6 completed, 5 not yet recruiting, 4 unknown, 3 active not recruiting. 22 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 22 | Completed 6, Not yet recruiting 5, Unknown 4, Active not recruiting 3, Recruiting 2, Enrolling by invitation 1, Suspended 1 |
Follow Pulp Necrosis: new trials by email Literature Review of Pulp Necrosis trials Research Report on Pulp Necrosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinical and Inflammatory Outcomes of Regenerative Endodontic Treatment Using Injectable Platelet-Rich Fibrin in Mature Necrotic Teeth With Chronic Apical Periodontitis. Conventional Root Canal Treatment, Regenerative Endodontic Treatment with i-PRF, Injectable Platelet-Rich Fibrin (i-PRF) - Chronic Apical Periodontitis, Pulp Necrosis | Not applicable | Not yet recruiting | Medipol University | 120 | 2026-11-15 | 2026-11-03 |
| Efficiency of Asiaticoside as Intracanal Medication in Revascularization Process Intracanal medication - Immature Permanent Teeth With Open Apex, Pulp Necrosis | Not applicable | Recruiting | Mansoura University | 20 | 2026-10-01 | 2026-09-23 |
| Conventional and Nano-Metronidazole Irrigation With/Without Activation in Necrotic Teeth With Apical Periodontitis Metronidazole 0.5%, Nano-formulated Metronidazole 0.5%, Sodium Hypochlorite 2.5% - Pulp Necrosis, Apical Periodontitis | Not applicable | Recruiting | October 6 University | 60 | 2026-10-01 | 2026-10-27 |
| Antibacterial Effect and Postoperative Pain After Triton Irrigation Protocol in Necrotic Mandibular Molar triton irrigation protocol, conventional irrigation group - Pulp Necrosis | Not applicable | Not yet recruiting | sara hosny mostafa | 36 | 2026-03-01 | 2026-02-27 |
| This Study Compares Two Different Ways of Cleaning and Shaping Root Canals During Root-canal Treatment: the Step-down Technique and the Step-back Technique. Iu Want to Find Out Which Method Causes Less Pain After the Procedure. Patients Will be Randomly Placed Into One of the Two Groups, Treated Wit Step down technique - Pulp Necrosis | Not applicable | Not yet recruiting | Armed Forces Post Graduate Medical Institute (AFPGMI), Rawalpindi | 110 | 2026-02-01 | 2025-12-18 |
| Evaluation of Post-operative Pain and Bacterial Load Reduction After Application of Three Intra-canal Medications (Cocoa Husk Versus Calcium Hydroxide With and Without Cocoa) in Necrotic Mandibular First Molar. Root canal treatment with intracanal medication by calcium hydroxide for one week., Root canal treatment with intracanal medication by cocoa husk for one week, Root canal treatment with intracanal medication by calcium hydroxide with cocoa husk for one week. - Pulp Necrosis, Postoperative Pain | Not applicable | Active not recruiting | Future University in Egypt | 36 | 2026-01-06 | 2026-08-27 |
| Evaluation of Pulpotomy Versus Pulpectomy in Primary Molars With Irreversible Pulpitis or Necrotic Pulp Pulpotomy, Pulpectomy - Pulp Therapy, Pulpitis - Irreversible | Not applicable | Not yet recruiting | Ajman University | 30 | 2025-12-01 | 2025-11-17 |
| Comparison of Ultrasonic vs 980-nm Diode Laser Irrigant Activation for Reducing Residual Bacterial DNA in Necrotic Teeth Ultrasonic Activation, 980-nm Diode Laser Activation - Pulp Necrosis, Root Canal Infection | Not applicable | Completed | Hasanuddin University | 16 | 2025-10-13 | 2026-05-26 |
| Regenerative Root Canal Treatment of Immature Teeth Using Omega-3 Fatty Acids Omega -3 fatty acids, Calcium Hydroxide (Ca(OH)2) - Immature Permanent Teeth With Open Apex, Pulp Necrosis | Not applicable | Active not recruiting | Mansoura University | 20 | 2025-10-01 | 2026-01-28 |
| Evaluation of Bone Healing After Obturation With Dia-Root Bio Sealer (Calcium Silicate-based Sealer CSBS) Using Three Obturation Techniques Dia-Root Bio Sealer, Single cone (SC) Obturation technique, Warm Vertical compaction (WVC) technique - Periapical Periodontitis, Chronic Periapical Periodontitis | Not applicable | Suspended | Ain Shams University | 63 | 2025-07-29 | 2026-07-07 |
| Moringa Oleifera vs Sodium Hypochlorite for Root Canal Irrigation in Nonvital Primary Molars Sodium hypochlorite, Moringa Oleifera Leaf Extract - Dental Caries, Pulp Necrosis | Not applicable | Not yet recruiting | Cairo University | 38 | 2025-07-20 | 2025-06-03 |
