128 completed, 65 unknown, 34 recruiting, 27 not yet recruiting. 96 Not applicable, 28 Phase 4, 10 Phase 2, 8 Phase 3, 1 Early Phase 1.
Follow Postoperative Delirium: new trials by email Literature Review of Postoperative Delirium trials Research Report on Postoperative Delirium
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cerebral Oximetry During Awake Carotid Endarterectomy Masked continuous cerebral oximetry, Standardised awake neurological test, Serial cognitive assessment - Carotid Stenosis, Carotid Artery Diseases | Not yet recruiting | Nguyen Toan Thang | 150 | 2027-01-01 | 2026-09-11 | |
| Transcranial Doppler and Artificial Intelligence Prediction of Postoperative Delirium in Heart Valve Surgery Postoperative Delirium, Heart Valve Diseases | Not yet recruiting | Osman Sila Aydin | 120 | 2026-10-01 | 2026-10-05 | |
| Postoperative Delirium and Analgesia in Elderly Patients adductor canal block and biFes block including bupivacain, Periarticular infiltration - Postoperative Delirium, Postoperative Pain, Acute | Not applicable | Not yet recruiting | Ankara City Hospital Bilkent | 300 | 2026-10-01 | 2026-09-30 |
| Intrathecal Dexmedetomidine and Postoperative Delirium in Elderly Hip Fracture Surgery Dexmedetomidine, Hyperbaric Bupivacaine with Normal Saline - Postoperative Delirium, Hip Fractures | Phase 2 / Phase 3 | Not yet recruiting | Assiut University | 130 | 2026-10-01 | 2026-09-09 |
| Evaluation of a Hospital Program to Prevent Postoperative Delirium in Older Patients Multicomponent delirium prevention program - Postoperative Delirium, Delirium Prevention | Not applicable | Not yet recruiting | Universitätsklinikum Hamburg-Eppendorf | 720 | 2026-10-01 | 2026-08-26 |
| Effects of Remimazolam on Postoperative Cognitive Dysfunction and Neuroinflammatory Biomarkers in Patients Undergoing Aortic Arch Surgery Remimazolam Besylate, propofol - Aortic Aneurysm of the Proximal Arch, Aortic Aneurysms Arch | Phase 4 | Not yet recruiting | Seoul National University Hospital | 80 | 2026-10-01 | 2026-09-17 |
| Music Intervention to Reduce Anxiety and Prevent Delirium in Older Adults Undergoing Cardiac Surgery Music Intervention Group - Postoperative Delirium, Preoperative Anxiety | Not applicable | Not yet recruiting | KU Leuven | 256 | 2026-10-01 | 2026-10-01 |
| BrainProtect-guided, Real-time Cerebral Autoregulation Monitoring and Protection of Brain During Cardiac Surgery With Cardiopulmonary Bypass Requiring Heart-lung Machine BrainProtect System, Standard perioperative management - Cerebral Autoregulation Impairment, Postoperative Cognitive Dysfunction | Not applicable | Not yet recruiting | Scienceforbrain, UAB | 304 | 2026-09-30 | 2026-10-14 |
| Creatine and Perioperative Brain Health Creatine monohydrate, Placebo - Neurocognitive Disorders, Postoperative Delirium | Not applicable | Not yet recruiting | Massachusetts General Hospital | 120 | 2026-09-01 | 2026-08-10 |
| Lemborexant Use for Cognition Improvement in Postoperative Delirium in Elderly Patients: A Randomized Controlled Trial Lemborexant Pill, Placebo tablet - Postoperative Delirium | Phase 2 | Not yet recruiting | Beijing Tiantan Hospital | 992 | 2026-09-01 | 2026-07-14 |
| Perioperative Transcranial Photobiomodulation and Delayed Neurocognitive Recovery in Older Patients Transcranial photobiomodulation therapy, Transcranial pseudo-photobiomodulation - Older Adults, Surgery | Not applicable | Recruiting | Peking University First Hospital | 130 | 2026-08-05 | 2026-08-10 |
| Dynamic Multimodal Delirium Warning After Cardiac Surgery Postoperative Delirium, Cardiac Surgical Procedures | Not yet recruiting | Southeast University, China | 200 | 2026-07-06 | 2026-07-08 | |
| PROSEVO Trial (Propofol-Sevoflurane Delirium Target Trial Emulation) Postoperative Delirium | Recruiting | Charite University, Berlin, Germany | 100000 | 2026-06-03 | 2026-06-04 | |
| Ketamine and Dexmedetomidine for Delirium in Joint Arthroplasty Ketamine - Postoperative Delirium, Postoperative Cognitive Dysfunction | Not applicable | Not yet recruiting | Istinye University | 80 | 2026-05-05 | 2025-05-09 |
| Opioid-free Anesthesia and Postoperative Delirium OFA group, OBA group - Postoperative Delirium, Gastrointestinal Tumors | Phase 1 | Not yet recruiting | Qianfoshan Hospital | 174 | 2026-05-01 | 2026-05-22 |
