60 completed, 18 recruiting, 17 unknown, 10 active not recruiting. 32 Not applicable, 23 Phase 2, 16 Phase 1, 5 Early Phase 1, 5 Phase 3.
Follow Progressive Supranuclear Palsy: new trials by email Literature Review of Progressive Supranuclear Palsy trials Research Report on Progressive Supranuclear Palsy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Evaluate the Safety, Tolerability and Pharmacodynamics of NIO752 in Primary Tauopathies NIO752, Placebo - Progressive Supranuclear Palsy, Corticobasal Degeneration | Phase 2 | Not yet recruiting | Novartis Pharmaceuticals | 48 | 2026-10-23 | 2026-10-09 |
| VisMemoPD Protocol: an Observational Pilot Study on Spatial and Topographical Memory in Patients With Parkinson's Disease and Parkinsonism Multimodal visuospatial and topographical memory assessment - Parkinson's Disease, Parkinsonism | Not yet recruiting | IRCCS San Raffaele Roma | 80 | 2026-09-01 | 2026-09-18 | |
| Remote Monitoring in Progressive Supranuclear Palsy (PSP) Progressive Supranuclear Palsy, Parkinson Disease | Not yet recruiting | Massachusetts General Hospital | 85 | 2026-09-01 | 2026-07-29 | |
| Wellness in PSP and CBD Exercise and Peer Support - Progressive Supranuclear Palsy, Corticobasal Degeneration | Not applicable | Recruiting | Silke Cresswell | 30 | 2026-04-10 | 2026-09-28 |
| Individualized Transcranial Magnetic Stimulation in Parkinsonian Disorders TMS - Parkinson's Disease, Multiple System Atrophy | Not applicable | Recruiting | Peking University First Hospital | 50 | 2025-12-22 | 2026-06-29 |
| tDCS as Treatment for Motor Function Transcranial direct current stimulation (TDCS), Stimulation Arm - Progressive Supranuclear Palsy, Cortical Basal Ganglionic Degeneration | Not applicable | Recruiting | Baycrest | 20 | 2025-10-30 | 2025-12-18 |
| Art Therapy in Progressive Supranuclear Palsy Art Thrapy - Progressive Supranuclear Palsy | Not applicable | Active not recruiting | Vanderbilt University Medical Center | 19 | 2025-01-14 | 2026-10-05 |
| Art Therapy in Progressive Supranuclear Palsy Art Thrapy - Progressive Supranuclear Palsy(PSP), Progressive Supranuclear Palsy (PSP) | Not applicable | Completed | Baylor College of Medicine | 20 | 2025-01-14 | 2026-09-16 |
| The CurePSP Genetics Program Whole genome sequencing will be performed at the NIH - PSP, PSP - Progressive Supranuclear Palsy | Recruiting | Massachusetts General Hospital | 1000 | 2024-10-08 | 2026-01-14 | |
| A Study to Assess the Efficacy, Safety, and Pharmacokinetics of FNP-223 to Slow Progression of Progressive Supranuclear Palsy (PSP) FNP-223, Placebo - Progressive Supranuclear Palsy | Phase 2 | Active not recruiting | Ferrer Internacional S.A. | 241 | 2024-07-23 | 2025-10-15 |
| The Use of the CUE1/CUE1+ in People With Parkinson's Disease and Related Disorders CUE1 non-invasive device, CUE1+ device active vs sham CUE1+ device - Parkinson's Disease and Parkinsonism, Progressive Supranuclear Palsy | Not applicable | Recruiting | Queen Mary University of London | 70 | 2024-03-25 | 2024-11-21 |
| The NADAPT Study: a Randomized Double-blind Trial of NAD Replenishment Therapy for Atypical Parkinsonism Nicotinamide Riboside, Placebo - Progressive Supranuclear Palsy, Multiple System Atrophy | Phase 2 | Recruiting | Haukeland University Hospital | 330 | 2024-03-05 | 2025-01-10 |
| Early Biomarkers of Neurodegeneration in Parkinsonian Syndromes 7 Tesla MRI - Parkinson Disease, Progressive Supranuclear Palsy | Not applicable | Not yet recruiting | Assistance Publique Hopitaux De Marseille | 63 | 2024-01-15 | 2023-12-05 |
| AMX0035 and Progressive Supranuclear Palsy AMX0035, Placebo - Progressive Supranuclear Palsy, PSP | Phase 2 / Phase 3 | Completed | Amylyx Pharmaceuticals Inc. | 139 | 2023-12-21 | 2026-04-30 |
| Administration of GV1001 for the Treatment of Progressive Supranuclear Palsy Who Completed Study GV1001-PSP-CL2-011 GV1001 Placebo, GV1001 1.12mg - Progressive Supranuclear Palsy | Phase 2 | Completed | GemVax & Kael | 67 | 2023-12-12 | 2025-11-21 |
| Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling Dementia, Alzheimer Disease | Recruiting | University Health Network, Toronto | 500 | 2023-11-11 | 2025-11-20 | |
