TDP-43 Proteinopathies
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Learn More About the Long-Term Safety of Tofersen (Qalsody) in Chinese Participants With SOD-1 Amyotrophic Lateral Sclerosis (ALS) Tofersen - Amyotrophic Lateral Sclerosis | Phase 4 | Active not recruiting | Biogen | 12 | 2025-12-11 | 2026-08-13 |
| Effects of L-Carnitine in Amyotrophic Lateral Sclerosis Patients With CHCHD10 Mutations L-Carnitine Injection，1000mg once daily - Amyotrophic Lateral Sclerosis (ALS) | Phase 4 | Completed | ChaodongWang | 4 | 2024-07-18 | 2025-04-08 |
| Lemborexant for Insomnia in a Patient With Dementia: An N-of-1 Trial Lemborexant 5 MG - Insomnia, Dementia | Phase 4 | Recruiting | Nova Scotia Health Authority | 1 | 2023-12-11 | 2025-02-21 |
| Clinical Study to Evaluate the Efficacy and Safety of FB1006 in the Treatment of ALS Patients FB1006, Placebo - Sporadic and Familial Amyotrophic Lateral Sclerosis | Phase 4 | Recruiting | Peking University Third Hospital | 64 | 2023-01-18 | 2023-11-22 |
| EMERALD TRIAL Open Label Extension Study MediCabilis CBD oil - Amyotrophic Lateral Sclerosis, Cannabis | Phase 4 | Unknown | Gold Coast Hospital and Health Service | 7 | 2021-05-17 | 2023-04-03 |
| Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech AV-1451 - PPA, Non-fluent Aphasia | Phase 4 | Recruiting | Mayo Clinic | 50 | 2018-07-01 | 2025-11-12 |
| Efficacy of Pain Treatment on Depression in Patients With Dementia Paracetamol, Buprenorphine, Paracetamol placebo - Depression, Pain | Phase 4 | Completed | University of Bergen | 163 | 2014-08-01 | 2017-04-04 |
| Mexiletine for the Treatment of Muscle Cramps in ALS Mexiletine, Placebo - Muscle Cramps in Amyotrophic Lateral Sclerosis | Phase 4 | Completed | Bjorn Oskarsson, MD | 23 | 2013-05-01 | 2017-08-28 |
| Memantine and Changes of Biological Markers and Brain PET Imaging in Alzheimer's Disease Memantine - Alzheimer's Disease | Phase 4 | Completed | Shanghai Mental Health Center | 26 | 2008-07-01 | 2010-12-03 |
| Imaging of Brain Amyloid Plaques in the Aging Population Pittsburgh Compound B (C-11 PiB), F-18 FDG, Tau (18-F-AV-1451) - Alzheimer's Disease, Dementia With Lewy Bodies | Phase 4 | Enrolling by invitation | Mayo Clinic | 8000 | 2008-04-01 | 2026-06-23 |
| Non-Invasive Ventilation in Amyotrophic Lateral Sclerosis Non invasive ventilation delivered with one of the ventilator specifically designed for NIV and given to the patient by the home care providers, Non invasive ventilation - Amyotrophic Lateral Sclerosis, Chronic Respiratory Failure | Phase 4 | Unknown | Fondazione Salvatore Maugeri | 50 | 2008-01-01 | 2010-03-29 |
| Feasibility of Telesurveillance and Home Cough Assistance for Amyotrophic Lateral Patients (ALS) telesurveillance - Amyotrophic Lateral Sclerosis | Phase 4 | Completed | Fondazione Salvatore Maugeri | 40 | 2007-10-01 | 2016-02-04 |
| Memantine (10mg BID) for the Frontal and Temporal Subtypes of Frontotemporal Dementia memantine, Placebo pill - Frontal Lobe Dementia, Frontotemporal Lobe Dementia | Phase 4 | Completed | University of California, San Francisco | 81 | 2007-10-01 | 2020-11-17 |
| Serotonergic Function and Behavioural and Psychological Symptoms of Frontotemporal Dementia Citalopram - Frontotemporal Dementia | Phase 4 | Completed | Sunnybrook Health Sciences Centre | 22 | 2006-09-01 | 2017-05-05 |
| Amantadine for the Treatment of Behavioral Disturbance in Frontotemporal Dementia (FTD) Amantadine, Placebo - Dementia | Phase 4 | Withdrawn | Johns Hopkins University | 2005-09-01 | 2017-08-14 | |
| A 52 Week Open Label Trial of Memantine for Frontotemporal Lobar Degeneration Memantine - Frontotemporal Lobar Degeneration | Phase 4 | Completed | University of California, San Francisco | 2004-05-01 | 2012-11-12 | |
| CARE Canadian ALS Riluzole Evaluation Riluzole - Amyotrophic Lateral Sclerosis | Phase 4 | Completed | Sanofi | 414 | 2001-01-01 | 2007-10-11 |
Amyotrophic Lateral Sclerosis (8) · Dementia (6) · Frontotemporal Dementia (6) · Alzheimer Disease (3) · Frontotemporal Lobar Degeneration (3) · Dementia, Vascular (2) · Lewy Body Disease (2) · Mental Disorders (2) · Motor Neuron Disease (2) · Agnosia (1) · Aphasia (1) · Aphasia, Broca (1) · Aphasia, Primary Progressive (1) · Apraxias (1) · Cognitive Dysfunction (1)
Central Nervous System Diseases (17) · Metabolic Diseases (17) · Nervous System Diseases (17) · Neurodegenerative Diseases (17) · Nutritional and Metabolic Diseases (17) · Proteostasis Deficiencies (17) · Brain Diseases (9) · Neurocognitive Disorders (9) · Mental Disorders (8) · Neuromuscular Diseases (8) · Spinal Cord Diseases (8) · Frontotemporal Lobar Degeneration (6) · Motor Neuron Disease (6) · Dementia (3)
Memantine (3) · 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole (1) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (1) · Acetaminophen (1) · Amantadine (1) · Buprenorphine (1) · Citalopram (1) · Mexiletine (1) · Noninvasive Ventilation (1) · Riluzole (1) · Sugars (1) · Telemedicine (1) · lemborexant (1) · tau Proteins (1) · tofersen (1)
Fondazione Salvatore Maugeri (2) · Mayo Clinic (2) · University of California, San Francisco (2) · Biogen (1) · Bjorn Oskarsson, MD (1) · ChaodongWang (1) · Gold Coast Hospital and Health Service (1) · Johns Hopkins University (1) · Nova Scotia Health Authority (1) · Peking University Third Hospital (1) · Sanofi (1) · Shanghai Mental Health Center (1) · Sunnybrook Health Sciences Centre (1) · University of Bergen (1)
United States (5) · China (4) · Canada (3) · Italy (2) · Australia (1) · Norway (1)
Adam L. Boxer, M.D., Ph.D. (1) · Ane Erdal, PhD candidate (1) · Bjorn Oskarsson, MD (1) · Bruce Miller, M.D. (1) · David M Blass, M.D. (1) · Elisabeth Flo, PhD (1) · Fan DongSheng (1) · Jennifer Whitwell, PhD (1) · Krista Lanctot, PhD (1) · Laurent-Didier Jacobs (1) · Nathan Herrmann, MD (1) · Shifu Xiao, MD. PhD. (1) · Stefano Nava (1)
PMID 19812461, PMID 20407305, PMID 21878805, PMID 23290598, PMID 24491372, PMID 29487556, PMID 29725986, PMID 33189083
R01AG011378 (1), R01DC012519 (1), U01AG006786 (1)