Cranial Nerve Diseases: Clinical Trials

755 completed, 274 unknown, 222 recruiting, 103 not yet recruiting. 513 Not applicable, 260 Phase 2, 210 Phase 1, 125 Phase 3, 63 Phase 4.

By phase and status

Phase	Trials	Status
Not applicable	513	Completed 233, Unknown 111, Recruiting 71, Not yet recruiting 44, Terminated 21, Active not recruiting 14, Withdrawn 10, Enrolling by invitation 7, Suspended 2
Phase 2	260	Completed 125, Unknown 37, Terminated 33, Recruiting 31, Active not recruiting 14, Not yet recruiting 10, Withdrawn 7, Enrolling by invitation 2, Suspended 1
Phase 1	210	Completed 125, Recruiting 25, Terminated 20, Unknown 17, Not yet recruiting 10, Active not recruiting 6, Withdrawn 6, Suspended 1
Phase 3	125	Completed 52, Unknown 24, Terminated 15, Recruiting 13, Active not recruiting 9, Withdrawn 9, Not yet recruiting 3
Phase 4	63	Completed 35, Unknown 11, Withdrawn 5, Terminated 4, Not yet recruiting 3, Recruiting 3, Active not recruiting 2
Early Phase 1	38	Completed 14, Unknown 8, Recruiting 7, Withdrawn 4, Not yet recruiting 3, Terminated 2

Follow Cranial Nerve Diseases: new trials by email Literature Review of Cranial Nerve Diseases trials Research Report on Cranial Nerve Diseases

