51 completed, 16 recruiting, 16 unknown, 9 enrolling by invitation. 22 Phase 2, 21 Not applicable, 18 Phase 1, 4 Phase 3, 3 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Alzheimer's Tau Platform: Regimen A - AADvac1 AADvac1, Donanemab - Preclinical Alzheimer's Disease, Prodromal Alzheimer's Disease | Phase 2 | Enrolling by invitation | Paul S. Aisen | 450 | 2026-11-03 | 2026-09-08 |
| A Study to Evaluate the Safety, Tolerability and Pharmacodynamics of NIO752 in Primary Tauopathies NIO752, Placebo - Progressive Supranuclear Palsy, Corticobasal Degeneration | Phase 2 | Not yet recruiting | Novartis Pharmaceuticals | 48 | 2026-10-23 | 2026-10-09 |
| Restoring Cervical Lymphatic Drainage in Alzheimer's Disease Cervical lymphovenous anastomosis (LVA) - Alzheimer, Alzheimer Dementia (AD) | Not applicable | Recruiting | University of Siena | 5 | 2026-07-01 | 2026-10-02 |
| A Study to Evaluate the Efficacy of NIO752 in Participants With Progressive Supranuclear Palsy NIO752, Placebo - Progressive Supranuclear Palsy Richardson Syndrome (PSP-RS) | Phase 3 | Recruiting | Novartis Pharmaceuticals | 300 | 2026-06-03 | 2026-10-15 |
| Links Between Self-awareness and Sociocognitive Processes in Neurodegenerative Diseases Computer-based facial expression recognition task, Computerized affective task, UCLA Structured Insight Interview - Frontotemporal Dementia, Behavioral Variant, Alzheimer Disease | Recruiting | Assistance Publique - Hôpitaux de Paris | 34 | 2026-04-01 | 2026-04-15 | |
| Learning Amyloid and Tau Results Disclose amyloid, tau results, Follow-up Assessments - Alzheimer Disease | Enrolling by invitation | University of Wisconsin, Madison | 240 | 2026-02-17 | 2026-06-24 | |
| First-in-Human Study for the Safety and Evaluation of Two 4R Tau Ligands as Potential PET Radioligands for Imaging Tau Protein in the Brain [18F]ABBV-964i, [18F]ABBV-965i, Lead Candidate - Progressive Supranuclear Palsy (PSP), Healthy Participants | Early Phase 1 | Completed | Invicro | 11 | 2025-11-17 | 2026-07-10 |
| Daridorexant for Alzheimer Disease Prevention Daridorexant 50 mg, Placebo - Alzheimer Disease (AD) | Phase 2 | Recruiting | Douglas Mental Health University Institute | 240 | 2025-10-14 | 2025-12-19 |
| Investigator Initiated Study for the Safety and Efficacy in Frontotemporal Dementia NS101 IV infusion, Placebo IV Infusion - Dementia Frontotemporal | Phase 2 | Not yet recruiting | Hee-Jin Kim | 15 | 2025-10-01 | 2025-09-04 |
| A Dual Orexin Receptor Antagonist to Reduce Biomarkers of Neurodegeneration in Adults With Insomnia. Lemborexant 10 MG, Placebo - Insomnia | Phase 2 | Recruiting | Woolcock Institute of Medical Research | 20 | 2025-05-13 | 2026-09-18 |
| Vortioxetine for the Treatment of Mood and Cognitive Symptoms in Frontotemporal Dementia Vortioxetine - Fronto-temporal Dementia, Fronto-temporal Lobar Dementia | Phase 2 | Recruiting | Johns Hopkins University | 50 | 2025-03-20 | 2026-03-09 |
| ETASCAI Pilot Project Active 1 ETAS®, Active 2 ETAS®, Placebo - Cognition, Affect (Mental Function) | Not applicable | Completed | University of Reading | 45 | 2025-02-24 | 2025-11-19 |
| Understanding Mechanisms of Synaptic Degeneration Underlying Clinical Symptoms in Patients With MDs and NDs. Schizophrenia Disorder, Frontotemporal Dementia, Behavioral Variant | Enrolling by invitation | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 150 | 2025-02-01 | 2025-12-11 | |
| The Skin as a Window to the Central Nervous System in Frontotempolar Lombar Degeneration Skin biopsy - Frontotemporal Lobar Degeneration | Not applicable | Recruiting | Nantes University Hospital | 80 | 2024-12-17 | 2024-12-20 |
| Incremental Diagnostic Value of Tau-PET With [18F]RO948 vs Amyloid-PET in Patients With Cognitive Impairment PET/CT with RO958 (experimental) - Dementia, Alzheimer Disease | Not applicable | Recruiting | University Hospital, Geneva | 120 | 2024-12-03 | 2025-12-23 |
| A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease LY3954068, Placebo, Flortaucipir F18 - Alzheimer Disease | Phase 1 | Recruiting | Eli Lilly and Company | 48 | 2024-08-15 | 2026-08-24 |
| Family Caregiver Online Survey (Dementia and Swallowing Difficulties) Dementia, Dysphagia | Completed | University of Oregon | 219 | 2023-11-07 | 2025-12-18 | |
| Tau PET Imaging in Opioid Use Disorder 18F-PI-2620 PET/CT - Opioid-Related Disorders | Early Phase 1 | Completed | University of Pennsylvania | 12 | 2023-09-21 | 2026-06-09 |
| Localized Analysis of Normalized Distance From Scalp to Cortex and Personalized Evaluation (LANDSCAPE) Transcranial Magnetic Stimulation - Aging, Dementia Alzheimers | Enrolling by invitation | Chinese University of Hong Kong | 488 | 2023-06-15 | 2025-01-14 | |
| BioFINDER-Brown: Examination of Alzheimer's Disease Biomarkers Flutemetamol F18 Injection, [18F]-RO6958948 Injection, [18F]-MK-6240 Injection - Alzheimer Disease, Mild Cognitive Impairment | Enrolling by invitation | Butler Hospital | 200 | 2023-06-14 | 2024-12-17 |
Showing 20 of 103. Sign in to see all of them.
