7 completed, 5 recruiting, 2 terminated, 2 unknown. 18 Phase 2, 7 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 18 | Completed 7, Recruiting 5, Terminated 2, Unknown 2, Withdrawn 2 |
| Phase 3 | 7 | Recruiting 3, Completed 2, Terminated 2 |
| Phase 1 | 1 | Completed 1 |
Follow Status Epilepticus: new trials by email Literature Review of Status Epilepticus trials Research Report on Status Epilepticus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Prehospital Early Administration of Ketamine for Status Epilepticus in Epileptic Kids (PEAK-SEEK) Ketamine, Midazolam - Convulsive Status EPILEPTICUS | Phase 2 / Phase 3 | Recruiting | Sohag University | 668 | 2025-08-03 | 2025-08-05 |
| Ketamine and Levetiracetam as Second-line Antiseizure Medication for Status Epilepticus in Children Ketamine, Levetiracetam, Placebo - Generalized Convulsive Status Epilepticus | Phase 2 / Phase 3 | Recruiting | Sohag University | 124 | 2025-07-02 | 2025-07-03 |
| PeRampanel fOr Status ePilEpticus pRophylaxis Post-cardiac Arrest Perampanel, Placebo - Heart Arrest, Seizures | Phase 2 | Recruiting | University of California, San Francisco | 52 | 2024-05-20 | 2026-07-29 |
| buRst-supprESsion TO Stop Refractory Status Epilepticus Post-cardiac Arrest Burst Suppression EEG Target Intravenous Anesthesia, Seizure Suppression EEG Target Intravenous Anesthesia - Hypoxia-Ischemia, Brain, Heart Arrest | Phase 2 | Recruiting | University of California, San Francisco | 30 | 2023-08-07 | 2026-07-29 |
| Safety and Efficacy Study of IV Ganaxolone as Adjuvant Therapy for Established Status Epilepticus (ESE) IV Ganaxolone, IV Placebo - Status Epilepticus | Phase 2 | Withdrawn | Marinus Pharmaceuticals | 2023-04-01 | 2024-05-07 | |
| Combined Ketamine and Midazolam for Generalized Convulsive Status Epilepticus Ketamine, Midazolam, Placebo - Generalized Convulsive Status Epilepticus | Phase 2 / Phase 3 | Completed | Sohag University | 144 | 2023-03-21 | 2024-10-29 |
| Exogenous Ketone Esters for Refractory Status Epileptics Exogenous ketone ester - Status Epilepticus | Phase 2 / Phase 3 | Recruiting | Sohag University | 50 | 2023-01-10 | 2024-11-27 |
| VIGABatrin in Post-anoxic STATus Epilepticus - Phase IIa Vigabatrin Only Product - Status Epilepticus, Electrographic, Coma | Phase 2 | Completed | University of Florida | 6 | 2021-09-22 | 2024-07-23 |
| Effectiveness of Combined Levetiracetam and Midazolam in Generalized Convulsive Status Epilepticus in Children Levetiracetam, Midazolam, Placebo - Status Epilepticus, Generalized Convulsive Status Epilepticus | Phase 2 | Completed | Sohag University | 144 | 2021-06-20 | 2022-09-21 |
| A Study to Evaluate Efficacy and Safety of Vatiquinone for Treating Mitochondrial Disease in Participants With Refractory Epilepsy Vatiquinone, Placebo - Mitochondrial Diseases, Drug Resistant Epilepsy | Phase 2 / Phase 3 | Terminated | PTC Therapeutics | 68 | 2020-09-28 | 2026-03-31 |
| Intravenous Ganaxolone as Adjunctive Therapy to Treat Subjects With Status Epilepticus IV Ganaxolone active, IV Placebo, non-active - Status Epilepticus, Convulsive Status EPILEPTICUS | Phase 2 | Completed | Marinus Pharmaceuticals | 17 | 2018-02-19 | 2023-03-09 |
| Phenobarbital Versus Valproate for Generalized Convulsive Status Epilepticus Phenobarbital, Valproate - Generalized Convulsive Status Epilepticus | Phase 2 | Unknown | Xuanwu Hospital, Beijing | 120 | 2017-02-16 | 2019-07-09 |
