20 completed. 20 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 20 | Completed 20 |
| Phase 2 | 2 | Completed 2 |
Follow Spasm: new trials by email Literature Review of Spasm trials Research Report on Spasm
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Etoricoxib/Tizanidine Versus Etoricoxib for Acute Low Back Pain Associated to Muscle Spasm Etoricoxib + Tizanidine fixed dose, Etoricoxib fixed dose - Acute Low-back Pain, Muscle Spasm; Back Pain | Phase 3 | Completed | Laboratorios Silanes S.A. de C.V. | 136 | 2024-09-18 | 2026-01-09 |
| Study of Abobotulinum Toxin Versus Neubotulinum Toxin Injection For Hemifacial Spasm in Thai Patients Injection botulinum toxin A ( Dysport 100 unit or Neuronox 33.33 unit) - Hemifacial Spasm | Phase 3 | Completed | Department of Medical Services Ministry of Public Health of Thailand | 107 | 2024-05-01 | 2026-08-17 |
| A Comparison of Recovery After Impacted Wisdom Tooth Removal serratiopeptidase, Escin, Conventional drugs - Impacted Mandibular Third Molar Extraction, Post Operative Complications | Phase 3 | Completed | University of Science and Technology, Yemen | 24 | 2023-11-30 | 2025-12-26 |
| Use of Corticosteroids in Third Molar Surgery Dexamethasone 4 Mg/mL Injectable Solution, MethylPREDNISolone 40 Mg/mL Injectable Suspension - Inflammation, Pain, Postoperative | Phase 2 / Phase 3 | Completed | Universidad de Granada | 84 | 2022-01-15 | 2023-12-06 |
| Effect of Topically-applied Milrinone or Nitroglycerin on Internal Mammary Artery Free Flow The topical application of a vasodilator on the LIMA graft - Internal Mammary Artery Syndrome, Vasodilation | Phase 3 | Completed | Damascus University | 46 | 2022-01-01 | 2026-03-19 |
| Efficacy and Safety of Tolperisone in Subjects With Pain Due to Acute Back Muscle Spasm Tolperisone Hydrochloride, Placebo - Back Muscle Spasm, Back Pain | Phase 3 | Completed | Neurana Pharmaceuticals, Inc. | 1004 | 2020-12-15 | 2022-03-22 |
| Safety and Efficacy of Mexidol® for ADHD in Children Aged 6-12 Mexidol, Placebo, Mexidol + Placebo - Attention Deficit Hyperactivity Disorder (ADHD), Anxiety Disorders and Symptoms | Phase 3 | Completed | Pharmasoft | 333 | 2019-07-13 | 2025-08-17 |
| Efficacy and Safety of SHP465 at 6.25 mg in the Treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) in Children Aged 6-12 Years SHP465, Placebo - Attention Deficit Hyperactivity Disorder (ADHD) | Phase 3 | Completed | Shire | 89 | 2017-12-09 | 2021-06-02 |
| Safety and Efficacy Study in Preschool Children Aged 4-5 Years With Attention-deficit/Hyperactivity Disorder (ADHD) Placebo, SPD489 (Lisdexamfetamine dimesylate), SPD489 - Attention Deficit Hyperactivity Disorder (ADHD) | Phase 3 | Completed | Shire | 199 | 2017-09-06 | 2021-06-08 |
| Cyclobenzaprine HCl Extended Release 15 mg Versus Placebo in Treatment of Cervical and/or Lower Back Pain Due to Muscle Spasms of Local Origin Cyclobenzaprine HCl, Placebo - Neck Pain, Back Pain | Phase 3 | Completed | Takeda | 180 | 2016-10-12 | 2019-04-08 |
| Randomized Clinical Trial Comparing Transradial Catheterization With or Without Spasmolytic Drugs Nitroglycerin, Placebo - Cardiac Catheterisation | Phase 3 | Completed | Instituto de Cardiologia de Santa Catarina | 328 | 2015-02-01 | 2019-05-31 |
| Open-label Extension Evaluating Methylphenidate Hydrochloride Extended Release in Adults With Attention Deficit/Hyperactivity Disorder Ritalin LA (methylphenidate hydrochloride extended release) - Attention Deficit/Hyperactivity Disorder | Phase 3 | Completed | Novartis Pharmaceuticals | 299 | 2011-04-01 | 2014-11-24 |
| Time Course of Response to Methylphenidate HCl ER Capsules in Children 6 to 12 Years With ADHD in Classroom Setting Methylphenidate Hydrochloride Extended Release Capsule, Placebo - Attention Deficit Hyperactivity Disorder, ADHD | Phase 3 | Completed | Rhodes Pharmaceuticals, L.P. | 26 | 2011-01-19 | 2022-12-13 |
