115 completed, 20 unknown, 10 not yet recruiting, 9 terminated. 74 Not applicable, 21 Phase 3, 16 Phase 4, 10 Phase 2, 5 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sleep Quality, Caregiver Burden, Stress, and Self-Efficacy in Parents of Children With Spastic Diplegic Cerebral Palsy: A Comparison by Night Orthosis Use Cerebral Palsy, Sleep Disorders | Not yet recruiting | Atılım University | 150 | 2026-11-01 | 2026-10-08 | |
| HEARTBEAT SOUND FOR BREASTFEEDİNG DİFFİCULTİES: A RANDOMİZED CONTROLLED TRİAL Standardized Maternal Heartbeat Sound Application - Sleep, Circadian Rhythm | Not applicable | Not yet recruiting | Hakan Avan | 80 | 2026-10-25 | 2026-10-19 |
| A Study to Learn About the Monthly Dosing Study Medicine Called Berobenatide in Adults With Breathing Problems During Sleep and Overweight or Obesity Who Do Not Use a Breathing Machine (PAP) (VESPER-OSA 2) Berobenatide, Placebo - Apnea, Sleep Disorders | Phase 3 | Not yet recruiting | Pfizer | 258 | 2026-10-19 | 2026-10-19 |
| A Study to Learn About the Monthly Dosing Study Medicine Called Berobenatide in Adults With Breathing Problems During Sleep and Overweight or Obesity Who Use a Breathing Machine (PAP) (VESPER-OSA 1) Berobenatide, Placebo - Apnea, Sleep Disorders | Phase 3 | Recruiting | Pfizer | 258 | 2026-09-17 | 2026-10-13 |
| Efficacy of CBT-I With Adjuvant Melatonin in Older Adults Chronic Insomnia Cognitive behavioural therapy for insomnia, Melatonin 3 mg immediate-release, Psychoeducation - Insomnia, Aging | Not applicable | Recruiting | The University of Hong Kong | 183 | 2026-08-01 | 2026-08-21 |
| Diaphragmatic Breathing Exercises on Sleep Disorders un Polycystic Ovarian Syndrome Diaphragmatic breathing exercises, Lifestyle modification advices - Polycystic Ovarian Syndrome (PCOS), Pittsburg Sleep Quality Index | Not applicable | Recruiting | Adly A Adam | 54 | 2026-07-11 | 2026-07-14 |
| Effect of Progressive Muscle Relaxation and Diaphragmatic Breathing on Sleep Disturbances in Chemotherapy Patients Progressive Muscle Relaxation and Diaphragmatic Breathing - Sleep Disturbance, Sleep Disorders | Not applicable | Not yet recruiting | Cairo University | 40 | 2026-07-01 | 2026-06-10 |
| PREDiction of Different Variants of Sleep Stages for the Diagnosis Support of Chronic Insomnia and Epilepsy Chronic Insomnia, Epilepsy | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 1500 | 2026-06-01 | 2026-04-29 | |
| Intranasal Dexmedetomidine-esketamine on Sleep and Cognition in Older Adults With Mild-to-moderate Cognitive Impairment Dexmedetomidine-esketamine combination, Placebo - Older Adults, Cognitive Impairment | Phase 4 | Not yet recruiting | Peking University First Hospital | 60 | 2026-06-01 | 2026-06-01 |
| Optimization of Melatonin Administration in Healthy Adults Mel 2 mg 30 min, Mel 2 mg 3 h, Mel 4 mg 30 min - Sleep Disorders | Not applicable | Not yet recruiting | IRCCS Fondazione Stella Maris | 14 | 2026-05-01 | 2026-04-07 |
| A Longitudinal Follow-Up Study on Predicting Major Depressive Disorder From Rest-Activity Rhythm Profiles Major Depressive Disorder (MDD), Sleep Disorders | Not yet recruiting | Chinese University of Hong Kong | 160 | 2026-02-01 | 2026-02-05 | |
| Plant Protein With Ashwagandha-Rhodiola for Sleep Quality Plant Protein Supplement, Rhodiola rosea Extract, Ashwagandha KSM-66 - Sleep Quality, Sleep Disorders | Not applicable | Completed | Universidad Pablo de Olavide | 100 | 2025-11-01 | 2026-03-10 |
| Clinical Trial of the Safety and Tolerability of the Drug MMH-450 in Healthy Volunteers MMH-450 - Sleep Disorders | Phase 1 | Completed | Materia Medica Holding | 18 | 2025-08-15 | 2026-08-04 |
| An Exploratory Study of Chenghuang Circadian Rhythm Regulator in Subjects With Sleep Disorders Chenghuang Circadian Rhythm Regulator - Sleep Disorders | Not applicable | Completed | Shanghai Cell Therapy Group Co.,Ltd | 15 | 2025-06-06 | 2026-02-17 |
| Impact of Sleep Disorders and Digital Support on Older People's Health Sleep Disorders, Frailty | Not yet recruiting | University of Parma | 300 | 2025-05-01 | 2025-04-25 | |
