2031 completed, 629 recruiting, 520 unknown, 235 terminated. 1644 Not applicable, 717 Phase 2, 449 Phase 1, 357 Phase 3, 140 Phase 4.
Follow Spinal Cord Diseases: new trials by email Literature Review of Spinal Cord Diseases trials Research Report on Spinal Cord Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Patient-centered Assessment of the Effects of Powered Exoskeleton Use in People With Spinal Cord Injury Rehabilitation - Spinal Cord Injuries | Not applicable | Suspended | Istituto Nazionale Assicurazione contro gli Infortuni sul Lavoro | 18 | 2030-01-01 | 2026-03-27 |
| A Multiple Dose Study to Investigate Safety, Tolerability and Pharmacokinetics of TBN Tetramethylpyrazine nitrone (TBN) tablet / Placebo - Healthy | Phase 1 | Not yet recruiting | Guangzhou Magpie Pharmaceuticals Co., Ltd. | 16 | 2028-09-01 | 2026-09-11 |
| Device for Bladder Control for Men With SCI Noninvasive electrical stimulation device to improve bladder control - Neurogenic Bladder | Phase 1 / Phase 2 | Not yet recruiting | VA Office of Research and Development | 12 | 2028-06-01 | 2026-06-25 |
| Efficacy of iPSC-Derived Motor Neuron Cells (XS228) in Subacute Spinal Cord Injury: A Phase II Randomized Controlled Trial Allogeneic Human Induced Pluripotent Stem Cell (iPSC)-Derived Motor Neuron Progenitor Cells, Placebo - Spinal Cord Injury, Safety | Phase 2 | Not yet recruiting | XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd. | 60 | 2028-05-25 | 2025-11-25 |
| Testosterone Therapy With or Without Finasteride After Spinal Cord Injury: TRT-SCI Trial testosterone cypionate, finasteride, placebo injection - Spinal Cord Injury, Spinal Cord Injuries | Phase 2 / Phase 3 | Not yet recruiting | VA Office of Research and Development | 300 | 2027-10-01 | 2026-08-04 |
| Evaluation of Donor-Derived B Cell Infusions in Patients With Amyotrophic Lateral Sclerosis (ALS) B cell infusion - ALS - Amyotrophic Lateral Sclerosis | Phase 1 | Not yet recruiting | Mark Poznansky | 10 | 2027-09-01 | 2026-09-24 |
| Combining Low Oxygen Therapy and an Adenosine A2a Receptor Antagonist to Improve Functional Mobility After Spinal Cord Injury Istradefylline, low oxygen therapy - Spinal Cord Injuries, Myelopathy | Phase 1 / Phase 2 | Not yet recruiting | Randy Trumbower, PT, PhD | 40 | 2027-09-01 | 2026-03-20 |
| Empowerment Program to Reduce Treatment of Asymptomatic Bacteriuria in Veterans With Spinal Cord Injury Empowerment Program - Spinal Cord Injury, Spinal Cord Disease | Not applicable | Not yet recruiting | VA Office of Research and Development | 30 | 2027-08-02 | 2026-08-19 |
| Cardiocentric Inotropic Optimization in Spinal Cord Injury Dobutamine crossover - SCI - Spinal Cord Injury | Early Phase 1 | Not yet recruiting | University of British Columbia | 8 | 2027-06-01 | 2026-10-13 |
| Combined rTMS and tSCS for Upper Limb Recovery in Cervical SCI Transcranial Magnetic Stimulation, Transcutaneous Spinal Cord Stimulation - Spinal Cord Injuries (SCI) | Not applicable | Not yet recruiting | National University Hospital, Singapore | 24 | 2027-03-30 | 2026-05-14 |
| Safety Study of XT-150 in Participants With ALS XT-150 - Amyotrophic Lateral Sclerosis (ALS) | Phase 1 | Not yet recruiting | Xalud Therapeutics, Inc. | 8 | 2027-03-01 | 2026-07-29 |
| Xo-Motion R Exoskeleton in SCI-Adoption Study XoMotionR- assisted locomotor training - Spinal Cord Injury | Not applicable | Not yet recruiting | University of Alberta | 16 | 2027-03-01 | 2026-09-16 |
| Combined TMS-tSCS for Lower Limb Rehabilitation in Chronic Incomplete SCI Transcranial Magnetic Stimulation, Transcutaneous Spinal Cord Stimulation - Spinal Cord Injuries (SCI) | Not applicable | Not yet recruiting | National University Hospital, Singapore | 24 | 2027-01-01 | 2026-05-19 |
| Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT) INTENT Neural Interface System - Tetraplegia/Tetraparesis, Amyotrophic Lateral Sclerosis (ALS) | Not applicable | Recruiting | Johns Hopkins University | 5 | 2027-01-01 | 2026-10-09 |
| A Prospective Study of the Safety and Efficacy of 3D-printed Non-rigid Biomimetic Implant in Cervical and Thoracolumbar Spine 3D-printed custom-made non-rigid biomimetic implant - Spinal Tumor | Not applicable | Not yet recruiting | National Taiwan University Hospital | 18 | 2027-01-01 | 2025-12-17 |
| Umbilical Cord Mesenchymal Stem Cells Therapy (19#iSCLife®-SA) for Patients With Spinocerebellar Ataxia Intravenous infusion, Intrathecal injection, umbilical cord mesenchymal stem cell - Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia Type 2 | Phase 2 | Not yet recruiting | Sclnow Biotechnology Co., Ltd. | 45 | 2026-12-31 | 2026-04-23 |
