50 completed, 15 terminated, 13 unknown, 11 recruiting. 29 Phase 4, 24 Phase 3, 17 Phase 2, 15 Not applicable, 6 Phase 1.
Follow this drug Literature Review of Piperacillin, Tazobactam Drug Combination trials Research Report on Piperacillin, Tazobactam Drug Combination
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Piperacillin/Tazobactam Versus Ceftriaxone and Metronidazole for Children With Perforated Appendicitis Piperacillin/Tazobactam, Ceftriaxone + Metronidazole - Appendicitis Perforated, Appendectomy, Laparoscopic | Phase 3 | Not yet recruiting | McMaster Children's Hospital | 180 | 2027-04-01 | 2026-10-09 |
| Targeted Versus Standard Peri-operative Antibiotic Prophylaxis in Patients Colonized With Carbapenemase Producing Enterobacterales Undergoing Liver Transplantation Ceftazidime - Avibactam ( CAZ-AVI), Meropenem-Vaborbactam, Imipenem+Relebactam - Liver Transplant, Carbapenem-resistant Enterobacterales | Phase 3 | Not yet recruiting | IRCCS Azienda Ospedaliero-Universitaria di Bologna | 168 | 2026-10-01 | 2026-08-12 |
| The Vancomycin Piperacillin/Tazobactam (VPT) Patient Safety Trial (VPS) Piperacillin + Tazobactam, meropenem - Infection, Acute Kidney Injury | Phase 4 | Recruiting | Bassett Healthcare | 852 | 2026-08-17 | 2026-10-15 |
| Postoperative Anti-infective Strategy Following Pancreaticoduodenectomy in Patients With Preoperative Biliary Stent Antibioprophylaxis (Piperacillin-tazobactam), 5 days Antibiotherapy (Piperacillin-tazobactam) - Pancreaticoduodenectomy, Antibiotherapy | Phase 3 | Not yet recruiting | University Hospital, Rouen | 326 | 2026-07-01 | 2026-06-09 |
| Prophylactic Antibiotics in Preventing Surgical Site Infection After Hepatobiliary Surgery in High-Resistant Settings Piperacillin-tazobactam - Hepatobiliary Surgery, Prophylactic Antibiotics | Not applicable | Recruiting | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 378 | 2026-05-24 | 2026-06-02 |
| Aminoglycosides in Early Sepsis Gentamicin + narrow spectrum betalactam, Cefotaxime, Piperacillin-tazobactam - Sepsis | Phase 4 | Recruiting | University Hospital, Akershus | 1900 | 2026-04-23 | 2026-04-24 |
| Continuous Antibiotic Infusion In Children Benzylpenicillin - Infection | Phase 3 | Recruiting | Tampere University Hospital | 150 | 2026-04-21 | 2026-05-08 |
| Subcutaneous Piperacillin/Tazobactam Compared With Intravenous Treatment Piperacillin, Tazobactam Drug Combination - Bacteria Infection, Piperacillin, Tazobactam Drug Combination | Phase 2 | Recruiting | Azienda Sanitaria Universitaria Friuli Centrale | 240 | 2026-03-24 | 2026-03-19 |
| A Pragmatic Clinical Trial Comparing the Risk of Acute Kidney Injury During Treatment With Vancomycin and Piperacillin-Tazobactam vs. Vancomycin and Cefepime in Hospitalized Patients Vancomycin, Piperacillin-tazobactam, Cefepime - Acute Kidney Injury | Phase 4 | Recruiting | University of Pennsylvania | 750 | 2026-01-28 | 2026-02-13 |
| Precision Dosing of Beta-lactam Antibiotics in Critically Ill Children Beta-lactam antibiotic, Beta-lactam model-informed precision dosing - Amoxicillin-clavulanate, Piperacillin-tazobactam | Phase 4 | Recruiting | University Hospital, Ghent | 58 | 2025-07-09 | 2026-09-17 |
| Empirical Meropenem Versus Piperacillin/Tazobactam for Adult Patients With Sepsis Meropenem, Piperacillin/Tazobactam - Sepsis, Septic Shock | Phase 4 | Recruiting | Scandinavian Critical Care Trials Group | 5800 | 2025-06-26 | 2025-07-03 |
| Appropriateness of Antibiotic Combination Therapy for Severe Community-acquired Pneumonia in South Korea Piperacillin/Tazobactam, Piperacillin/tazobactam + Levofloxacin - Severe Community-acquired Pneumonia (sCAP) | Not applicable | Not yet recruiting | CHOSEOK YOON | 100 | 2025-06-15 | 2025-05-18 |
| Piperacillin/Tazobactam Versus ceftriAxone and Metronidazole for Children With Perforated Appendicitis (ALPACA) Piperacillin/tazobactam, Normal saline, CefTRIAXone Injection - Appendicitis Perforated | Phase 2 | Completed | McMaster Children's Hospital | 16 | 2024-09-09 | 2026-07-07 |
