95 completed, 37 recruiting, 22 unknown, 11 active not recruiting. 45 Not applicable, 33 Phase 2, 23 Phase 1, 10 Phase 3, 8 Early Phase 1.
Follow Ophthalmoplegia: new trials by email Literature Review of Ophthalmoplegia trials Research Report on Ophthalmoplegia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Digital Health Technologies for Progressive Supranuclear Palsy and Dementia With Lewy Bodies Progressive Supranuclear Palsy(PSP), Dementia With Lewy Bodies (DLB) | Not yet recruiting | BioSensics | 60 | 2027-01-15 | 2026-10-13 | |
| A Study to Evaluate the Safety, Tolerability and Pharmacodynamics of NIO752 in Primary Tauopathies NIO752, Placebo - Progressive Supranuclear Palsy, Corticobasal Degeneration | Phase 2 | Not yet recruiting | Novartis Pharmaceuticals | 48 | 2026-10-23 | 2026-10-09 |
| Study Evaluating the Effect of Transcranial Direct Current Stimulation (tDCS) Targeting the Right Inferior Frontal Gyrus on Inhibitory Control in Patients With PSP tDCS, or transcranial direct current stimulation - PSP - Progressive Supranuclear Palsy | Not applicable | Not yet recruiting | Nantes University Hospital | 20 | 2026-09-15 | 2026-09-14 |
| Tributyrin for Progressive Supranuclear Palsy (PSP): Virtual Trial Tributyrin, Placebo - Parkinson Disease, Multiple System Atrophy | Phase 1 / Phase 2 | Recruiting | Prabesh Kanel | 15 | 2026-09-01 | 2026-10-07 |
| VisMemoPD Protocol: an Observational Pilot Study on Spatial and Topographical Memory in Patients With Parkinson's Disease and Parkinsonism Multimodal visuospatial and topographical memory assessment - Parkinson's Disease, Parkinsonism | Not yet recruiting | IRCCS San Raffaele Roma | 80 | 2026-09-01 | 2026-09-18 | |
| Remote Monitoring in Progressive Supranuclear Palsy (PSP) Progressive Supranuclear Palsy, Parkinson Disease | Not yet recruiting | Massachusetts General Hospital | 85 | 2026-09-01 | 2026-07-29 | |
| The Progressive Supranuclear Palsy Clinical Trial Platform - Regimen B: LM11A-31 LM11A-31, Matching Placebo - PSP - Progressive Supranuclear Palsy | Phase 2 | Enrolling by invitation | Adam Boxer | 147 | 2026-07-29 | 2026-08-12 |
| The Progressive Supranuclear Palsy Clinical Trial Platform - Regimen A: AADvac1 AADvac1, Matching Placebo - PSP - Progressive Supranuclear Palsy | Phase 2 | Enrolling by invitation | Adam Boxer | 146 | 2026-07-29 | 2026-08-13 |
| The Progressive Supranuclear Palsy Clinical Trial Platform AADvac1, LM11A-31 - Progressive Supranuclear Palsy(PSP) | Phase 2 | Recruiting | Adam Boxer | 440 | 2026-07-29 | 2026-10-22 |
| Prospective Natural History Study of POLG Disease PolG, Primary Mitochondrial Myopathy | Recruiting | The POLG Foundation | 300 | 2026-06-17 | 2026-09-15 | |
| Early Molecular Biomarkers for Differentiating Parkinsonian Syndromes PARKINSON DISEASE (Disorder), Atypical Parkinsonism | Not yet recruiting | International Institute of Molecular and Cell Biology in Warsaw | 200 | 2026-06-04 | 2026-05-28 | |
| A Study to Evaluate the Efficacy of NIO752 in Participants With Progressive Supranuclear Palsy NIO752, Placebo - Progressive Supranuclear Palsy Richardson Syndrome (PSP-RS) | Phase 3 | Recruiting | Novartis Pharmaceuticals | 300 | 2026-06-03 | 2026-10-15 |
| Wellness in PSP and CBD Exercise and Peer Support - Progressive Supranuclear Palsy, Corticobasal Degeneration | Not applicable | Recruiting | Silke Cresswell | 30 | 2026-04-10 | 2026-09-28 |
| Ultra-High Resolution PET in Aging, Neurodegeneration and Psychotic Disorders UHR PET/CT scan of the brain with ¹⁸F-FDG, UHR PET/CT scan of the brain with ¹⁸F-PE2I, UHR PET/CT scan of the brain with ¹⁸F-SynVesT-1 - Alzheimer Dementia (AD), ALS - Amyotrophic Lateral Sclerosis | Not applicable | Recruiting | Universitaire Ziekenhuizen KU Leuven | 300 | 2026-02-13 | 2026-04-03 |
| Individualized Transcranial Magnetic Stimulation in Parkinsonian Disorders TMS - Parkinson's Disease, Multiple System Atrophy | Not applicable | Recruiting | Peking University First Hospital | 50 | 2025-12-22 | 2026-06-29 |
| Biofluid Research on Age-Related or Inherited Neurodegeneration Frontotemporal Degeneration (FTD), ALS (Amyotrophic Lateral Sclerosis) | Recruiting | University of Pennsylvania | 1000 | 2025-12-12 | 2026-09-01 | |
| First-in-Human Study for the Safety and Evaluation of Two 4R Tau Ligands as Potential PET Radioligands for Imaging Tau Protein in the Brain [18F]ABBV-964i, [18F]ABBV-965i, Lead Candidate - Progressive Supranuclear Palsy (PSP), Healthy Participants | Early Phase 1 | Completed | Invicro | 11 | 2025-11-17 | 2026-07-10 |
| Multi-Center Study of Natural History in Atypical Parkinsonian Syndromes (MAPS-NH) We did not apply any interventions; only observational research was conducted. - Multiple System Atrophy, Dementia With Lewy Bodies (DLB) | Recruiting | Second Affiliated Hospital of Soochow University | 500 | 2025-11-12 | 2026-09-08 | |
| tDCS as Treatment for Motor Function Transcranial direct current stimulation (TDCS), Stimulation Arm - Progressive Supranuclear Palsy, Cortical Basal Ganglionic Degeneration | Not applicable | Recruiting | Baycrest | 20 | 2025-10-30 | 2025-12-18 |
| Collection of Digital Parameters From Parts of the Neurological Examination Using an Eye Tracker Geriatric, Parkinsons Disease (PD) | Not yet recruiting | University of Kiel | 600 | 2025-08-31 | 2025-08-26 |
Showing 20 of 189. Sign in to see all of them.