| A Multi-Modal Remote Monitoring Platform for Frontotemporal Lobar Degeneration (FTLD) Syndromes PAMSys, LEGSys - PSP, CBD | Active not recruiting | Massachusetts General Hospital | 60 | 2023-07-28 | 2026-01-21 | |
| GV1001 Subcutaneous(SC) for the Treatment of Progressive Supranuclear Palsy (PSP) GV1001 Placebo, GV1001 0.56mg, GV1001 1.12mg - Progressive Supranuclear Palsy | Phase 2 | Completed | GemVax & Kael | 78 | 2023-06-14 | 2026-02-10 |
| Speech Accessibility Project Parkinson Disease, Progressive Supranuclear Palsy | Completed | University of Illinois at Urbana-Champaign | 485 | 2023-03-15 | 2025-08-17 | |
| NMR Based Metabolomic Study of Serum Biomarkers in Patients With Parkinson's Disease and Atypical Parkinsonian Syndrome Progressive Supranuclear Palsy, Multiple System Atrophy | Unknown | Fujian Medical University Union Hospital | 180 | 2023-02-01 | 2024-07-08 |
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Supranuclear Palsy, Progressive (117) · Parkinson Disease (42) · Multiple System Atrophy (37) · Corticobasal Degeneration (31) · Parkinsonian Disorders (19) · Lewy Body Disease (15) · Alzheimer Disease (14) · Frontotemporal Dementia (12) · Neurodegenerative Diseases (8) · Pick Disease of the Brain (7) · Cognitive Dysfunction (6) · Amyotrophic Lateral Sclerosis (5) · Dementia (5) · Huntington Disease (5) · Tauopathies (5)
Basal Ganglia Diseases (117) · Central Nervous System Diseases (117) · Cranial Nerve Diseases (117) · Eye Diseases (117) · Neurologic Manifestations (117) · Ocular Motility Disorders (117) · Ophthalmoplegia (117) · Paralysis (117) · Pathological Conditions, Signs and Symptoms (117) · Signs and Symptoms (117) · Brain Diseases (116) · Nervous System Diseases (115) · Movement Disorders (114) · Tauopathies (112) · Neurodegenerative Diseases (109)
Transcranial Direct Current Stimulation (3) · coenzyme Q10 (3) · florbetapir (3) · ((18)F)PI-2620 (2) · Observation (2) · Physical Therapy Modalities (2) · Saline Solution (2) · Transcranial Magnetic Stimulation (2) · davunetide (2) · 2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (1) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (1) · Acetylcarnitine (1) · Amantadine (1) · Apomorphine (1) · Blood Specimen Collection (1)
IRCCS San Raffaele Roma (4) · University of California, San Francisco (4) · Massachusetts General Hospital (3) · Assistance Publique Hopitaux De Marseille (2) · Chang Gung Memorial Hospital (2) · Fondazione Europea di Ricerca Biomedica Ferb Onlus (2) · GemVax & Kael (2) · Institut National de la Santé Et de la Recherche Médicale, France (2) · Invicro (2) · Kliniken Beelitz GmbH (2) · Lahey Clinic (2) · Life Molecular Imaging GmbH (2) · Molecular NeuroImaging (2) · Nantes University Hospital (2) · National Institute of Neurological Disorders and Stroke (NINDS) (2)
United States (54) · Germany (16) · France (14) · Italy (14) · United Kingdom (10) · Canada (8) · Spain (8) · China (4) · South Korea (4) · Australia (2) · Austria (2) · Belgium (2) · Israel (2) · Japan (2) · Poland (2)
Adam Boxer, MD, PhD (3) · Andrea Pilotto, MD (2) · Andrew Stephens, MD, PhD (2) · Diana Apetauerova, MD (2) · Florin Gandor, MD (2) · Giuseppe Frazzitta, MD (2) · Maria C Tartaglia, M.D. (2) · Sang Jae Kim (2) · Adam Boxer, M.D., PhD. (1) · Adam L. Boxer, M.D., Ph.D. (1) · Alastair Noyce, PhD (1) · Albert Montillo, PhD (1)
PMID 28436538, PMID 38825840, PMID 19029129, PMID 19771175, PMID 21386111, PMID 21829612, PMID 23017648, PMID 23706025, PMID 24438512, PMID 24860459, PMID 24873720, PMID 26469868, PMID 27136096, PMID 27160012, PMID 27583276, PMID 28158197, PMID 29973911, PMID 31122495, PMID 31325988, PMID 31621619, PMID 32078894, PMID 33609476, PMID 33649343, PMID 34232829, PMID 34712113, PMID 34937781, PMID 38082255, PMID 38563872, PMID 38692728, PMID 39344233, PMID 40288787, PMID 40368603, PMID 41219570, PMID 41239890, PMID 41526364, PMID 41864233, PMID 42399256, PMID 42418748, PMID 42876454
2008 (1), 2016 (1), 2019 (1), 2023 (1), P50NS123067 (1), R01AG024040 (1), R01AG031278 (1), R01AG059417 (1), R01NS089757 (1), U01NS050095 (1), U01NS112010 (1), U01NS119562 (1)