Alzheimer Disease (53) · Dementia (31) · Cognitive Dysfunction (20) · Frontotemporal Dementia (18) · Plaque, Amyloid (14) · Supranuclear Palsy, Progressive (12) · Tauopathies (10) · Lewy Body Disease (8) · Corticobasal Degeneration (7) · Neurodegenerative Diseases (7) · Cognition Disorders (6) · Dementia, Vascular (6) · Parkinson Disease (6) · Aphasia, Primary Progressive (5)
Brain Diseases (100) · Central Nervous System Diseases (100) · Frontotemporal Lobar Degeneration (100) · Mental Disorders (99) · Nervous System Diseases (99) · Neurocognitive Disorders (99) · Frontotemporal Dementia (85) · Neurodegenerative Diseases (76) · Dementia (72) · Tauopathies (54) · Pathological Conditions, Signs and Symptoms (46) · Nutritional and Metabolic Diseases (26) · Metabolic Diseases (25) · Neurologic Manifestations (25) · Signs and Symptoms (25)
7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (7) · AADvac1 (4) · florbetapir (4) · 4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene (3) · Genetic Testing (2) · Lithium (2) · MK-6240 (2) · Memantine (2) · Observation (2) · Oxytocin (2) · PI-2620 (2) · Spinal Puncture (2) · THK5351 (2) · Transcranial Direct Current Stimulation (2) · ((18)F)PI-2620 (1)
University of California, San Francisco (5) · University of Southern California (5) · University of Pennsylvania (4) · Axon Neuroscience SE (3) · National Institute of Neurological Disorders and Stroke (NINDS) (3) · Novartis Pharmaceuticals (3) · Assistance Publique - Hôpitaux de Paris (2) · Chinese University of Hong Kong (2) · Eli Lilly and Company (2) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (2) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (2) · Mayo Clinic (2) · University of California, Los Angeles (2) · Xuanwu Hospital, Beijing (2) · APRINOIA Therapeutics, LLC (1)
United States (49) · Canada (18) · France (9) · United Kingdom (9) · Spain (7) · Germany (6) · Italy (6) · Australia (5) · China (5) · Sweden (5) · Netherlands (4) · South Korea (4) · Japan (3) · Argentina (2) · Austria (2)
Adam Boxer, MD, PhD (3) · Michael W. Weiner, MD (3) · Paul Aisen, MD (3) · Elizabeth C Finger, MD (2) · Ronald Petersen, MD, PhD (2) · Adam L Boxer, MD, PhD (1) · Adam M. Brickman, Ph.D. (1) · Aimee Spector, PhD, DClinPsy (1) · Alessandro Martorana, MD, PhD (1) · Alwin Cunje, MD, PhD (1) · Andres Lozano, MD, PhD (1) · Ariel Gildengers, MD (1) · Bernard Bonnin, MD PhD (1) · Biao Chen, Doctor (1)
PMID 34187867, PMID 38853879, PMID 39219209, PMID 39324520, PMID 42862762, PMID 10720283, PMID 1580810, PMID 16799555, PMID 17909133, PMID 21792308, PMID 22674572, PMID 23165340, PMID 24011928, PMID 25503617, PMID 26441570, PMID 27307127, PMID 27421618, PMID 27814297, PMID 27955995, PMID 30355322, PMID 31834916, PMID 33773598, PMID 34057284, PMID 34937781, PMID 34942516, PMID 35184428, PMID 36057375, PMID 37095250, PMID 3736630, PMID 37897201, PMID 37902726, PMID 38000822, PMID 38578117, PMID 38594621, PMID 38848116, PMID 38959435, PMID 39580468, PMID 40248174, PMID 40501510, PMID 40809903, PMID 41164840, PMID 41281734, PMID 41389437, PMID 41673497, PMID 41770546, PMID 41864233, PMID 42366274, PMID 42441396
2016 (2), U01AG024904 (2), 1RF1AG058067-01A1 (1), 2015 (1), 2017 (1), 2023 (1), 2RF1AG038465-06 (1), K23AG088248 (1), P01AG025831 (1), P30AG066509 (1), R01AG031278 (1), R01AG038791 (1), R01AG050440 (1), R01AG055299 (1), R01AG055389 (1)