| Antibacterial Efficacy and Outcomes of Root Canal Irrigation Methods Final Irrigation with 2.5% Sodium Hypochlorite, Passive Ultrasonic Irrigation (PUI) with Sodium Hypochlorite, XP-Endo Finisher Activation with Sodium Hypochlorite - Pulp Necrosis, Apical Periodontitis | Not applicable | Enrolling by invitation | National and Kapodistrian University of Athens | 66 | 2025-04-01 | 2025-06-03 |
| CLINICAL AND RADIOGRAPHIC SUCCESS OF MODIFIED LSTR TECHNIQUES IN PRIMARY SECOND MOLARS 3Mix-MP Antibiotic Paste, 3Mix-NS Antibiotic Paste, 2Mix-MP Antibiotic Paste - Pulp Necrosis, Irreversible Pulpitis | Not applicable | Completed | Uşak University | 64 | 2024-11-26 | 2026-09-29 |
| In Vivo Pulp Thermal Changes During Different Slenderization Techniques High-Speed Air-Driven Drill (Airotor and Bur), Orthodontic IPR Kit (Oscillating System) - Irreversible Pulpitis, Reversible Pulpitis | Not applicable | Active not recruiting | Armed Forces Institute of Dentistry, Pakistan | 30 | 2024-09-29 | 2026-02-17 |
| CGF-Enhanced Autologous Pulp Transplantation in Mature Necrotic Teeth Autologous Pulp Transplantation With Concentrated Growth Factor - Pulp Necrosis, Apical Periodontitis | Not applicable | Completed | Kahramanmaras Sutcu Imam University | 6 | 2024-01-01 | 2026-01-07 |
| PRF and CGF Scaffolds With EDTA in Regeneration Blood Clot + 5% EDTA, Blood Clot + 17% EDTA, PRF + 5% EDTA - Pulp Necrosis, Immature Permanent Teeth | Not applicable | Completed | Kahramanmaras Sutcu Imam University | 30 | 2023-10-01 | 2025-12-12 |
| Discoloration of Endosequence and Mineral Trioxde Aggregate in Revascularization of Necrotic Immature Permanent Teeth Revascularization - Pulp Necrosis | Not applicable | Unknown | Cairo University | 24 | 2023-06-01 | 2022-07-19 |
| Cryotherapy and Intracanal Medicaments for Postoperative Pain in Apical Periodontitis Placement of calcium hydroxide as an intracanal medicament, Placement of metformin as an intracanal medicament, Application of calcium hydroxide as an intracanal medicament together with intracanal cryotherapy - Symptomatic Apical Periodontitis, Pulp Necrosis | Not applicable | Completed | Celalettin Topbaş | 80 | 2023-03-01 | 2026-09-16 |
| Effectiveness of Regenerative Endodontics Therapy for Single-rooted Mature Permanent Tooth With Pulp Necrosis PRF, BC - Pulp Necrosis | Not applicable | Unknown | Southern Medical University, China | 346 | 2020-03-16 | 2020-03-23 |
| Success Rate of Single Versus Two Visit Regenerative Treatment Protocol in Non Vital Mature Anterior Teeth Single visit pulp regeneration, Two visit pulp regeneration - Pulp Necrosis, Periapical Lesion | Not applicable | Unknown | Cairo University | 40 | 2019-01-01 | 2018-10-24 |
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Dental Pulp Necrosis (22) · Periapical Periodontitis (6) · Pain, Postoperative (4) · Bicuspid Aortic Valve Disease (1) · Dental Caries (1) · Necrosis (1) · Periapical Abscess (1)
Dental Pulp Diseases (22) · Pathologic Processes (22) · Pathological Conditions, Signs and Symptoms (22) · Stomatognathic Diseases (22) · Tooth Diseases (22) · Necrosis (21) · Jaw Diseases (6) · Mouth Diseases (6) · Periapical Diseases (6) · Periodontal Diseases (6) · Periodontitis (6) · Neurologic Manifestations (4) · Pain (4) · Postoperative Complications (4) · Signs and Symptoms (4)
Sodium Hypochlorite (2) · Blood Coagulation (1) · Calcium Hydroxide (1) · Docosahexaenoic Acids (1) · Edetic Acid (1) · Methods (1) · Pemetrexed (1) · Photochemotherapy (1) · Prolactin-Releasing Hormone (1) · Pulpectomy (1) · Pulpotomy (1) · Root Canal Obturation (1) · mineral trioxide aggregate (1) · proliferation regulatory factors, human urine (1) · tricalcium silicate (1)
Cairo University (5) · Kahramanmaras Sutcu Imam University (2) · Mansoura University (2) · Ain Shams University (1) · Ajman University (1) · Armed Forces Institute of Dentistry, Pakistan (1) · Armed Forces Post Graduate Medical Institute (AFPGMI), Rawalpindi (1) · Celalettin Topbaş (1) · Future University in Egypt (1) · Hasanuddin University (1) · Medipol University (1) · National and Kapodistrian University of Athens (1) · October 6 University (1) · Southern Medical University, China (1) · Uşak University (1)
Egypt (7) · Turkey (Türkiye) (4) · Pakistan (2) · China (1) · Greece (1) · Indonesia (1)
Aliye Kamalak (2) · Alaina Tariq Mughal, BDS, FCPS (R) (1) · Giorge Tzanetakis, Dr (PhD) (1) · Mohammed M Nagy, Professor (1) · Mostafa Shaker, PhD (1) · Randa Youssef, PHD (1) · Sara H Fahmy, Lecturer of Endodontics (1) · Wanghong Zhao, Doctor (1)
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