14 completed, 8 not yet recruiting, 4 unknown, 3 active not recruiting. 21 Not applicable, 4 Early Phase 1, 4 Phase 4, 2 Phase 1, 2 Phase 2.
Follow Pulp Necrosis: new trials by email Literature Review of Pulp Necrosis trials Research Report on Pulp Necrosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Frankincense Versus Sodium Hypochlorite for Root Canal Disinfection Sodium hypochlorite 3%, Frankincense-based irrigant - Pulp Necrosis, Root Canal Infection | Early Phase 1 | Not yet recruiting | Oman Dental College | 30 | 2027-01-19 | 2026-09-22 |
| Efficiency of Asiaticoside as Intracanal Medication in Revascularization Process Intracanal medication - Immature Permanent Teeth With Open Apex, Pulp Necrosis | Not applicable | Recruiting | Mansoura University | 20 | 2026-10-01 | 2026-09-23 |
| Conventional and Nano-Metronidazole Irrigation With/Without Activation in Necrotic Teeth With Apical Periodontitis Metronidazole 0.5%, Nano-formulated Metronidazole 0.5%, Sodium Hypochlorite 2.5% - Pulp Necrosis, Apical Periodontitis | Not applicable | Recruiting | October 6 University | 60 | 2026-10-01 | 2026-10-27 |
| Chloramphenicol, Tetracycline, Zinc Oxide and Eugenol Paste (CTZ Paste) for Emergency Dental Treatment in Public Health Settings: A Randomized Trial CTZ Paste, ZOE Pulpectomy - Pulp Disease, Dental, Pulp Necrosis | Early Phase 1 | Not yet recruiting | University of Sao Paulo | 110 | 2026-06-08 | 2026-05-12 |
| Lesion Sterilization and Tissue Repair Antibiotic Paste Versus Zinc Oxide and Eugenol Pulpectomy for Treatment of Primary Molars With Pulp Necrosis Group A - LSTR Therapy (CTZ Paste), Group B - ZOE Pulpectomy - Pulp Necrosis | Phase 1 / Phase 2 | Not yet recruiting | University of Faisalabad | 180 | 2026-05-01 | 2026-03-19 |
| Antibacterial Effect and Postoperative Pain After Triton Irrigation Protocol in Necrotic Mandibular Molar triton irrigation protocol, conventional irrigation group - Pulp Necrosis | Not applicable | Not yet recruiting | sara hosny mostafa | 36 | 2026-03-01 | 2026-02-27 |
| This Study Compares Two Different Ways of Cleaning and Shaping Root Canals During Root-canal Treatment: the Step-down Technique and the Step-back Technique. Iu Want to Find Out Which Method Causes Less Pain After the Procedure. Patients Will be Randomly Placed Into One of the Two Groups, Treated Wit Step down technique - Pulp Necrosis | Not applicable | Not yet recruiting | Armed Forces Post Graduate Medical Institute (AFPGMI), Rawalpindi | 110 | 2026-02-01 | 2025-12-18 |
| Antibacterial Effect of Two Different Intracanal Medicaments and Their Effect on Post-operative Pain Calcium Hydroxide (Ca(OH)2), chitosan nanoparticles gel - Pulp Necrosis | Phase 4 | Not yet recruiting | Ain Shams University | 52 | 2026-02-01 | 2026-02-05 |
| Evaluation of Post-operative Pain and Bacterial Load Reduction After Application of Three Intra-canal Medications (Cocoa Husk Versus Calcium Hydroxide With and Without Cocoa) in Necrotic Mandibular First Molar. Root canal treatment with intracanal medication by calcium hydroxide for one week., Root canal treatment with intracanal medication by cocoa husk for one week, Root canal treatment with intracanal medication by calcium hydroxide with cocoa husk for one week. - Pulp Necrosis, Postoperative Pain | Not applicable | Active not recruiting | Future University in Egypt | 36 | 2026-01-06 | 2026-08-27 |
| Evaluation of Pulpotomy Versus Pulpectomy in Primary Molars With Irreversible Pulpitis or Necrotic Pulp Pulpotomy, Pulpectomy - Pulp Therapy, Pulpitis - Irreversible | Not applicable | Not yet recruiting | Ajman University | 30 | 2025-12-01 | 2025-11-17 |
| Professional Practices Regarding Treatment of Non-vital Primary Teeth Among Dental Surgeons in France Pulpitis - Irreversible, Pulp Necrosis | Recruiting | University Hospital, Strasbourg, France | 100 | 2025-11-07 | 2026-03-03 | |
| Comparison of Ultrasonic vs 980-nm Diode Laser Irrigant Activation for Reducing Residual Bacterial DNA in Necrotic Teeth Ultrasonic Activation, 980-nm Diode Laser Activation - Pulp Necrosis, Root Canal Infection | Not applicable | Completed | Hasanuddin University | 16 | 2025-10-13 | 2026-05-26 |
