21 completed. 21 Phase 2, 4 Phase 1, 4 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 21 | Completed 21 |
| Phase 1 | 4 | Completed 4 |
| Phase 3 | 4 | Completed 4 |
Follow Respiratory Failure: new trials by email Literature Review of Respiratory Failure trials Research Report on Respiratory Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sedation vs No Sedation in Mechanically Ventilated COPD Patients Midalozam - Chronic Obstructive Pulmonary Disease, Respiratory Failure | Phase 2 | Completed | Al-Azhar University | 100 | 2025-04-14 | 2026-06-02 |
| CONFOCAL-2 Interventional Pilot Study Autoregulation-based precision blood pressure management - Critical Illness, Respiratory Failure | Phase 1 / Phase 2 | Completed | Queen's University | 16 | 2022-07-29 | 2025-12-22 |
| Acetaminophen and Ascorbate in Sepsis: Targeted Therapy to Enhance Recovery Intravenous Acetaminophen (room temperature), Intravenous Vitamin C (refrigerated), 5% Dextrose (room temperature) - Acute Respiratory Distress Syndrome, Critical Illness | Phase 2 | Completed | Massachusetts General Hospital | 488 | 2021-10-13 | 2024-09-27 |
| Nebulised Heparin in Patients With Severe COVID-19 Nebulised unfractionated heparin (UFH) - Covid19, Respiratory Failure | Phase 2 / Phase 3 | Completed | Australian National University | 57 | 2020-11-01 | 2025-11-05 |
| Tenecteplase in Patients With COVID-19 Tenecteplase, Placebo - COVID-19, Respiratory Failure | Phase 2 | Completed | Hooman Poor | 13 | 2020-09-25 | 2023-04-06 |
| Efficacy of CONvalescent Plasma in Patients With COVID-19 Treated With Mechanical Ventilation Convalescent Plasma, Standard of Care - Covid19, Mechanical Ventilation Complication | Phase 2 | Completed | University of Liege | 475 | 2020-09-11 | 2024-10-29 |
| Use of Angiotensin-(1-7) in COVID-19 Angiotensin-(1-7), Placebo - Infection, Coronavirus, Respiratory Failure | Phase 1 / Phase 2 | Completed | Erasme University Hospital | 112 | 2020-08-05 | 2021-11-09 |
| Infusion of Prostacyclin (Iloprost) vs Placebo for 72-hours in COVID-19 Patients With Respiratory Failure Iloprost, Isotonic saline - COVID-19, Respiratory Failure | Phase 2 | Completed | Pär Johansson | 80 | 2020-06-15 | 2024-05-07 |
| Fibrinolytic Therapy to Treat ARDS in the Setting of COVID-19 Infection Alteplase 50 MG [Activase] - Severe Acute Respiratory Syndrome, Respiratory Failure | Phase 2 | Completed | Denver Health and Hospital Authority | 50 | 2020-05-14 | 2022-01-20 |
| A Study of the Effectiveness of an Off Label Mefloquine Use for the Treatment of Patients With COVID19 Mefloquine, Hydroxychloroquine, Mefloquine + azithromycin + / - tocilizumab - Pneumonia, Viral, Respiratory Failure | Phase 2 / Phase 3 | Completed | Burnasyan Federal Medical Biophysical Center | 320 | 2020-04-08 | 2021-01-27 |
| Enhanced Platelet Inhibition in Critically Ill Patients With COVID-19 Tirofiban Injection, Clopidogrel, Acetylsalicylic acid - Pneumonia, Viral, Corona Virus Infection | Phase 2 | Completed | University of Milan | 5 | 2020-04-06 | 2020-04-29 |
| Self-management of Sedative Therapy by Ventilated Patients Dexmedetomidine - Critical Illness, Anxiety | Phase 2 / Phase 3 | Completed | Mayo Clinic | 161 | 2016-11-01 | 2025-10-02 |
| CYCLE Pilot Randomized Trial In-bed cycle ergometer (Restorative Therapies RT300 Supine), Routine physiotherapy - Intensive Care Unit Acquired Weakness, Critical Care | Phase 2 | Completed | McMaster University | 113 | 2015-03-01 | 2022-12-05 |
| The Effect of Thiamine vs. Placebo on VO2 in Critical Illness Thiamine - Critically Ill, Respiratory Failure | Phase 2 | Completed | Beth Israel Deaconess Medical Center | 66 | 2013-10-01 | 2017-10-02 |
| Nebulized Hypertonic Saline for Mechanically Ventilated Children Hypertonic saline (3%), Placebo (0.9% saline) - Respiratory Failure | Phase 1 / Phase 2 | Completed | University Hospitals Cleveland Medical Center | 18 | 2013-10-01 | 2016-06-28 |
