210 completed, 74 recruiting, 51 unknown, 15 not yet recruiting. 289 Not applicable, 28 Phase 2, 14 Phase 1, 9 Phase 3, 6 Phase 4.
Follow Aphasia: new trials by email Literature Review of Aphasia trials Research Report on Aphasia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Combined Intervention Program for Non-fluent Aphasia Based on Neuroplasticity CIPAN = MIT + CIAT, MIT + MIT, CIAT + CIAT - Non-fluent Aphasia | Not applicable | Not yet recruiting | Universidad de Granada | 48 | 2027-01-01 | 2026-08-14 |
| Listen Aphasia Pilot Study LISTEN (AI-based AAC smartphone app) - Aphasia, Malignant Brain Tumor | Not applicable | Not yet recruiting | Dana-Farber Cancer Institute | 80 | 2027-01-01 | 2026-07-28 |
| BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Aphasia BrainGate Neural Interface System - Expressive Aphasia, Aphasia Following Cerebral Infarction | Not applicable | Not yet recruiting | Leigh R. Hochberg, MD, PhD. | 5 | 2026-11-01 | 2026-10-22 |
| Study of Cognitive-Linguistic Profiles: The Role of Executive Control in Aphasia Neuropsychological tests, Speech-language assessments - Stroke | Not applicable | Not yet recruiting | University Hospital, Toulouse | 30 | 2026-09-01 | 2026-08-14 |
| Cross-cultural Adaptation and Multicenter Validation of the Italian Versions of the Brief Evaluation of Receptive Aphasia (BERA) and SWallowing Assessment in Disorders of Consciousness (SWADOC) Italian SWallowing Assessment in Disorders of Consciousness (SWADOC), Italian Brief Evaluation of Receptive Aphasia (BERA) - Consciousness Disorders, Severe Acquired Brain Injury | Not yet recruiting | Alfonso Magliacano | 79 | 2026-09-01 | 2026-07-17 | |
| Effects of Semantic Context on Criterion-learning Naming Treatment in Aphasia Criterion-learning practice - Aphasia | Not applicable | Not yet recruiting | Albert Einstein Healthcare Network | 12 | 2026-08-01 | 2026-07-13 |
| Superiority Trial of Aphasia-focused Rehabilitation With tDCS Stimulation tDCS - Aphasia, Broca's Aphasia | Phase 2 / Phase 3 | Recruiting | University of South Carolina | 130 | 2026-07-14 | 2026-07-21 |
| Stimulating the Aging Brain Using Brain and Sensory Stimulation tACS or multisensory stimulation - Primary Progressive Aphasia | Not applicable | Recruiting | Medical College of Wisconsin | 20 | 2026-06-01 | 2026-06-16 |
| Recovery From Post-Stroke Aphasia With rTMS Targeting Left or Right Anterior Temporal Lobe continuous Theta Burst Stimulation, intermittent Theta Burst Stimulation, Transcranial Magnetic Stimulation Sham - Stroke, Aphasia | Not applicable | Recruiting | University of South Carolina | 45 | 2026-05-15 | 2026-05-29 |
| Targeted Transcranial Magnetic Stimulation to Improve Language and Speech in Patients With Primary Progressive Aphasia Training with Speech Language Therapy, Standard rTMS, Targeted rTMS - Primary Progressive Aphasia(PPA) | Not applicable | Enrolling by invitation | IRCCS San Raffaele | 75 | 2026-05-13 | 2026-05-20 |
| Implementing Transcranial Direct Current Stimulation in a Rehabilitation Setting transcranial direct current stimulation (tDCS) - Aphasia, Stroke | Not yet recruiting | Casa Colina Hospital and Centers for Healthcare | 30 | 2026-05-04 | 2026-04-17 | |
| LEXURE for Post-Stroke Aphasia LEXURE, Workbook - Aphasia | Not applicable | Recruiting | Nunaps Inc | 116 | 2026-04-16 | 2026-05-14 |
| Remotely-supervised Neuromodulation in PPA Lexical Retrieval Cascade Treatment, Remotely Supervised Transcranial Direct Current Stimulation- Active, Remotely Supervised Transcranial Direct Current Stimulation - Sham - Primary Progressive Aphasia(PPA), Progressive Aphasia | Not applicable | Recruiting | Maya Henry | 80 | 2026-04-15 | 2026-09-04 |
| Intervention for Communication Quality of Life in Primary Progressive Aphasia Multicomponent Lexical Retrieval Cascade Training, Multicomponent Video Implemented Script Training in Aphasia - Primary Progressive Aphasia(PPA), Semantic Dementia | Not applicable | Recruiting | Maya Henry | 30 | 2026-04-01 | 2026-04-21 |
| EFFECT OF ANODAL TRANSCRANIAL DIRECT CURRENT STIMULATION ON NAMING IN APHASIC PATIENTS WITH ACUTE ISCHEMIC STROKE Transcranial Direct Current Stimulation - Acute Ischemic Cerebrovascular Disease, Post Stroke Aphasia | Phase 3 | Not yet recruiting | Dr. Ram Manohar Lohia Hospital | 28 | 2026-03-31 | 2026-03-27 |
| Chinese-Specific Speech Imagery Coding Using High-Density ECoG Intraoperative high-density ECoG recording, Permanent high-density ECoG implantation - Aphasia, Dysarthria | Not applicable | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 50 | 2026-03-15 | 2026-03-10 |
| taVNS for Speech and Language Recovery in Aphasia taVNS, sham taVNS - Aphasia, Apraxia of Speech | Not applicable | Enrolling by invitation | University of Florida | 12 | 2026-01-01 | 2026-05-04 |
| Based on the Spatio-temporal Coding Characteristics of Frontotemporal Network, This Paper Explores the Mechanism of Five-tone Speech Training in Reshaping Language Fluency Function. Traditional Chinese Medicine Five-Tone Therapy, Melodic Intonation Training, Standard speech therapy; Routine medical treatment; Health education - Aphasia | Not applicable | Not yet recruiting | Fujian University of Traditional Chinese Medicine | 120 | 2025-12-31 | 2026-01-21 |
| Biofluid Research on Age-Related or Inherited Neurodegeneration Frontotemporal Degeneration (FTD), ALS (Amyotrophic Lateral Sclerosis) | Recruiting | University of Pennsylvania | 1000 | 2025-12-12 | 2026-09-01 | |
| Exploratory Evaluation of the Digital Therapeutic Device Zenicom for Subacute Stroke Aphasia Zenicog, Conventional Speech Therapy - Aphasia, Stroke | Phase 2 | Recruiting | Seoul National University Bundang Hospital | 20 | 2025-12-10 | 2026-02-10 |
Showing 20 of 395. Sign in to see all of them.