| Orthopedic Procedures and Postoperative Delirium in Older Adults in the Czech Republic Frailty, Cognitive Impairment | Recruiting | Tomas Bata Hospital, Czech Republic | 400 | 2026-04-24 | 2026-07-09 | |
| Correlation Between Preoperative Sleep and Postoperative Brain and Renal Dysfunction Postoperative Delirium, Acute Kidney Injury | Completed | Xijing Hospital | 549 | 2026-04-10 | 2026-08-04 | |
| Cognitive Dysfunction and Delirium After TUR-M in Elderly Patients Cognitive and Delirium Assessment (MoCA and CAM) - Postoperative Delirium, Postoperative Cognitive Dysfunction | Recruiting | Muğla Sıtkı Koçman University | 150 | 2026-04-05 | 2026-07-22 | |
| Impact of Esketamine on Delayed Neurocognitive Recovery in Older Patients Esketamine 1, Esketamine 2, Esketamine 3 - Elderly, Noncardiac Surgery | Phase 4 | Not yet recruiting | Peking University First Hospital | 120 | 2026-04-01 | 2026-04-14 |
| EEG-Guided Analgesic Titration During General Anesthesia to Improve Early Neurocognitive Recovery in Older Patients Alpha Optimization, Emergence from anesthesia with Dexmedetomidine - Postoperative Delirium | Not applicable | Not yet recruiting | Columbia University | 600 | 2026-04-01 | 2026-01-07 |
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Emergence Delirium (268) · Postoperative Cognitive Complications (53) · Delirium (32) · Cognitive Dysfunction (18) · Pain, Postoperative (11) · Frailty (7) · Postoperative Complications (7) · Neurocognitive Disorders (5) · Alzheimer Disease (4) · Cognition Disorders (4) · Hip Fractures (4) · Sleep Initiation and Maintenance Disorders (4) · Stroke (4) · Pain (3) · Parkinson Disease (3)
Pathologic Processes (268) · Pathological Conditions, Signs and Symptoms (268) · Neurobehavioral Manifestations (267) · Signs and Symptoms (267) · Confusion (266) · Mental Disorders (266) · Nervous System Diseases (266) · Neurologic Manifestations (266) · Neurocognitive Disorders (263) · Postoperative Complications (261) · Delirium (236) · Cognition Disorders (60) · Cognitive Dysfunction (44) · Brain Diseases (17) · Central Nervous System Diseases (17)
Dexmedetomidine (24) · Propofol (15) · Saline Solution (11) · Mental Status and Dementia Tests (6) · Sevoflurane (6) · Desflurane (4) · Ketamine (4) · Lidocaine (4) · Ropivacaine (3) · remimazolam (3) · Blood Specimen Collection (2) · Cognitive Training (2) · Control Groups (2) · Fentanyl (2) · Isoflurane (2)
Beijing Tiantan Hospital (10) · Charite University, Berlin, Germany (8) · Peking University First Hospital (8) · University Hospital, Basel, Switzerland (6) · Chinese PLA General Hospital (5) · Universitätsklinikum Hamburg-Eppendorf (5) · National University Hospital, Singapore (4) · RenJi Hospital (4) · Xuzhou Central Hospital (4) · Affiliated Hospital of Nantong University (3) · Beijing Chao Yang Hospital (3) · Beth Israel Deaconess Medical Center (3) · General Hospital of Ningxia Medical University (3) · Heart and Brain Research Group, Germany (3) · Henan Provincial People's Hospital (3)
China (85) · United States (25) · Turkey (Türkiye) (23) · Germany (17) · South Korea (7) · Russia (6) · Singapore (6) · Switzerland (6) · United Kingdom (6) · Belgium (5) · Chile (5) · Egypt (5) · Italy (5) · Spain (5) · Thailand (5)
Dong-Xin Wang, MD, PhD (8) · Claudia Spies, MD, Prof. (6) · Liwei Wang, Doctor (4) · Nicolai Goettel, MD (4) · Yangzi Zhu, Doctor (4) · Lian Kah Ti (3) · Jeff Silverstein, MD (2) · Jun Zhang, PhD (2) · Marius Butz, Dipl.-Psych. (2) · Miles Berger, MD, PhD (2) · Tibo Gerriets, Prof.Dr.med. (2) · Valery Likhvantsev (2) · Weidong Mi, PhD (2) · Xinli Ni, doctor (2)
PMID 18577850, PMID 22762316, PMID 28576285, PMID 28593326, PMID 28973626, PMID 10335730, PMID 10839257, PMID 11161124, PMID 11797025, PMID 12145033, PMID 15071384, PMID 15344424, PMID 15851892, PMID 15992223, PMID 16914695, PMID 18219451, PMID 18686756, PMID 19017895, PMID 19106695, PMID 19745202, PMID 19825486, PMID 20007989, PMID 20069607, PMID 20084351, PMID 20373345, PMID 20601860, PMID 20669525, PMID 21037129, PMID 21359918, PMID 21592324, PMID 22032658, PMID 23027226, PMID 23312124, PMID 23426334, PMID 23587637, PMID 23820102, PMID 23835589, PMID 23867200, PMID 23992774, PMID 24206937, PMID 24316434, PMID 24410107, PMID 24517920, PMID 24595780, PMID 24693389, PMID 24931688, PMID 25048507, PMID 25355258, PMID 25375388, PMID 25788770
2019 (2), 2014 (1), 2016 (1), R01AG029656 (1), R01AG046634 (1), R01AG053582 (1), R01AG075005 (1)