6 completed, 3 recruiting, 1 active not recruiting, 1 enrolling by invitation. 4 Phase 1, 3 Phase 2, 2 Phase 3, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 4 | Completed 3, Terminated 1 |
| Phase 2 | 3 | Completed 2, Recruiting 1 |
| Phase 3 | 2 | Recruiting 2 |
| Early Phase 1 | 1 | Completed 1 |
Follow ((18)F)PI-2620: new trials by email Literature Review of ((18)F)PI-2620 trials Research Report on ((18)F)PI-2620
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of Tau-Pathology in Sporadic and LRRK2 Parkinson's Disease [18F]PI-2620 - Parkinson's Disease | Phase 2 | Recruiting | Michael J. Fox Foundation for Parkinson's Research | 60 | 2025-05-12 | 2026-08-10 |
| Alzheimer's Disease Neuroimaging Initiative 4 Neuraceq, Amyvid, Tauvid - Mild Cognitive Impairment, Alzheimer Disease | Enrolling by invitation | University of Southern California | 1500 | 2023-06-09 | 2026-09-29 | |
| [18F]PI-2620 Phase 3 Histopathological Study [18F]PI-2620 - Alzheimer Disease | Phase 3 | Recruiting | Lantheus Biosciences Ltd. | 200 | 2022-12-01 | 2026-10-23 |
| PET Imaging Tau Accumulation in FTLD and Atypical Alzheimer's Using [18F]-PI-2620 [18F]-PI-2620 - Frontotemporal Lobar Degeneration, Alzheimer Disease | Phase 3 | Recruiting | University of Pennsylvania | 72 | 2022-09-19 | 2026-09-21 |
| Test-retest Study With [18F]PI-2620 in PSP-RS and NDC [18F]-PI2620 - Progressive Supranuclear Palsy | Phase 1 | Completed | Life Molecular Imaging GmbH | 15 | 2022-03-10 | 2026-10-26 |
| PPMI Tau PET Imaging [18F] PI-2620 - Parkinson Disease | Phase 2 | Completed | Michael J. Fox Foundation for Parkinson's Research | 23 | 2021-08-30 | 2023-04-21 |
| Imaging [18F]PI-2620 and [18F]Florbetaben in Military Service Members With Blast Related Mild Traumatic Brain Injury [18F]PI-2620 - Mild Traumatic Brain Injury | Phase 1 | Terminated | Life Molecular Imaging SA. | 18 | 2021-06-07 | 2024-05-14 |
| Evaluation of Imaging Characteristics of [18F]PI-2620 PET in AD and PSP Patients Using High and Low Specific Activity [18F]-PI2620 - Alzheimer Disease, Progressive Supranuclear Palsy | Phase 1 | Completed | Life Molecular Imaging GmbH | 10 | 2020-11-12 | 2026-10-26 |
| Evaluation Comparing Tau PET Radiotracers, [18F]GTP1 and [18F]PI-2620 or [18F]MK-6240 in Subjects With Normal Cognition or Prodromal to Moderate Alzheimer's Disease [18F]GTP1, [18F]PI-2620, [18F]MK-6240 - Alzheimer Disease (AD) | Phase 1 | Completed | Genentech, Inc. | 40 | 2020-10-26 | 2023-07-12 |
| Linking Tau PET to Medial Temporal Lobe Subregions With High Resolution MRI 2-(2-([18F]fluoro)pyridin-4-yl)-9H-pyrrolo[2,3-b:4,5-c']dipyridine - Mild Cognitive Impairment | Active not recruiting | University of Pennsylvania | 150 | 2020-03-11 | 2026-09-16 | |
| Longitudinal Changes of [18F]PI-2620 Positron Emission Tomography in Subjects With Cognitively Normal, Mild Cognitive Impairment and Alzheimer's Disease [18F]PI-2620 - Cognitively Normal, Mild Cognitive Impairment | Phase 2 | Completed | Jae Seung Kim | 84 | 2019-04-09 | 2023-09-06 |
| Evaluation of [18F]PI-2620 as a Potential Positron Emission Computed Tomography Radioligand for Imaging Tau Protein in the Brain [18F]PI-2620 - Healthy Volunteer, Alzheimer Disease | Early Phase 1 | Completed | Asan Medical Center | 20 | 2018-06-04 | 2020-12-14 |
Alzheimer Disease (7) · Cognitive Dysfunction (3) · Parkinson Disease (3) · Supranuclear Palsy, Progressive (2) · Tauopathies (2) · Brain Concussion (1) · Brain Injuries, Traumatic (1) · Cognition Disorders (1) · Dementia (1) · Frontotemporal Dementia (1) · Frontotemporal Lobar Degeneration (1) · Pick Disease of the Brain (1) · Plaque, Amyloid (1)
Life Molecular Imaging GmbH (2) · Michael J. Fox Foundation for Parkinson's Research (2) · University of Pennsylvania (2) · Asan Medical Center (1) · Genentech, Inc. (1) · Jae Seung Kim (1) · Lantheus Biosciences Ltd. (1) · Life Molecular Imaging SA. (1) · University of Southern California (1)
United States (8) · Germany (2) · South Korea (2) · Canada (1)
Andrew Stephens, MD, PhD (3) · Alireza Atri, MD, PhD (1) · David Wolk, MD (1) · Jeffrey S Phillips (1) · Ken Marek, MD (1) · Matthias Brendel, MD (1) · Michael Weiner, MD (1) · Paul Aisen, MD (1) · Ronald Petersen, MD, PHD (1)
U19AG024904 (1)