8 recruiting, 7 not yet recruiting, 6 completed, 3 unknown. 11 Not applicable, 5 Phase 4, 3 Phase 2, 3 Phase 3, 1 Early Phase 1.
Follow Opioid: new trials by email Literature Review of Opioid trials Research Report on Opioid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| MedSMA℞T Mobile ED MedSMA℞T Mobile - Opiate-Related Disorders, Opiate Use Disorder | Not applicable | Not yet recruiting | Olufunmilola Abraham | 244 | 2027-08-01 | 2026-10-09 |
| Fentanyl Versus Opioid Free Multimodal Analgesia for Perioperative Pain Control in Children With Mild to Moderate Obstructive Sleep Apnea Group A: Fentanyl-Based Analgesia, Group B: Opioid-Free Multimodal Analgesia - Adenotonsillectomy, Obstructive Sleep Apnea (OSA) | Not applicable | Not yet recruiting | Ain Shams University | 64 | 2026-11-30 | 2026-02-27 |
| Suzetrigine in Tonsillectomy for Opioid-sparing Pain Management Suzetrigine, Acetaminophen, oxycodone - Tonsillectomy, Pharyngoplasty | Phase 4 | Not yet recruiting | Stanford University | 58 | 2026-11-01 | 2026-09-16 |
| How Does the Opioid System Shape Stress and Social Behaviour in Men and Women and What Role Does Childhood Unpredictability Play? Morphine, Placebo - Stress, Early Life Stress | Not applicable | Recruiting | Sara L. Kroll | 72 | 2026-09-24 | 2026-09-28 |
| Suzetrigine Post DIEP Suzetrigine Group - Post-operative Pain, DIEP Flap Breast Reconstruction | Phase 3 | Not yet recruiting | Vanderbilt University Medical Center | 198 | 2026-09-01 | 2026-09-24 |
| Dexmedetomidine for Refractory Pain in Palliative Cancer Patients Cancer, Palliative Care, Patient Care | Recruiting | St. Olavs Hospital | 30 | 2026-04-10 | 2026-10-21 | |
| Impact Evaluation of the Therapeutic Initiative's Prescribing Portrait and Therapeutics Letter on Opioid Use by Dentists Regular intervention, Enhanced intervention - Clinical Audit, Quality Improvement | Not applicable | Not yet recruiting | University of British Columbia | 3498 | 2026-01-06 | 2026-01-08 |
| Opioid Consumption After Thoracotomy and Factors Affecting Postoperative Acute Pain Opioid Analgesic, Pain Medicine - Thoracic Anesthesia, Thoracotomy | Completed | Ankara Ataturk Sanatorium Training and Research Hospital | 35 | 2026-01-05 | 2026-11-03 | |
| Two Post-Operative Pain Protocols at Discharge for Orthopaedic Patients Discharge pain medication prescription - Orthopaedic Related Pain (Musculoskeletal Pain), Opioid | Not applicable | Recruiting | Massachusetts General Hospital | 100 | 2025-10-06 | 2026-06-25 |
| Study on the Relationship Between Opioid Drugs and the Therapeutic Efficacy of Immunotherapy Pain Management, Immune Checkpoint Inhibitor | Not yet recruiting | Hubei Cancer Hospital | 100 | 2025-09-17 | 2025-09-23 | |
| The Effect of Opioid Free Anesthesia Using Ultrasound-Guided Bilateral Transversus Abdominus Plane Block and Dexmedetomidine Infusion Opioid Free Anesthesia, Control group (general anesthesia) - Anesthesia, Opioid | Not applicable | Not yet recruiting | Tanta University | 150 | 2025-08-30 | 2025-08-11 |
| Erector Spinae Block in Reducing Peri-operative Opioid Consumption in Total Abdominal Hystrectomy Erector Spinae (ESP) Block with Bupivacaine (Marcaine®), Placebo - Erector Spinae Block, Enhanced Recovery After Surgery (ERAS) Protocol | Phase 4 | Recruiting | Kulsoom International Hospital | 60 | 2025-08-01 | 2025-09-17 |
| Lidocaine-based Versus Opioid-based Induction of Anesthesia in Emergency Laparotomy Lidocaine, Fentanyl, Propofol - Post-induction Hypotension, Lidocaine | Phase 4 | Completed | Cairo University | 149 | 2025-02-01 | 2026-03-05 |
| GLP-1R Agonist Treatment for Opioid Use Disorder Semaglutide Pen Injector, Placebo - Opioid Use Disorder, Opioid Abuse and Addiction | Phase 2 | Recruiting | Milton S. Hershey Medical Center | 200 | 2025-01-27 | 2026-08-28 |