| Intravascular Laser and Electroacupuncture for Sciatica With Insomnia: A Pilot Trial Electroacupuncture, Intravascular Low-Level Laser Therapy (ILIB) - Sleep Disorders, Sciatica | Not applicable | Completed | Le Hoang Minh Quan | 66 | 2025-04-01 | 2026-07-01 |
| Study of Sleep Quality in the Intensive Care Unit and Association with Weaning from Invasive Ventilation in Patients with Chronic Obstructive Bronchopneumopathy. COPD, COPD Exacerbation | Not yet recruiting | University Hospital, Grenoble | 42 | 2025-01-01 | 2024-10-23 | |
| Electronic Six-Image Pulse Diagnosis for TCM Syndrome Identification in Sleep Disorders Three-Dimensional Electronic Pulse Diagnosis, Expert Traditional Chinese Medicine Syndrome Differentiation - Sleep Disorders, Traditional Chinese Medicine Syndrome | Completed | Southern Medical University Hospital of Integrated Traditional Chinese and Western Medicine | 201 | 2025-01-01 | 2026-07-10 | |
| Cognitive Performance, Sleep Disturbances and Fatigue in Multiple Sclerosis No Intervention: Observational Cohort - Multiple Sclerosis, Remitting-Relapsing Multiple Sclerosis | Recruiting | Heinrich-Heine University, Duesseldorf | 837 | 2024-11-01 | 2026-03-06 | |
| Sleep Disturbance and Daytime Fatigue as Predictors of Cognitive Decline and Functional Decline in Chronic Rhinosinusitis Self-Reported Questionnaires for Sleep, Fatigue, and Quality of Life - Chronic Rhinosinusitis, Sleep Disorders | Completed | Sinai University | 134 | 2024-09-15 | 2025-11-21 |
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Sleep Wake Disorders (170) · Sleep Initiation and Maintenance Disorders (37) · Fatigue (21) · Depression (16) · Parasomnias (14) · Anxiety Disorders (12) · Sleep Apnea Syndromes (12) · Stress Disorders, Post-Traumatic (10) · Breast Neoplasms (9) · Obesity (7) · Pain (7) · Sleep Apnea, Obstructive (7) · Alzheimer Disease (6) · Disorders of Excessive Somnolence (6) · Mental Disorders (6)
Pathological Conditions, Signs and Symptoms (170) · Neurologic Manifestations (169) · Signs and Symptoms (169) · Nervous System Diseases (167) · Mental Disorders (164) · Sleep Disorders, Intrinsic (54) · Dyssomnias (53) · Behavior (24) · Respiratory Tract Diseases (23) · Central Nervous System Diseases (20) · Respiration Disorders (20) · Behavioral Symptoms (19) · Brain Diseases (17) · Neurocognitive Disorders (16) · Apnea (15)
Melatonin (9) · Zolpidem (8) · Cognitive Behavioral Therapy (6) · Mirtazapine (5) · Therapeutics (5) · Prazosin (4) · Modafinil (3) · Sugars (3) · Control Groups (2) · Dexmedetomidine (2) · Early Intervention, Educational (2) · Exercise (2) · Mass Screening (2) · N-((1-((5-(4-fluorophenyl)-2-methyl-4-thiazolyl)carbonyl)-2-piperidinyl)methyl)-4-benzofurancarboxamide (2) · Paroxetine (2)
US Department of Veterans Affairs (7) · Brigham and Women's Hospital (4) · GlaxoSmithKline (4) · Merck Sharp & Dohme LLC (4) · Assistance Publique - Hôpitaux de Paris (3) · Brasilia University Hospital (3) · Itamar-Medical, Israel (3) · Massachusetts General Hospital (3) · Sanofi (3) · University Hospital, Strasbourg, France (3) · University of Chicago (3) · VA Office of Research and Development (3) · Alliance for Clinical Trials in Oncology (2) · Cairo University (2) · Child Psychopharmacology Institute (2)
United States (73) · France (12) · Germany (9) · Canada (8) · Brazil (7) · China (7) · Israel (6) · Egypt (4) · Italy (3) · South Korea (3) · Switzerland (3) · Turkey (Türkiye) (3) · Australia (2) · Greece (2) · Hong Kong (2)
Bernard BH Hirschel, Professor (2) · Bill J Duke, M.A., Ph.D. (2) · Dong-Xin Wang, MD, PhD (2) · Kaloyan S Tanev, MD (2) · Mary E. Long, PhD (2) · Michael Kohrman, M.D. (2) · Murray Raskind, MD (2) · Yushiro Yamashita, MD, PhD (2) · Ahmed M Othman, Professor (1) · Amit Sood, MD (1)
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U10CA081851 (2), 2008 (1), K23RR020783 (1), M01RR000865 (1), P01AG020677 (1), P20AA017839 (1), P30CA006973 (1), P30CA015083 (1), P30CA068485 (1), R01HL062252 (1), R01MH024652 (1), R01MH053575 (1), R01NR016191 (1), R21AT002713 (1), R25HL116378 (1)