15 terminated. 15 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 15 | Terminated 15 |
Follow Shock: new trials by email Literature Review of Shock trials Research Report on Shock
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparison of Extubation Delay After Prolonged Sedation Prolonged sedation with isoflurane, Prolonged sedation with midazolam - Septic Shock | Phase 4 | Terminated | University Hospital, Rouen | 1 | 2020-12-15 | 2026-02-10 |
| Study on Early Intra-aortic Balloon Pump Placement in Acute Decompensated Heart Failure Complicated by Cardiogenic Shock Early intra-aortic balloon pump (IABP) implantation, Standard of care as vasoactive agent - Cardiogenic Shock | Phase 4 | Terminated | Niguarda Hospital | 100 | 2020-05-04 | 2024-10-23 |
| Efficacy of Dexamethasone Treatment for Patients With ARDS Caused by COVID-19 Dexamethasone - Acute Respiratory Distress Syndrome Caused by COVID-19 | Phase 4 | Terminated | Hospital Universitario de Gran Canaria Doctor Negrín | 19 | 2020-04-03 | 2021-02-03 |
| The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock Vitamin C, Hydrocortisone, Thiamine - Sepsis, Septic Shock | Phase 4 | Terminated | University Medical Centre Ljubljana | 5 | 2017-09-26 | 2019-02-19 |
| Optimization of Therapeutic Human Serum Albumin Infusion in Selected Critically Ill Patients Human serum albumin infusion 4%, Human serum albumin infusion 20% - Shock, Systemic Inflammatory Response Syndrome (SIRS) | Phase 4 | Terminated | University Hospital, Strasbourg, France | 138 | 2016-09-01 | 2021-09-20 |
| Vasculopathic Injury and Plasma as Endothelial Rescue in Septic Shock Trial. VIPER-Sepsis (EudraCT no. 2016-000707-81) OctaplasLG®, Ringer-acetat - Septic Shock | Phase 4 | Terminated | Copenhagen University Hospital, Rigshospitalet | 5 | 2016-09-01 | 2018-01-09 |
| Optimized Caloric-proteic Nutrition in Septic and Septic Shock Patients Peptamen intense, Novasource senior - Sepsis, Septic Shock | Phase 4 | Terminated | Hospital Sao Domingos | 10 | 2016-06-01 | 2022-03-29 |
| Use of Amiodarone in Atrial Fibrillation Associated With Severe Sepsis or Septic Shock Amiodarone - New Onset Atrial Fibrillation, Severe Sepsis | Phase 4 | Terminated | The University of Texas Health Science Center at San Antonio | 9 | 2016-05-01 | 2019-04-02 |
| Phenylephrine Versus Norepinephrine for Septic Shock in Critically Ill Patients Phenylephrine, Norepinephrine - Septic Shock, Sepsis | Phase 4 | Terminated | Vanderbilt University Medical Center | 17 | 2014-08-01 | 2018-06-13 |
| Standard Vs Adjusted Dosing of Piperacillin/Tazobactam in Acute Renal Failure and Septic Shock Piperacillin/Tazobactam - Septic Shock, Acute Renal Failure | Phase 4 | Terminated | Fraser Health | 20 | 2009-01-01 | 2015-09-14 |
| Hemodynamic and Inflammatory Effects of Abrupt Versus Tapered Corticosteroid Discontinuation in Septic Shock hydrocortisone, Normal Saline - Septic Shock | Phase 4 | Terminated | The Cleveland Clinic | 11 | 2008-05-01 | 2018-04-02 |
| Minimally-Invasive Cardiovascular Hemodynamic Optimization (MiCHO) Versus Early Goal-Directed Therapy (EGDT) in the Management of Septic Shock Esophageal Doppler monitoring - CardioQ, Deltex Inc, Central line with CVP and continuous ScvO2 monitoring - Severe Sepsis, Septic Shock | Phase 4 | Terminated | Loma Linda University | 5 | 2007-06-01 | 2014-06-25 |
| Adrenal Insufficiency in Septic Shock Corticosteroid - Septic Shock, Acute Adrenal Insufficiency | Phase 4 | Terminated | The Methodist Hospital Research Institute | 32 | 2007-05-01 | 2011-06-29 |
| Ganciclovir Pharmacokinetics in Patients Undergoing Continuous Renal Replacement Therapy intravenous (IV) ganciclovir - Acute Renal Failure, Cytomegalovirus Infections | Phase 4 | Terminated | University of Oslo School of Pharmacy | 6 | 2005-12-01 | 2007-06-28 |
| Comparison of Standard Treatment Versus Standard Treatment Plus Extracorporeal Life Support (ECLS) in Myocardial Infarction Complicated With Cardiogenic Shock Extra-Corporeal Life Support -Impella 2.5 - Myocardial Infarction, Shock, Cardiogenic | Phase 4 | Terminated | University Hospital, Caen | 19 | 2005-06-01 | 2010-08-02 |
Shock, Septic (10) · Sepsis (6) · Acute Kidney Injury (2) · Multiple Organ Failure (2) · Shock, Cardiogenic (2) · Arrhythmias, Cardiac (1) · COVID-19 (1) · Critical Illness (1) · Cytomegalovirus Infections (1) · Edema (1) · Emergencies (1) · Hypoalbuminemia (1) · Myocardial Infarction (1) · Systemic Inflammatory Response Syndrome (1)
Pathologic Processes (15) · Pathological Conditions, Signs and Symptoms (15) · Infections (12) · Inflammation (11) · Systemic Inflammatory Response Syndrome (10) · Sepsis (4) · Cardiovascular Diseases (3) · Heart Diseases (3) · Disease Attributes (2) · Female Urogenital Diseases (2) · Female Urogenital Diseases and Pregnancy Complications (2) · Infarction (2) · Ischemia (2) · Kidney Diseases (2)
Adrenal Cortex Hormones (2) · Hydrocortisone (2) · Saline Solution (2) · Sodium Chloride (2) · Amiodarone (1) · Ascorbic Acid (1) · Central Venous Catheters (1) · Dexamethasone (1) · Drug Implants (1) · Ganciclovir (1) · Isoflurane (1) · Midazolam (1) · Norepinephrine (1) · Phenylephrine (1) · Piperacillin, Tazobactam Drug Combination (1)
Copenhagen University Hospital, Rigshospitalet (1) · Fraser Health (1) · Hospital Sao Domingos (1) · Hospital Universitario de Gran Canaria Doctor Negrín (1) · Loma Linda University (1) · Niguarda Hospital (1) · The Cleveland Clinic (1) · The Methodist Hospital Research Institute (1) · The University of Texas Health Science Center at San Antonio (1) · University Hospital, Caen (1) · University Hospital, Rouen (1) · University Hospital, Strasbourg, France (1) · University Medical Centre Ljubljana (1) · University of Oslo School of Pharmacy (1) · Vanderbilt University Medical Center (1)
United States (5) · France (3) · Canada (1) · Denmark (1) · Italy (1) · Norway (1) · Slovenia (1) · Spain (1)
Anders Hartmann, MD, Ph.D. (1) · Bethany A Kalich (1) · H. Bryant Nguyen, MD (1) · Jan F Bugge, MD, Ph.D. (1) · Jorge A Guzman, MD (1) · Laura J Moore, MD (1) · Massimo Massetti, MD (1) · Matthew Wiens, BSc PharmD (1) · Per I Johansson, MD (1) · Raj Keriwala, MD, MPH (1)
PMID 27449641, PMID 32043986, PMID 32799933, PMID 40162941
UL1RR024975-01 (1), UL1TR000445-06 (1)