Stroke (184) · Aphasia, Primary Progressive (75) · Communication Disorders (41) · Language (37) · Aphasia, Broca (35) · Frontotemporal Dementia (35) · Anomia (29) · Alzheimer Disease (27) · Language Disorders (24) · Apraxias (23) · Dementia (21) · Primary Progressive Nonfluent Aphasia (20) · Ischemic Stroke (19) · Communication (14)
Pathological Conditions, Signs and Symptoms (395) · Signs and Symptoms (394) · Neurobehavioral Manifestations (393) · Neurologic Manifestations (393) · Nervous System Diseases (392) · Speech Disorders (382) · Language Disorders (371) · Communication Disorders (354) · Brain Diseases (283) · Central Nervous System Diseases (283) · Cardiovascular Diseases (200) · Vascular Diseases (199) · Cerebrovascular Disorders (197) · Mental Disorders (136) · Neurocognitive Disorders (88)
Transcranial Direct Current Stimulation (42) · Speech Therapy (20) · Transcranial Magnetic Stimulation (17) · Language Therapy (10) · Control Groups (4) · 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole (3) · Exercise (3) · Therapeutics (3) · Blood Specimen Collection (2) · Donepezil (2) · Memantine (2) · Standard of Care (2) · 4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene (1) · 4-deethylatrazine (1) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (1)
VA Office of Research and Development (15) · Johns Hopkins University (12) · University of Pennsylvania (12) · Shirley Ryan AbilityLab (10) · Medical College of Wisconsin (9) · Changping Laboratory (8) · University of Chicago (8) · Mayo Clinic (6) · Albert Einstein Healthcare Network (5) · Georgetown University (5) · US Department of Veterans Affairs (5) · University College, London (5) · University of South Carolina (5) · Boston University Charles River Campus (4) · City, University of London (4)
United States (206) · Canada (21) · United Kingdom (21) · France (19) · Germany (16) · China (13) · Italy (13) · Spain (13) · Sweden (8) · Belgium (6) · South Korea (6) · Switzerland (6) · Turkey (Türkiye) (6) · Pakistan (5) · Poland (5)
Hesheng Liu, PhD (6) · H. Branch Coslett, MD (4) · Kyrana Tsapkini, PhD (4) · Maya L Henry, PhD (4) · Amy D. Rodriguez, PhD (3) · Julie L Wambaugh, PhD (3) · Leora Cherney, PhD (3) · Priyanka Shah-Basak, PhD (3) · William Evans, PhD (3) · Agnes Floel, MD (2) · Alexander P Leff, Professor (2) · Aneta Kielar, PhD (2) · Caterina Breitenstein, PhD (2) · Diane L. Kendall, PhD (2) · Dylan Edwards, Ph.D. (2)
PMID 15118944, PMID 19695692, PMID 20299861, PMID 30128538, PMID 33441454, PMID 10350414, PMID 10568646, PMID 10796360, PMID 10990547, PMID 11556941, PMID 11849307, PMID 15087552, PMID 15109995, PMID 15766771, PMID 16006338, PMID 16635494, PMID 16737714, PMID 17030751, PMID 17900904, PMID 19158063, PMID 19453637, PMID 19673813, PMID 19818232, PMID 20040569, PMID 20159655, PMID 20438853, PMID 20714075, PMID 21197418, PMID 21233468, PMID 21636820, PMID 21794852, PMID 21825004, PMID 21842404, PMID 21864891, PMID 22215032, PMID 23050517, PMID 23071199, PMID 23108446, PMID 23280015, PMID 23613966, PMID 23695900, PMID 23695909, PMID 23695913, PMID 23799617, PMID 23828834, PMID 24059983, PMID 24166562, PMID 24687207, PMID 24961525, PMID 25075917
R01AG055425 (4), P50DC014664 (3), R01DC015516 (3), 2016 (2), P01AG066597 (2), R01DC019325 (2), 1RF1AG050967-01A1 (1), 2017 (1), 2019 (1), 2023 (1), F31DC020352 (1), I01RX000832 (1), I21RX002566 (1), K23DC021744 (1), K99DC023302 (1)