| Regenerative Root Canal Treatment of Immature Teeth Using Omega-3 Fatty Acids Omega -3 fatty acids, Calcium Hydroxide (Ca(OH)2) - Immature Permanent Teeth With Open Apex, Pulp Necrosis | Not applicable | Active not recruiting | Mansoura University | 20 | 2025-10-01 | 2026-01-28 |
| Evaluation of Bone Healing After Obturation With Dia-Root Bio Sealer (Calcium Silicate-based Sealer CSBS) Using Three Obturation Techniques Dia-Root Bio Sealer, Single cone (SC) Obturation technique, Warm Vertical compaction (WVC) technique - Periapical Periodontitis, Chronic Periapical Periodontitis | Not applicable | Suspended | Ain Shams University | 63 | 2025-07-29 | 2026-07-07 |
| Moringa Oleifera vs Sodium Hypochlorite for Root Canal Irrigation in Nonvital Primary Molars Sodium hypochlorite, Moringa Oleifera Leaf Extract - Dental Caries, Pulp Necrosis | Not applicable | Not yet recruiting | Cairo University | 38 | 2025-07-20 | 2025-06-03 |
| Antibacterial Efficacy and Outcomes of Root Canal Irrigation Methods Final Irrigation with 2.5% Sodium Hypochlorite, Passive Ultrasonic Irrigation (PUI) with Sodium Hypochlorite, XP-Endo Finisher Activation with Sodium Hypochlorite - Pulp Necrosis, Apical Periodontitis | Not applicable | Enrolling by invitation | National and Kapodistrian University of Athens | 66 | 2025-04-01 | 2025-06-03 |
| CLINICAL AND RADIOGRAPHIC SUCCESS OF MODIFIED LSTR TECHNIQUES IN PRIMARY SECOND MOLARS 3Mix-MP Antibiotic Paste, 3Mix-NS Antibiotic Paste, 2Mix-MP Antibiotic Paste - Pulp Necrosis, Irreversible Pulpitis | Not applicable | Completed | Uşak University | 64 | 2024-11-26 | 2026-09-29 |
| Dexamethasone Treatment for Patients Undergoing Endodontics Dexamethasone 4 mg, Ibuprofen group - Endodontic Treatment, Pulp Necrosis | Phase 4 | Completed | University of Salamanca | 82 | 2024-11-04 | 2025-04-04 |
| In Vivo Pulp Thermal Changes During Different Slenderization Techniques High-Speed Air-Driven Drill (Airotor and Bur), Orthodontic IPR Kit (Oscillating System) - Irreversible Pulpitis, Reversible Pulpitis | Not applicable | Active not recruiting | Armed Forces Institute of Dentistry, Pakistan | 30 | 2024-09-29 | 2026-02-17 |
| Diagnostic Accuracy of Cold, Heat, and Electric Pulp Tests Pulp Sensibility Tests - Dental Pulp Disease, Pulp Necrosis | Completed | Istanbul University | 175 | 2024-06-30 | 2026-02-27 |
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Dental Pulp Necrosis (34) · Periapical Periodontitis (9) · Pain, Postoperative (5) · Dental Pulp Diseases (2) · Periapical Abscess (2) · Bicuspid Aortic Valve Disease (1) · Dental Caries (1) · Fistula (1) · Hypersensitivity (1) · Necrosis (1)
Pathologic Processes (34) · Pathological Conditions, Signs and Symptoms (34) · Stomatognathic Diseases (34) · Tooth Diseases (34) · Necrosis (33) · Dental Pulp Diseases (32) · Jaw Diseases (10) · Mouth Diseases (10) · Periapical Diseases (10) · Periodontal Diseases (10) · Periodontitis (10) · Neurologic Manifestations (5) · Pain (5) · Postoperative Complications (5) · Signs and Symptoms (5)
Pemetrexed (3) · mineral trioxide aggregate (3) · Apexification (2) · Calcium Hydroxide (2) · Sodium Hypochlorite (2) · Blood Coagulation (1) · Ciprofloxacin (1) · Dexamethasone (1) · Docosahexaenoic Acids (1) · Edetic Acid (1) · Methods (1) · Metronidazole (1) · Minocycline (1) · Photochemotherapy (1) · ProRoot MTA (1)
Cairo University (5) · Ain Shams University (2) · Kahramanmaras Sutcu Imam University (2) · Mansoura University (2) · The University of Texas Health Science Center at San Antonio (2) · Ajman University (1) · Al-Azhar University (1) · Armed Forces Institute of Dentistry, Pakistan (1) · Armed Forces Post Graduate Medical Institute (AFPGMI), Rawalpindi (1) · Celalettin Topbaş (1) · Future University in Egypt (1) · Hasanuddin University (1) · Inonu University (1) · Istanbul University (1) · Kenneth Hargreaves (1)
Egypt (8) · Turkey (Türkiye) (6) · United States (3) · Pakistan (2) · China (1) · France (1) · Greece (1) · Indonesia (1) · Oman (1) · Spain (1) · United Kingdom (1)
Aliye Kamalak (2) · Alaina Tariq Mughal, BDS, FCPS (R) (1) · Ayca Yilmaz, Assoc. Prof. (1) · C C Youngson (1) · Giorge Tzanetakis, Dr (PhD) (1) · Kenneth Hargreaves, DDS, PhD (1) · Kenneth M Hargreaves, DDS, PhD (1) · Kenneth M Hargreaves, DDS,PhD (1) · Mervat IB Fawzy, Professor (1) · Mohammed M Nagy, Professor (1)
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