529 completed, 214 recruiting, 149 unknown, 77 terminated. 308 Phase 2, 303 Not applicable, 194 Phase 1, 96 Phase 3, 24 Early Phase 1.
Follow TDP-43 Proteinopathies: new trials by email Literature Review of TDP-43 Proteinopathies trials Research Report on TDP-43 Proteinopathies
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Multiple Dose Study to Investigate Safety, Tolerability and Pharmacokinetics of TBN Tetramethylpyrazine nitrone (TBN) tablet / Placebo - Healthy | Phase 1 | Not yet recruiting | Guangzhou Magpie Pharmaceuticals Co., Ltd. | 16 | 2028-09-01 | 2026-09-11 |
| Evaluation of Donor-Derived B Cell Infusions in Patients With Amyotrophic Lateral Sclerosis (ALS) B cell infusion - ALS - Amyotrophic Lateral Sclerosis | Phase 1 | Not yet recruiting | Mark Poznansky | 10 | 2027-09-01 | 2026-09-24 |
| Safety Study of XT-150 in Participants With ALS XT-150 - Amyotrophic Lateral Sclerosis (ALS) | Phase 1 | Not yet recruiting | Xalud Therapeutics, Inc. | 8 | 2027-03-01 | 2026-07-29 |
| A Study of Single Ascending Doses of NI112 in Adults With Amyotrophic Lateral Sclerosis (ALS) NI112, Placebo - Amyotrophic Lateral Sclerosis (ALS) | Phase 1 | Not yet recruiting | Sachi Bioworks Inc. | 40 | 2027-01-22 | 2026-10-30 |
| Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT) INTENT Neural Interface System - Tetraplegia/Tetraparesis, Amyotrophic Lateral Sclerosis (ALS) | Not applicable | Recruiting | Johns Hopkins University | 5 | 2027-01-01 | 2026-10-09 |
| Study to Investigate the Safety of the Transplantation (by Injection) of Human Glial Restricted Progenitor Cells (hGRPs; Q-Cells®) Into Subjects With Amyotrophic Lateral Sclerosis (ALS) Q-Cells - Amyotrophic Lateral Sclerosis | Phase 1 / Phase 2 | Not yet recruiting | Q Therapeutics, Inc. | 30 | 2026-12-01 | 2026-07-08 |
| Personalized Antisense Oligonucleotide Therapy for a Participant With TARDBP ALS nL-TARDB-002 - Amyotrophic Lateral Sclerosis (ALS) | Phase 1 / Phase 2 | Enrolling by invitation | n-Lorem Foundation | 1 | 2026-12-01 | 2026-07-14 |
| Brain-Computer Interface Communication Device for People With ALS Cognixion ONE AR-BCI configuration, Cognixion ONE screen-based BCI configuration, Existing eye-gaze speech generating device - Amyotrophic Lateral Sclerosis | Not applicable | Recruiting | Cognixion | 30 | 2026-11-15 | 2026-10-16 |
| A Wearable Sensor Platform for Remote Monitoring of Individuals on the Frontotemporal Dementia Spectrum Frontotemporal Lobar Degeneration (FTLD), Frontotemporal Dementia (FTD) | Not yet recruiting | BioSensics | 60 | 2026-11-01 | 2026-10-13 | |
| Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients (DetectAI) Mini-mental State Examination, Addenbrooke's Cognitive Examination, Speech Task - Picture Description - Dementia (Diagnosis), Alzheimer Dementia (AD) | Not yet recruiting | Zealand University Hospital | 440 | 2026-11-01 | 2026-09-02 | |
| A Study of LY3873862 in Participants With Sporadic or Familial Amyotrophic Lateral Sclerosis (ALS). LY3873862, CYP450 Drug Cocktail, Placebo - Amyotrophic Lateral Sclerosis, Cytochrome P-450 Enzyme System | Phase 1 | Not yet recruiting | Eli Lilly and Company | 32 | 2026-11-01 | 2026-10-20 |
| Imaging Assessment of Swallowing and Speech Muscles in Inclusion Body Myositis IBM, Inclusion Body Myositis | Recruiting | Johns Hopkins University | 30 | 2026-11-01 | 2026-10-28 | |
