146 completed, 30 unknown, 12 recruiting, 7 not yet recruiting. 62 Not applicable, 58 Phase 4, 16 Phase 3, 13 Phase 2, 1 Phase 1.
Follow Neuromuscular Blockade: new trials by email Literature Review of Neuromuscular Blockade trials Research Report on Neuromuscular Blockade
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| LIA vs. LIA + ACB-iPACK Block for Total Knee Arthroplasty Local infiltration analgesia, Ultrasound-guided adductor canal block - Nerve Block, Neuromuscular Blockade | Not applicable | Not yet recruiting | Women's College Hospital | 60 | 2027-01-01 | 2025-07-16 |
| Low-Dose Rocuronium Maintenance During Spine Surgery With Intraoperative Neurophysiological Monitoring Low-Dose Rocuronium Maintenance, Rocuronium - Spine Surgery, Intraoperative Neurophysiological Monitoring | Not applicable | Recruiting | Bach Mai Hospital | 62 | 2026-10-07 | 2026-10-16 |
| Effect of Neuromuscular Blockade on Video Laryngeal Mask Airway Ventilation Normal Saline (Rocuronium 0 mg/kg), Rocuronium 0.3 mg/kg, Rocuronium 0.6 mg/kg - Airway Management, Neuromuscular Blockade | Phase 4 | Not yet recruiting | Korea University Guro Hospital | 96 | 2026-09-07 | 2026-09-18 |
| Safety and Efficacy of HRS-9190 Compared to Rocuronium for Tracheal Intubation and Bolus Maintenance in Adults HRS-9190, Rocuronium - Neuromuscular Blockade | Phase 3 | Recruiting | Jiangsu HengRui Medicine Co., Ltd. | 320 | 2026-09-02 | 2026-09-22 |
| TetraGraph to Evaluate Onset and Recovery Times of Rocuronium TetraGraph - Surgery, Neuromuscular Blockade | Not applicable | Enrolling by invitation | Nationwide Children's Hospital | 130 | 2026-08-25 | 2026-09-09 |
| Acceleromyography Versus Electromyography for Neuromuscular Recovery Assessment at the End of Surgery Simultaneous Acceleromyography and Electromyography Monitoring - Neuromuscular Blockade, Cholecystectomy | Not yet recruiting | Clínica Dávila | 70 | 2026-08-01 | 2026-07-31 | |
| Erector Spinae Block vs. Placebo Block Study Erector spinae plane block, Placebo Block - Breast Cancer, Nerve Block | Not applicable | Not yet recruiting | Women's College Hospital | 60 | 2026-06-01 | 2025-07-16 |
| Effect of Sarcopenia and Frailty on Rocuronium Pharmacodynamics in Geriatric Patients Sarcopenia, Frailty | Completed | Konya Meram State Hospital | 100 | 2026-05-13 | 2026-07-28 | |
| Safety and Efficacy of HRS-9190 Compared to Cisatracurium for Continuous Intravenous Infusion in Adults HRS-9190; under Inhalational Anesthesia, HRS-9190; under Intravenous Anesthesia, Cisatracurium (under Inhalational Anesthesia). - Neuromuscular Blockade | Phase 2 | Completed | Jiangsu HengRui Medicine Co., Ltd. | 67 | 2026-04-10 | 2026-09-08 |
| Safety and Efficacy of HRS-9190 Compared to Rocuronium for Bolus Maintenance in Adults HRS-9190, Rocuronium - Neuromuscular Blockade | Phase 2 | Completed | Jiangsu HengRui Medicine Co., Ltd. | 103 | 2026-03-06 | 2026-05-29 |
| Comparison of Two Quantitative EMG Monitors for Deep Neuromuscular Block in Laparoscopic/Robotic and VATS Surgery TetraGraph (Senzime)-Guided Neuromuscular Monitoring (Dominant Hand), TwitchView (Blink)-Guided Neuromuscular Monitoring (Dominant Hand) - Neuromuscular Blockade | Not applicable | Recruiting | Ohio State University | 35 | 2026-02-09 | 2026-07-15 |
| Safety and Efficacy of HRS-9190 Compared to Rocuronium for Tracheal Intubation in Adults HRS-9190 - Neuromuscular Blockade | Phase 2 | Completed | Jiangsu HengRui Medicine Co., Ltd. | 70 | 2025-10-30 | 2026-01-29 |
| Risk of Acute Complications With Rocuronium vs Cisatracurium in Patients With Chronic Kidney Disease Rocuronium, Cisatracurium, Sugammadex - Post Operative Pulmonary Complications, Neuromuscular Blockade | Phase 4 | Recruiting | The University of Texas Medical Branch, Galveston | 490 | 2025-08-26 | 2026-10-20 |
| International Focus Group Discussion on Neuromuscular Monitoring. Focus-Group discussion - Anesthesia, Neuromuscular Blockade | Suspended | Universitair Ziekenhuis Brussel | 16 | 2025-07-01 | 2026-05-04 | |
| NMBA Reversal and Postoperative Urinary Retention Choice of reversal agent (sugammadex or neostigmine [with muscaranic antagonist]) - Neuromuscular Blocking Agents, Urinary Retention After Procedure | Active not recruiting | Beth Israel Deaconess Medical Center | 70000 | 2025-06-08 | 2026-01-23 | |
