16 completed, 7 terminated, 3 unknown, 1 recruiting. 27 Phase 2, 3 Phase 3, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 27 | Completed 16, Terminated 7, Unknown 3, Recruiting 1 |
| Phase 3 | 3 | Completed 2, Unknown 1 |
| Phase 1 | 2 | Completed 2 |
Follow Spasm: new trials by email Literature Review of Spasm trials Research Report on Spasm
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Guanfacine for Hyperactivity in Children With Down Syndrome (HYPEbeGONE_DS) Guanfacine Hydrochloride Immediate Release, Placebo - Hyperactivity in Children With Down Syndrome, Impulsivity in Children With Down Syndrome | Phase 2 | Terminated | Rachel G. Greenberg, MD, MB, MHS | 3 | 2024-12-09 | 2026-04-17 |
| Treatment With Cannabis Oil Containing CBD, THC, CBDV or CBG vs. Placebo of Persons With ADHD Cannabis oil - ADHD, Hyperactivity | Phase 2 | Terminated | Brlev Agricultural Crops Ltd | 8 | 2022-07-31 | 2023-04-25 |
| Use of Corticosteroids in Third Molar Surgery Dexamethasone 4 Mg/mL Injectable Solution, MethylPREDNISolone 40 Mg/mL Injectable Suspension - Inflammation, Pain, Postoperative | Phase 2 / Phase 3 | Completed | Universidad de Granada | 84 | 2022-01-15 | 2023-12-06 |
| Web-Based Program in Helping Patients With Head and Neck Cancer Adhere to Swallowing Exercises and Coping Strategies Internet-Based Intervention, Quality-of-Life Assessment, Questionnaire Administration - Throat Carcinoma | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 300 | 2019-03-18 | 2026-10-06 |
| Tolperisone in Acute Muscle Spasm of the Back Tolperisone, Placebo - Back Pain, Acute Pain | Phase 2 | Completed | Neurana Pharmaceuticals, Inc. | 415 | 2019-02-01 | 2022-02-01 |
| Effectiveness of Light-emitting Diode (LED) Photobiomodulation in the Extraction of Retained Lower Third Molars LED group, Sham group - Pain, Postoperative, Edema | Phase 2 | Unknown | University of Nove de Julho | 34 | 2018-09-01 | 2018-10-11 |
| Wumeiwan Jiawei Fang Use in Patients With Blepharospasm Wumeiwan Jiawei Fang, botulinum toxin A - Dry Eye Syndromes, Meige Syndrome | Phase 2 / Phase 3 | Unknown | China Academy of Chinese Medical Sciences | 80 | 2018-01-12 | 2022-11-17 |
| A Phase 2 Study of Radiprodil in Subjects With Drug-resistant Infantile Spasms (IS) Radiprodil - Infantile Spasms (IS) | Phase 2 | Terminated | UCB Biopharma S.P.R.L. | 3 | 2017-12-04 | 2019-09-17 |
| A Study to Assess the Safety and Effectiveness of FLX-787 in Subjects With Charcot-Marie-Tooth Disease Experiencing Muscle Cramps. FLX-787-ODT (orally disintegrating tablet), Placebo ODT - Charcot-Marie-Tooth Disease | Phase 2 | Terminated | Flex Pharma, Inc. | 27 | 2017-10-16 | 2018-08-29 |
| A Study to Assess FLX-787 in Subjects With Motor Neuron Disease Experiencing Muscle Cramps. FLX-787-ODT (orally disintegrating tablet), Placebo ODT - Motor Neuron Disease | Phase 2 | Terminated | Flex Pharma, Inc. | 54 | 2017-07-28 | 2018-08-29 |
| Vaginal Diazepam for the Treatment of Female Pelvic Pain Diazepam, Placebo - Pelvic Floor Disorders, Pelvic Pain | Phase 2 | Completed | Raymond Foster | 50 | 2013-09-01 | 2024-09-03 |
| Efficacy of a Multi-strain Probiotic in the Treatment of Irritable Bowel Syndrome Kyodophilus multi-strain probiotic capsules, Kyodophilus Matching Placebo Capsules - Irritable Bowel Syndrome, Digestive System Diseases | Phase 1 / Phase 2 | Completed | The Canadian College of Naturopathic Medicine | 100 | 2013-06-01 | 2015-03-17 |
| Trismus Trial of Therabite vs Wooden Spatula in Head and Neck Cancer Patients Wooden spatula, Therabite - Oropharyngeal Cancer, Oral Cancer | Phase 2 | Completed | Brynn Chappell | 71 | 2012-12-01 | 2015-10-01 |
| Omega-3 Fatty Acids for Hyperactivity Treatment in Autism Spectrum Disorder Omega-3 Fatty Acids, Placebo - Autism Spectrum Disorders, Hyperactivity | Phase 2 | Completed | Hugo W. Moser Research Institute at Kennedy Krieger, Inc. | 57 | 2012-09-01 | 2020-08-31 |