| Efficacy Study of Acetazolamide Versus Diazepam in Continuous Spike and Wave/Landau-Kleffner Syndrome Diazepam, Acetazolamide - Landau-Kleffner Syndrome, Status Epilepticus, Electrographic | Phase 2 / Phase 3 | Terminated | Mayo Clinic | 3 | 2016-09-01 | 2020-06-11 |
| Levetiracetam Versus Sodium Valproate in Children With Refractory Generalized Convulsive Status Epilepticus Intravenous levetiracetam, Sodium valproate - Grand Mal Status Epilepticus | Phase 2 | Completed | Banaras Hindu University | 80 | 2015-01-01 | 2016-09-30 |
| Study to Evaluate SAGE-547 Injection as Adjunctive Therapy for the Treatment of Super-Refractory Status Epilepticus SAGE-547 - Super-refractory Status Epilepticus | Phase 1 / Phase 2 | Completed | Supernus Pharmaceuticals, Inc. | 25 | 2014-03-21 | 2025-09-15 |
| Efficacy and Safety Study Comparing Lorazepam and Diazepam for Children in the Emergency Department With Seizures (Status 2) lorazepam or diazepam - Status Epilepticus | Phase 2 / Phase 3 | Completed | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 259 | 2008-02-01 | 2012-12-18 |
| Intravenous Levetiracetam as First-line Anticonvulsive Treatment in Patients With Non-convulsive Status Epilepticus first-line i/v-levetiracetam - Status Epilepticus, Non-Convulsive | Phase 2 | Withdrawn | University Hospital, Basel, Switzerland | 2008-01-01 | 2015-03-10 | |
| Safety and Tolerability Study of Levetiracetam to Treat Patients With Status Epilepticus levetiracetam (add-on) - Status Epilepticus | Phase 2 | Unknown | Medical Center Haaglanden | 12 | 2006-10-01 | 2007-04-02 |
Seizures (5) · Heart Arrest (3) · Coma (1) · Diffuse Cerebral Sclerosis of Schilder (1) · Drug Resistant Epilepsy (1) · Epilepsy (1) · Hypoxia-Ischemia, Brain (1) · Landau-Kleffner Syndrome (1) · Leigh Disease (1) · MELAS Syndrome (1) · MERRF Syndrome (1) · Mitochondrial Diseases (1) · Mitochondrial encephalopathy (1) · Nerve Degeneration (1)
Nervous System Diseases (18) · Neurologic Manifestations (18) · Pathological Conditions, Signs and Symptoms (18) · Signs and Symptoms (18) · Seizures (13) · Brain Diseases (4) · Cardiovascular Diseases (4) · Central Nervous System Diseases (4) · Heart Diseases (3) · Cerebrovascular Disorders (2) · Epilepsy (2) · Epileptic Syndromes (2) · Vascular Diseases (2) · Autoimmune Diseases (1) · Autoimmune Diseases of the Nervous System (1)
Ketamine (3) · Levetiracetam (3) · Midazolam (3) · Diazepam (2) · Valproic Acid (2) · Acetazolamide (1) · Lorazepam (1) · Phenobarbital (1) · Vigabatrin (1) · alpha-tocotrienol quinone (1) · brexanolone (1) · ganaxolone (1) · perampanel (1)
Sohag University (5) · Marinus Pharmaceuticals (2) · University of California, San Francisco (2) · Banaras Hindu University (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Mayo Clinic (1) · Medical Center Haaglanden (1) · PTC Therapeutics (1) · Supernus Pharmaceuticals, Inc. (1) · University Hospital, Basel, Switzerland (1) · University of Florida (1) · Xuanwu Hospital, Beijing (1)
United States (8) · Egypt (5) · Canada (2) · China (1) · France (1) · Italy (1) · Japan (1) · Netherlands (1) · Poland (1) · Spain (1) · Sweden (1) · Switzerland (1) · United Kingdom (1)
Abdelrahim A Sadek, MD, PhD (3) · Edilberto Amorim, MD (2) · Carolina B Maciel, MD, MSCR (1) · Charles Vecht, MD, PhD (1) · James Chamberlain, MD (1) · Katherine C. Nickels, M.D. (1) · Maciej Gasior, MD, PhD (1) · Rajniti Prasad, MD (1) · Robert Lasser, MD, MBA (1) · Vinay Penematsa, MD (1)
PMID 12628059, PMID 16861095, PMID 16886975, PMID 24756515, PMID 27993298, PMID 35067230, PMID 35748707