41 completed, 13 recruiting, 11 unknown, 8 terminated. 38 Not applicable, 20 Phase 3, 15 Phase 2, 5 Phase 1, 5 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| One-Hour Positive Pressure Ventilation After a T-Piece Spontaneous Breathing Trial One-hour positive pressure ventilation, Immediate extubation - Airway Extubation, Extubation Failure | Not applicable | Not yet recruiting | Hospital do Coracao | 4000 | 2027-01-01 | 2026-09-22 |
| One-Hour Positive Pressure Ventilation After a Pressure Support Spontaneous Breathing Trial One-hour positive pressure ventilation, Immediate extubation - Airway Extubation, Weaning Mechanical Ventilation | Not applicable | Not yet recruiting | Hospital do Coracao | 4000 | 2027-01-01 | 2026-09-22 |
| Characterization of Weaning Practices in ICUs of Global South Countries Weaning From Mechanical Ventilation, Weaning Failure | Recruiting | Hospital do Coracao | 900 | 2026-05-25 | 2026-09-23 | |
| III Brazilian Registry of Heart Failure Heart Failure | Not yet recruiting | Hospital do Coracao | 2000 | 2026-04-20 | 2026-04-16 | |
| Hypofractionated Radiotherapy Plus Temozolamide in Patients Younger Than 70 Years With Glioblastoma Hypofractionated Radiation Therapy - Glioblastoma (GBM) | Not applicable | Not yet recruiting | Hospital do Coracao | 10 | 2026-04-01 | 2026-03-25 |
| Hydrogen Peroxide and Ultraviolet Light for Disinfecting Surfaces in Intensive Care Units Aerosol of hydrogen peroxide, Irradiation of ultraviolet light - Infection, Hospital, Antimicrobial | Not applicable | Recruiting | Hospital Israelita Albert Einstein | 5000 | 2026-01-05 | 2026-04-15 |
| Oral Care Layered Enhancement for Improved Oral Hygiene in Intensive Care Units Oral hygiene bundle - Mechanical Ventilation, Infection Prevention | Not applicable | Not yet recruiting | Hospital do Coracao | 4800 | 2025-09-01 | 2025-08-19 |
| V-IMMUNE: A Novel Immunoglobulin Therapy for Immunodeficiency Intravenous immunoglobulin (IVIG) - Immunodeficiencies, Primary Immunodeficiencies (PID) | Phase 3 | Recruiting | On Pharma Importadora, Exportadora e Distribuidora de Medicamentos LTDA. | 50 | 2025-08-15 | 2026-01-20 |
| V-IMMUNE® for Immune Thrombocytopenia 5% (5g/100 ml) intravenous immunoglobin - Immune Thrombocytopenia (ITP) | Phase 3 | Recruiting | On Pharma Importadora, Exportadora e Distribuidora de Medicamentos LTDA. | 31 | 2025-07-18 | 2026-01-20 |
| Low Dose Radiotherapy for Heart Failure Radiation Therapy - Heart Failure - NYHA II - IV | Phase 1 / Phase 2 | Not yet recruiting | Hospital do Coracao | 10 | 2025-07-14 | 2025-06-25 |
| Polypill and Colchicine for Risk Reduction in Atherosclerotic Cardiovascular Disease Cardiovascular Polypill (Valsartan, Atorvastatin, Aspirin), Colchicine 0.5 mg, Usual Care Group - Atherothrombotic Diseases, Atherosclerotic Cardiovascular Disease (ASCVD) | Phase 3 | Recruiting | Hospital do Coracao | 7713 | 2025-06-12 | 2026-01-22 |
| Quality Improvement Intervention for a Safe Antimicrobial Use Reduction in Critically Ill Patients Educational Quality Improvement Intervention - Infection, Antimicrobial Stewardship | Not applicable | Recruiting | Hospital Sirio-Libanes | 9000 | 2025-06-01 | 2025-12-03 |
| Relationship Between Pulse Pressure and Stroke Volume in the Critically Ill Patients: The ANDROMEDA-PEGASUS Study Critical Illness | Recruiting | Pontificia Universidad Catolica de Chile | 1500 | 2025-05-01 | 2025-05-29 | |
