20 recruiting. 20 Phase 3, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 20 | Recruiting 20 |
| Phase 2 | 4 | Recruiting 4 |
Follow Shock: new trials by email Literature Review of Shock trials Research Report on Shock
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Trial of Adjunctive Fludrocortisone (50mcg, 100mcg or Placebo) in Critically Ill Patients With Septic Shock Receiving Hydrocortisone, Evaluating Survival and Functional Recovery and the Influence of Transcriptomic Response Fludrocortisone 50 mcg daily, Fludrocortisone 100 mcg daily, Placebo - Septic Shock | Phase 3 | Recruiting | The George Institute | 2200 | 2026-10-16 | 2026-10-30 |
| Randomized Evaluation of Istaroxime for Stabilization in Acute Heart Failure-Cardiogenic Shock istaroxime, placebo - Cardiogenic Shock | Phase 2 / Phase 3 | Recruiting | Seismic Pharmaceuticals Operations LLC | 600 | 2026-09-09 | 2026-09-23 |
| Ivabradine in the Acute Management of Cardiogenic Shock Ivabradine 5mg Tab, Placebo Oral Tablet - Cardiogenic Shock Post Myocardial Infarction | Phase 3 | Recruiting | National Institute of Cardiovascular Diseases, Pakistan | 200 | 2026-04-20 | 2026-07-20 |
| Systematic Adjunction of Vasopressine in Septic Shock Vasopressin administration, Sodium chloride administration - Septic Shock | Phase 3 | Recruiting | Assistance Publique Hopitaux De Marseille | 120 | 2026-03-24 | 2026-10-26 |
| Early Methylene Blue in the Microhemodynamics of Septic Patients Methylene blue infusion - Septic Shock, Hypoperfusion | Phase 2 / Phase 3 | Recruiting | Centro de Estudos e Pesquisa em Emergencias Medicas e Terapia Intensiva | 50 | 2026-01-09 | 2026-03-27 |
| Weaning Approaches for Vasopressin in Sepsis Titrated weaning of vasopressin., Abrupt weaning of vasopressin. - Septic Shock | Phase 3 | Recruiting | Hospital Nossa Senhora da Conceicao | 82 | 2025-10-01 | 2026-01-02 |
| NexCAR19 (Talikabtagene Autoleucel) in Relapsed/Refractory B-Cell Malignancies (NexCAR19) Talikabtagene Autoleucel - Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia (B-ALL), Relapsed/Refractory Non-Hodgkin Lymphoma | Phase 2 / Phase 3 | Recruiting | Health Institutes of Turkey | 40 | 2025-09-11 | 2026-03-30 |
| A Combination Therapy With Ceftazidime and Fosfomycin Will be Compared to Ceftazidime Alone in Hospitalized Adult Patients With Suspected Severe Gram-negative Bacterial Infections Ceftazidime± avibactam with fosfomycin, Ceftazidime± avibactam with placebo - Gram Negative Infections, Sepsis and Septic Shock | Phase 3 | Recruiting | Angela HUTTNER | 100 | 2025-08-25 | 2025-09-26 |
| Effect at 3 Months of Early Empagliflozin Initiation in Cardiogenic Shock Patients on Mortality, Rehospitalization, Left Ventricular Ejection Fraction and Renal Function. Empagliflozin 10 MG - Cardiogenic Shock | Phase 3 | Recruiting | Central Hospital, Nancy, France | 164 | 2024-12-16 | 2025-06-27 |
| Norepinephrine and Vasopressin for Rescue Versus Early Vasopressin for Vasopressor Dependent Sepsis Early Vasopressin, Norepinephrine and Vasopressin for Rescue - Septic Shock | Phase 3 | Recruiting | Hospital do Coracao | 2800 | 2024-11-21 | 2026-01-30 |
| Massive Transfusion in Children-2: A Trial Examining Life Threatening Hemorrhage in Children Low Titer Group O Whole Blood (LTOWB), Placebo, Tranexamic Acid (TXA) - Hemorrhagic Shock, Trauma Injury | Phase 3 | Recruiting | Philip Spinella | 1000 | 2024-11-01 | 2026-09-17 |
| Comparison of Early Proton Pump Inhibitor Initiation Versus Usual Care on Acute Kidney Injury in Hemorrhagic Shock Patients Protonix (Pantoprazole) 40 mg q 12 hrs for 2 days, Protonix (pantoprazole) 40 mg q 24 hrs for 2 days - Acute Kidney Injury | Phase 2 / Phase 3 | Recruiting | The University of Texas Health Science Center, Houston | 100 | 2024-09-07 | 2026-02-19 |
| Early Initiated Vasopressor Therapy in the Emergency Department Noradrenaline - Shock, Shock, Septic | Phase 3 | Recruiting | Odense University Hospital | 320 | 2023-12-08 | 2025-07-01 |
