7 completed, 4 terminated. 3 Phase 3, 3 Phase 4, 2 Not applicable, 2 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 3 | Completed 3 |
| Phase 4 | 3 | Completed 2, Terminated 1 |
| Not applicable | 2 | Terminated 2 |
| Phase 2 | 2 | Completed 1, Terminated 1 |
| Phase 1 | 1 | Terminated 1 |
Follow fosphenytoin: new trials by email Literature Review of fosphenytoin trials Research Report on fosphenytoin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Antiseizure Medication in Seizure Networks at Early Acute Brain Injury Phenobarbital Sodium Injection, Levetiracetam, Lacosamide Injectable Product - Brain Injuries, Acute, Brain Injuries, Traumatic | Phase 4 | Terminated | University of North Carolina, Chapel Hill | 5 | 2023-11-20 | 2025-11-14 |
| The Efficacy and Safety of Levetiracetam Versus Fosphenytoin in Convulsive Status Epilepticus Levetiracetam Injection, Fosphenytoin Injection - Status Epilepticus | Phase 4 | Completed | Dhaka Medical College | 62 | 2023-05-15 | 2026-10-07 |
| Phenytoin as Treatment for Acute Exacerbations of Trigeminal Neuralgia - a Prospective Systematic Study of 20 Patients Fosphenytoin - Trigeminal Neuralgia | Completed | Danish Headache Center | 15 | 2018-11-01 | 2022-03-24 | |
| Established Status Epilepticus Treatment Trial Fosphenytoin, Levetiracetam, Valproic acid - Benzodiazepine Refractory Status Epilepticus | Phase 3 | Completed | University of Virginia | 478 | 2015-10-01 | 2021-06-14 |
| Comparison Between Lorazepam, Clonazepam and Clonazepam + Fosphenytoin for the Treatment of Out-of-hospital Generalized Status Epilepticus Clonazepam, Fosphenytoin, Placebo - Status Epilepticus, Epilepsy | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 434 | 2013-06-26 | 2018-10-11 |
| Intravenous Lacosamide Compared With Fosphenytoin in the Treatment of Patients With Frequent Nonconvulsive Seizures fPHT, LCM - Nonconvulsive Seizures | Phase 2 | Completed | Aatif Husain | 74 | 2012-05-01 | 2018-06-11 |
| A Pilot Study of NSICU Assessment of Seizure Prophylaxis With Lacosamide lacosamide, Fosphenytoin - Traumatic Brain Injury | Not applicable | Terminated | University of Alabama at Birmingham | 11 | 2010-05-01 | 2014-04-28 |
| The Study of NPC-06 - Investigation of Safety, Efficacy and Pharmacokinetics of Fosphenytoin fosphenytoin - Epilepsy | Phase 3 | Completed | Nobelpharma | 40 | 2009-05-01 | 2010-05-24 |
| Antiepileptic Drugs and Vascular Risk Markers phenytoin, valproate, levetiracetam - Subarachnoid Hemorrhage | Not applicable | Terminated | Thomas Jefferson University | 52 | 2009-04-01 | 2017-12-18 |
| Double Cord Blood Transplant for Patients With Malignant and Non-malignant Disorders Alemtuzumab, Total Body Irradiation, Melphalan - Leukemia, Lymphoma | Phase 1 / Phase 2 | Terminated | Columbia University | 1 | 2007-09-06 | 2019-03-27 |
| IV Keppra in the Emergency Department for Prevention of Early Recurrent Seizures Keppra, Fosphenytoin, Dilantin - Tonic-clonic Seizure | Phase 4 | Completed | Emory University | 158 | 2007-07-01 | 2013-12-12 |
Seizures (4) · Status Epilepticus (3) · Brain Injuries, Traumatic (2) · Epilepsy (2) · Acute Pain (1) · Anemia (1) · Brain Injuries (1) · Brain Ischemia (1) · Coma (1) · Emergencies (1) · Epilepsy, Tonic-Clonic (1) · Heart Arrest (1) · Hypoxia, Brain (1) · Hypoxia-Ischemia, Brain (1) · Immunologic Deficiency Syndromes (1)
Aatif Husain (1) · Assistance Publique - Hôpitaux de Paris (1) · Columbia University (1) · Danish Headache Center (1) · Dhaka Medical College (1) · Emory University (1) · Nobelpharma (1) · Thomas Jefferson University (1) · University of Alabama at Birmingham (1) · University of North Carolina, Chapel Hill (1) · University of Virginia (1)
United States (6) · Bangladesh (1) · Denmark (1) · France (1) · Japan (1)
Aatif Husain, MD (1) · Debra Houry, MD (1) · Dr Md Amirul Islam, MBBS (1) · Dr Reaz Mahmud, MD (1) · Eiji Nakagawa, M.D. (1) · Emilio G. Cediel, MD (1) · Jaideep Kapur, MBBS, PhD (1) · James Chamberlain, MD (1) · Jerzy P Szaflarski, M.D., PhD (1) · Jordan Elm, PhD (1) · Prakash Satwani, MD (1) · Robert Silbergleit, MD (1)
PMID 23953988, PMID 31161706, PMID 31774955, PMID 32203691, PMID 32446674, PMID 33336359, PMID 33567109, PMID 33742783, PMID 34032604, PMID 35469443, PMID 35718575
K23NS058669 (1), U01NS088034 (1)