14 completed, 7 terminated, 5 unknown, 5 withdrawn. 12 Phase 3, 8 Not applicable, 8 Phase 4, 5 Phase 2, 3 Phase 1.
Follow Phenobarbital: new trials by email Literature Review of Phenobarbital trials Research Report on Phenobarbital
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of Electrocardiogram (ECG) Safety of Sezaby in Neonatal Seizures Sezaby - Neonatal Seizure | Phase 4 | Not yet recruiting | Sun Pharma Advanced Research Company Limited | 45 | 2026-12-01 | 2026-11-06 |
| Comparison Of Fenofibrate Vs Phenobarbitone As Adjunct To Phototherapy In Reducing Total Serum Bilirubin In Indirect Hyperbilirubinemia In Neonates Fenofibrate + Phototherapy, Phenobarbitone + Phototherapy - Jaundice, Neonatal | Phase 4 | Not yet recruiting | Rubab Fatima | 70 | 2026-10-01 | 2026-08-19 |
| Phenobarbital for Agitated Delirium Phenobarbital, Conventional therapy group - Agitated Delirium, Delirium Confusional State | Phase 3 | Withdrawn | Duke University | 2026-06-01 | 2026-11-06 | |
| Treatment of Seizures in Neonate With HIE Phenobarbital, Levetiracetam - Neonatal Seizures, HIE - Hypoxic - Ischemic Encephalopathy | Phase 4 | Not yet recruiting | Mansoura University | 66 | 2026-01-01 | 2025-12-16 |
| Levetiracetam Versus Phenobarbital in Benzodiazepines Unresponsive Paediatric Prolonged Seizures Levetiracetam IV, Phenobarbital - Seizure | Not applicable | Recruiting | Ministry of Health and Sports, Myanmar | 180 | 2025-07-22 | 2025-08-01 |
| Levetiracetam Versus Phenobarbitone for the Treatment of Neonatal Seizures in a Tertiary Care Hospital. Levetiracetam, Phenobarbital Sodium Injection - Neonatal Seizures | Not applicable | Completed | Hayat Abad Medical Complex, Peshawar | 260 | 2024-04-08 | 2026-02-10 |
| Antiseizure Medication in Seizure Networks at Early Acute Brain Injury Phenobarbital Sodium Injection, Levetiracetam, Lacosamide Injectable Product - Brain Injuries, Acute, Brain Injuries, Traumatic | Phase 4 | Terminated | University of North Carolina, Chapel Hill | 5 | 2023-11-20 | 2025-11-14 |
| A Dose Escalation Study of Levetiracetam in the Treatment of Neonatal Seizures Levetiracetam Injection, Phenobarbital Sodium Injection - Neonatal Seizure, Neonatal Encephalopathy | Phase 2 | Recruiting | University of California, San Diego | 133 | 2023-03-24 | 2026-10-15 |
| Possible Immuno-Modulatory Effect of Tocilizumab in Patients With Refractory Status Epilepticus. Tocilizumab Prefilled Syringe [Actemra]. propofole, phenobarbital, midazolam - Epilepsy | Phase 3 | Unknown | Damanhour University | 50 | 2022-06-25 | 2022-11-15 |
| Lacosamide in Neonatal Status Epilepticus Lacosamide, Phenobarbital - Epilepsy | Phase 3 | Unknown | Sherief Abd-Elsalam | 60 | 2022-03-01 | 2022-03-22 |
| Phenobarbital for Severe Acute Alcohol Withdrawal Syndrome Phenobarbital Sodium, Inactive placebo - Alcohol Withdrawal Delirium, Alcohol Withdrawal | Not applicable | Terminated | Unity Health Toronto | 8 | 2021-06-11 | 2023-11-02 |
| Efficacy and Safety of Intravenous Phenobarbital in Neonatal Seizures Phenobarbital Sodium Injection - Epilepsy, Benign Neonatal | Phase 3 | Terminated | NEMA Research, Inc. | 4 | 2021-03-12 | 2023-10-26 |
| Phenobarbital vs Ativan for Alcohol Withdrawal in the Intensive Care Unit Phenobarbital, Lorazepam - Alcohol Withdrawal, Alcohol Withdrawal Delirium | Phase 4 | Unknown | OSF Healthcare System | 142 | 2020-07-06 | 2020-10-08 |
| Study to Evaluate Phenobarbital Sodium Injection for the Treatment of Neonatal Seizures Phenobarbital Sodium Injection - Neonatal Seizure | Phase 3 | Withdrawn | PharPoint Research, Inc. | 2019-11-01 | 2019-08-28 | |