| Vitamin D in Ventilated ICU Patients Enteral Vitamin D3 50,000 IU, Enteral Vitamin D3 100,000IU, Inactive substance - Respiratory Failure | Phase 2 | Completed | Emory University | 31 | 2011-07-01 | 2017-01-09 |
| Ganciclovir/Valganciclovir for Prevention of CMV Reactivation in Acute Injury of the Lung and Respiratory Failure IV Ganciclovir, Placebo - Acute Lung Injury, Acute Respiratory Distress Syndrome | Phase 2 | Completed | Fred Hutchinson Cancer Center | 160 | 2011-03-10 | 2018-08-21 |
| Donor Simvastatin Treatment in Organ Transplantation Simvastatin 80mg, Control Rx - Heart Failure, Respiratory Failure | Phase 2 / Phase 3 | Completed | Helsinki University Central Hospital | 84 | 2010-06-01 | 2017-09-19 |
| Effect of Inspiratory Muscle Training on Duration of Mechanical Ventilation Support IMST, Sham IMST - Respiratory Failure | Phase 1 / Phase 2 | Completed | University of Florida | 76 | 2010-05-01 | 2013-12-11 |
| Sedation Management in Pediatric Patients Supported on Mechanical Ventilation Nurse Implemented Goal-Directed Comfort Algorithm - Respiratory Failure | Phase 2 | Completed | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 245 | 2004-02-01 | 2015-10-07 |
Showing 20 of 21. Sign in to see all of them.
Respiratory Insufficiency (21) · COVID-19 (6) · Critical Illness (5) · Coronavirus Infections (3) · Respiratory Distress Syndrome (3) · Pneumonia, Viral (2) · Severe Acute Respiratory Syndrome (2) · Acute Lung Injury (1) · Anxiety Disorders (1) · Cross Infection (1) · Delirium (1) · Embolism and Thrombosis (1) · Heart Failure (1) · Infections (1) · Liver Failure (1)
Respiration Disorders (21) · Respiratory Tract Diseases (21) · Lung Diseases (11) · Infections (10) · Pathologic Processes (8) · Pathological Conditions, Signs and Symptoms (8) · Virus Diseases (8) · Coronaviridae Infections (7) · Disease Attributes (7) · Nidovirales Infections (7) · RNA Virus Infections (7) · Respiratory Tract Infections (7) · Pneumonia (6) · Pneumonia, Viral (5) · Coronavirus Infections (4)
Sodium Chloride (2) · Aspirin (1) · Azithromycin (1) · Clopidogrel (1) · Dexmedetomidine (1) · Etomidate (1) · Fondaparinux (1) · Ganciclovir (1) · Glucose (1) · Hydroxychloroquine (1) · Iloprost (1) · Mefloquine (1) · Midazolam (1) · Saline Solution (1) · Saline Solution, Hypertonic (1)
Al-Azhar University (1) · Australian National University (1) · Beth Israel Deaconess Medical Center (1) · Burnasyan Federal Medical Biophysical Center (1) · Denver Health and Hospital Authority (1) · Emory University (1) · Erasme University Hospital (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Fred Hutchinson Cancer Center (1) · Helsinki University Central Hospital (1) · Hooman Poor (1) · Massachusetts General Hospital (1) · Mayo Clinic (1) · McMaster University (1) · Pär Johansson (1)
United States (13) · Canada (2) · Australia (1) · Belgium (1) · Brazil (1) · Denmark (1) · Egypt (1) · Finland (1) · Italy (1) · Russia (1)
Ajit Limaye, MD (1) · Ana Martins Valle (1) · Anders Perner, MD, PhD (1) · Boyd Taylor Thompson, MD (1) · Ernest E Moore, MD (1) · Filippo Annoni (1) · Frank MP van Haren, MD, PhD (1) · Greg Martin, MD, MSc (1) · Hooman Poor, MD (1) · J Mocco, MD (1) · Jeanne L Jacoby, MD (1) · Karl B Lemstrom, MD, PhD (1) · Katherine Berg, MD (1) · Linda L Chlan, RN, PhD (1) · Louise Kimball, PhD, RN (1)
PMID 27059469, PMID 27419080, PMID 28829877, PMID 30558653, PMID 30956804, PMID 31352795, PMID 31455384, PMID 31741746, PMID 32838109, PMID 32847626, PMID 33287790, PMID 33331622, PMID 33502773, PMID 34592318, PMID 35244208, PMID 37355270, PMID 37889107, PMID 38762798, PMID 38865147, PMID 39231898, PMID 39317833, PMID 39432177, PMID 39467285, PMID 41788496
R01HL130881 (1), U01HL102547 (1)