37 completed, 26 recruiting, 5 active not recruiting, 5 terminated. 51 Not applicable, 8 Phase 2, 6 Phase 1, 3 Early Phase 1, 1 Phase 4.
Follow Aphasia, Primary Progressive: new trials by email Literature Review of Aphasia, Primary Progressive trials Research Report on Aphasia, Primary Progressive
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Stimulating the Aging Brain Using Brain and Sensory Stimulation tACS or multisensory stimulation - Primary Progressive Aphasia | Not applicable | Recruiting | Medical College of Wisconsin | 20 | 2026-06-01 | 2026-06-16 |
| Targeted Transcranial Magnetic Stimulation to Improve Language and Speech in Patients With Primary Progressive Aphasia Training with Speech Language Therapy, Standard rTMS, Targeted rTMS - Primary Progressive Aphasia(PPA) | Not applicable | Enrolling by invitation | IRCCS San Raffaele | 75 | 2026-05-13 | 2026-05-20 |
| Remotely-supervised Neuromodulation in PPA Lexical Retrieval Cascade Treatment, Remotely Supervised Transcranial Direct Current Stimulation- Active, Remotely Supervised Transcranial Direct Current Stimulation - Sham - Primary Progressive Aphasia(PPA), Progressive Aphasia | Not applicable | Recruiting | Maya Henry | 80 | 2026-04-15 | 2026-09-04 |
| Intervention for Communication Quality of Life in Primary Progressive Aphasia Multicomponent Lexical Retrieval Cascade Training, Multicomponent Video Implemented Script Training in Aphasia - Primary Progressive Aphasia(PPA), Semantic Dementia | Not applicable | Recruiting | Maya Henry | 30 | 2026-04-01 | 2026-04-21 |
| Biofluid Research on Age-Related or Inherited Neurodegeneration Frontotemporal Degeneration (FTD), ALS (Amyotrophic Lateral Sclerosis) | Recruiting | University of Pennsylvania | 1000 | 2025-12-12 | 2026-09-01 | |
| Clinical Study of Neflamapimod in Patients With Primary Progressive Aphasia Neflamapimod, Placebo - Nonfluent Variant Primary Progressive Aphasia (nfvPPA) | Phase 2 | Active not recruiting | EIP Pharma Inc | 20 | 2025-10-02 | 2026-07-06 |
| Long Term Effect of Brain Stimulation in PPA TMS, tDCS, Sham TMS - Primary Progressive Aphasia(PPA) | Not applicable | Recruiting | Hospital San Carlos, Madrid | 80 | 2025-09-15 | 2026-04-23 |
| STELLA-FTD: Examination of a Behavior Change Intervention for FTD Family Care Partners STELLA-FTD Control, STELLA-FTD Test - Frontotemporal Dementia, Caregiver Burden | Not applicable | Recruiting | Oregon Health and Science University | 640 | 2025-06-23 | 2025-10-27 |
| Propranolol in Primary Progressive Aphasia Propranolol, Magnetic Resonance Imaging (MRI), Placebo - Aphasia, Primary Progressive | Early Phase 1 | Recruiting | University of Missouri-Columbia | 30 | 2025-01-13 | 2026-07-17 |
| Predict to Prevent PGRN Disease Clinical, behavioral and cognitive evaluation, blood sampling, brain MRI - Frontotemporal Dementia (FTD), GRN Related Frontotemporal Dementia | Not applicable | Withdrawn | Assistance Publique - Hôpitaux de Paris | 2025-01-01 | 2025-03-21 | |
| Effects of Transcranial Direct Current Stimulation (tDCS) on Inhibition and Brain Function in Primary Progressive Aphasia tDCS, SHAM - Aphasia, Primary Progressive | Not applicable | Recruiting | Centre Hospitalier Universitaire de Nice | 20 | 2024-11-04 | 2024-11-05 |
| Speech and Language Interventions for Italian People With PPA Behavioral Treatment - Primary Progressive Aphasia(PPA) | Recruiting | Istituti Clinici Scientifici Maugeri SpA | 30 | 2024-09-01 | 2026-10-26 | |
| Communication Bridge 3 Study Communication Bridge™, Evidence-Based Impairment Focused - Primary Progressive Aphasia | Phase 2 | Recruiting | University of Chicago | 200 | 2024-08-23 | 2026-06-01 |
| Communication Bridge Pilot Study Communication Bridge - Primary Progressive Aphasia | Not applicable | Active not recruiting | University of Chicago | 12 | 2024-06-28 | 2025-08-07 |
| Educational Support Group Program for Bilingual and Spanish-speaking Carepartners and People With Progressive Aphasia Psychosocial educational, support group and implementation of strategies - Alzheimer Disease, Dementia | Early Phase 1 | Recruiting | University of Texas at Austin | 120 | 2024-05-21 | 2026-06-10 |
| Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia Active tDCS + Language Therapy, Sham tDCS + Language Therapy - Primary Progressive Aphasia, Logopenic Progressive Aphasia | Phase 2 | Recruiting | Johns Hopkins University | 180 | 2024-02-13 | 2026-05-05 |
| Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling Dementia, Alzheimer Disease | Recruiting | University Health Network, Toronto | 500 | 2023-11-11 | 2025-11-20 | |
| Transmagnetic Stimulation Pilot in Primary Progressive Aphasia Intermittent theta burst stimulation - Primary Progressive Aphasia | Not applicable | Completed | HealthPartners Institute | 3 | 2023-10-02 | 2025-06-03 |
| A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN) Intrathalamic AAV.PGRN administration, Intrathalamic AVB-101 - Frontotemporal Dementia, FTD | Phase 1 / Phase 2 | Recruiting | AviadoBio Ltd | 18 | 2023-08-30 | 2026-08-13 |
| Home-based tDCS in Frontotemporal Dementia or Alzheimer's Disease Computerized Cognitive Training, Active tDCS (tDCS) on DLPFC - Mild Cognitive Impairment, Primary Progressive Aphasia | Not applicable | Terminated | Johns Hopkins University | 5 | 2023-08-10 | 2026-10-21 |
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Frontotemporal Dementia (34) · Alzheimer Disease (25) · Aphasia (23) · Primary Progressive Nonfluent Aphasia (20) · Dementia (18) · Corticobasal Degeneration (11) · Neurodegenerative Diseases (11) · Supranuclear Palsy, Progressive (11) · Frontotemporal Lobar Degeneration (9) · Apraxias (8) · Pick Disease of the Brain (8) · Amyotrophic Lateral Sclerosis (7) · Neurocognitive Disorders (7) · Cognitive Dysfunction (6)
Pathological Conditions, Signs and Symptoms (84) · Signs and Symptoms (84) · Neurobehavioral Manifestations (83) · Neurologic Manifestations (83) · Central Nervous System Diseases (82) · Mental Disorders (82) · Nervous System Diseases (82) · Brain Diseases (81) · Language Disorders (79) · Speech Disorders (79) · Communication Disorders (78) · Neurocognitive Disorders (77) · Dementia (66) · Aphasia (61) · Nutritional and Metabolic Diseases (45)
Transcranial Direct Current Stimulation (8) · Speech Therapy (6) · Language Therapy (5) · Transcranial Magnetic Stimulation (3) · Blood Specimen Collection (2) · Therapeutics (2) · 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole (1) · 4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene (1) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (1) · AADvac1 (1) · Behavior Therapy (1) · Exercise (1) · Genetic Testing (1) · Magnetic Resonance Imaging (1) · Observation (1)
Johns Hopkins University (7) · University of Chicago (7) · University of Pennsylvania (5) · Mayo Clinic (4) · University of California, San Francisco (4) · University of Texas at Austin (4) · Hospital San Carlos, Madrid (3) · Baycrest (2) · IRCCS Centro San Giovanni di Dio Fatebenefratelli (2) · IRCCS San Raffaele (2) · Maya Henry (2) · Medical College of Wisconsin (2) · Northwestern University (2) · Peking Union Medical College Hospital (2) · University Health Network, Toronto (2)
United States (53) · Canada (13) · Italy (7) · Spain (5) · United Kingdom (4) · France (3) · Netherlands (2) · Sweden (2) · Belgium (1) · China (1) · Germany (1) · Poland (1)
Kyrana Tsapkini, PhD (4) · Maya L Henry, PhD (4) · Aneta Kielar, PhD (2) · Emily Rogalski, Ph.D (2) · Emily Roglaski, PhD (2) · Maria C Tartaglia, M.D. (2) · Aaron Meyer, PhD (1) · Adam Boxer, MD, PhD (1) · Adam L Boxer, MD, PhD (1) · Adam L. Boxer, M.D., Ph.D. (1) · Aimee Mooney, MA, CCC-SLP (1) · Alessandro Martorana, MD, PhD (1) · Allan Young, Professor (1) · Allison Lindauer, PhD, APRN (1) · Argye E Hillis, MD, MA (1)
PMID 33441454, PMID 28713256, PMID 30258975, PMID 33031971, PMID 33827960, PMID 34006157, PMID 34487043, PMID 34489348, PMID 34875098, PMID 34937781, PMID 35492244, PMID 35667724, PMID 35698099, PMID 35790423, PMID 36662282, PMID 37287321, PMID 37508992, PMID 37821924, PMID 37838080, PMID 37955923, PMID 38807183, PMID 40070907, PMID 40754329, PMID 40788648, PMID 40809903, PMID 40857539, PMID 41041680, PMID 41812391, PMID 41864233, PMID 42161537, PMID 42818139
R01AG055425 (4), P01AG066597 (2), 1RF1AG050967-01A1 (1), 2017 (1), 2023 (1), F31DC020352 (1), P30AG072979 (1), R01AG054519 (1), R01AG075111 (1), R01AG075404 (1), R01AG077444 (1), R01AG084523 (1), R01DC007683 (1), R01DC012519 (1), R01DC014475 (1)