| A Study to Evaluate the Safety, Tolerability and Pharmacodynamics of NIO752 in Primary Tauopathies NIO752, Placebo - Progressive Supranuclear Palsy, Corticobasal Degeneration | Phase 2 | Not yet recruiting | Novartis Pharmaceuticals | 48 | 2026-10-23 | 2026-10-09 |
| Evaluation of the Feasibility and Efficacy of a Chronic Brain-computer Interface for Speech Rehabilitation in Patients With Locked-in-syndrome (LIS) Chronic speech BCI - Locked in Syndrome, ALS (Amyotrophic Lateral Sclerosis) | Not applicable | Not yet recruiting | University Hospital, Grenoble | 3 | 2026-10-10 | 2026-07-13 |
| A Study to Learn About the Safety of BIIB147 and Its Effects in Adults With Amyotrophic Lateral Sclerosis (ALS) BIIB147, Placebo - Amyotrophic Lateral Sclerosis | Phase 1 / Phase 2 | Recruiting | Biogen | 69 | 2026-10-07 | 2026-10-26 |
| iBCI Optimization for Veterans With Paralysis Mobile neural decoding platform (mobile iBCI) - Spinal Cord Injury, Amyotrophic Lateral Sclerosis | Not applicable | Not yet recruiting | VA Office of Research and Development | 2 | 2026-10-02 | 2026-07-27 |
| Pilot Trial Utilizing β-hydroxy-β-methylbutyrate to Lower IGFBP7 Levels in People With ALS β-hydroxy-β-methylbutyrate (HMB) - Amyotrophic Lateral Sclerosis ALS | Phase 1 | Not yet recruiting | Duke University | 100 | 2026-10-01 | 2026-09-08 |
| Development in Home Mechanical Ventilation for Patient With Amyotrophic Lateral Sclerosis. Amyotrophic Lateral Sclerosis, Home Mechanical Ventilation | Not yet recruiting | Copenhagen University Hospital, Rigshospitalet | 400 | 2026-10-01 | 2026-09-15 | |
| Colchicine Effect on Amyotrophic Lateral Sclerosis Patients Colchicine 0.5 MG Oral Tablet, Placebo Oral Tablet - Amyotrophic Lateral Sclerosis | Phase 2 | Not yet recruiting | Azienda Ospedaliero-Universitaria di Modena | 87 | 2026-10-01 | 2026-09-10 |
| Safety, Tolerability, and Pharmacodynamic Exploration of Orelabrutinib in Patients With Amyotrophic Lateral Sclerosis (ALS) Orelabrutinib - Amyotrophic Lateral Sclerosis (ALS) | Phase 1 | Not yet recruiting | Liu Qing | 12 | 2026-10-01 | 2026-10-15 |
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Riluzole (24) · Blood Specimen Collection (17) · Spinal Puncture (11) · Memantine (10) · Dexpramipexole (8) · Edaravone (8) · Transcranial Magnetic Stimulation (8) · Transcranial Direct Current Stimulation (7) · sodium phenylbutyrate and taurursodiol (7) · CK-2017357 (6) · Magnetic Resonance Imaging (6) · Noninvasive Ventilation (6) · Sodium Chloride (6) · Creatine (5) · Observation (5)
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PMID 35790423, PMID 36008843, PMID 16434671, PMID 17980667, PMID 19251627, PMID 22415951, PMID 22529995, PMID 23300829, PMID 23463272, PMID 23952636, PMID 24067398, PMID 25982504, PMID 26751635, PMID 29287521, PMID 30124008, PMID 30814647, PMID 31566651, PMID 32896088, PMID 33441454, PMID 33827960, PMID 34349004, PMID 34433481, PMID 34536404, PMID 35492244, PMID 35532908, PMID 35577511, PMID 37254449, PMID 37396808, PMID 38010108, PMID 39457678, PMID 40067754, PMID 40067755, PMID 40067821, PMID 41224659, PMID 41366786, PMID 10540002, PMID 11015796, PMID 11050032, PMID 11586297, PMID 11750036, PMID 11976975, PMID 12092785, PMID 12566600, PMID 12921793, PMID 14718694, PMID 15034582, PMID 15084121, PMID 15505150, PMID 15657798, PMID 15753425
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