| Efficacy and Safety of Methylphenidate HCl ER Capsules in Children and Adolescents With ADHD Methylphenidate Hydrochloride Extended Release Capsules, Placebo - Attention Deficit Hyperactivity Disorder, ADHD | Phase 3 | Completed | Rhodes Pharmaceuticals, L.P. | 230 | 2010-11-01 | 2023-02-22 |
| Topical Radial Artery Vasodilation Nitroglycerin and lidocaine, Placebo - Cardiac Catheterization, Spasm | Phase 2 / Phase 3 | Completed | University of California, San Francisco | 86 | 2010-07-01 | 2018-09-25 |
| Effect of Working Memory Training on ADHD Brain Function Working memory training, Functional magnetic resonance imaging (fMRI) - Attention-Deficit/Hyperactivity Disorder (Combined-subtype) | Phase 3 | Completed | Hartford Hospital | 37 | 2009-07-01 | 2014-05-30 |
| Study Evaluating the Safety and Efficacy of CLONICEL® to Treat Children and Adolescents With Attention Deficit Hyperactivity Disorder (ADHD) high dose clonidine HCl sustained release, low dose clonidine HCl sustained release, placebo - Attention Deficit Disorder With Hyperactivity | Phase 3 | Completed | Addrenex Pharmaceuticals, Inc. | 236 | 2007-10-01 | 2010-03-24 |
| Evaluation of Eperisone HCl in the Treatment of Acute Musculoskeletal Spasm Associated With Low Back Pain - A Double Blind, Randomised, Placebo Controlled Clinical Trial Eperisone - Muscle Spasm; Back Pain | Phase 3 | Completed | Eisai Inc. | 240 | 2006-04-01 | 2014-04-21 |
| Assessment of Effectiveness and Safety of Dysport® for the Treatment of Hemifacial Spasm Botulinum toxin type A - Hemifacial Spasm | Phase 3 | Completed | Ipsen | 332 | 2005-12-01 | 2020-04-28 |
| Attention-Deficit Hyperactivity Disorder (ADHD) Study With Adults Extended-release bupropion hydrochloride - Attention Deficit Disorder | Phase 3 | Completed | GlaxoSmithKline | 162 | 2002-10-01 | 2013-02-12 |
Attention Deficit Disorder with Hyperactivity (9) · Back Pain (4) · Impulsive Behavior (3) · Hemifacial Spasm (2) · Pain (2) · Trismus (2) · Acute Pain (1) · Aneurysm (1) · Anxiety Disorders (1) · Inflammation (1) · Neck Pain (1) · Neurodevelopmental Disorders (1) · Oppositional Defiant Disorder (1) · Pain, Postoperative (1)
Nervous System Diseases (20) · Neurologic Manifestations (20) · Neuromuscular Manifestations (20) · Pathological Conditions, Signs and Symptoms (20) · Signs and Symptoms (20) · Attention Deficit and Disruptive Behavior Disorders (9) · Mental Disorders (9) · Neurodevelopmental Disorders (8) · Pain (4) · Behavior (3) · Mouth Diseases (2) · Stomatognathic Diseases (2) · Cardiovascular Diseases (1) · Pathologic Processes (1)
Nitroglycerin (3) · Amoxicillin (1) · Botulinum Toxins, Type A (1) · Dexamethasone (1) · Diclofenac (1) · Escin (1) · Etoricoxib (1) · Lidocaine (1) · Lisdexamfetamine Dimesylate (1) · Magnetic Resonance Imaging (1) · Methylphenidate (1) · Methylprednisolone (1) · Metronidazole (1) · Milrinone (1) · Saline Solution (1)
Rhodes Pharmaceuticals, L.P. (2) · Shire (2) · Addrenex Pharmaceuticals, Inc. (1) · Damascus University (1) · Department of Medical Services Ministry of Public Health of Thailand (1) · Eisai Inc. (1) · GlaxoSmithKline (1) · Hartford Hospital (1) · Instituto de Cardiologia de Santa Catarina (1) · Ipsen (1) · Laboratorios Silanes S.A. de C.V. (1) · Neurana Pharmaceuticals, Inc. (1) · Novartis Pharmaceuticals (1) · Pharmasoft (1) · Takeda (1)
United States (10) · Russia (2) · Belgium (1) · Brazil (1) · China (1) · Colombia (1) · Denmark (1) · Germany (1) · India (1) · Mexico (1) · Spain (1) · Sweden (1) · Syria (1) · Thailand (1) · Yemen (1)
Sharon B. Wigal, Ph.D. (2) · Wei-wei Chang, Ph.D. (2) · Andrew Boyle, MBBS, PhD (1) · Anna N. Platonova, Cand.Med.Sci, MD (1) · Anna S. Nezabudkina, MD (1) · Dina D. Gainetdinova, Dr.Med.Sci, Prof. (1) · Dr. Dilip Pawar (1) · Elena M. Kryukova, MD (1) · Elena V. Levitina, Dr.Med.Sci, Prof. (1) · Elmira S. Sagutdinova, Cand.Med.Sci, MD (1) · Irina N. Vakula, MD (1) · Laurence Greenhill, M.D. (1)
PMID 21241954, PMID 22619887, PMID 23582415, PMID 25183661, PMID 25470572, PMID 25877989, PMID 33185468, PMID 34192885, PMID 35201607, PMID 35577034, PMID 40975435