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Assessment of Laryngopharyngeal Sensation: Cancer Survivor Cohort Cheung-Bearelly Aesthesiometer, Transnasal Laryngoscopy, Questionnaires - Presbylarynx, Aspiration		Suspended	University of California, San Francisco	505	2027-06-30	2026-11-05
Focused Versus Multi-Target Trigger Point Injection for Chronic Myofascial Neck Pain Lidocaine 1% Trigger Point Injection - Myofacial Pain Syndrome, Chronic Neck Pain	Not applicable	Not yet recruiting	Mardin Artuklu University	100	2027-04-01	2026-10-20
Proactively Intervening On Early Cranial Nerve Injury As A Delayed Sequela Of Oropharyngeal Cancer: A Randomized Feasibility Clinical Trial For Pro-Habilitation (proNERVE RCT) Prednisone, Ajovy, Manual Therapy - Cranial Nerve Injury, Oropharyngeal Cancer	Phase 1	Not yet recruiting	M.D. Anderson Cancer Center	48	2027-03-01	2026-09-21
Digital Health Technologies for Progressive Supranuclear Palsy and Dementia With Lewy Bodies Progressive Supranuclear Palsy(PSP), Dementia With Lewy Bodies (DLB)		Not yet recruiting	BioSensics	60	2027-01-15	2026-10-13
Observational Safety Study in Women With Neuromyelitis Optica Spectrum Disorder (NMOSD) Exposed to UPLIZNA® During Pregnancy UPLIZNA - Neuromyelitis Optica Spectrum Disorder, Pregnancy Related		Recruiting	Amgen	60	2027-01-15	2026-10-29
Role of ChatGPT in Vestibular Schwannoma Management Use of chatGPT for 1 week - Vestibular Schwannoma	Not applicable	Withdrawn	University of Southern California		2027-01-01	2026-01-13
Usefulness and Feasibility of Ultrasound in Office Laryngology Procedures Ultrasound for cough, Ultrasound for vocal fold atrophy or vocal fold paresis/paralysis, Ultrasound for dysphagia - Cough, Vocal Cord Atrophy	Not applicable	Not yet recruiting	Weill Medical College of Cornell University	200	2027-01-01	2026-06-16
A Randomized Trial of Botulinum Toxin A vs Strabismus Surgery for Esotropia >10 to ≤30PD Botulinum toxin A, bilateral medial rectus recession - Esotropia	Phase 3	Not yet recruiting	Jaeb Center for Health Research	244	2027-01-01	2026-04-06
Recurrent Laryngeal Nerve Monitoring During Pediatric Aerodigestive Tract and Cardiac Surgery Intraoperative laryngeal nerve monitor - Unilateral Vocal Cord Paralysis, Unilateral Vocal Cord Paresis	Not applicable	Not yet recruiting	University of Alberta	90	2027-01-01	2026-10-27
A Phase IIb Study of Nabiximols for Spasticity Due to Neuromyelitis Optica Spectrum Disorders Nabiximols, Placebo - NMO Spectrum Disorder, Spasticity, Muscle	Phase 2	Withdrawn	Michael, Levy M.D.,Ph.D.		2026-12-31	2025-07-16
Safety and Efficacy of BAFFR CART for Relapsed/ Refractory Neuromyelitis Optica Spectrum Disorder Anti-BAFFR CART - Neuromyelitis Optica Spectrum Disorder	Phase 1 / Phase 2	Not yet recruiting	Tianjin Medical University General Hospital	20	2026-12-01	2026-10-16
Single Dose 4-Aminopyridine for Diagnosing Recurrent Laryngeal Nerve Paralysis Continuity After Trauma 4-Aminopyridine - Vocal Cord Paralysis, Recurrent Laryngeal Nerve Palsy	Phase 1	Not yet recruiting	Milton S. Hershey Medical Center	50	2026-12-01	2026-09-21
Laryngotracheal Lesions in Adults With Long-Term Tracheostomy Standardized Three-Station Bronchoscopy - Laryngotracheal Lesions, Tracheostomy Complications		Not yet recruiting	Hongying Jiang, MD	220	2026-12-01	2026-10-28
Selumetinib for NF2-Related Schwannomatosis Selumetinib - Neurofibromatosis Type 2, NF2	Phase 2	Not yet recruiting	Beijing Tiantan Hospital	20	2026-12-01	2026-10-28
Twenty-five Years of Advanced RadioTherapy at San Raffaele Hospital Advanced radiotherapy techniques - Malignant Tumor, Benign Neoplasm		Not yet recruiting	IRCCS San Raffaele	10000	2026-11-15	2026-10-29
Subclinical Optic Nerve Changes After Le Fort I Osteotomy RNFL-OCT and Optic Disc Assessment, Diagnostic Test, Preoperative CBCT Measurement of Pterygomaxillary Junction - Optic Nerve Diseases		Not yet recruiting	Yağmur Malkoc	50	2026-11-04	2026-11-10
Emerging Indications for Hyperbaric Oxygen Treatment Hyperbaric oxygen treatment (HBOT), 100% Oxygen - Post-COVID-19 Condition, Ulcerative Colitis	Phase 4	Not yet recruiting	Jay C. Buckey Jr.	100	2026-11-01	2026-09-09
Natural History of MTBI-related Convergence Insufficiency & Effectiveness of Vision Therapy for MTBI-related CI Office-Based Vergence/Accommodative Therapy with Movement (OBVAM) - Convergence Insufficiency	Phase 2	Not yet recruiting	Salus University	100	2026-11-01	2025-02-27
Attention-based Binocular Training for Impaired Stereopsis (BRAVE) Attention-Guided Dichoptic Visual Search Training, Zero-Disparity Dichoptic Visual Search Task - Amblyopia, Strabismus	Not applicable	Not yet recruiting	Centre for Eye and Vision Research	56	2026-11-01	2026-09-03
Effect of Ketamine-Propofol Total Intravenous Anesthesia Versus Sevoflurane-Based Anesthesia on Postoperative Vomiting in Children Undergoing Strabismus Surgery Ketamine and Propofol, Sevoflurane - Postoperative Vomiting, Postoperative Nausea and Vomiting	Phase 4	Not yet recruiting	Assiut University	50	2026-11-01	2026-10-13

Showing 20 of 1573. Sign in to see all of them.