| Prehospital Analgesia INtervention Trial (PAIN) Ketamine Hydrochloride, Fentanyl Citrate - Traumatic Injury | Phase 3 | Recruiting | Jason Sperry | 994 | 2023-11-27 | 2026-03-09 |
| Effect of Early Use of Levosimendan Versus Placebo on Top of a Conventional Strategy of Inotrope Use on a Combined Morbidity-mortality Endpoint in Patients With Cardiogenic Shock Levosimendan 2.5 MG/ML Injectable Solution, Placebo - Cardiogenic Shock | Phase 3 | Recruiting | Pr Bruno LEVY | 610 | 2023-07-03 | 2025-08-05 |
| The Danish Out-of-Hospital Cardiac Arrest Study Dexamethasone, Backrest elevation, Early wakeup call - Out-Of-Hospital Cardiac Arrest, Post-Cardiac Arrest Syndrome | Phase 3 | Recruiting | Christian Hassager | 1000 | 2023-06-16 | 2025-01-24 |
| LANdiolol MIcrocirculatory Effects During Septic chOc (MILANOS) Landiolol - Septic Shock | Phase 3 | Recruiting | Assistance Publique - Hôpitaux de Paris | 44 | 2022-07-18 | 2025-08-01 |
| Management of Shock in Children With SAM or Severe Underweight and Diarrhea Blood and Dopamine, Blood and adrenaline - Shock Hypovolemic, Shock, Septic | Phase 3 | Recruiting | International Centre for Diarrhoeal Disease Research, Bangladesh | 135 | 2021-08-17 | 2025-04-16 |
| Comparison of Landiolol Versus Standard of Care for Prevention of Mortality in Patients Hospitalized for a Septic Shock With Hypercontractility echocardiography, Landiolol - Septic Shock, Tachycardia | Phase 3 | Recruiting | Centre Hospitalier Universitaire, Amiens | 360 | 2021-02-01 | 2025-08-24 |
| Stress Hydrocortisone In Pediatric Septic Shock Hydrocortisone, sodium succinate, Normal saline - Septic Shock | Phase 3 | Recruiting | Jerry Zimmerman | 500 | 2019-03-11 | 2025-10-30 |
Shock, Septic (11) · Shock, Cardiogenic (4) · Sepsis (3) · Diabetes Insipidus (2) · Heart Failure (2) · Shock, Hemorrhagic (2) · Accidental Injuries (1) · Acute Kidney Injury (1) · Burkitt Lymphoma (1) · Cholera (1) · Critical Illness (1) · Cytokine Release Syndrome (1) · Delirium (1) · Emergencies (1)
Pathologic Processes (20) · Pathological Conditions, Signs and Symptoms (20) · Infections (12) · Inflammation (12) · Systemic Inflammatory Response Syndrome (12) · Sepsis (8) · Cardiovascular Diseases (7) · Heart Diseases (6) · Vascular Diseases (6) · Infarction (4) · Ischemia (4) · Myocardial Infarction (4) · Myocardial Ischemia (4) · Necrosis (4)
Norepinephrine (2) · landiolol (2) · Blood Specimen Collection (1) · Dexamethasone (1) · Dopamine (1) · Epinephrine (1) · Fentanyl (1) · Fludrocortisone (1) · Fosfomycin (1) · Hydrocortisone (1) · Istaroxime (1) · Ivabradine (1) · Ketamine (1) · Methylene Blue (1) · Olanzapine (1)
Angela HUTTNER (1) · Assistance Publique - Hôpitaux de Paris (1) · Assistance Publique Hopitaux De Marseille (1) · Central Hospital, Nancy, France (1) · Centre Hospitalier Universitaire, Amiens (1) · Centro de Estudos e Pesquisa em Emergencias Medicas e Terapia Intensiva (1) · Christian Hassager (1) · Health Institutes of Turkey (1) · Hospital Nossa Senhora da Conceicao (1) · Hospital do Coracao (1) · International Centre for Diarrhoeal Disease Research, Bangladesh (1) · Jason Sperry (1) · Jerry Zimmerman (1) · National Institute of Cardiovascular Diseases, Pakistan (1) · Odense University Hospital (1)
France (5) · Brazil (4) · United States (4) · Denmark (2) · Pakistan (2) · Armenia (1) · Australia (1) · Bangladesh (1) · Canada (1) · Israel (1) · Japan (1) · Malaysia (1) · Saudi Arabia (1) · Singapore (1) · Sweden (1)
Abdul Hakeem, MD FACC, FSCAI, FASE (1) · Asim Ali, MBBS (1) · Bruno M Tomazini, MD (1) · Christian Hassager, MD DMSc (1) · David Wypij, PhD (1) · Gabe Coitler (1) · Jason Sperry, MD (1) · Jerry J Zimmerman MD, MD, PhD (1) · Jesper Kjaergaard, MD PhD DMSc (1)
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2023 (1), R01HD096901 (1)