20 completed, 8 recruiting, 3 unknown, 2 not yet recruiting. 24 Not applicable, 4 Phase 2, 3 Phase 1, 3 Phase 3, 1 Phase 4.
Follow Aphasia, Broca: new trials by email Literature Review of Aphasia, Broca trials Research Report on Aphasia, Broca
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Combined Intervention Program for Non-fluent Aphasia Based on Neuroplasticity CIPAN = MIT + CIAT, MIT + MIT, CIAT + CIAT - Non-fluent Aphasia | Not applicable | Not yet recruiting | Universidad de Granada | 48 | 2027-01-01 | 2026-08-14 |
| BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Aphasia BrainGate Neural Interface System - Expressive Aphasia, Aphasia Following Cerebral Infarction | Not applicable | Not yet recruiting | Leigh R. Hochberg, MD, PhD. | 5 | 2026-11-01 | 2026-10-22 |
| Superiority Trial of Aphasia-focused Rehabilitation With tDCS Stimulation tDCS - Aphasia, Broca's Aphasia | Phase 2 / Phase 3 | Recruiting | University of South Carolina | 130 | 2026-07-14 | 2026-07-21 |
| Aphasia Physical EXercise Study: Randomized Trial High-intensity physical exercise, Low-intensity physical exercise - Aphasia, Acquired, Aphasia | Not applicable | Recruiting | University of California, Berkeley | 120 | 2025-12-01 | 2026-03-19 |
| Comparing Traditional Semantic Feature Analysis (tSFA) and Semantic Feature Analysis + Metacognitive Strategy Training (SFA+MST) Semantic Feature Analysis (traditional), Semantic Feature Analysis + Metacognitive Strategy Training - Aphasia, Aphasia Following Cerebral Infarction | Phase 2 | Recruiting | Teachers College, Columbia University | 40 | 2025-07-28 | 2026-06-25 |
| Mirror Speech Entrainment: A Novel Technique for Voice Personalized Speech Entrainment for Nonfluent Aphasia Mirror speech entrainment, Traditional speech entrainment: auditory-only, Traditional speech entrainment: auditory-visual - Aphasia Non Fluent, Stroke | Not applicable | Active not recruiting | University of South Florida | 20 | 2025-05-01 | 2026-09-22 |
| Effects of PACE Technique in Patients With Aphasia experimental, control group conventional therapy - Aphasia, Broca | Not applicable | Completed | Riphah International University | 16 | 2025-03-18 | 2026-04-09 |
| Music Therapy for Rehabilitation in Post-stroke Non-fluent Aphasia: the Indian Adaptation Speech rehabilitation - Stroke Rehabilitation, Aphasia, Broca | Not applicable | Recruiting | All India Institute of Medical Sciences | 60 | 2024-06-01 | 2026-10-13 |
| Effects of High-intensity Exercise Training on Physical Fitness, Cognition, Language in Post-stroke Aphasia Low-intensity physical exercise, High-intensity physical exercise - Aphasia, Acquired, Aphasia | Not applicable | Completed | University of California, Berkeley | 12 | 2023-12-11 | 2026-02-17 |
| Effectiveness of TDCS Over Broca's Area in Verb Naming: a Randomized, Double-Blind, Crossover Study Active treatment, Sham Stimulation - Aphasia Non Fluent, Stroke | Not applicable | Completed | I.R.C.C.S. Fondazione Santa Lucia | 32 | 2023-12-04 | 2025-01-15 |
| Combining tDCS and CILT in Non-fluent Aphasia tDCS, Placebo - Aphasia, Non-fluent Aphasia | Not applicable | Completed | University of Minnesota | 10 | 2023-04-24 | 2025-12-09 |
| Home-Based Exercise in Primary Progressive Aphasia (HEPPA) Home-based multicomponent exercise intervention program - Primary Progressive Aphasia, Neurodegenerative Diseases | Not applicable | Completed | Montreal Heart Institute | 13 | 2023-04-05 | 2025-02-06 |
| High-frequency nrTMS on the Contralateral Broca Mirror Area for Glioma Patients With Early Postoperative Aphasia nrTMS treatment, nrTMS sham - Non-fluent Aphasia, Glioma | Not applicable | Unknown | Beijing Neurosurgical Institute | 48 | 2023-04-01 | 2023-03-28 |
| Effects of Neuronavigated Theta Burst Stimulation in Therapy of Post-stroke Aphasia Noninvasive transcranial brain stimulation: excitatory iTBS, Noninvasive transcranial brain stimulation: inhibitory cTBS, Individual speech-language therapy (SLT) - Stroke, Ischemic, Aphasia Non Fluent | Not applicable | Recruiting | Institute of Psychiatry and Neurology, Warsaw | 45 | 2022-09-02 | 2026-03-31 |
| Sensory-Motor Integration for Speech Rehabilitation in Patients With Post-stroke Aphasia Enriched rehabilitation, Simple rehabilitation - Aphasia Non Fluent, Stroke | Not applicable | Recruiting | University Hospital, Grenoble | 80 | 2022-05-05 | 2026-10-02 |