Narrower conditions

Neuromyelitis Optica (172)  ·  Supranuclear Palsy, Progressive (171)  ·  Trigeminal Neuralgia (139)  ·  Strabismus (134)  ·  Multiple Sclerosis (105)  ·  Neuroma, Acoustic (98)  ·  Optic Neuritis (87)  ·  Astrocytoma (83)  ·  Bell Palsy (83)  ·  Optic Nerve Glioma (82)  ·  Esthesioneuroblastoma, Olfactory (74)  ·  Parkinson Disease (67)  ·  Medulloblastoma (64)  ·  Oligodendroglioma (63)  ·  Optic Nerve Diseases (61)

Broader conditions

Nervous System Diseases (1561)  ·  Eye Diseases (944)  ·  Pathological Conditions, Signs and Symptoms (613)  ·  Signs and Symptoms (508)  ·  Neurologic Manifestations (496)  ·  Optic Nerve Diseases (459)  ·  Central Nervous System Diseases (447)  ·  Ocular Motility Disorders (386)  ·  Brain Diseases (374)  ·  Stomatognathic Diseases (354)  ·  Mouth Diseases (344)  ·  Neoplasms (341)  ·  Neoplasms by Site (328)  ·  Neurodegenerative Diseases (321)

Interventions

Botulinum Toxins, Type A (16)  ·  Filgrastim (16)  ·  Methylprednisolone (16)  ·  Carboplatin (15)  ·  Bevacizumab (14)  ·  Prednisone (12)  ·  Radiotherapy (12)  ·  Temozolomide (12)  ·  Adrenal Cortex Hormones (11)  ·  Radiosurgery (11)  ·  Rituximab (11)  ·  Cyclophosphamide (10)  ·  Etoposide (10)  ·  Dexamethasone (9)  ·  Lidocaine (9)

Sponsors

National Cancer Institute (NCI) (41)  ·  National Eye Institute (NEI) (21)  ·  Beijing Tiantan Hospital (20)  ·  Assiut University (16)  ·  University of California, San Francisco (16)  ·  Cairo University (14)  ·  Tianjin Medical University General Hospital (14)  ·  Fondation Ophtalmologique Adolphe de Rothschild (13)  ·  Massachusetts General Hospital (13)  ·  Children's Oncology Group (12)  ·  Stanford University (11)  ·  Biogen (10)  ·  Hospices Civils de Lyon (10)  ·  Johns Hopkins University (10)  ·  NYU Langone Health (10)

Countries

United States (584)  ·  China (171)  ·  France (137)  ·  United Kingdom (100)  ·  Canada (95)  ·  Italy (82)  ·  Germany (76)  ·  Egypt (61)  ·  Turkey (Türkiye) (60)  ·  Spain (53)  ·  South Korea (43)  ·  Australia (34)  ·  Pakistan (33)  ·  Denmark (30)  ·  Taiwan (28)

Top investigators

Adam Boxer, MD, PhD (8)  ·  Michael Levy, MD, PhD (7)  ·  Fu-Dong Shi, MD,PhD (4)  ·  Irene Litvan, MD (4)  ·  Mitchell Scheiman, OD (4)  ·  Robert W Arnold, MD (4)  ·  Sahar TA Abdelaziz, MD (4)  ·  Ana-Maria Vranceanu, PhD (3)  ·  Anne-Marie Wills, MD (3)

Results publications

PMID 33263359, PMID 36449262, PMID 34108929, PMID 34516656, PMID 38825840, PMID 40743487, PMID 1527657, PMID 15642806, PMID 16044063, PMID 17917842, PMID 18852411, PMID 19574236, PMID 19645909, PMID 21211990, PMID 22027076, PMID 26199618, PMID 26604914, PMID 26606867, PMID 26892229, PMID 27857759, PMID 27904503, PMID 28436538, PMID 30194931, PMID 31640452, PMID 33676197, PMID 34498507, PMID 35790423, PMID 36007339, PMID 36724181, PMID 36809645, PMID 38917142, PMID 40288333, PMID 10449559, PMID 10503856, PMID 10630935, PMID 10916328, PMID 11162985, PMID 11587600, PMID 11704310, PMID 11710496, PMID 11981398, PMID 12128137, PMID 12140424, PMID 12525530, PMID 12544040, PMID 12621288, PMID 12760985, PMID 12925338, PMID 12943357, PMID 1463007

NIH funding

2017 (9), U01CA081457 (9), U01CA097452 (8), 2016 (6), 2019 (6), U10CA098543 (6), 2014 (5), P30CA068485 (5), U10EY011751 (5), 2015 (4), 2023 (3), P30CA043703 (3), R01AG085029 (3), U10CA031946 (3), 2008 (2)