Supranuclear Palsy, Progressive (170) · Parkinson Disease (63) · Multiple System Atrophy (55) · Corticobasal Degeneration (49) · Lewy Body Disease (27) · Alzheimer Disease (26) · Parkinsonian Disorders (25) · Frontotemporal Dementia (18) · Amyotrophic Lateral Sclerosis (13) · Ophthalmoplegia, Chronic Progressive External (12) · Pick Disease of the Brain (12) · Neurodegenerative Diseases (11) · Tauopathies (11) · Dementia (10) · Frontotemporal Lobar Degeneration (8)
Cranial Nerve Diseases (189) · Eye Diseases (189) · Neurologic Manifestations (189) · Ocular Motility Disorders (189) · Paralysis (189) · Pathological Conditions, Signs and Symptoms (189) · Signs and Symptoms (189) · Nervous System Diseases (187) · Central Nervous System Diseases (182) · Brain Diseases (179) · Basal Ganglia Diseases (170) · Neurodegenerative Diseases (164) · Movement Disorders (163) · Tauopathies (159)
Observation (4) · Transcranial Direct Current Stimulation (4) · florbetapir (4) · Transcranial Magnetic Stimulation (3) · coenzyme Q10 (3) · gosuranemab (3) · tilavonemab (3) · ((18)F)PI-2620 (2) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (2) · AADvac1 (2) · Blood Specimen Collection (2) · Cysteamine (2) · LM11A-31 (2) · Physical Therapy Modalities (2) · Rivastigmine (2)
University of California, San Francisco (8) · University of Pennsylvania (5) · Adam Boxer (4) · IRCCS San Raffaele Roma (4) · Massachusetts General Hospital (4) · Molecular NeuroImaging (4) · AbbVie (3) · Assistance Publique Hopitaux De Marseille (3) · Biogen (3) · Fondation Ophtalmologique Adolphe de Rothschild (3) · Invicro (3) · Mayo Clinic (3) · Nantes University Hospital (3) · National Institute of Neurological Disorders and Stroke (NINDS) (3) · Novartis Pharmaceuticals (3)
United States (95) · Germany (24) · Italy (24) · France (23) · United Kingdom (22) · Canada (15) · Spain (14) · China (9) · Australia (7) · Netherlands (7) · Belgium (6) · South Korea (6) · Japan (5) · Austria (4) · Poland (4)
Adam Boxer, MD, PhD (8) · Irene Litvan, MD (4) · Anne-Marie Wills, MD (3) · Julio Rojas-Martinez, MD, PhD (3) · Adam L Boxer, MD, PhD (2) · Andrea Pilotto, MD (2) · Andrew Stephens, MD, PhD (2) · Danna Jennings, MD (2) · Diana Apetauerova, MD (2) · Florin Gandor, MD (2) · Giuseppe Frazzitta, MD (2)
PMID 38825840, PMID 28436538, PMID 35790423, PMID 17784944, PMID 19029129, PMID 19771175, PMID 21386111, PMID 21829612, PMID 23017648, PMID 23550093, PMID 23706025, PMID 24438512, PMID 24860459, PMID 24873720, PMID 26469868, PMID 26881179, PMID 27136096, PMID 27160012, PMID 27231659, PMID 27583276, PMID 28158197, PMID 29973911, PMID 31122495, PMID 31325988, PMID 31621619, PMID 31710340, PMID 32078894, PMID 33609476, PMID 33649343, PMID 33827960, PMID 33894193, PMID 34006157, PMID 34232829, PMID 34289275, PMID 34385707, PMID 34489348, PMID 34712113, PMID 34736158, PMID 34934801, PMID 34937781, PMID 35410449, PMID 35492244, PMID 37838080, PMID 37955923, PMID 38082255, PMID 38563872, PMID 38578117, PMID 38692728, PMID 38959435, PMID 39344233
2016 (3), R01AG085029 (3), 2017 (2), P01AG066597 (2), 1UF1AG094587-01 (1), 2008 (1), 2019 (1), 2023 (1), K23NS121402 (1), KL2TR002370 (1), P2CHD086844 (1), P30AG072979 (1), P50NS123067 (1), R01AG024040 (1), R01AG031278 (1)