| National Network for Cardiovascular Genomics: Advancing Cardiovascular Healthcare for Hereditary Diseases in Brazil's Unified Health System Through a Multicenter Registry whole genome sequencing - Cardiomyopathy, Hypertrophic, Cardiomyopathy, Dilated | Recruiting | Hospital do Coracao | 1211 | 2025-04-30 | 2026-05-08 | |
| Use of Vasopressin in Patients at High Risk of Acute Kidney Injury Admitted to the ICU Vasopressin, 0,9% saline solution - Critical Illness | Phase 2 | Recruiting | Hospital do Coracao | 60 | 2025-04-10 | 2025-04-13 |
| Effect of Continuous Prolonged Prone Position Versus Intermittent Daily Prone Position in ARDS Daily prone position sessions, Prolonged prone position sessions - Acute Respiratory Distress Syndrome | Not applicable | Recruiting | Pontificia Universidad Catolica de Chile | 780 | 2025-04-07 | 2026-05-18 |
| CRYoablation for Small Tumors As Local Treatment - SIX Trial cryoablation, Breast Surgery (Lumpectomy or Mastectomy) - Breast Cancer, Breast Neoplasm | Phase 3 | Recruiting | Hospital do Coracao | 750 | 2025-03-01 | 2025-06-26 |
| LIQUID BIOPSY FOCUSING ON CIRCULATING TUMOR CELLS AND CIRCULATING TUMOR DNA AS PRECISION MEDICINE IN GASTROINTESTINAL TUMORS No Interventions - Cancer of Rectum, Cancer of Pancreas | Active not recruiting | Hospital do Coracao | 273 | 2025-01-10 | 2025-04-27 | |
| Norepinephrine and Vasopressin for Rescue Versus Early Vasopressin for Vasopressor Dependent Sepsis Early Vasopressin, Norepinephrine and Vasopressin for Rescue - Septic Shock | Phase 3 | Recruiting | Hospital do Coracao | 2800 | 2024-11-21 | 2026-01-30 |
| An Adapted Brazilian Cardioprotective Diet, Phytosterols and Krill Oil in Familial Hypercholesterolemia (DICA-FH) Placebo phytosterol, Placebo krill oil, Phytosterol - Familial Hypercholesterolemia | Not applicable | Active not recruiting | Hospital do Coracao | 300 | 2024-10-23 | 2026-05-12 |
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COVID-19 (11) · Critical Illness (7) · Respiratory Distress Syndrome (6) · Coronavirus Infections (5) · Pneumonia, Ventilator-Associated (5) · Cardiovascular Diseases (4) · Heart Failure (4) · Respiratory Insufficiency (4) · Breast Neoplasms (3) · Coronary Artery Disease (3) · Cross Infection (3) · Hyperlipoproteinemia Type II (3) · Hypertension (3) · Myocardial Infarction (3) · Obesity (3)
Atorvastatin (3) · Hydroxychloroquine (3) · Azithromycin (2) · Cryosurgery (2) · Electric Stimulation (2) · Noninvasive Ventilation (2) · Phytosterols (2) · Positive-Pressure Respiration (2) · Rivaroxaban (2) · Saline Solution (2) · V-Set Domain-Containing T-Cell Activation Inhibitor 1 (2) · Vasopressins (2) · 4-azidobenzylcarazolol (1) · Acetylcysteine (1) · Anti-Infective Agents (1)
Brazil (78) · Chile (4) · Argentina (3) · Colombia (3) · Australia (1) · Canada (1) · China (1) · Ecuador (1) · Mexico (1) · New Zealand (1) · Peru (1) · Russia (1) · Ukraine (1) · Uruguay (1)
Alexandre B Cavalcanti, MD, PhD (5) · Aline Marcadenti, PhD (5) · Leticia Kawano-Dourado, MD (4) · Otavio Berwanger, MD,PhD (4) · Alessandra Gorgulho, MD, MSc (3) · Antonio De Salles, M.D., Ph.D. (3) · Bruno M Tomazini, MD (3) · Otavio Berwanger, MD, PhD (3) · Alexandre B Cavalcanti, MD (2) · Alexandre B Cavalcanti, PhD (2) · Alexandre Biasi Cavalcanti, MD, PhD (2) · Bernardete Weber, PhD (2) · Bruno Tomazini, MD (2) · Erlon O Abreu-Silva, MSc (2)
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