12 completed, 2 unknown, 1 not yet recruiting, 1 terminated. 16 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 16 | Completed 12, Unknown 2, Not yet recruiting 1, Terminated 1 |
Follow Sleep Disorders: new trials by email Literature Review of Sleep Disorders trials Research Report on Sleep Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intranasal Dexmedetomidine-esketamine on Sleep and Cognition in Older Adults With Mild-to-moderate Cognitive Impairment Dexmedetomidine-esketamine combination, Placebo - Older Adults, Cognitive Impairment | Phase 4 | Not yet recruiting | Peking University First Hospital | 60 | 2026-06-01 | 2026-06-01 |
| the Efficacy and Safety of Agomelatine in the Patients With Parkinson's Disease Agomelatine or PIacebo - Parkinson Disease, Depression | Phase 4 | Unknown | Second Affiliated Hospital of Soochow University | 240 | 2019-07-01 | 2019-06-06 |
| Impacts of Low-Dose Dexmedetomidine on Sleep Quality in Mechanically Ventilated ICU Patients Dexmedetomidine, Placebo (normal saline) - Aged, Postoperative Period | Phase 4 | Completed | Peking University First Hospital | 80 | 2017-11-17 | 2019-12-11 |
| Effect of Melatonin on Sleep Quality in Patients Dementia Melatonin 5 mg, Placebo - Sleep Disorders, Dementia | Phase 4 | Completed | Hospital Universitario Dr. Jose E. Gonzalez | 40 | 2016-01-15 | 2017-02-28 |
| Atripla to Stribild Switch Study to Evaluate Sleep Disturbances Stribild - HIV, AIDS | Phase 4 | Completed | Midtown Medical Center, Tampa, FL | 21 | 2015-02-01 | 2017-07-28 |
| The Effects of Milnacipran on Sleep Disturbance in Fibromyalgia Milnacipran, Placebo - Sleep Disorders, Fibromyalgia | Phase 4 | Completed | Mansoor Ahmed M.D. | 19 | 2010-11-01 | 2019-08-21 |
| Effect of Guanfacine Extended-Release on Attention Deficit Hyperactivity Disorder (ADHD)-Associated Insomnia Guanfacine extended-release tablets, Placebo comparator - Attention-Deficit/Hyperactivity Disorder, Attention Deficit Disorder | Phase 4 | Terminated | Children's Specialized Hospital | 29 | 2010-06-01 | 2014-08-11 |
| Sleep Satisfaction and Psychomotor Performance of Adults ZOLPIDEM - Sleep Disorders | Phase 4 | Completed | Sanofi | 30 | 2010-03-01 | 2012-07-17 |
| Efficacy and Safety Assessment of ZOlpidem (Stilnox CR) in Patients With Chronic insomNIA ZOLPIDEM SL800750 - Sleep Disorders | Phase 4 | Completed | Sanofi | 135 | 2009-11-01 | 2010-10-05 |
| Sleep Disturbances in Hospitalized Children Melatonin, Placebo tablets - Sleep Disorders | Phase 4 | Unknown | Tel-Aviv Sourasky Medical Center | 60 | 2008-10-01 | 2008-09-09 |
| Efficacy and Safety of Armodafinil for Adults With Excessive Sleepiness Obstructive Sleep Apnea/Hypopnea and Depression armodafinil, placebo - Sleep Disorders, Obstructive Sleep Apnea | Phase 4 | Completed | Cephalon | 249 | 2007-10-01 | 2013-07-19 |
| Functional Melatonin Replacement for Sleep Disruptions in Individuals With Tetraplegia Ramelteon, Placebo - Insomnia, Spinal Cord Injury | Phase 4 | Completed | US Department of Veterans Affairs | 12 | 2007-07-01 | 2014-05-22 |
| Impact of Smoking Cessation on Sleep - 5 Bupropion, Transdermal Nicotine Patch, Placebo Bupropion - Tobacco Use Cessation, Sleep Disorders | Phase 4 | Completed | National Institute on Drug Abuse (NIDA) | 59 | 2005-08-01 | 2017-01-12 |
| Study Evaluating Totelle® in Menopausal Symptoms and Sexual Function Totelle® - Hot Flashes, Sleep Disorders | Phase 4 | Completed | Wyeth is now a wholly owned subsidiary of Pfizer | 100 | 2004-12-01 | 2008-08-05 |
| Insomnia and Daytime Function in Osteoarthritis zolpidem - Sleep Disorders | Phase 4 | Completed | Sanofi | 170 | 2003-03-01 | 2012-02-17 |
| Characteristics of Sleep Patterns in Young Adults With and Without Insomnia Zolpidem, Escitalopram, Placebo - Sleep Disorders | Phase 4 | Completed | University of Pittsburgh | 69 | 2002-02-01 | 2016-03-30 |
Sleep Wake Disorders (16) · Sleep Initiation and Maintenance Disorders (4) · Acquired Immunodeficiency Syndrome (1) · Attention Deficit Disorder with Hyperactivity (1) · Chronobiology Disorders (1) · Cognitive Dysfunction (1) · Dementia (1) · Depression (1) · Depressive Disorder, Major (1) · Disorders of Excessive Somnolence (1) · Dysthymic Disorder (1) · Fibromyalgia (1) · Hot Flashes (1) · Parasomnias (1) · Parkinson Disease (1)
Mental Disorders (16) · Nervous System Diseases (16) · Neurologic Manifestations (16) · Pathological Conditions, Signs and Symptoms (16) · Signs and Symptoms (16) · Dyssomnias (5) · Sleep Disorders, Intrinsic (5) · Central Nervous System Diseases (3) · Behavior (2) · Brain Diseases (2) · Neurocognitive Disorders (2) · Apnea (1) · Attention Deficit and Disruptive Behavior Disorders (1) · Basal Ganglia Diseases (1) · Behavioral Symptoms (1)
Zolpidem (4) · Melatonin (2) · Saline Solution (2) · Sugars (2) · Bupropion (1) · Citalopram (1) · Dexmedetomidine (1) · Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination (1) · Escitalopram (1) · Guanfacine (1) · Milnacipran (1) · Modafinil (1) · Pramipexole (1) · Tobacco Use Cessation Devices (1) · agomelatine (1)
Sanofi (3) · Peking University First Hospital (2) · Cephalon (1) · Children's Specialized Hospital (1) · Hospital Universitario Dr. Jose E. Gonzalez (1) · Mansoor Ahmed M.D. (1) · Midtown Medical Center, Tampa, FL (1) · National Institute on Drug Abuse (NIDA) (1) · Second Affiliated Hospital of Soochow University (1) · Tel-Aviv Sourasky Medical Center (1) · US Department of Veterans Affairs (1) · University of Pittsburgh (1) · Wyeth is now a wholly owned subsidiary of Pfizer (1)
United States (6) · China (2) · Argentina (1) · Brazil (1) · Israel (1) · Mexico (1)
Dong-Xin Wang, MD, PhD (2) · Chun-Feng Liu, MD (1) · Daniel J. Buysse, MD (1) · Edward W Braun, MD (1) · Gary Swan (1) · Guillermo Guajardo, MD (1) · Jamie M. Zeitzer, PhD (1) · Mansoor Ahmed, MD (1) · Noel Cyrill, MD (1) · Nosson S Goldfarb, M.D. (1) · Rozina Aamir, MS, MBA (1) · Thomas A Rugino, MD (1)
PMID 18052566, PMID 18583104, PMID 18673165, PMID 20051221, PMID 24090266, PMID 26414990, PMID 33189083, PMID 34674490, PMID 36117973
R01MH024652 (1)