8 completed, 4 recruiting, 3 unknown. 6 Phase 3, 5 Phase 2, 3 Phase 4, 1 Not applicable, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 6 | Completed 4, Recruiting 2 |
| Phase 2 | 5 | Completed 4, Unknown 1 |
| Phase 4 | 3 | Recruiting 2, Unknown 1 |
| Not applicable | 1 | Unknown 1 |
| Phase 1 | 1 | Unknown 1 |
Follow landiolol: new trials by email Literature Review of landiolol trials Research Report on landiolol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Predicting Early Circulatory Deterioration After Short-Acting Beta-Blocker Treatment in Intensive Care Patients Esmolol, Landiolol - Critical Illness | Completed | Shanghai Zhongshan Hospital | 2541 | 2026-08-01 | 2026-09-29 | |
| LANdiolol to Avoid TAchycardia in Patients at Risk for Cardiovascular Events Undergoing Major Non-cardiac Surgery Landiolol - Perioperative Myocardial Injury, Autonomic Dysfunction | Phase 4 | Recruiting | Insel Gruppe AG, University Hospital Bern | 114 | 2026-04-24 | 2026-05-05 |
| Landiolol in Mitral Valve Surgery Landiolol, Placebo - Cardiac Failure, Low Cardiac Output Syndrome | Phase 4 | Recruiting | Università Vita-Salute San Raffaele | 1500 | 2025-01-28 | 2025-12-29 |
| LANdiolol MIcrocirculatory Effects During Septic chOc (MILANOS) Landiolol - Septic Shock | Phase 3 | Recruiting | Assistance Publique - Hôpitaux de Paris | 44 | 2022-07-18 | 2025-08-01 |
| Beta-blockade With Landiolol in Out-of-hospital Cardiac Arrest Landiolol, Sodium Chloride (NaCl) 0.9% - Cardiac Arrest | Phase 1 / Phase 2 | Unknown | Medical University of Vienna | 32 | 2021-03-03 | 2023-03-17 |
| Comparison of Landiolol Versus Standard of Care for Prevention of Mortality in Patients Hospitalized for a Septic Shock With Hypercontractility echocardiography, Landiolol - Septic Shock, Tachycardia | Phase 3 | Recruiting | Centre Hospitalier Universitaire, Amiens | 360 | 2021-02-01 | 2025-08-24 |
| Prevention of Atrial Fibrillation by Low-dose Landiolol Administration After Cardiac Surgery Landiolol, Saline - Atrial Fibrillation, Cardiac Surgery | Phase 3 | Completed | CMC Ambroise Paré | 400 | 2021-01-27 | 2026-04-08 |
| Landiolol for Rate Control in Decompensated Heart Failure Due to Atrial Fibrillation Intensive heart rate control with landiolol, Standard approach to heart rate control - Atrial Fibrillation, Atrial Fibrillation Rapid | Not applicable | Unknown | Institute for Clinical and Experimental Medicine | 40 | 2020-11-05 | 2021-01-06 |
| Comparison of Two Strategies for the Management of Atrial Fibrillation After Cardiac Surgery Landiolol, Amiodarone - Atrial Fibrillation, Cardiac Surgery | Phase 4 | Unknown | University Hospital, Caen | 380 | 2019-12-13 | 2020-01-10 |
| Landiolol in Postoperative Atrial Fibrillation Landiolol, Placebo - Atrial Fibrillation | Phase 3 | Completed | Hospices Civils de Lyon | 58 | 2019-01-17 | 2025-08-06 |
| Study of ONO-1101 in Patients Scheduled for Multi-Slice Computed Tomography (CT) ONO-1101 - Coronary Artery Disease | Phase 3 | Completed | Ono Pharmaceutical Co., Ltd. | 258 | 2009-06-01 | 2012-06-13 |
| Study of ONO-1101 in Patients Scheduled for Coronary Angiography ONO-1101 - Coronary Artery Disease | Phase 2 | Completed | Ono Pharmaceutical Co., Ltd. | 183 | 2007-11-01 | 2012-06-13 |
| Pilot Study of ONO-1101 in Patients Scheduled for Multi-slice CT ONO-1101 - Coronary Artery Disease | Phase 2 | Completed | Ono Pharmaceutical Co., Ltd. | 90 | 2006-04-01 | 2012-06-13 |
| Controlled Study of ONO-1101 in Patients With Postoperative Tachyarrhythmias in Japan ONO-1101 - Postoperative Supraventricular Tachyarrythmia | Phase 2 / Phase 3 | Completed | Ono Pharmaceutical Co., Ltd. | 165 | 2001-06-01 | 2012-10-11 |
| Controlled Study of ONO-1101 in Patients With Postoperative Tachyarrhythmias in Japan ONO-1101 - Postoperative Supraventricular Tachyarrythmia | Phase 2 | Completed | Ono Pharma USA Inc | 100 | 1996-12-01 | 2012-10-11 |
Atrial Fibrillation (4) · Coronary Artery Disease (3) · Shock, Septic (2) · Cardiac Output, Low (1) · Critical Illness (1) · Heart Arrest (1) · Heart Failure (1) · Primary Dysautonomias (1) · Tachycardia (1) · Ventricular Dysfunction, Left (1) · Ventricular Fibrillation (1)
Ono Pharmaceutical Co., Ltd. (4) · Assistance Publique - Hôpitaux de Paris (1) · CMC Ambroise Paré (1) · Centre Hospitalier Universitaire, Amiens (1) · Hospices Civils de Lyon (1) · Insel Gruppe AG, University Hospital Bern (1) · Institute for Clinical and Experimental Medicine (1) · Medical University of Vienna (1) · Ono Pharma USA Inc (1) · Shanghai Zhongshan Hospital (1) · University Hospital, Caen (1) · Università Vita-Salute San Raffaele (1)
France (5) · Japan (3) · Austria (1) · China (1) · Czechia (1) · Italy (1) · Switzerland (1)
Project Leader, Development Planning (2) · Edouard Caspersen, MD (1) · Julien Amour, MD, PhD (1) · Michael M Holzer, MD (1) · Mitsunobu Tanimoto (1) · Pierre Squara, MD (1) · Project Leaders Development Planning (1) · Shinichi Kikawa (1)
PMID 23784548, PMID 33902917, PMID 37226174, PMID 41203473, PMID 41761704
2018 (1), 2019 (1)