| Remote Neurobased Approach to Aphasia Therapy Mobile evidence-based aphasia therapy, Conventional aphasia rehabilitation - Aphasia, Broca, Aphasia, Wernicke | Not applicable | Completed | Institute for Bioengineering of Catalonia | 15 | 2021-11-29 | 2022-03-10 |
| Speech Hero Home Therapy for Aphasia At home Speech Hero therapy app - Broca Aphasia | Not applicable | Completed | Flint Rehabilitation Devices, LLC | 10 | 2021-07-20 | 2022-02-07 |
| Music After Stroke To Enhance Rehabilitation Ipod with music, ipod with books to listen, ipod only with usual care - Stroke, Acute, Expressive Aphasia | Not applicable | Unknown | Pace University | 12 | 2021-04-30 | 2021-03-11 |
| Repetitive Transcranial Magnetic Stimulation and Multi-modality Aphasia Therapy for Post-stroke Non-fluent Aphasia 1Hz inhibitory rTMS, 1Hz sham rTMS, Multi-Modality Aphasia Therapy (M-MAT) - Stroke, Aphasia, Non-fluent | Not applicable | Completed | University of Calgary | 46 | 2021-04-15 | 2024-08-12 |
| Speech Entrainment for Aphasia Recovery SET (Speech Entrainment Therapy) 3 weeks, SET (Speech Entrainment Therapy) 4.5 weeks, SET (Speech Entrainment Therapy) 6 weeks - Aphasia, Aphasia Non Fluent | Phase 2 | Completed | Medical University of South Carolina | 80 | 2020-08-21 | 2025-11-14 |
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Aphasia (23) · Stroke (22) · Ischemic Stroke (5) · Aphasia, Primary Progressive (4) · Aphasia, Wernicke (4) · Primary Progressive Nonfluent Aphasia (4) · Anomia (3) · Apraxias (3) · Frontotemporal Dementia (3) · Language (3) · Aphasia, Conduction (2) · Language Disorders (2) · Motor Activity (2) · Neurodegenerative Diseases (2)
Nervous System Diseases (35) · Neurobehavioral Manifestations (35) · Neurologic Manifestations (35) · Pathological Conditions, Signs and Symptoms (35) · Signs and Symptoms (35) · Communication Disorders (34) · Speech Disorders (34) · Language Disorders (33) · Brain Diseases (27) · Central Nervous System Diseases (27) · Cardiovascular Diseases (22) · Cerebrovascular Disorders (22) · Vascular Diseases (22) · Aphasia (12) · Mental Disorders (8)
Transcranial Direct Current Stimulation (4) · 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole (1) · 4-deethylatrazine (1) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (1) · Brain-Computer Interfaces (1) · Control Groups (1) · Neural Prostheses (1) · Rehabilitation of Speech and Language Disorders (1) · SET protein, human (1) · Transcranial Magnetic Stimulation (1) · carbidopa, levodopa drug combination (1)
Mayo Clinic (3) · Shirley Ryan AbilityLab (2) · University of Calgary (2) · University of California, Berkeley (2) · University of Minnesota (2) · University of South Carolina (2) · All India Institute of Medical Sciences (1) · Beijing Neurosurgical Institute (1) · Flint Rehabilitation Devices, LLC (1) · Fundación Cardiovascular de Colombia (1) · I.R.C.C.S. Fondazione Santa Lucia (1) · Institute for Bioengineering of Catalonia (1) · Institute of Psychiatry and Neurology, Warsaw (1) · Isra University (1) · Leigh R. Hochberg, MD, PhD. (1)
United States (18) · Canada (4) · Pakistan (2) · Spain (2) · Colombia (1) · France (1) · India (1) · Italy (1) · Poland (1)
Maria Ivanova, PhD (2) · Brenda Rapp, PhD (1) · Carlo Caltagirone, MD, PhD (1) · Cynthia K Thompson, PhD (1) · David Caplan, MDCM, PhD (1) · Federico A Silva, MD,MSc (1) · Fidel Vila-Rodriguez, MD (1) · Jennifer Whitwell, PhD (1) · Julius Fridriksson, PhD, CCC-SLP (1) · Katarzyna E Polanowska, PhD (1) · Keith A Josephs, M.D. MST, MSc (1) · Keith Josephs, MD (1) · Leigh R Hochberg, MD, PhD (1) · Leonardo Bonilha, MD, PhD (1) · Leora R Cherney, PhD (1)
PMID 10350414, PMID 10568646, PMID 11556941, PMID 15087552, PMID 15109995, PMID 15118944, PMID 16635494, PMID 17030751, PMID 19158063, PMID 19695692, PMID 19818232, PMID 20299861, PMID 20438853, PMID 20714075, PMID 22215032, PMID 23613966, PMID 24961525, PMID 25658635, PMID 26704258, PMID 27445970, PMID 27867260, PMID 28093560, PMID 28357141, PMID 28573050, PMID 28603329, PMID 28690782, PMID 29367334, PMID 29411008, PMID 30814941, PMID 30913976, PMID 31103888, PMID 31419597, PMID 31627014, PMID 32282965, PMID 32907594, PMID 32949711, PMID 36525719, PMID 36526425, PMID 37295011, PMID 39999397, PMID 41203433
P50DC012283 (1), P50DC014664 (1), R01DC012519 (1), R01DC022663 (1), R21DC009876 (1), U01DC017521 (1), U01DC022447 (1)