| Evaluation of Virtual Reality for Reducing Opioid Use After Cardiac and Thoracic Surgery Interactive Virtual Reality, Passive Virtual Reality - Heart Surgery, Thoracic Surgery | Not applicable | Recruiting | Filomena R B G Galas | 60 | 2024-12-10 | 2026-04-15 |
| Bilateral Erector Spinae Plane Block as an Opioid Sparing Technique for Selective Dorsal Rhizotomy in Pediatric Patients With Spastic Cerebral Palsy Erector Spinae Plane Block - Erector Spinae Plane Block, Opioid | Not applicable | Completed | Tanta University | 30 | 2024-09-17 | 2025-11-21 |
| Acute Preoperative Pain and Chronic Post-surgical Pain in Emergency Surgery questionnaire, phone call - Chronic Postsurgical Pain, Acute Pain | Not applicable | Recruiting | Centre Hospitalier Universitaire, Amiens | 693 | 2024-08-29 | 2026-01-16 |
| Role of High Frequency RTMS in Management of Opioid Use Disorder rTMS, Psychotherapy - Addiction, Opioid | Not applicable | Enrolling by invitation | Assiut University | 40 | 2024-08-22 | 2024-11-14 |
| Low-Dose Ketamine Infusion During Burn Wound Care Ketamine, 0.9% NaCl - Burn, Pain | Phase 4 | Recruiting | University of Tennessee | 140 | 2024-07-08 | 2024-12-13 |
| Perioperative Analgesia Modes in Minimally Invasive Esophagectomy Preemptive flurbiprofen axetil, Postoperative flurbiprofen axetil, Patient-controlled analgesia pump - Esophageal Cancer, Perioperative Analgesia | Phase 2 / Phase 3 | Unknown | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 102 | 2022-10-10 | 2025-03-20 |
Showing 20 of 26. Sign in to see all of them.
Pain (5) · Agnosia (4) · Pain, Postoperative (4) · Opioid-Related Disorders (3) · Acute Pain (2) · Behavior, Addictive (2) · Labor Pain (2) · Brain Neoplasms (1) · Burns (1) · Cancer Pain (1) · Cerebral Palsy (1) · Chemically-Induced Disorders (1) · Dissociative Disorders (1) · Esophageal Neoplasms (1) · Gambling (1)
Neurologic Manifestations (13) · Pathological Conditions, Signs and Symptoms (13) · Signs and Symptoms (13) · Nervous System Diseases (7) · Pain (7) · Behavior (4) · Mental Disorders (4) · Neurobehavioral Manifestations (4) · Pathologic Processes (4) · Perceptual Disorders (4) · Postoperative Complications (3) · Brain Diseases (2) · Central Nervous System Diseases (2) · Chemically-Induced Disorders (2) · Compulsive Behavior (2)
Fentanyl (3) · Acetaminophen (2) · Analgesics, Opioid (1) · Anesthesia, General (1) · Bupivacaine (1) · Control Groups (1) · Dental Occlusion (1) · Ketamine (1) · Lidocaine (1) · Morphine (1) · Naloxone (1) · Oxycodone (1) · Parapsychology (1) · Propofol (1) · Psychotherapy (1)
Tanta University (2) · Ain Shams University (1) · Alza Corporation, DE, USA (1) · Ankara Ataturk Sanatorium Training and Research Hospital (1) · Assiut University (1) · Baylor College of Medicine (1) · Cairo University (1) · Cancer Institute and Hospital, Chinese Academy of Medical Sciences (1) · Centre Hospitalier Universitaire, Amiens (1) · Filomena R B G Galas (1) · Finnish Institute for Health and Welfare (1) · Hubei Cancer Hospital (1) · Kulsoom International Hospital (1) · Massachusetts General Hospital (1) · Medical University of Warsaw (1)
United States (6) · Egypt (5) · Canada (2) · Turkey (Türkiye) (2) · Brazil (1) · China (1) · Finland (1) · France (1) · Norway (1) · Pakistan (1) · Poland (1) · Switzerland (1)
Arun Aneja, MD PhD (1) · Colin Dormuth, ScD (1) · Eman F Ali,, M.D. (1) · Galen Perdikis, MD (1) · Hannu Alho, Prof. (1) · Harry Neveling, MD, FRCPC (1) · Hulya Bilgin (1) · Jehan Elkholy, M.D. (1) · Jennifer Nyland, PhD (1) · Kareem MA Nawwar, M.D. (1) · Merihan Ahmed, Resident (1) · Mohsen M Waheeb, M.D. (1) · Olufunmilola Abraham, PhD (1)
PMID 17877652, PMID 18380946, PMID 22647429, PMID 23835792, PMID 26154185, PMID 27171828, PMID 30829658, PMID 30997633, PMID 32950246, PMID 33228979, PMID 34053151, PMID 34597955, PMID 35472586, PMID 35925157, PMID 36091708, PMID 36130734, PMID 37355243, PMID 37556082, PMID 40502777, PMID 40914728, PMID 41168808
UH3DA050325 (1)