| Assessment of Safety and Effectiveness of Spatial StimelMD (SSMD) in Subjects With Upper Limb Neuromotor Impairments SSMD, Functional Electrical Stimulation (FES) - Stroke, TBI | Not applicable | Not yet recruiting | Motion Informatics LTD | 120 | 2026-12-30 | 2026-02-11 |
| Multi-Modal Digital Monitoring of Disease Symptoms in Spinocerebellar Ataxia Spinocerebellar Ataxia (SCA) | Not yet recruiting | BioSensics | 25 | 2026-12-15 | 2026-10-01 | |
| NO AD: Use of Nitric Oxide (NO) Donors for the Prevention of Autonomic Dysreflexia (AD) During Bowel Care Following SCI Glyceryl Trinitrate Only Product in Oromucosal Dose Form, Placebo sublingual spray - Spinal Cord Injuries, Autonomic Dysreflexia | Phase 2 | Not yet recruiting | Simon Fraser University | 26 | 2026-12-01 | 2026-04-23 |
| Dorsal Root Ganglion Stimulation After Lower Motor Neuron Damage Abbot Dorsal Root Ganglion Neurostimulator - Spinal Cord Injuries, Lower Motor Neuron Disease | Not applicable | Not yet recruiting | Peter J. Grahn, Ph.D. | 1 | 2026-12-01 | 2026-09-15 |
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Spinal Cord Injuries (1931) · Amyotrophic Lateral Sclerosis (972) · Muscular Atrophy, Spinal (277) · Poliomyelitis (263) · Motor Neuron Disease (159) · Quadriplegia (158) · Stroke (139) · Diphtheria (114) · Tetanus (114) · Friedreich Ataxia (110) · Multiple Sclerosis (109) · Spinal Cord Neoplasms (103) · Paraplegia (102) · Spinocerebellar Ataxias (92)
Central Nervous System Diseases (3972) · Nervous System Diseases (3944) · Wounds and Injuries (1971) · Trauma, Nervous System (1928) · Neuromuscular Diseases (1670) · Neurodegenerative Diseases (1574) · Nutritional and Metabolic Diseases (1162) · Motor Neuron Disease (1145) · Metabolic Diseases (1144) · Proteostasis Deficiencies (973) · TDP-43 Proteinopathies (968) · Pathological Conditions, Signs and Symptoms (922) · Signs and Symptoms (784) · Neurologic Manifestations (735)
Blood Specimen Collection (35) · Exercise (32) · Riluzole (31) · Poliovirus Vaccine, Inactivated (28) · nusinersen (28) · Transcranial Direct Current Stimulation (27) · diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae b conjugate-hepatitis B vaccine (27) · Transcranial Magnetic Stimulation (26) · Surveys and Questionnaires (21) · Rehabilitation (19) · Risdiplam (18) · Sodium Chloride (18) · Physical Therapy Modalities (16) · Botulinum Toxins, Type A (15) · Spinal Puncture (15)
VA Office of Research and Development (78) · National Institute of Neurological Disorders and Stroke (NINDS) (53) · University of Miami (53) · GlaxoSmithKline (48) · Assistance Publique - Hôpitaux de Paris (46) · Shirley Ryan AbilityLab (46) · Swiss Paraplegic Research, Nottwil (45) · US Department of Veterans Affairs (45) · Biogen (43) · University of British Columbia (43) · Sanofi Pasteur, a Sanofi Company (42) · Kessler Foundation (39) · James J. Peters Veterans Affairs Medical Center (38) · Peking University Third Hospital (30) · Washington University School of Medicine (30)
United States (1754) · Canada (344) · France (308) · China (250) · Italy (219) · United Kingdom (205) · Germany (183) · Spain (173) · Switzerland (147) · Netherlands (126) · Belgium (119) · Australia (108) · Turkey (Türkiye) (101) · Taiwan (81) · Japan (76)
Mark S Nash, PhD (12) · William Bauman, MD (11) · Merit Cudkowicz, MD (10) · Jeremy Shefner, MD, PhD (8) · Andrei Krassioukov, MD,PhD,FRCPC (7) · Alberto Benussi, MD (6) · Bjorn Oskarsson, MD (6) · Edelle C Field-Fote, PT, PhD (6)
PMID 31420846, PMID 34383289, PMID 37148485, PMID 28899825, PMID 40739200, PMID 18406958, PMID 21762873, PMID 25001669, PMID 26873055, PMID 27939059, PMID 30247091, PMID 30407030, PMID 32867698, PMID 36008843, PMID 38014747, PMID 38705943, PMID 39134021, PMID 39287519, PMID 39446982, PMID 41224659, PMID 42152086, PMID 10569435, PMID 14722039, PMID 15224087, PMID 16434671, PMID 16543552, PMID 17335974, PMID 17562928, PMID 17980667, PMID 18506712, PMID 19027233, PMID 19251627, PMID 19406289, PMID 19406290, PMID 19440247, PMID 21303266, PMID 21779958, PMID 22153001, PMID 22330108, PMID 22415951, PMID 22529995, PMID 22985379, PMID 23002086, PMID 23082850, PMID 23085704, PMID 23141478, PMID 23300829, PMID 23463272, PMID 23952636, PMID 24067398
2023 (27), 2025 (19), 2017 (16), 2019 (15), 2014 (11), 2018 (9), 2016 (7), 2015 (6), U01CA081457 (5), U01CA097452 (4), U54NS092091 (3), 1OT2NS136938 (2), 1OT2NS136939 (2), 2005 (2), N01NS42361 (2)