| Effect on Tear Functions of Pretarsal and Preseptal Techniques of Botulinum Toxin Type A Injection in Hemifacial Spasm preseptal injection of botulinum toxin type A, pretarsal injection of Botulinum toxin type A - Hemifacial Spasm | Phase 2 | Unknown | Khon Kaen University | 26 | 2012-04-01 | 2012-03-28 |
| Proof-of-Concept, Calcium Aluminosilicate Anti-Diarrheal (CASAD) for Treatment of Clostridium Difficile Infection Calcium Aluminosilicate Anti-Diarrheal (CASAD) - Diarrhoea, Clostridium Difficile | Phase 2 | Terminated | Salient Pharmaceuticals Incorporated | 2 | 2012-03-01 | 2013-03-08 |
| Classroom-based Distance Intervention for Teachers of Children With Attention Deficit Hyperactivity Disorder Teacher Help for ADHD - Attention Deficit Hyperactivity Disorder (ADHD) | Phase 2 | Completed | Dalhousie University | 116 | 2012-02-01 | 2014-03-28 |
| Safety and Efficacy Study of Antioxidants for the Treatment of the Fragile X Syndrome Ascorbic Acid (Vitamin C) and Alpha-tocopherol (Vitamin E), Placebo - Fragile X Syndrome | Phase 2 | Completed | Yolanda de Diego Otero | 30 | 2010-12-01 | 2015-04-14 |
| Topical Radial Artery Vasodilation Nitroglycerin and lidocaine, Placebo - Cardiac Catheterization, Spasm | Phase 2 / Phase 3 | Completed | University of California, San Francisco | 86 | 2010-07-01 | 2018-09-25 |
| Efficacy of a Multi-strain Probiotic in the Treatment of Irritable Bowel Syndrome (IBS) Kyodophilus multi-strain probiotic capsules, Kyodophilus Matching Placebo Capsules - Irritable Bowel Syndrome, Digestive System Diseases | Phase 1 / Phase 2 | Completed | The Canadian College of Naturopathic Medicine | 128 | 2010-05-01 | 2011-04-01 |
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Attention Deficit Disorder with Hyperactivity (7) · Trismus (5) · Impulsive Behavior (4) · Diarrhea (3) · Muscle Cramp (3) · Anxiety Disorders (2) · Blepharospasm (2) · Colonic Diseases, Functional (2) · Constipation (2) · Digestive System Diseases (2) · Head and Neck Neoplasms (2) · Irritable Bowel Syndrome (2) · Mouth Neoplasms (2) · Mucopolysaccharidosis IV (2)
Neurologic Manifestations (27) · Neuromuscular Manifestations (27) · Pathological Conditions, Signs and Symptoms (27) · Signs and Symptoms (27) · Nervous System Diseases (25) · Mental Disorders (9) · Neurodevelopmental Disorders (9) · Attention Deficit and Disruptive Behavior Disorders (7) · Behavior (5) · Central Nervous System Diseases (4) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (4) · Genetic Diseases, Inborn (4) · Pain (4) · Metabolic Diseases (3)
Botulinum Toxins, Type A (2) · Amphetamine (1) · Ascorbic Acid (1) · Calcium Aluminosilicate (1) · Dexamethasone (1) · Diazepam (1) · Docosahexaenoic Acids (1) · Fatty Acids, Omega-3 (1) · Guanfacine (1) · Lidocaine (1) · Methylprednisolone (1) · Mexiletine (1) · Nitroglycerin (1) · Physical Therapy Modalities (1) · Tolperisone (1)
Flex Pharma, Inc. (2) · The Canadian College of Naturopathic Medicine (2) · Brlev Agricultural Crops Ltd (1) · Brynn Chappell (1) · China Academy of Chinese Medical Sciences (1) · Copenhagen University Hospital, Rigshospitalet (1) · Dalhousie University (1) · Enzymotec (1) · Hugo W. Moser Research Institute at Kennedy Krieger, Inc. (1) · Khon Kaen University (1) · M.D. Anderson Cancer Center (1) · National Institute of Neurological Disorders and Stroke (NINDS) (1) · Neurana Pharmaceuticals, Inc. (1) · Otsuka Pharmaceutical Development & Commercialization, Inc. (1) · Rachel G. Greenberg, MD, MB, MHS (1)
United States (12) · Canada (4) · Israel (3) · Spain (2) · Brazil (1) · China (1) · Denmark (1) · France (1) · Thailand (1) · United Kingdom (1)
Dugald Seely, ND (2) · Aarthi Narasimhan, MD (1) · Abraham Weizman, MD (1) · Andrew Boyle, MBBS, PhD (1) · Bjorn Oskarsson, MD (1) · David V Herin, Ph.D (1) · Dr. Michael Lyon (1) · Eileen H Shinn (1) · Lucia M Perez Costillas, MD PhD (1) · Mati Berkovitch (1) · Nachum Vaisman, MD (1) · Nezihe Elik, PhD (1) · Nicolas Johnson, MD (1) · Paul A Law, M.D. (1)
PMID 18469236, PMID 21807480, PMID 23582415, PMID 24839884, PMID 25187257, PMID 25229260, PMID 25733754, PMID 28576350, PMID 29280763, PMID 29526341, PMID 29602860, PMID 8501266
2009 (1), 2016 (1), P50DA009262 (1)