| Alcohol Withdrawal Syndrome Treated With Adjunctive Phenobarbital or Ketamine Ketamine, Phenobarbital, Lorazepam - Alcohol Withdrawal Syndrome | Phase 4 | Withdrawn | Santa Barbara Cottage Hospital | 2019-04-12 | 2019-09-19 | |
| Clonidine Versus Phenobarbital as Adjunctive Therapy for Neonatal Abstinence Syndrome Phenobarbital, Clonidine - Neonatal Abstinence Syndrome | Phase 2 | Completed | University of Tennessee Medical Center | 25 | 2018-10-01 | 2021-11-10 |
| Pharmacokinetics of Antiepileptics in Patients on CRRT Levetiracetam, Lacosamide, Phenytoin - Acute Kidney Injury, Renal Insufficiency | Completed | University of Maryland, Baltimore | 18 | 2017-11-20 | 2021-10-05 | |
| Population Pharmacokinetics of Antiepileptic in Pediatrics Valproic acid, carbamazepine, phenobarbital - Epilepsy | Completed | Assistance Publique - Hôpitaux de Paris | 753 | 2017-06-19 | 2025-11-20 | |
| Efficacy of Levetiracetam in Control of Neonatal Seizures Guided by an EEG Levetiracetam, Phenobarbital - Neonatal Seizures | Phase 4 | Unknown | Cairo University | 40 | 2017-03-25 | 2017-04-11 |
| Phenobarbital Versus Valproate for Generalized Convulsive Status Epilepticus Phenobarbital, Valproate - Generalized Convulsive Status Epilepticus | Phase 2 | Unknown | Xuanwu Hospital, Beijing | 120 | 2017-02-16 | 2019-07-09 |
Showing 20 of 36. Sign in to see all of them.
Epilepsy (7) · Neonatal Abstinence Syndrome (4) · Seizures (4) · Status Epilepticus (3) · Alcohol Withdrawal Delirium (2) · Brain Injuries (2) · Hypoxia-Ischemia, Brain (2) · Intracranial Hemorrhages (2) · Acute Kidney Injury (1) · Alcohol Withdrawal Seizures (1) · Anxiety Disorders (1) · Brain Injuries, Traumatic (1) · Brain Ischemia (1) · Burkitt Lymphoma (1) · Cerebral Hemorrhage (1)
Assistance Publique - Hôpitaux de Paris (1) · Baystate Medical Center (1) · Cairo University (1) · Children's Hospital of Fudan University (1) · Damanhour University (1) · Duke University (1) · Hannover Medical School (1) · Hayat Abad Medical Complex, Peshawar (1) · Institute of Child Health (1) · Jonathan Rosenson (1) · Mansoura University (1) · Mid-Atlantic Epilepsy and Sleep Center, LLC (1) · Ministry of Health and Sports, Myanmar (1) · NEMA Research, Inc. (1) · NICHD Neonatal Research Network (1)
United States (18) · Egypt (4) · China (2) · Bangladesh (1) · Burma (1) · Canada (1) · France (1) · Germany (1) · Jordan (1) · New Zealand (1) · Pakistan (1) · Puerto Rico (1) · South Africa (1) · United Kingdom (1)
Aliaa A Ali, MD (1) · Avroy A. Fanaroff, MD (1) · Barbara J. Stoll, MD (1) · Barry Lester, PhD (1) · Bhagat Aulakh, MD (1) · Brian Neville, Professor (1) · Carrie Brusseau, PharmD (1) · Cynthia M Sharpe, M.D. (1) · David K. Stevenson, MD (1) · Edward F. Donovan, MD (1) · Emilio G. Cediel, MD (1) · Hans U Bucher, Prof (1) · Helge Frieling, Prof., MD (1) · Iman F Iskander, MD (1) · James A. Lemons, MD (1)
PMID 32385134, PMID 10625862, PMID 12114906, PMID 15791116, PMID 17145735, PMID 23921284, PMID 23949834, PMID 25172096, PMID 29179233, PMID 29913015, PMID 30237016, PMID 30289769, PMID 31156538, PMID 31340400, PMID 31691849, PMID 31987653, PMID 33670692, PMID 34124790, PMID 34231914, PMID 34867732, PMID 35065662, PMID 35311411, PMID 35673948, PMID 36401982, PMID 36578326, PMID 36823477, PMID 37781273, PMID 38902005, PMID 9250849, PMID 987769
M01RR000070 (1), M01RR000750 (1), M01RR000997 (1), M01RR006022 (1), M01RR008084 (1), U01HD019897 (1), U10HD021364 (1), U10HD021385 (1), U10HD021415 (1), U10HD027851 (1), U10HD027853 (1), U10HD027856 (1), U10HD027871 (1), U10HD027880 (1), U10HD027881 (1)