| Sarcopenia and Neuromuscular Block in Gastrointestinal Cancer Surgery Standard Anesthesia Management - Gastrointestinal Cancer, Sarcopenia | Completed | Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital | 100 | 2025-06-01 | 2026-04-30 | |
| Skeletal Muscle Index and a Neuromuscular Blocking Agent Neuromuscular Blockade | Completed | Seoul National University Bundang Hospital | 90 | 2025-05-09 | 2026-08-21 | |
| Evaluation of Neuromuscular Blockade Responses in Statin-Using and Non-Using Patients TOF (Train-of-Four) monitoring for depth of neuromuscular blockade. - Neuromuscular Blockade, Statin-Associated Myopathy | Not yet recruiting | Ankara City Hospital Bilkent | 104 | 2025-02-15 | 2025-02-19 | |
| Ephedrine for Reducing Onset Time of Rocurinium in Elderly Patients Ephedrine Hydrochloride 30 mg/ml, Saline (NaCl 0,9 %) (placebo) - Neuromuscular Blockade | Phase 4 | Completed | Matias Vested | 80 | 2025-01-13 | 2026-09-11 |
| Abdominal Muscle Volume and a Neuromuscular Blocking Agent preoperative computed tomography - Neuromuscular Blockade | Not yet recruiting | Seoul National University Bundang Hospital | 90 | 2025-01-07 | 2025-01-10 |
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Delayed Emergence from Anesthesia (16) · Postoperative Complications (7) · Critical Illness (4) · Pneumoperitoneum (4) · Pain (3) · Respiratory Distress Syndrome (3) · Arrhythmias, Cardiac (2) · Blood Loss, Surgical (2) · Bradycardia (2) · Frailty (2) · Hip Fractures (2) · Inflammation (2) · Muscle Hypotonia (2) · Pain, Postoperative (2) · Renal Insufficiency (2)
Pathological Conditions, Signs and Symptoms (47) · Pathologic Processes (36) · Signs and Symptoms (17) · Postoperative Complications (16) · Nervous System Diseases (14) · Neurologic Manifestations (14) · Respiratory Tract Diseases (9) · Digestive System Diseases (7) · Disease Attributes (7) · Neuromuscular Manifestations (7) · Urogenital Diseases (7) · Female Urogenital Diseases (6) · Female Urogenital Diseases and Pregnancy Complications (6) · Lung Diseases (6) · Male Urogenital Diseases (6)
Sugammadex (62) · Rocuronium (44) · Neostigmine (34) · cisatracurium (12) · Glycopyrrolate (10) · Atropine (8) · Magnesium Sulfate (8) · Neuromuscular Blockade (7) · Sodium Chloride (7) · Neuromuscular Blocking Agents (5) · Saline Solution (5) · Succinylcholine (5) · Remifentanil (3) · Ropivacaine (3) · Dexamethasone (2)
Merck Sharp & Dohme LLC (15) · Seoul National University Bundang Hospital (8) · Seoul National University Hospital (8) · Copenhagen University Hospital, Rigshospitalet (6) · Herlev Hospital (5) · University Health Network, Toronto (5) · Christoph Czarnetzki (4) · Jiangsu HengRui Medicine Co., Ltd. (4) · Central Hospital, Nancy, France (3) · Pontificia Universidade Catolica de Sao Paulo (3) · Radboud University Medical Center (3) · Technical University of Munich (3) · University Hospital Ulm (3) · University of Texas Southwestern Medical Center (3) · Ankara University (2)
United States (43) · South Korea (22) · Denmark (18) · China (10) · France (10) · Canada (9) · Germany (9) · Italy (9) · Turkey (Türkiye) (9) · Belgium (8) · Brazil (7) · Netherlands (7) · Switzerland (6) · Spain (5) · Czechia (4)
Richard Brull, MD (4) · Manfred Blobner, MD PhD (3) · Tiffany Moon, MD (3) · Ah-Young Oh, MD.,Ph.D. (2) · Aleksandar Beric, MD (2) · Brandon M Togioka, MD (2) · Casper C Kjaer, MD (2) · Eduardo T Moro, MD (2) · Ismar L Cavalcanti, PhD (2) · Jakob L Thomsen, MD (2) · Kim I Albers, MD (2) · Manfred Blobner, M.D. (2) · Matias Vested (2) · Matias Vested, MD, PhD (2)
PMID 24240315, PMID 20595196, PMID 24977638, PMID 25125097, PMID 27405749, PMID 28044330, PMID 30130260, PMID 30985540, PMID 39453841, PMID 4037404, PMID 10201662, PMID 10449559, PMID 10754616, PMID 11465590, PMID 11748387, PMID 12456412, PMID 12638566, PMID 12943357, PMID 15519876, PMID 17307778, PMID 17312210, PMID 17561516, PMID 17562049, PMID 18603747, PMID 18635478, PMID 18769654, PMID 19194156, PMID 1952146, PMID 19713265, PMID 19919585, PMID 20234315, PMID 20442261, PMID 20523215, PMID 20592851, PMID 20592852, PMID 20601860, PMID 20683334, PMID 20851113, PMID 20876699, PMID 20885293, PMID 20996123, PMID 22183158, PMID 22732111, PMID 23344123, PMID 23452344, PMID 23461992, PMID 23573135, PMID 23851450, PMID 24121610, PMID 24305646
2017 (3), 2019 (2), 2008 (1), 2014 (1), U01HL123020 (1), UL1TR002378 (1)