| eXtended Antibiotic Prophylaxis for Intermediate- and High-risk Glands After Pancreatoduodenectomy to Reduce CR-POPF Piperacillin/Tazobactam, Amoxicillin/ Clavulanic acid - Pancreatic Fistula | Phase 2 | Terminated | Case Comprehensive Cancer Center | 3 | 2024-01-18 | 2024-09-24 |
| Comparison Between Carbapenems and Noncarbapenem Beta-lactam Antibiotics in Septic Burn Patients Meropenem I.V. 2g as a 3 hour infusion every 8 hours, Tazocin (pipercillin/tazobactam) - Sepsis | Phase 1 / Phase 2 | Active not recruiting | Ain Shams University | 400 | 2024-01-01 | 2025-10-03 |
| Ceftolozane/Tazobactam vs. Piperacillin/Tazobactam for the Treatment of Bacteremia in Hemato-oncological Patients Ceftolozane/tazobactam, Piperacillin/tazobactam - Hematologic Neoplasms, Neutropenia | Not applicable | Unknown | Instituto Nacional de Cancerologia de Mexico | 226 | 2023-11-07 | 2024-06-04 |
| Comparing Oral Versus Parenteral Antimicrobial Therapy Amoxicillin, amoxicillin-clavulanate, cefadroxil, cefpodoxime, cefalexin, ciprofloxacin, delafloxacin, doxycycline, levofloxacin, linezolid, Ampicillin, ampicillin-sulbactam, cefazolin, cefepime, ceftaroline, ceftazidime, ceftazidime-avibactam, dalbavancin, daptomycin, ertapenem - Endovascular Infection, Bone and Joint Infection | Phase 4 | Terminated | West Virginia University | 94 | 2023-08-04 | 2025-08-26 |
| Model-based Dose Versus Empirical Dose of Piperacillin/Tazobactam in Preterm Neonates With Late-onset Sepsis. Piperacillin/tazobactam - Late-Onset Neonatal Sepsis | Phase 4 | Unknown | Shandong University | 332 | 2023-07-31 | 2023-08-08 |
| PipEracillin/Tazobactam Versus mERoPENem for Treatment of AmpC Producing Blood Stream Infections Piperacillin / Tazobactam Injection, Meropenem - Beta Lactam Resistant Bacterial Infection, Enterobacteriaceae Infections | Phase 4 | Withdrawn | Rambam Health Care Campus | 2022-07-01 | 2025-07-24 | |
| Efficacy of Piperacillin-tazobactam as Empirical Antimicrobial Therapy for VAP Among ESBL-E Carriers. Piperacillin-tazobactam - Enterobacteriaceae Infections | Not applicable | Completed | University Hospital, Bordeaux | 9 | 2022-02-16 | 2026-05-19 |
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Sepsis (13) · Infections (10) · Appendicitis (7) · Bacterial Infections (7) · Pneumonia (6) · Acute Kidney Injury (5) · Bacteremia (5) · Shock, Septic (5) · Critical Illness (4) · Enterobacteriaceae Infections (4) · Febrile Neutropenia (4) · Fever (4) · Hematologic Neoplasms (4) · Intraabdominal Infections (4) · Neutropenia (4)
Wyeth is now a wholly owned subsidiary of Pfizer (8) · M.D. Anderson Cancer Center (3) · University Hospital Tuebingen (3) · Chinese PLA General Hospital (2) · Hospital Universitari de Bellvitge (2) · McMaster Children's Hospital (2) · Melinta Therapeutics, Inc. (2) · Memorial Sloan Kettering Cancer Center (2) · Rambam Health Care Campus (2) · The University of Queensland (2) · University Hospital, Ghent (2) · West Virginia University (2) · AbbVie (1) · Ain Shams University (1) · Allecra (1)
United States (33) · Canada (12) · Italy (10) · Spain (10) · Belgium (8) · China (8) · France (8) · Germany (7) · Israel (6) · Czechia (5) · Australia (4) · Denmark (4) · Greece (4) · Hungary (4) · Romania (4)
Issam I Raad (2) · Mical Paul, MD (2) · Noa Eliakim-Raz, MD (2) · Roni Bitterman, MD (2) · Alaa Atamna, MD (1) · Allison R Lauver, PharmD (1) · Amin M Alousi (1) · Annelize Koch, MBChB (1) · Annick de Jaeger, MD (1) · Arif R. Sarwari, MD, MSc, MBA (1)
PMID 15276398, PMID 15327406, PMID 15840453, PMID 16368644, PMID 17359318, PMID 17487675, PMID 1750226, PMID 19588358, PMID 20350927, PMID 20458318, PMID 20594297, PMID 21649882, PMID 22530208, PMID 22569355, PMID 22907572, PMID 23772043, PMID 24348219, PMID 24614374, PMID 24949994, PMID 25084971, PMID 25623485, PMID 26039810, PMID 26888908, PMID 26926644, PMID 27522443, PMID 28101605, PMID 28137820, PMID 28288784, PMID 28290120, PMID 28601833, PMID 28779462, PMID 29084742, PMID 29271816, PMID 29435949, PMID 29486041, PMID 29608680, PMID 29677389, PMID 29937192, PMID 30208454, PMID 30790601, PMID 30861061, PMID 31060383, PMID 31238116, PMID 31262767, PMID 31317556, PMID 31548185, PMID 31814149, PMID 31833540, PMID 31933547, PMID 32011685
2015 (2), 2018 (2), 2023 (2), 2025 (2), 2005 (1), 2017 (1), P30CA016672 (1)